• 대한한의학원전학회지
• /
• 제25권2호
• /
• pp.125-139
• /
• 2012

Objective : This study began with a recognition of the increase in internal disorders caused by functional impairment of the Spleen-Stomach(脾胃) due to modern dietary culture and environment. Method : Way of studying is select and analysis sentences which is include 'Stomach-Yin(胃陰)', 'Stomach-Jin(胃津)', 'Spleen-Stomach-Yin(脾胃陰)', 'Stomach-Yang(胃陽)', 'Spleen-Stomach-Yang (脾胃陽)' in Imjeungjinamuian(臨證指南醫案), and organize relevant paper. Result & Conclusion : In the history of the Spleen-Stomach Theory(脾胃學說), the theoretical mainstream was focused on On-yang(溫養), which was supplemented with methods of sweeten-cool-moisturize(甘凉濡潤) and communication-descent(通降法) by Ye, Tianshi(葉天士). Ye, Tianshi followed the academic theory of Li, Dongyuan(李東垣), putting emphasis on Stomach-gi(胃氣), along with some unique developments of his own. He specifically argued that the Spleen and Stomach be treated separately, and while accepting the methods of Li Dong-yuan in Spleen treatment, asserted that the Stomach-Yin be treated with medicinals with sweet/plain and sweet/cool/moist(甘平與甘凉濡潤) characteristics, and Stomach-Yang be kept firmly, as to prevent obstruction and reflux, by means of medicinals that communicate the Yang softly(通陽柔劑). As a result, the Yin-Yang(陰陽), Dryness-Dampness(燥濕) and Cold-Heat(寒熱) balance of the Yin-Jang (陰臟), Spleen and the Yang-Bu(陽腑), Stomach, the Stomach-Yin and Stomach-Yang was achieved both theoretically and in treatment by means of both communication and supplementation, adding accuracy to clinical application of the Spleen-Stomach Theory.

• 사상체질의학회지
• /
• 제22권2호
• /
• pp.82-92
• /
• 2010

1. Objectives: The purpose of this study is to investigate the anti-aging and anti-oxidative effects of Seungyangikki-tang decoction(SY) in spleen, pancreas and stomach cells of Sprague-Dawley(SD) rats. 2. Methods: This experiment was used by the tissue of spleen, pancreas and stomach cells of 6, 52 and 68 weeks old SD rats. We devided each group by three. One group as normal group was non-treated cells, another group as control group was saline-treated cells, and the other group as experimental group was SY treated cells. After culture for 48 hours, each groups measured the level of SOD, GSH, MDA and NO in the tissue of kidney, bladder and spleen cells. 3. Results and Conclusions: SOD activity was significantly increased in spleen cell of 6, 68w-SY group, pancreas cell of 52,68w-SY group and in stomach cell of 52w-SY group compared with those of the control groups. GSH concentration was significantly increased in spleen cell of 6,68w-SY group and in pancreas cell of 6w-SY group compared with those of the control groups. MDA concentration was significantly decreased in spleen cell of 68w-SY group and in stomach cell of 68w-SY group compared with those of the control groups. NO concentration was significantly decreased in spleen cell of 68w-SY group, stomach cell of 68w-SY group compared with those of the control groups.

• 대한본초학회지
• /
• 제31권4호
• /
• pp.35-41
• /
• 2016

Objective : The purpose of this study is to investigate the anti-oxidative effect of Jeokbaekhaogwanjoong-tang (JGT) distillate in spleen cells of aged rats.Methods : This experiment was performed using spleen cells of 10w, 52w, 72w old sprague dawley (SD) rats. The spleen cells of 10, 52, 72 weeks old rats were divided into three groups; DW group, Vit. C group, and JGT group. The cells of DW group were treated with distilled water. The cells of Vit.C group were treated with Vitamin C. And the cells of JGT group were treated with JGT distillate. After the treatment of DW, Vit.C, and JGT, the levels of superoxide dismutase (SOD), glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA) were measured.Results : In the spleen cells of 72 weeks old rats, SOD activity was significantly increased in the JGT group compared to those in the DW group and the Vit.C group. In the spleen cells of 52 weeks old rats, GSH activity was significantly increased in the JGT group compared to the Vit.C group, and NO concentration was significantly decreased in the JGT group compared to the DW group and the Vit.C group. MDA concentration was not changed significantly in any cell groups by the treatment of JGT distillate.Conclusions : Jeokbaekhaogwanjoong-tang (JGT) distillate may have an anti-oxidative effects in the spleen cells of aged rats. Further investigation is needed for the anti-aging effect of JGT.

• 대한한방소아과학회지
• /
• 제30권2호
• /
• pp.72-81
• /
• 2016

Objectives The purpose of this study is to understand the correlation between spleen deficiency syndrome, body mass index (BMI) and eating habit in children and adolescents and to provide foundation of preventive care and treatment. Methods A survey was conducted with 115 children and adolescents, who were 4th, 5th and 6th grade of elementary school in Gwangju from March 2nd, 2016 to April 8th, 2016. Body mass index (BMI) was calculated using the measured height and weight. Spleen deficiency syndrome and eating habit in children and adolescents were investigated by using the Deficiency of the Spleen Questionnaire and Korean Children's Eating Behaviour Questionnaire (K-CEBQ). A data analysis was performed by using SPSS 23.0 program. Results 1. There was no statistically significant correlation between spleen deficiency syndrome and body mass index (BMI). 2. Children and adolescents with spleen deficiency syndrome were interested in food rather than avoided it. 3. There was a positive correlation between body mass index (BMI) and FR (Food responsiveness), "Food approach". The correlation between the healthy weight group and FR is statistically significant negative correlation. Conclusions Due to various limitations, it is difficult to generalize the correlation between spleen deficiency syndrome, body mass index (BMI) and eating habit in children and adolescents. Therefore additional research is necessary to confirm this study's findings.

• 동의생리병리학회지
• /
• 제24권6호
• /
• pp.911-920
• /
• 2010

The basic principles in the "Spleen-stomach theory(脾胃論)" sets up the phases and roles of spleen-stomach (脾胃) by establishing Earth(地 坤 土) and exposing the reality of spleen-stomach(脾胃) of human body which has its own shape and form with Heaven's reality exhibited. The meaning of Earth is based on the constant meaning of Earth in 'Earth Original-Earth as extended and stable ground(坤元一正之土)' giving form and shape, and Earth's movement with circulation, then exposes itself as 'Earth as plowing land(耕種之土)' concerning both the application of Five Phases and the physical characteristics of Earth. The Yin-Yang recognition on Earth is revealed as Yin Earth(陰土)-Yang Earth(陽土). Spleen(脾) was established as Yin Earth(陰土) and Stomach(胃) as Yang Earth(陽土). The seasonal assignment of Earth is Indian Summer(長夏), which is divided from Summer, and becomes Heat(熱), and the Yin-Yang recognition of Earth comes to be the meaning of the center and border. According to the Five Phasic recognition, it becomes Earth(土) and gets to be Dampness(濕) in accordance with Six Qi(六氣). 'Extreme Yin(至陰)' indicates Qi's status exposing the fundamental meaning regarding the role of creating, changing, and propelling Spleen-Stomach(脾胃) as a characteristic Yin Earth. Earth comprehends 'Four Courses(四維)' meaning, recognizes them as four parts of the 12 Earth's Branches(辰戌丑未) and the terminals of four seasons(四季之末), and has the meaning of the president of the change in four seasons. The theory of principle in the "Spleen-stomach theory(脾胃論)" stands on the basis of the 'Form Qi theory(形氣論)' and that of 'Upbearing, Downbearing, Floating, and Sinking theory(升降浮沈論)'. It manifests the theory of movement in the interaction between Form(形) and Qi(氣), and 'Qi Interior Form Exterior(氣裏形表)' indicates that Qi(氣) moves interiorly and Form(形) exteriorly.

• 혜화의학회지
• /
• 제17권2호
• /
• pp.87-99
• /
• 2008

To investigate the effects of ESWTT on rheumatoid arthritis in collagen-induced arthritis mice model, the animals were orally administrated with the extract following by analyzing the changes of lymphocyte composition in spleen with flow cytometry. These results suggest as follows; 1. ESWTT decreased the total cell number of spleen at 400 and 200 mg/kg about 41% and 32%, respectively. 2. ESWTT reduced the number of CD19+ cells in spleen at 400 and 200 mg/kg about 51% and 46%, respectively. 3. ESWTT down-regulated the number spleen CD3+ cells approximately 26% at 400 mg/kg-treated group. 4. ESWTT decreased the number of CD3+/CD69+ cells in spleen at 400 and 200 mg/kg about 79% and 76%, respectively. 5. ESWTT reduced the number of CD4+ and CD8+ cells in spleen, however, the results were not significant. 6. ESWTT decreased the number of CD4+/CD25+ cells in spleen at 400 and 200 mg/kg about 60% and 56%, respectively. Taken together these results, ESWTT has an efficacy on rheumatoid arthritis through inhibiting the proliferation of lymphocytes such as B and T cells.

• 대한한의학회지
• /
• 제19권2호
• /
• pp.125-136
• /
• 1998

This study is on the etiological factors of the obesity, symptoms of a disease caused by the etiological factors and the method of medical treatment resulted from symptoms of a disease, it is based on Dong-Yi Bo Gam. The conclusion of this study is as follows. 1. The final metabolic of fat is depend on the defensive energy. The shape of fatty layer is changed by the point where the defensive energy is replenish or not. So 'Goin(暠人)' 'Bein(肥人)' and 'Yuckin(肉人)' is made a discriminated and there is defferent between 'Besudaeso(肥瘦大小)' and 'Herlqidaso(血氣多少)'. 2. Etiological factors of obesity is ; essential substance from cereals overcome the primodial energy, spleen and stomach are strong at once, spleen and stomach are weak at once, spleen is disturbed by evil energy, retention of phlegm and fluid, muscle is weak, blood is excess but energy (qi)is weak, hua-sid(華食) eating the sweat food very often, a rich fatty diet. 3. To investigate each syndrome as etiological factons, essential substance from cereals overcome primodial energy is divided into two case: one is the food increase itself because of the weakness of stomach energy (qi), the other is not to digest the food because liver overact spleen by seven emotion. The obesity because of strengthen of the spleen and stomach at once do not feel hungry very well and spleen and stomach do not damaged easily by overacting. The obesity because of weakness of spleen and stomach at once, and disturbace in spleen cause by evil energy, gain the weight even if they eat food a little. Also it is hard to move four limbs. Weakness of muscle is weakness of spleen and stomach. Weakness of muscle is caused by weakness of spleen and stomach. That is the case of faining the weight because of eating food with an empty stomach. The obsity caused by retention of fluid has intestine rumbling and gain the weight suddenly. 4. The method of medical treatment fallowing to the etiological factors: The food is inclined to increase itself caused by weakness of stomach energy, In case of the obseity caused by this phenomenon. We can use Decoction for Reinforcing Middle wanner and Replenishing Qi(補中益氣湯), five tastes il-going-san(左味異功散) and so on. The method of medical treatment on obsity caused by strengthen of spleen and stomach is not referred yet. But we must investigate about using peptic powder(平胃散), ji-chul-huan(枳朮丸) for strengthen of stomach qi (胃氣). If the obesity appear caused by weakness of spleen and stomach and disturbance in spleen as to evil energy, and in the same time stomach qi is weak, we can use li-gong san(異功散). If not only obesity but also indigestion, we can use Decoction for naurishing the stomach and promotion eating(養胃進食湯). If not only obesity but also weakness of spleen and stomach, we can use Decoction for Reinforcing Middle warmer and replenishing Qi(補中益氣湯). The energy being weak, we can use Decoction for six noble drugs(六君子湯). If the obesity appear because of retention of fluid, we can use sin-chul-huan(神朮丸). On the obesit, caused by excess of blood and weakness of qi(血管氣虛), there is not method of mectical treatment yet, but the method of medical treatment that we count of first important maybe to invigorate the spleen and the lung qi and to disperse and recitify the depressed liver energy(疏肝利氣). The method of medical treament about the obesity caused by a rich fatty diet is not mentioned yet, but it is important to improve the lifestyle of food and we think that invigorate the spleen, and the lung-qi(補疏肝氣) and disperse and recitify the depressed liver-energy (??肝利機) amy count of first important. 5.There is useful medicine for weight down for example Herb tea(茶), red bean, wax gourd, etc. 6.The etiological factors of the obesity that revive frequently is weakness of qi(氣虛), from 形成氣衰, deficiency of yang, hasty of qi, damp and so on. The symptoms and sign of a disease that revive frequently to the obesity is appoplexia(中風), leucorrhea, reddish and whitish turbid, feeling of fullness in the upper abdomen, diabetes and so on.

• 한국환경보건학회지
• /
• 제17권2호
• /
• pp.127-139
• /
• 1991

Four group(Control I II, Treatment I II ) of Rats, each consisting of 10 rats, were studied Methylmercury Chloride MMc was orally given to Sprague-Dawley male at does of 10mg/kg (5 mg/kg $\cdot$ day), 10mg/kg after two weeks. This study was designed to investigate the distribution, the difference and the ratio of organic mercury, total mercury, zinc and copper in tissue, in each others group. The result were as follows: 1. There was no significantly difference in the body weight between two groups( p > 0.05). 2. There was significantly difference in the distribution of zinc concentration in liver, kidndey, blood, spleen between control I and treatment I, and in blood, spleen between control II and treatment II (P < 0.05). 3. There was significantly difference in the distribution of copper concentration in kidney, blood between control I and treatment I, and in spleen brain between control II and treatment II. 4. The ratio of zinc concentration in treatment/control was high at spleen. 5. The ratio of methylmercury/totalmercury was high at spleen.

• Fisheries and Aquatic Sciences
• /
• 제3권1호
• /
• pp.23-25
• /
• 2000

To compare the respiratory burst activity potential of the phagocytes isolated from head kidney, spleen, and peripheral blood 1ll cultured rockfish (Sebastes schlegeli), chemiluminescent (CL) response analysis was performed. The phagocytes isolated from peripheral blood showed greater and faster CL response to the opsonized zymosan compared to that of the phagocytes isolated from kidney or spleen. This may imply a significant role of the blood phagocytes in defence mechanism of rockfish. The different responses found in the CL analysis among the phagocytes isolated from peripheral blood, kidney, and spleen may reflect differences in activation state or activity of phagocytes.

• 대한한의학원전학회지
• /
• 제22권4호
• /
• pp.29-32
• /
• 2009

We have explored the five-element pattern of "River Table(河圖)" in the "Naegyeong(內經)", and conclude that this pattern is one of the five-element patterns applied in the "Naegyeong". Based on this pattern, we can exactly understand the eum(陰) and yang(陽) range of five Jang-organs, why the spleen is the extreme eum, why the spleen is the isolated Jang, how the spleen governs four seasons, the ascending and descending of visceral gi(氣), as well as why it can be applied in clinic that the spleen and stomach are the pivot of the ascending and descending of visceral gi(氣).