• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.137-144
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• 1994

Spherical multicellular aggregates of adult rat hepatocytes (spheroid) which have tissue like structure, were formed and immobilized in the pores of polyurethane foam (PUF) which was used as a culture substratum. These hepatocyte/spheroids, about 100 $\mu\textrm{m}$ in diameter, have maintained higher differentiated functions than those of hepatocyte/monolayer for about 3 weeks in serum-free medium. Then, we designed a prototype module of an artificial liver support system using a PUF/spheroid packed-bed, in which hepatocyte/spheroids were immobilized at high density. The urea synthesis activity of the artificial liver was maintained at least 10 days in 100% rat blood plasma. We start examining the performance of hybrid artificial liver in an ex vivo extracorporeal experiment with an acute hepatic failure rat.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2004년도 추계 학술대회논문집
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• pp.131-136
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• 2004

Thermal control of satellite propellant tank is achieved by patch heaters enabled by thermostat's behavior. It is important to attach the thermostat on the appropriate position of the propellant tank. However its position cannot be given with exact numerics because tank is spherical. Actually the position for thermostat is designated in relevant drawing approximately, therby, the engineer practices depending on his own experience and intuition. The sensitivity analysis for the position of thermostat is performed such that the influence on the thermal behavior and control of tank is examined quantatively. When assembling tank module, the reasonable performance on the thermal control is believed with possible human errors if the uncertainty in the position of thermostat is not quite large.

• 한국산업보건학회지
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• 제25권1호
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• pp.95-103
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• 2015

Objectives: This study was conducted in order to better understand the conceptual model and Stoffenmanager nano module and apply it to the synthesis and packing processes of nanomaterials. Methods: Site visits were conducted to five nanomaterial production processes. Product and exposure variables were investigated in these workplaces. Hazard banding and exposure classification of the synthesis and packing processes of nanomaterials were conducted using documents and the website of Stoffenmanager Nano. Results: The five sites featured different products, packing tasks, ventilation and local exhaust, and others. The hazards for nano-nickel and copper were classified as E. The hazards for both fumed silica and indium tin oxide were classified as D. The hazard for spherical silica was classified as C. The exposure classes in the synthesis process of nanomaterials ranged from 2 through 4. The exposure classes in the packing process of nanomaterials ranged from 1 through 4. Conclusions: Application of Stoffenmanager nano to the synthesis and packing processes of nanomaterials helped to better understand the control level of the work environment and to suggest appropriate actions. The comparison of each process showed the effect of the production process and handling of solids and ventilation on exposure class.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.129-130
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• 1994

The science of toxicology is the understanding of the mechanisms by which exogenous agents produce deleterious effects in biological systems. The actions of chemicals such as drugs are ultimately exerted at the cellular and gene levels. Over the past decade. several in vitro alternative methods such as cultured cells for assessing the toxicity of various xenobiotics have been proposed to reduce the use of animals. In this workshop three advanced methods will be presented. These methods are novel important models for toxicologic studies. Dr. Tabuchis group has establishcd two immortalized gastric surface mucosa cell lines from the pminary cultore of gastric fundic mucosal cells of adult transgenic mice harboring a temperature sensitive simian virus 40 large T-anugen gene. As the immortalized cell lines of various tissues possess unique characteristics to maintain their normal functions for several months, these cell lines are extremely useful for not only toxicity testing but also pharmacological screening in new drug development. Professor Funatsu have studied the formation of spherical multicelluar aggregates of adult rat hepatocytes(spheroid) having tissue like structure. The sphcroid shown thre is a prototype module of an artificial liver support system. Thus, the urea synthesis activity of the artificial liver was maintained at least to days in 100％ rat blood plasma. Dr. Takezawa and his coworkers have developed a novel culture system of multicellular spheroids considered 〃organoids〃 by utilizing a thermo-responsive polymer as a substratum of anchorage dependent cells. His final goal is to reconstitute the organoids of various normal organs, e.g., liver, skin etc. and also abnormal deseased organs such as tumor.

• 한국항행학회논문지
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• 제3권2호
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• pp.139-146
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• 1999

비행 시뮬레이터는 엔진 모듈, 항법장치 모듈, 계기 모듈로 구성된다. 여기에는 두 가지의 문제점을 가지고 있다. 첫째는, 각 모듈별로 사용하는 좌표계가 서로 다르다는 점이다. 이를 해결하기 위해 본 논문에서는 각기 독자적인 좌표계를 일치시키기 위한 방법을 고안하였다. 둘째는, 지구 형태가 완전한 구 모양을 따르고 있다고 가정하고 구 삼각공식을 이용하여 거리와 방위각을 계산하게 되면 많은 연산량이 요구된다. 본 논문애서는 근거리 비행시 구 삼각공식 대신 평면 근사화 방식을 사용함으로써 우수한 결과를 얻음을 확인하였다. 연산 속도는 구 삼각공식 사용시 $4.95{\times}10^{-4}$초에서 평면 근사화 방식을 사용시 $1.648{\times}10^{-4}$초로 향상됨을 확인하였다.

• 한국광학회지
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• 제4권3호
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• pp.243-251
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• 1993

두개의 모듈(module)로서 이루어진 telephoto형 망원경 대물렌즈의 각각의 모듈에 대해 Seidel 1차 수차중 구면수차계수와 코마계수를 영으로 하고, 또 종색수차계수를 영으로 하는 조건을 Gauss괄호를 써서 표현하고, 이어서 이들 연립방정식의 해를 구함으로서 눈으로 직접 관찰하는데 쓰이는 조준용광학계의 최초설계가 유도되었다. 이어서 눈의 분해능에 걸맞게 최적화 수치계산을 수행하여서 최종설계를 얻었다. Aplanat조건을 만족하고 색수차가 제거된 이 telephoto 형 망원경 대물렌즈의 f/${\sharp} 와 half field angle은 각각 8.5, 0.$3^{\circ}$이고 초점거리와 telephoto ratios 는 각각 30cm, 0.839이었다.

• Ocean Systems Engineering
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• 제11권4호
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• pp.313-330
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• 2021

In this study, the dynamic interaction between an Arctic Spar and drifting level ice is examined in time domain using the newly developed ice-hull-mooring coupled dynamics program. The in-house program, CHARM3D, which is the hull-riser-mooring coupled dynamic simulator is extended by coupling with the open-source discrete element method (DEM) simulator, LIGGGHTS. In the LIGGGHTS module, the parallel-bonding method is implemented to model the level ice using an assembly of multiple bonded spherical particles. As a case study, a spread-moored Artic Spar platform, whose hull surface near waterline is the inverted conical shape, is chosen. To determine the breaking-related DEM parameter (the critical bonding strength), the four-point numerical bending test is used. A series of numerical simulations is systematically performed under the various ice conditions including ice drift velocity, flexural strength, and thickness. Then, the effects of these parameters on the ice force, platform motions, and mooring tensions are discussed. The simulations reveal various features of dynamic interactions between the drifting ice and moored platform for various ice conditions including the novel synchronous resonance at low ice speed. The newly developed simulator is promising and can repeatedly be used for the future design and analysis including ice-floater-mooring coupled dynamics.

• 한국터널지하공간학회 논문집
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• 제25권2호
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• pp.101-120
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• 2023

전기비저항 탐사 방법은 매질의 표면에 관입된 두 전극의 전위차와 전류와의 관계를 통해 전기 저항을 측정하고, 형상 계수를 이용하여 매질의 고유한 특성인 전기비저항을 계산한다. 현장 및 실대형 크기의 전기비저항 실험은 전극과 매질 사이의 접촉 면적이 적고, 전극 간 거리가 충분하기 때문에 계산상 편의를 위해서 동일한 표면적을 가진 반구형으로 치환하여 전기비저항을 산정한다. 하지만, 실내 소규모 크기의 전기비저항 실험은 전극의 지오메트리(전극의 관입 깊이, 전극사이의 거리, 전극의 길이와 반지름 크기)로 인해서, 등전위면과 전류 흐름이 달라지게 되므로, 궁극적으로 전기비저항값의 오차를 야기한다. 본 연구는 기존 연구에서 유도된 4가지 전극 형상(반구, 원기둥, 반구형 팁을 가진 원기둥, 콘형 팁을 가진 원기둥)에 따른 전기 저항 이론식을 정리하고, 전극 형상을 고려한 전기 저항 수치 해석을 실시하였으며, 이론식과 수치 해석 결과들의 비교를 통해서 개발된 수치 해석 모듈을 검증하였다. 또한, 각 전극 형상에 따른 전극 주변과 전극사이에 형성된 전기 저항 분포를 분석하였다. 추가적으로, 현장 전기비저항 탐사에서 주로 사용되는 콘형 팁을 가진 원기둥 전극의 전기적 특성에 따른 전류 흐름 분포를 고찰하였다.

• Journal of Microbiology and Biotechnology
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• 제26권10호
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• pp.1746-1754
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• 2016

Recently, spherical beads entrapping quorum quenching (QQ) bacteria have been reported as effective moving QQ-media for biofouling control in MBRs for wastewater treatment owing to their combined effects of biological (i.e., quorum quenching) and physical washing. Taking into account both the mass transfer of signal molecules through the QQ-medium and collision efficiencies of the QQ-medium against the filtration membranes in a bioreactor, a cylindrical medium (QQ-cylinder) was developed as a new shape of moving QQ-medium. The QQ-cylinders were compared with previous QQ-beads in terms of the QQ activity and the physical washing effect under identical loading volumes of each medium in batch tests. It was found that the QQ activity of a QQ-medium was highly dependent on its specific surface area, regardless of the shape of the medium. In contrast, the physical washing effect of a QQ-medium was greatly affected by its geometric structure. The enhanced anti-biofouling property of the QQ-cylinders relative to QQ-beads was confirmed in a continuous laboratory-scale MBR with a flat-sheet membrane module.

• 한국항공우주학회지
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• 제32권7호
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• pp.126-132
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• 2004

위성 추진제 탱크의 열제어는 써모스탯에 의해 작동되는 히터를 이용해 수행된다. 적절한 위치에 써모스탯을 부착하는 것이 관건이지만 구형 탱크에서는 부착위치를 수치적으로 정확하게 부여하는 것이 불가능하다. 실제로는 도면에 대략적으로 위치를 제시한 후 작업자의 경험과 판단에 의존하여 써모스탯을 부착하는 것이 현실이다. 그러므로 써모스탯의 부착위치에 대한 민감도 해석을 수행함으로써 그에 따른 탱크의 열적 거동 및 열제어에 미치는 영향을 정량적으로 파악하였다. 실제 탱크 모듈 조립시 써모스탯의 부착위치에 대한 오차가 존재하더라도 설계 도면에 명시된 값보다 크게 벗어나지 않는 한 탱크의 열제어 성능은 충분히 보장되리라 판단된다.