• 한국해안·해양공학회논문집
• /
• 제26권1호
• /
• pp.9-15
• /
• 2014

암석과 같은 입자들로 구성된 구조체의 거동을 일반적인 요소망을 이용한 유한요소해석으로 구현하기 어렵다. 이는 입자로 구성된 구조체의 거동 해석시 입자간의 상호작용을 무시할 수 없기 때문이다. 본 연구에서는 입자로 구성된 구조체(rock-berm)의 분할에 Smooth Particle Hydrodynamics (SPH) 기법을 이용하여 충돌해석을 수행하고 이를 기존의 Lagrange 기법을 사용한 해석결과와 비교하여 SPH 기법의 적용 가능성을 알아보았다. 결과적으로 SPH 기법이 입자로 구성된 구조체의 충돌해석에 사실적인 모사가 가능한 것으로 파악되었다.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.263.2-264
• /
• 2002

SPH-l is a herbal medicine composing oriental prescription. We have studied the antidiabetic effect and mechanism of SPH-l in insulin-resistant diabetic db/db mice. Mice were grouped and treated for 3 weeks as follows: control group was administrated with tap water orally: treated group was administrated with SPH-l orally at dose of 500 mg/kg. SPH-l lowered plasma glucose level by 67% as compared to the diabetic control (omitted)

• 한국항공우주학회지
• /
• 제43권1호
• /
• pp.8-22
• /
• 2015

지금까지 인젝터의 수치적 시뮬레이션은 대부분 Eulerian 기법의 바탕위에서 이루어져 왔다. 그러나 액체제트의 미립화현상과 복잡한 공기와의 경계면 변화를 나타내는데 있어 기존의 기법들이 갖는 선천적인 단점이 존재하며 따라서 본 연구에서는 새로운 Smoothed Particle Hydrodynamics(SPH)라는 입자 기법을 도입하였다. 수치적 시뮬레이션을 위해 먼저 해석을 위한 SPH 코드를 개발하였으며 본 논문에서는 인젝터 문제를 정확하게 나타내는데 있어 필수적인 알고리즘중 하나인 다상유동모사에 대한 검증문제가 제시 되어 있다. 마지막으로 다양한 인젝터 종류 중 하나인 액체-액체 동축형 스월 인젝터에 대한 시뮬레이션이 수행되었으며 실제실험과의 비교를 진행하였다.

• Interaction and multiscale mechanics
• /
• 제1권2호
• /
• pp.251-278
• /
• 2008

In this study, we investigate the discontinuous-derivative treatment at the gas-liquid interface in underwater explosion (UNDEX) problems by using the Moving Least Squares-Smoothed Particle Hydrodynamics (MLS-SPH) method, which is known as one of the particle methods suitable for problems where large deformation and inhomogeneity occur in the whole domain. Because the numerical oscillation of pressure arises from derivative discontinuity in the UNDEX analysis using the standard SPH method, the MLS shape function with Discontinuous-derivative Basis Function (DBF) that is able to represent the derivative discontinuity of field function is utilized in the MLS-SPH formulation in order to suppress the nonphysical pressure oscillation. The effectiveness of the MLS-SPH with DBF is demonstrated in comparison with the standard SPH and conventional MLS-SPH though a shock tube problem and benchmark standard problems of UNDEX of a trinitrotoluene (TNT) charge.

• 천문학회보
• /
• 제40권1호
• /
• pp.74.3-74.3
• /
• 2015

We present 2D- photometric decompositions of ~1,200 nearby dwarf galaxies. Our representative sample is derived from 'A catalog of Visually classified galaxies in the Local Universe'(Ann, Seo and Ha APJS,,,2015) of which galaxy morphological types are determined by visual inspection of color images using the Sloan Digital Sky Survey data release 7. In this catalog, dwarf galaxies were divided into 5 subtypes : dS0, dE, dSph, dEbc, dEblue with distinction of the presence of nucleation in dE, dSph, and dS0. The dSph types are less brighter than other types, and galaxies with nuclei are slightly brighter than those with no nuclei in the same types. Sersic index n have a range 1~1.5, and $dE_{un}$ and $dSph_{un}$ galaxies have n less than 1, and $dSph_n$ galaxies have largest values. We performed two-dimensional decomposition of galaxies using GALFIT, and analyzed their structural components, and residual features which are seen in the residual image.

• 대한유전성대사질환학회지
• /
• 제20권1호
• /
• pp.1-13
• /
• 2020

Gaucher disease (GD)는 glucocerebrosidase 유전자(GBA)의 돌연변이에 의하여 발병하는 전세계적으로 가장 유병율이 높은 리소좀 축적질환이다. GD는 신경학적인 증상의 유무에 따라 3가지 임상형으로 구분된다. 신경병증 GD인 2형과 3형의 경우는 대뇌에서 glucosylceramide (GlcCer)와 glucosylsphingosine (GlcSph)의 농도가 증가하면서 신경세포의 심각한 손실이 야기되는 특징을 보인다. 신경교종에서 유래한 H4 세포를 GD에서 증가하는 기질인 GluCer와 GlcSph를 첨가하여 배양하였을 때, 심각한 DNA손상과 더불어 세포의 사멸이 야기되는 것과 이러한 신경세포의 사멸은 GluCer 보다는 GlcSph을 처리하였을 때 더 현저하게 증가하는 것을 관찰하였다. H4 세포에 히스톤 탈아세틸화 효소(HDAC) 6의 저해제인 tubacin과 GlcSph을 함께 처리하였을 경우에는 DNA손상은 물론 GlcSph에 의하여 유도된 세포사멸과 관련된 단백질 인자들의 발현이 모두 감소되었다. 본 연구를 통해 GlcSph이 세포사멸을 통하여 신경병증 GD의 발병에 주요한 역할을 한다는 것을 알 수 있었고, HDAC6 저해제가 신경병증 GD 환자를 위한 치료제 후보물질로 제시될 수 있는 가능성을 확인하였다.

• International Journal of Naval Architecture and Ocean Engineering
• /
• 제11권2호
• /
• pp.796-808
• /
• 2019

In this paper, a Smoothed Particle Hydrodynamics (SPH) method is extended to simulate the ice failure process and ice-ship interactions. The softening elastoplastic model integrating Drucker-Prager yield criterion is embedded into the SPH method to simulate the failure progress of ice. To verify the accuracy of the proposed SPH method, two benchmarks are presented, which include the elastic vibration of a cantilever beam and three-point bending failure of the ice beam. The good agreement between the obtained numerical results and experimental data indicates that the presented SPH method can give the reliable and accurate results for simulating the ice failure progress. On this basis, the extended SPH method is employed to simulate level ice interacting with sloping structure and three-dimensional ice-ship interaction in level ice, and the numerical data is validated through comparing with experimental results of a 1:20 scaled Araon icebreaker model. It is shown the proposed SPH model can satisfactorily predict the ice breaking process and ice breaking resistance on ships in ice-ship interaction.

• 한국축산식품학회지
• /
• 제36권1호
• /
• pp.8-13
• /
• 2016

This study investigated the effect of soy protein hydrolysates (SPH) prepared by varying subcritical media on the physicochemical properties of pork patties. For resource of SPH, two different soybean species (Glycine max Merr.) of Daewonkong (DWK) and Saedanbaek (SDB) were selected. SPH was prepared by subcritical processing at 190℃ and 25 MPa under three different of media (water, 20% ethanol and 50% ethanol). Solubility and free amino group content revealed that water was better to yield larger amount of SPH than ethanol/water mixtures, regardless of species. Molecular weight (Mw) distribution of SPH was also similar between two species, while slightly different Mw distribution was obtained by subcritical media. For pork patty application, 50% ethanol treatment showed clear red color comparing to control after 14 d of storage. In addition, ethanol treatment had better oxidative stability than control and water treatment based on thiobarbituric acid-reactive substances (TBARS) analysis. For eating quality, although 20% ethanol treatment in SDB showed slightly higher cooking loss than control, generally addition of SPH did not affect the water-binding properties and hardness of pork patties. Consequently, the present study indicated that 50% ethanol was the best subcritical media to produce SPH possessing antioxidant activity, and the SPH produced from DWK exhibited better antioxidant activity than that produced SDB.

• 한국치위생학회지
• /
• 제8권2호
• /
• pp.53-66
• /
• 2008

There was to purpose of this study improves analyzing cause that prosthesis brings bite engaging that is inaccurate in patient's mouth, when supposed that all conducts that do in operatory and dental laboratory are perfect. Impression did check bite by alginate impression material and polymerization style silicon impression material that use usually in presence at a sickbed Irreversibility, hydrocolloid, alginate impression material washed in flowing water and poured anhydrite after wait about 8 minutes so that region that charge interest after impression check bite may become undoing. And hydrophile property addition polymerization style impression material poured anhydrite after blow 30 considering impression material dwell time and H2 gas occurrence time (5~15 minute) after have washed in flowing water. I got each 7 models, result that manufactures total 28 and measures by third dimension measuring instrument (Meteo, Korea) following sequence curing in tray holder and floor 1, By Alginate impression when is hardened in tray holder and when is hardened in the floor after do check bite, SPH 4, SPH5 all as there is synonymy appeared(P<0.05). By in case do not use average 0.1741 in case use tray holder in 0.0447 SPH5s in case do not use average 0.2838 pastas in case use tray holder in SPH4 0.0309, When did not use both SPH4 and SPH5 tray holder, when used tray holder, 1 appeared more greatly. 2. By amity sex addition polymerization style silicon impression when is hardened in tray holder after do check bite and when is hardened in the floor SPH 4, a11 of the SPH5s very big synonymy be(P>0.05). And in case use tray holder in 0.000657 pasta SPH5s in case do not use average 0.000129 pastas in case use tray holder in SPH4 average 0.000114 pastas, by in case do not use 0.000757, I appeared more greatly when used tray when did not use both SPH4 and SPH5 tray holder, but 1 appeared is not level to keep in mind(Table 8~9). 3 SPH4 was looked very big mindfulness in model that manufacture doing impression check bite by Alginate and model that do impression check bite by amity sex accessory penalty silicon without using tray holder(P< 0.001). I use tray holder and SPH4 did not appear synonymy in model that manufacture doing impression check bite by Alginate and model that do impression check bite by amity sex accessory penalty silicon(P>0.05). Study finding of above when see synthesis Alginate certainly tray holder use must and I could know that hardening method does not exert big influence on volume stability if remove impression sieve of excess because amity sex accessory penalty silicon passes over tray, Also, Alginate impression material previewed can get heading a conspiracy style that volume stability of accessory penalty silicon impression material degree is if use tray holder.

• BMB Reports
• /
• 제41권2호
• /
• pp.119-125
• /
• 2008

Our previous work confirmed that Sph2/LA1029 was a sphigomyelinase-like hemolyisn of Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai. Characteristics of both hemolytic and cytotoxic activities of Sph2 were reported in this paper. Sph2 was a heat-labile neutral hemolysin and had similar hemolytic behavior as the typical sphingomyelinase C of Staphylococcus aureus upon sheep erythrocytes. The cytotoxic activity of Sph2 was shown in mammalian cells such as BALB/C mouse lymphocytes and macrophages, as well as human L-02 liver cells. Transmission electron microscopic observation showed that the Sph2 treated BALB/C mouse lymphocytes were swollen and ruptured with membrane breakage. They also demonstrated condensed chromatin as a high-density area. Cytoskeleton changes were observed via fluorescence confocal microscope in Sph2 treated BALB/C mouse lymphocytes and macrophages, where both cytokine IL-$1{\beta}$ and IL-6 were induced. In addition, typical apoptotic morphological features were observed in Sph2 treated L-02 cells via transmission electron microscope and the percentage of apoptotic cells did increase after the Sph2 treatment detected by flow cytometry. Therefore, Sph2 was likely an apoptosis-inducing factor of human L-02 liver cells.