• Archives of Pharmacal Research
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• 제12권4호
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• pp.289-294
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• 1989

A computer program which can differentiate compounds whose absorbance spectra are very similar was developed. The program. [SPECMAN PLUS], written in Pascal provides automated spectral comparison techniques, utilizing the values of Root Mean of Squares (RMS) of differences. This comparison routine of the program can deal with spectra of compounds different concentrations and different spectral recording resolutions. In addition, the program was designed applicable to any spectral data of digital form. The program was applied to the UV spectra of 13 pencillins and 5 cephalosporins, whose absorbance spectra are so similar. As a result, all compounds examined could be differentiated from each other.

• Journal of applied mathematics & informatics
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• 제5권2호
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• pp.465-474
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• 1998

Results on the analytic behavior to the limiting spectral distribution of matrices of sample convariance type. studied in Marcenko and Pastur [2] are derived. using the Stieltjes transform it is shown that the limiting distrbution has a continuous derivative away from zero the derivative being analytic whenever it is positive and the behavior of it resembles the behavior of a square root function near the boundary of its support.

• Journal of applied mathematics & informatics
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• 제16권1_2호
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• pp.483-488
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• 2004

Results on the analytic behavior of the limiting spectral distribution of large dimensional random matrices, studied in Marcenko and Pastur [2], are derived. Using the Stieltjes transform, it is shown that the limiting distribution has a continuous derivative away from zero, the derivative being analytic whenever it is positive [3]. In the present paper, it is derived that the behavior of it resembles the behavior of a square root function near the boundary of its support.

• 약학회지
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• 제35권1호
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• pp.1-6
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• 1991

Fast Hartley transform(FHT) was used for the identification of derivative UV spectra of pharmaceuticals, with the advantages of relatively shorter computing time of FHT and more precise results. The arccosine value of dot product of two vectors of normalized FHT coefficients calculated from two compared derivative spectra was a reasonable parameter for the spectral identification. Using this parameter, the similar patterns of derivative spectra of 13 penicillins can be differenciated from each other. The concentration difference and the minor contamination did not interfere the results of identification procedures. All these procedures of identification were accomplished successfully by the computer program, [SPECMAN PLUS] version 1.30, which was developed for this article.

• Journal of Biosystems Engineering
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• 제22권2호
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• pp.247-255
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• 1997

This study was conducted to develop regression models predicting sugar and acid contents in intact fruits nondestructively by using the second derivative of absorbance spectrum measured with a spectrophotometer wavelength range of 400nm to 2, 400nm. The correlation analysis was made in wavelength range of 600nm to 1, 100nm and 600nm to 2, 400nm respectively, in order to examine the feasibility of using a real time spectrophotometer, which covers the former range, in predicting sugar and acid contents. The second derivative data of the spectrum were obtained by varying smoothing size and derivative size of the original absorbance spectrum. SAS statistical package program was used for the regression analysis. The sugar contents of Fuji apple, Shingo pear md Yumyung peach could be predicted with SEPs of 0.40, 1.17 and 0.77 respectively, in the spectrum range of 600 to 1, 100nm. The highest correlation coefficient of the titratible acidity of apple was -0.45 at 2, 346nm and regression models indicated determination coefficient less than 0.47.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2001년도 추계학술대회 논문집
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• pp.169-172
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• 2001

There are many people who suffer from simulation sickness when immersing in virtual reality. In this study, we analyzed two photoplethysmogram(PPG) parameters - a second derivative parameter and power spectral density ratios - in order to relate PPG parameters with simulation sickness. 36 young, healthy subjects were participated in the experiment, and each subject was equipped with a PPG electrode during his or her immersion. Simulation sickness section was defined as a 7 - second section which starts from the point where a subject reported simulation sickness, and normal section as a same-length section where no physical stimuli was presented to him or her. We compared the PPG parameters of the simulation sickness sections with the normal sections, - d/a ratio is believed to have lower value during vasodilation and higher value during vasoconstriction, however, we could not find much difference in the parameter between normal and simulation sickness sections. We also compared 1 to 10Hz power spectral density ratios in normal sections with in simulation sickness section, and found that 6 density ratios among them have different value. Therefore, the density ratios might be utilized as parameters to detect simulation sickness of subjects.

• 약학회지
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• 제30권4호
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• pp.185-192
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• 1986

Authors developed the computer application program (language: APPLE SOFT BASIC) for derivative spectrophotometry. By means of this program, derivative of spectral absorbance with respect to wavelength is recorded versus wavelength. To try this program in connection with spectrophotometer system, the authors have done the simultaneous quantitation of pyridoxine center dot HCl and nicotinamide in the mixture, and the result was compared with that of absorbance method.

• 한국지리정보학회지
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• 제16권4호
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• pp.16-28
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• 2013

최근 초분광영상의 활용 연구사례와 다양한 분광지수들의 개발과 평가가 지속적으로 증가하고 있다. 특히 식생원격탐사 분야에서는 식생의 스트레스와 활력에 대한 지표로 식생지수가 사용되며 일반적으로 NIR과 red 파장대의 두 개 혹은 이상의 분광밴드를 선택적으로 사용하고 있다. 항공 초분광영상은 좁고 연속적인 수많은 밴드를 가지기 때문에 식생지수를 위한 밴드선택에 혼돈을 야기할 수 있다. 만약 식생지수를 개발하는 과정에서 사용된 밴드와 항공기를 이용해 취득한 센서의 밴드정보와 동일하지 않다면, 탐지 대상의 광학특성에 대한 설명력이 높은 적절한 밴드를 선택하는 것이 필요하다. 따라서 본 연구에서는 NIR과 red 파장영역에 속하는 4개의 후보밴드를 선택하고 이들의 조합으로 계산된 NDVI(normalized difference vegetation index)와 MSRI(modified simple ratio index)를 산출하였다. 산출된 식생지수들에 대해서 각 지수들의 변이를 살펴보기 위해 변화탐지 기법의 차연산(image differencing)을 이용하였다. 또한 보다 직접적인 분석을 위해서 분광미분(spectral derivative)을 통하여 임상도로 구분되는 식생의 종류별 분광특성을 가장 잘 설명할 수 있는 밴드를 확인하였다. 연구 결과로 후보밴드들 중에서 red #3(680.2nm)와 NIR #2(801.7nm)가 수림에 영향을 적게 받고 밴드의 변동이 적은 적절한 밴드로 선택할 수 있었다.

• 대한수학회지
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• 제51권1호
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• pp.203-224
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• 2014

We propose and analyze a spectral Jacobi-collocation approximation for fractional order integro-differential equations of Fredholm-Volterra type. The fractional derivative is described in the Caputo sense. We provide a rigorous error analysis for the collection method, which shows that the errors of the approximate solution decay exponentially in $L^{\infty}$ norm and weighted $L^2$-norm. The numerical examples are given to illustrate the theoretical results.

• Bulletin of the Korean Chemical Society
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• 제32권1호
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• pp.109-112
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• 2011

A new derivative of tacrolimus was evaluated for its molecular weight, using LC-MS of the tacrolimus bulk active pharmaceutical ingredient (API) recovered through the purification of crude tacrolimus produced by Streptomyces clavuligerus CKD-1119. In addition, the molecular weight of the new derivative of tacrolimus was found to be at m/z 818 and was identified by $^{13}C$-NMR with peak assignments based on the differences in methyl group location resulting from the chemical structure. The structure of the new derivative, an unknown impurity of tacrolimus, was found to be 18-methyltacrolimus through comparison of the spectral data of the structural differences between ascomycin, tacrolimus, and the new derivative 18-methyltacrolimus.