• Journal of Life Science
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• v.20 no.7
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• pp.1005-1011
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• 2010

$\gamma$-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. GABA transporters (GATs) control extracellular GABA levels by reuptake of released GABA from the synaptic cleft. However, how GATs are regulated has not yet been elucidated. Here, we used the yeast two-hybrid system to identify the specific binding protein(s) that interacts with the carboxyl (C)-terminal region of GAT1, the major isoform in the brain and find a specific interaction with the ubiquitin-specific protease 14 (Usp14), a deubiquitinating enzyme. Usp14 protein bound to the tail region of GAT1 and GAT2 but not to other GAT members in the yeast two-hybrid assay. The C-terminal region of Usp14 is essential for interaction with GAT1. In addition, these proteins showed specific interactions in the glutathione S-transferase (GST) pull-down assay. An antibody to GAT1 specifically co-immunoprecipitated Usp14 from mouse brain extracts. These results suggest that Usp14 may regulate the number of GAT1 at the cell surface.

• Journal of the Society of Naval Architects of Korea
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• v.57 no.2
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• pp.61-69
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• 2020

Due to its flexibility of the composite propeller blade, it is necessary to design a shape capable of generating a desired load at a design point in consideration of the shape change of the propeller. In order to design it, we need to evaluate not only the hydrodynamic force around it, but also its structural response of flexible propeller according to its deformation. So, it is necessary to develop a design tool to predict the hydroelastic performance of a flexible propeller with deformation considering fluid-structure interaction and special operating conditions. Finally a design optimization tool for flexible propellermade of CFRP is required. In this study, a design methodology of the specific flexible composite propeller is suggested, considering fluid-structural interaction analysis of the specific flexible propeller.

• The Journal of Korea Robotics Society
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• v.18 no.4
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• pp.463-471
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• 2023

This paper proposes a method to estimate the level of interest shown by visitors towards a specific target, a guide robot, in spaces where a large number of visitors, such as exhibition halls and museums, can show interest in a specific subject. To accomplish this, we apply deep learning-based behavior recognition and object tracking techniques for multiple visitors, and based on this, we derive the behavior analysis and interest level of visitors. To implement this research, a personalized dataset tailored to the characteristics of exhibition hall and museum environments was created, and a deep learning model was constructed based on this. Four scenarios that visitors can exhibit were classified, and through this, prediction and experimental values were obtained, thus completing the validation for the interest estimation method proposed in this paper.

• Korean Management Science Review
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• v.20 no.2
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• pp.81-93
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• 2003

These days we come across many wicked problems whose solutions are beyond individuals intellectual ability. These problems can be resolved through collaborative group interaction. We developed an internet-based asynchronous group interaction support system, after looking into the collaborative problem solving process and the IBIS (Issue-Based Information System) argumentation model. It has the following characteristics ; 1) it is developed based on the modified IBIS model which is a model for group interaction to resolve wicked problems ; 2) it supports both processes of seeking and comparing solutions, while most similar systems do not have a feature to support the latter process ; 3) different structures can be defined dynamically according to the purpose of group interaction, so that it could be used for collaborative problem solving in a specific domain. To show the usability of the system, we carried out an experiment, whose result is shown at the end.

• 제어로봇시스템학회:학술대회논문집
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• 1987.10b
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• pp.63-68
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• 1987

In this study, a pantograph leg of the four legged walking vehicle is analysed with regard to mechanical energy consumption. Energy efficiency of the vehicle is estimated in terms of specific resistance varying body height, stride length and walking speed. The interaction between specific resistance and the parameters is investigated.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.30 no.2
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• pp.145-166
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• 2019

While a significant number of user-related models have been presented in Human Information Behavior (HIB) research community, the basic assumption of the present study is most of those models including information interaction models are multi-domain models associated with comprehensive research components. Based on such an assumption, this study discusses the shortcomings of multi-domain models and proposes the need to present a new type of model. Accordingly, the study elaborates four essential models of HIB reach community and presents a new type of model based on Specific Domain Focus Modeling (SDFM). As an example of such modeling, this study presents the present author's information retrieval interaction model based on the degree of connections between systems and information resources.

• The Plant Pathology Journal
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• v.24 no.3
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• pp.337-351
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• 2008

Host-pathogen interaction in rice bacterial blight pathosystem was analyzed for a better understanding of their relationship and recognition of stable pathogenicity among the populations of Xanthomonas oryzae pv. oryzae. A total number of 52 bacterial strains isolated from diseased leaf samples collected from 12 rice growing states and one Union Territory of India, were inoculated on 16 rice varieties, each possessing known genes for resistance. Analysis of variance revealed that the host genotypes(G) accounted for largest(78.4%) proportion of the total sum of squares(SS), followed by 16.5% due to the pathogen isolates(I) and 5.1% due to the $I{\times}G$ interactions. Application of the Additive Main effects and Multiplicative Interaction(AMMI) model revealed that the first two interaction principal component axes(IPCA) accounted for 66.8% and 21.5% of the interaction SS, respectively. The biplot generated using the isolate and genotypic scores of the first two IPCAs revealed groups of host genotypes and pathogen isolates falling into four sectors. A group of five isolates with high virulence, high absolute IPCA-1 scores, moderate IPCA-2 scores, low AMMI stability index '$D_i$' values and minimal deviations from additive main effects displayed in AMMI biplot as well as response plot, were identified as possessing stable pathogenicity across 16 host genotypes. The largest group of 27 isolates with low virulence, small IPCA-1 as well as IPCA-2 scores, low $D_i$ values and minimal deviations from additive main effect predictions, possessed stable pathogenicity for low virulence. The AMMI analysis and biplot display facilitated in a better understanding of the host-pathogen interaction, adaptability of pathogen isolates to specific host genotypes, identification of isolates showing stable pathogenicity and most discriminating host genotypes, which could be useful in location specific breeding programs aiming at deployment of resistant host genotypes in bacterial blight disease control strategies.

• Proceedings of the Korean Society of Toxicology Conference
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• 2004.11a
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• pp.23-25
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• 2004

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2006.11a
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• pp.113-120
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• 2006

In this paper, generation mechanisms of ocean freak waves are briefly introduced in the context of wave-current interaction phenomena. As an accurate and efficient numerical tool, the spectral element method is presented with general features and specific treatment for the wave-current interaction problem. The present model of the fluid motion is based on the Navier-Stokes equations incorporating a velocity-pressure formulation. In order to deal with the free surface motion, an Arbitrary Lagrangian-Eulerian (ALE) description is adopted. As an intermediate stage of development, solution procedure and characteristic aspects of the present modeling and numerical method features are addressed in detail, and numerical results for wave-current interaction is left as further study.

• International Journal of CAD/CAM
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• v.9 no.1
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• pp.93-102
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• 2010

Shaping realistic hairstyles for digital characters is a difficult, long and tedious task. The lack of appropriate interaction metaphors enabling efficient and simple, yet accurate hair modeling further aggravates the situation. This paper presents 3D interaction metaphors for modeling virtual hair using haptic interfaces. We discuss user tasks, ergonomic aspects, as well as haptics-based styling and fine-tuning tools on an experimental prototype. In order to achieve faster haptic rates with respect to the hair simulation and obtain a transparent rendering, we adapt our simulation models to comply with the specific requirements of haptic hairstyling actions and decouple the simulation of the hair strand dynamics from the haptic rendering while relying on the same physiochemical hair constants. Besides the direct use of the discussed interaction metaphors in the 3D modeling area, the presented results have further application potential in hair modeling facilities for the entertainment industry and the cosmetic sciences.