• 환경생물
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• 제22권2호
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• pp.247-258
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• 2004

Climatological, hydrological and planktonical research studies, measurements of primary production and photosynthetic efficiency from December 1976 to December 1978 have been carried out in two brackish lakes: Lake Etang de Berre and Lake Etang de Vaine located in the French Mediterranean coast, in the region of Carry-le-Rouet located on the north-west Mediterranean near Marseilles, and in fresh water inflows from 4 Rivers (Touloubre, Durance, Arc, Durancole) to Lake Etang de Berre. Physico-chemical parameters were measured for this study: water temperature, salinity, density, pH, alcalinity, dissolved oxygen (% saturation), phosphate, nitrate, nitrite, silicate etc. Diverse biological parameters were also studied: photosynthetic pigments, phaeopigments, specific composition and biomass of phytoplankton, primary pelagic production etc. Climatical factors were studied: air-temperature, solar-radiation, evaporation, direction (including strength) of winds, precipitation and freshwater volume of the four rivers. The changes in Lake ‘Etang de Berre’ ecosystem depend on the quality of the water in the Durance River, and on the effects of seawater near the entrance of the Caronte Canal. The water quality of the lake varies horizontally and vertically as a result of atmospheric phenomena, maritime currents and tides. The distribution of water temperatures is generally heterogeneous. Southeasterly winds and the Northeasterly Mistral wind are important in the origins of circulated and mixed water masses. These winds are both frequent and strong. They have, as a result, a great effect on the water environment of Lake Etang de Berre. In theory, the annual precipitation in this region is well over eight times the water mass of the lake. The water of the Durance River flows into Lake Etang de Berre through the EDF Canal, amounting to 90% of the precipitation. However, reduction of rainfall in dry seasons has a serious effect on the hydrological characteristics of the lake. The temperature in the winter is partially caused by the low temperature of fresh water, particularly that of the Durance River. The hydrological season of fresh and brackish water is about one month ahead of the hydrological season of sea water in its vicinity. The salinity of Lake Etang de Berre runs approximately 3$\textperthousand$, except at lower levels and near the entrance to the Caronte Canal. However, when the volume of the Durance River water is reduced in the summer and fall, the salinity rises to 15$\textperthousand$. In the lake, the ratio of fresh water to sea water is six to one (6:1). The large quantities of seston conveyed by rivers, particularly the Durance diversion, strongly reduce the transparency in the brackish waters. Although the amount of sunshine is also notable, transparency is slight because of the large amount of seston, carried chiefly by Tripton in the fresh water of the Durance River. Therefore, photosynthesis generally occurs only in the surface layer. The transparency progressively increases from freshwater to open seawater, as mineral particles sink to the bottom (about 1.7kg $m^{-2}a^{-1}$ on the average in brackish lakes). The concentration of dissolved oxygen and the rate of oxygen saturation in seawater (Carry-le-Rouet) ranged from 5.0 to 6.0 $m\ell$ㆍ.$1^{-1}$, and from 95 to 105%, respectively. The amount of dissolved oxygen in Etang de Berre oscillated between 2.9 and 268.3%. The monographs of phosphate, nitrate, nitrite and silicate were published as a part of a study on the ecology of phytoplankton in these environments. Horizontal and vertical distributions of these nutriments were studied in detail. The recent diversion of the Durance River into Lake Etang de Berre has effected a fundamental change in this formerly marine environment, which has had a great impact in its plankton populations. A total of 182 taxa were identified, including 111 Bacillariophyceae, 44 Chlorophyceae, and 15 Cyanophyceae. The most abundant species are small freshwater algae, mainly Chlorophyceae. The average density is about $10^{8}$ cells $1^{-1}$ in Lake Etang de Berre, and about double that amount in Lake Etang de Vaine. Differences in phytoplankton abundance and composition at the various stations or at various depths are slight. Cell biovolume V (equivalent to true biomass), plasma volume VP (‘useful’ biomass) and, simultaneously. the cell surface area S and S/V ratio through the measurement of cell dimensions were computed as the parameters of phytoplankton productivity and metabolism. Pigment concentrations are generally very high on account of phytoplankton blooms by Cyanophyceae, Chlorophyceae and Cryptophyceae. On the other hand, in freshwaters and marine waters, pigment concentrations are comparatively low and stable, showing slight annual variation. The variations of ATP concentration were closely related to those of chlorophyll a and phytoplankton blooms only in marine waters. The carbon uptake rates ranged between 38 and 1091 mg$Cm^{-2}d^{-1}$, with an average surface value of 256 mg; water-column carbon-uptake rates ranged between 240 and 2310 mg$Cm^{-2}d^{-1}$, with an average of 810, representing 290 mg$Cm^{-2}$, per year 45 000 tons per year of photosynthetized carbon for the whole lake. Gross photosynthetic production measured by the method of Ryther was studied over a 2-year period. The values obtained from marine water(Carry-le-Rouet) ranged from 23 to 2 337 mg$Cm^{-2}d^{-1}$, with a weighted average of 319, representing about 110 gCm$^{-2}$ per year. The values in brakish water (Etang de Berre) ranged from 14 to 1778 mg$Cm^{-2}d^{-1}$, with a weighted average of 682, representing 250 mg$Cm^{-2}$ per year and 38 400 tons per year of photosynthesized carbon for the whole lake.

• Journal of Preventive Medicine and Public Health
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• 제30권1호
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• pp.77-101
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• 1997

In September 1994, residents of Gozan-dong, Incheon City, made a petition to the government about their health problems which might be caused by previous glass fibre landfill nearby 'H' company. In february 1995, at regular academic meeting of occupational and environmental medicine, a research team of 'D' University presented that they had found glass fibres in groundwater of the area through their survey. They were suspicious of probable association between ingestion of groundwater contaminated with glass fibres and skin tumors among residents. A joint research team was formed and carried out the survey of environment concerning groundwater and its glass fibre existence, and health assessment of residents in the area and industrial workers of 'H' company during May to November, 1995. Analysis of groundwater flow system indicates that the flow lines from the glass fibre landfill pass through or terminate at the 6 houses around the landfill. This means that the groundwater of the 6 houses around the glass fibre landfill could be affected by some possible contaminants from the landfill, but the groundwater quality of the other houses was irrelevant to the landfill. The qualitative and qualitative analyses for glass fibres in 54 groundwater samples including those from the nearby 6 houses, were carried out using SEM equipped with EDS, resulting in no evidence for the presence of glass fibres in the waters. Major precipitates, formed in waters while boiling, were identified as calcium carbonates, in particulary, aragonites in needle form. The results of health assessments of 889 residents in Gozan-dong, participated in this study, showed statistically significant differences in past medical histories of skin tumor and respiratory disease between the exposed group (31 persons who inhabited in 6 houses around the landfill) and the control group, but no significant differences in past medical histories of other diseases, such as cancer mortality, current gastroscopic findings, current skin diseases and respiratory diseases, etc. Also, we could not prove any glass fibres in excised specimens of 9 skin tumors in both groups and there were no health problems possibly associated with glass fibres in employees of the 'H' company. After all, we could not authenticate the association, raised by prior investigators, between groundwater streams, assumedly contaminated with glass fibres or not, and specific disease morbidities or common disease/symptom prevalences. That is, we could not find any glass fibres in groundwater as the only exposure factor of this study hypothesis, and there were not enough certain evidences such as increasing disease prevalences, for examples, skin, respiratory and gastrointestinal diseases etc, possibly related to glass fibre exposure, in exposed group. As a matter of course, the conditions for confirming causal association, for example, strength of the association, consistency of the association, specificity of the association, temporality of the association and dose-response relationship etc, have not been satisfied. In conclusion, we were not able to certify the hypothesis that contamination of groundwater with glass fibres might cause any hazardous health effects in residents who used it for drinking.

• 지능정보연구
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• 제17권1호
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• pp.153-169
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• 2011

오늘날 기업의 마케팅에 있어 인터넷 환경의 이용은 필수적이며, 좀 더 효율적인 마케팅을 위해 다양한 방법들이 시도되고 있다. 기업들은 온라인마케팅을 통해 다양한 경품이나 포인트 등의 마케팅 비용을 사용하는 것으로 제품이나 서비스를 알려왔다. 특히 웹 2.0의 등장과 함께 기업은 좀 더 적극적으로 고객과 소통하기 위한 노력을 아끼지 않고 있다. 고객들은 회사의 웹사이트에 개인정보를 제공하는 형태로 회원가입을 하여 회사가 제공하는 혜택을 받으면서 제품 광고나 프로모션에 참여하게 된다. 그러나 온라인 마케팅의 운영측면에서 볼 때 현재의 회원관리 시스템은 회원의 모집과 운영에 있어서 효과적이지 못한 문제점이 나타나고 있다. 온라인 환경에서의 고객들은 오프라인 환경에서보다 명확한 자아를 덜 드러내기 때문에 회원가입 과정 중에 일부 악의적인 목적을 가진 고객들이 주변인의 개인정보를 이용하거나 조작하여 중복 아이디를 만들어 활동할 수 있게 된다. 이러한 취약점을 이용하여 중복가입 회원들은 고객들에게 돌아가야 할 경품이나 포인트 등을 가로채어 기업 마케팅 비용의 효율을 떨어뜨리고 있다. 그러나 증가하고 있는 마케팅 비용에 비해 중복회원의 선별 및 이들에 대한 제재를 위한 효과적 방법은 뚜렷하게 제시되지 않고 있다. 따라서 이를 방지하기 위한 체계적인 회원관리 시스템이 요구된다. 본 연구에서는 소셜 네트워크 분석 기법을 이용한 중복회원 식별방법을 제시하고 실제 온라인 고객데이터를 이용하여 그 효과성을 검증한다. 소셜 네트워크는 노드들의 관계를 표현하며, 관계의 유무, 방향 및 강도 등으로 연결 형태를 나타낼 수 있다. 특히 컴포넌트 분석방법은 소셜 네트워크 하위그룹 분석방법으로 네트워크의 내부 그룹을 구분하여 다양한 네트워크 특성을 식별하여 준다. 회원정보 분석에 있어 컴포넌트 분석방법은 전제회원 데이터 내의 의미 있는 정보를 이루고 있는 그룹을 식별하게 된다. 본 연구는 H사의 서로 다른 회원가입 기준을 가진 3개 웹사이트의 회원정보를 사용하여 진행되었다. 제안된 분석방법은 중복회원의 실체를 분석하고 시각화함으로써, 실무적인 측면에서 효율적인 마케팅의 증진을 도울 뿐만 아니라 신뢰성 있는 고객의 의견수렴 및 의사결정에도 도움이 될 것으로 기대된다.

• 한국유가공학회:학술대회논문집
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• 한국유가공기술과학회 2002년도 제54회 춘계심포지움 - 우유와 국민건강
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• pp.59-60
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• 2002

Edible films such as wax coatings, sugar and chocolate covers, and sausage casings, have been used in food applications for years$^{(1)}$ However, interest in edible films and biodegradable polymers has been renewed due to concerns about the environment, a need to reduce the quantity of disposable packaging, and demand by the consumer for higher quality food products. Edible films can function as secondary packaging materials to enhance food quality and reduce the amount of traditional packaging needed. For example, edible films can serve to enhance food quality by acting as moisture and gas barriers, thus, providing protection to a food product after the primary packaging is opened. Edible films are not meant to replace synthetic packaging materials; instead, they provide the potential as food packagings where traditional synthetic or biodegradable plastics cannot function. For instance, edible films can be used as convenient soluble pouches containing single-servings for products such as instant noodles and soup/seasoning combination. In the food industry, they can be used as ingredient delivery systems for delivering pre-measured ingredients during processing. Edible films also can provide the food processors with a variety of new opportunities for product development and processing. Depends on materials of edible films, they also can be sources of nutritional supplements. Especially, whey proteins have excellent amino acid balance while some edible films resources lack adequate amount of certain amino acids, for example, soy protein is low in methionine and wheat flour is low in lysine$^{(2)}$. Whey proteins have a surplus of the essential amino acid lysine, threonine, methionine and isoleucine. Thus, the idea of using whey protein-based films to individually pack cereal products, which often deficient in these amino acids, become very attractive$^{(3)}$. Whey is a by-product of cheese manufacturing and much of annual production is not utilized$^{(4)}$. Development of edible films from whey protein is one of the ways to recover whey from dairy industry waste. Whey proteins as raw materials of film production can be obtained at inexpensive cost. I hypothesize that it is possible to make whey protein-based edible films with improved moisture barrier properties without significantly altering other properties by producing whey protein/lipid emulsion films and these films will be suitable far food applications. The fellowing are the specific otjectives of this research: 1. Develop whey protein/lipid emulsion edible films and determine their microstructures, barrier (moisture and oxygen) and mechanical (tensile strength and elongation) properties. 2. Study the nature of interactions involved in the formation and stability of the films. 3. Investigate thermal properties, heat sealability, and sealing properties of the films. 4. Demonstrate suitability of their application in foods as packaging materials. Methodologies were developed to produce edible films from whey protein isolate (WPI) and concentrate (WPC), and film-forming procedure was optimized. Lipids, butter fat (BF) and candelilla wax (CW), were added into film-forming solutions to produce whey protein/lipid emulsion edible films. Significant reduction in water vapor and oxygen permeabilities of the films could be achieved upon addition of BF and CW. Mechanical properties were also influenced by the lipid type. Microstructures of the films accounted for the differences in their barrier and mechanical properties. Studies with bond-dissociating agents indicated that disulfide and hydrogen bonds, cooperatively, were the primary forces involved in the formation and stability of whey protein/lipid emulsion films. Contribution of hydrophobic interactions was secondary. Thermal properties of the films were studied using differential scanning calorimetry, and the results were used to optimize heat-sealing conditions for the films. Electron spectroscopy for chemical analysis (ESCA) was used to study the nature of the interfacial interaction of sealed films. All films were heat sealable and showed good seal strengths while the plasticizer type influenced optimum heat-sealing temperatures of the films, 130$^{\circ}$C for sorbitol-plasticized WPI films and 110$^{\circ}$C for glycerol-plasticized WPI films. ESCA spectra showed that the main interactions responsible for the heat-sealed joint of whey protein-based edible films were hydrogen bonds and covalent bonds involving C-0-H and N-C components. Finally, solubility in water, moisture contents, moisture sorption isotherms and sensory attributes (using a trained sensory panel) of the films were determined. Solubility was influenced primarily by the plasticizer in the films, and the higher the plasticizer content, the greater was the solubility of the films in water. Moisture contents of the films showed a strong relationship with moisture sorption isotherm properties of the films. Lower moisture content of the films resulted in lower equilibrium moisture contents at all aw levels. Sensory evaluation of the films revealed that no distinctive odor existed in WPI films. All films tested showed slight sweetness and adhesiveness. Films with lipids were scored as being opaque while films without lipids were scored to be clear. Whey protein/lipid emulsion edible films may be suitable for packaging of powder mix and should be suitable for packaging of non-hygroscopic foods$^{(5,6,7,8,)}$.

• 해양환경안전학회지
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• 제26권1호
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• pp.103-113
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• 2020

잭업 드릴링 리그 (Jack-up drilling rigs)는 해양자원개발 분야 중 석유 및 가스 탐사 산업에서 널리 사용되는 대표적인 해양구조물이다. 이러한 잭업 구조물은 대체로 얕은 수심에서 사용하도록 설계되었지만 에너지 산업의 추세로 대수심 및 가혹한 환경 조건에서도 사용이 가능한 설계가 요구되고 있다. 이러한 잭업구조물의 운영환경 확장에 따라서 과도한 설계를 최소화하고 신뢰성 반영된 설계법이 요구되었다. 기존의 해양구조물 산업에서 잭업 구조물의 설계법은 사용(혹은 허용)응력 설계 (WSD: Working (or Allowable) Stress Design) 방법을 사용하여 설계가 되고 있었다. 이러한 설치환경변화에 따라서 충분한 신뢰성을 확보가 가능한 하중 및 저항계수 (LRFD: Load and Resistance Factored Design) 방법을 최근 개발되었고 규정화가 되었다. LRFD 방법은 통계적 기반으로 한 한계상태설계 개념으로 잭업구조물의 구성구조부재의 하중과 전산수치해석을 이용한 강도의 불확성을 하중 및 저항 계수로 표현하는 설계법이다. 개발된 LRFD 방법은 실제 잭업구조물 설계의 적합성 판단을 위하여 기존의 WSD 방법과의 정량적인 비교 분석이 반드시 필요하다. 따라서 본 연구는 기존의 WSD와 LRFD 방법으로 이용하여 실 잭업 구조물의 레그 구조를 대상으로 상용유한요소해석코드를 이용하여 정량적인 UC (Unity Check)값을 기반으로 비교 분석하였다. 분석된 결과로 다양한 환경하중조건 하에서 LRFD 방법을 사용하여 잭업구조물의 레그(Leg) 설계에서 상당히 합리적인 UC 값을 가지고 기존 대표적인 WSD기법 중에 하나인 API-RP 코드 대비 약 31 % 차이가 분석되었다. 따라서 LRFD 설계 방법이 WSD 방법에 비해 구조 최적화 및 합리적인 설계에 더 유리하다는 것을 확인할 수 있었다.

• 한국건설순환자원학회논문집
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• 제1권1호
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• pp.89-97
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• 2005

최근 천연골재 자원의 고갈과 환경규제의 강화로 인해 콘크리트용 잔골재의 수급문제가 건설산업분야에서 시급히 해결해야할 문제로 대두되고 있어 폐기콘크리트를 활용한 재생잔골재의 콘크리트용 잔골재로의 활용을 위한 연구가 활발히 진행되고 있다. 한편 화학발전소 및 열병합발전소에서 발생되는 석탄회는 그 발생량이 계속적으로 증가하고 있으며, 석탄회중 플라이애시를 콘크리트용 혼화재료로서 사용할 경우 시공성 및 점성 개선, 장기강도 증가 및 수화열 저감 등 많은 장점으로 인하여 보통 콘크리트에서의 활용이 증가하고 있는 실정이나, 재생콘크리트의 혼화재로 활용하기 위한 연구는 미미한 실정이다. 따라서 본 연구에 서는 재생잔골재 및 플라이애시 대체율에 따른 굳지않은 특성, 경화특성, 내구특성을 실험 실증적으로 검토 분석함으로서 재생잔골재를 콘크리트용 잔골재로 활용할 수 있을 뿐만 아니라 플라이애시를 재생콘크리트의 혼화재로 활용하기 위한 기초자료를 제시하고자 하였다. 연구 결과 재생잔골재를 대체한 경우 굳지않은 성상, 정화성상 및 내구성상이 재생잔골재 100%을 치환했을 때 천연잔골재를 사용한 콘크리트와 유사한 수준으로 나타나 콘크리트용 잔골재로서 재생산골재의 활용이 가능한 것으로 사료되었으며, 플라이애시를 고품질 재생잔골재를 사용한 재생콘크리트용 혼화재로 활용함으로서 시공성, 공학적 특성 및 내구특성 등의 성능이 향상되는 것을 확인할 수 있었다.

• 대한토목학회논문집
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• 제31권3A호
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• pp.235-249
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• 2011

I형 PSC 거더에 새로운 설계 개념을 도입하여 낮은 형고의 장경간 거더를 설계하고, 실험을 통해서 적용성을 점검하였다. 본 연구에서 제안하는 거더는 복부에 개구부를 도입한 분절형 중공 프리캐스트 프리스트레스트 콘크리트 거더(HWPC거더, Holed Web Prestressed Concrete girders)이다. 이 거더의 설계에는 세 가지 설계 개념이 종합적으로 적용되었다. 먼저 장경간의 거더를 공장에서 프리캐스트로 타설하여 양생을 마친 후에 현장으로 운반하는 방법을 채택하여 현장에서 거더를 제작하는 경우보다 콘크리트의 품질 관리가 용이하게 하여 고강도 및 고성능 콘크리트를 적용하는 것이 가능하게 하였다. 또한 거더를 분절화하여 제작하여 국내의 도로 여건에서도 장경간 거더를 공장에서 현장으로 이동시킬 수 있게 하였다. 이로써 현장에서의 작업 기간도 단축시킬 수 있다. 두 번째로 거더의 복부에 원형의 개구부를 도입하여, 단부 정착장치의 반을 이 개구부 내에 이동하여 분산 배치하여, 분절 거더의 조립에 사용하였다. 개구부에 정착부를 분산 배치하면 단부에 설치되는 정착장치가 줄어들게 되므로 단부에 작용하는 응력이 줄어들게 된다. 아울러 자연스레 단부에 도입되는 휨모멘트는 줄어들고, 중앙부에 큰 휨모멘트가 도입되므로 외력으로 인한 휨모멘트 분포에 더 가까운 형상의 부모멘트를 거더에 도입할 수 있다. 거더에 개구부를 도입하면 거더 자중도 줄어든다. 그리고, 세째로 단부에 설치되는 정착구의 수가 줄기 때문에 단부에서는 다이아프램을 제거하고도 정착이 가능하다. 이렇게 거더의 전 단면에 걸쳐서 같은 폭의 복부폭을 사용하면 거더 제작을 자동화 하는데도 도움이 될 것이다. HWPC거더의 설계 기법을 검증하고, 다단계 긴장의 효과 및 실제교량에 적용할 때 발생할 수 있는 문제점을 고찰하기 위하여 실물 실험을 수행하였다. 길이 50 m, 높이 2 m인 거더 실험체를 분절형과 일체형으로 각각 1개씩 제작하여 휨실험을 수행하고, 결과를 비교하여 분석하였다. 분절형 거더와 일체형 거더는 처짐 및 균열생성 형상에서 근본적으로 유사하였다. 휨 강도, 처짐, 활하중 처짐제한 규정 등이 특정 설계기준을 만족하도록 설계하는 것이 가능하였다.

• 근관절건강학회지
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• 제8권1호
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• pp.122-140
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• 2001

The aims of this study were to understand and to predict the determinent factors affecting the exercise behaviors and physical fitness by testing the Pender's revised health promotion model, and to help the patients with rheumatoid arthritis and osteoarthritis perform the continous exercise program, and to help them maximize the physical effect such as muscle strength, endurance, and functional status and mental effects including self efficacy and quality of life, and improve the physical and mental well being, and to provide a basis for the nursing intervention strategies. Of the selected variables in this study, the endogenous variables included the physical fitness, exercise score, exercise participation, perceived benefits of action, perceived barriers of action to exercise, activity-related affect(depression) and perceived self-efficacy, interpersonal influences(family support), situational factors(duration of arthritis, fatigue) and the exogenous variables included personal sociocultural factor(education level), personal biologic factor(body mass index), personal psychologic factor(perceived health status) and prior related behavior factors(previous participation in exercise, life-style). We analyzed the clinical records of 208 patients with rheumatoid arthritis and degenerative arthritis who visited the outpatient clinics at H university hospital in Seoul. Data were composed of self reported qustionnaire and good of fitness score which were obtained by padalling the ergometer of bicycle for 9 minutes. SPSS Win 8.0 and Window LISREL 8.12a were used for statistical analysis. Of 75 hypothetical paths that influence on physical fitness, exercise participation, exercise score, perceived benefits of action, perceived barriers of action to exercise, activity-related affect(depression) and perceived self-efficacy, interpersonal influences(family support), situational factors(duration of arthritis, fatigue), 40 were supported. The physical fitness was directly influenced by life-style, perceived health status, education level, family support, fatigue, which explained 12% of physical fitness. The exercise participation were directly influenced by life-style, education level, past exercise behavior, perceived benefits of action, perceived barriers of action, depression and duration of arthritis, which explained 47% of exercise participation. Exercise score were directly affected by perceived self efficacy. BMI, life-style, past exercise behavior, perceived benefits of action, family support, perceived health status. perceived barriers of action, and fatigue, which explained 70%. Perceived benefits of action was directly influenced by BMI, life-style, which explained 39%. Perceived barriers of action were directly influeced by past exercise behavior, perceived health status, which explained 7%. Perceived self efficacy were directly influeced by level of education, perceived health status, life-style, which explained 57%. Depression were directly influeced by past exercise behavior, BMI, life-style, which explained 27%. Family support were directly influeced by life-style, perceived health status, which explained 29%. Fatigue were directly influeced by BMI, life-style, perceived health status. which explained 41%. Duration of arthritis were directly influeced by life-style, past exercise behavior, BMI, which explained 6%. In conclusion, important variables for physical fitness were life-style, and variable affecting exercise participation were life-style. Perceived self-efficacy of exercise was a significant predictor of exercise score. BMI, Life-style, perceived benefits of action, family support, past exercise behavior showed direct effects on perceived self-efficacy. Therefore, disease related factor should be minimized for physical performance and well being in nursing intervention for patients with rheumatoid arthritis, and plans to promote and continue exercise should be seeked to reduce disability. In addition, Exercise program should be planned and performed by the exact evaluation of exercise according to the ability of the patients and the contents to improve the importance of exercise and self efficacy in self control program, dedicated educational program should be involved. This study suggest that the methods to reduce the disease related factors, the importance of daily life-style, recognition of benefit of exercise, and educational program to promote self efficacy should be considered in the exercise behavior promotion and nursing intervention for continous performance. The significance of this study is also thought to provide patients with chronic arthritis the specific data for maximal physical and mental well being through exercise, chronic therapeutic procedure, daily adaptation and confrontation in nursing intervention.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6227-6232
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• 2012

Interleukin-4 receptor (IL-4R) gene single nucleotide polymorphisms (SNPs) are implicated in cancer development. However, results from the published reports have remained inconclusive. The objective of this study was to conduct a meta-analysis investigating the association between polymorphisms in IL-4R gene and cancer risk. Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) were searched for case-control studies published up to October 30, 2012 that investigated IL-4R polymorphisms and cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of any associations. Three IL-4R polymorphisms (Q576R, rs1801275; I75V, rs1805010; S503P, rs1805015) in 21 case-control studies were analyzed. Our meta-analysis indicated that these three polymorphisms are not associated with cancer risk when all studies were pooled together. In the subgroup analysis by tumor site, the results showed that Q576R G allele carriers were associated with a significantly decreased cervical cancer risk (recessive model: OR = 0.77, 95%CI = 0.60-0.98; homozygote comparison: OR = 0.76, 95%CI = 0.58-0.98). I75V G allele carriers were associated with a decreased risk of renal cancer (dominant model = 0.71, 95%CI = 0.57-0.89, heterozygote comparison: OR = 0.69, 95%CI = 0.55-0.87). When stratified by ethnicity, Q576R G allele carriers were associated with a decreased cancer risk in Caucasians (dominant model: OR = 0.90, 95%CI = 0.83-0.98; heterozygote comparison: OR = 0.89, 95%CI = 0.82-0.98). I75V G allele carriers were associated with a decreased cancer risk in Asians (heterozygote comparison: OR = 0.76, 95%CI = 0.62-0.94). S503P C allele carriers were also associated with a decreased cancer risk in Asians (CC VS TT: OR = 0.29, 95%CI = 0.08-0.99). Our results suggest that Q576R, I75V and S503P may be associated with a decreased cancer risk for certain types of cancers and in some specific ethnic groups. Future case-control studies with large sample size are needed to evaluate these associations in detail.

• Journal of Preventive Medicine and Public Health
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• 제20권1호
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• pp.10-39
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• 1987

Mortality rate and causes of death are regarded as an index of strength as well as level of development of a country. However, there is no accurate data for the causes of death in Korea due to lack of systematic vital data collection system. The objective of this study was to define the causes of death of the school teachers, its changing pattern, cause-specific mortality rate, and geographic variation. The study population included all of the teachers in primary school, middle and high schools, and college who joined in Korean Teachers' Union between 1968 and 1985 that provided a total of 1,972, 069 person-years to observe (1,384,911 man-years, 587,158 woman-years). There were 3,678 deaths in this period (3,377 males, 301 females). The most common cause of death was neoplasm which was followed by the diseases of circulatory system. The proportion of death of neoplasm was 1.5 times higher than that of the general population. Causes of death were classified into 5 major groups (neoplasm, diseases of circulatory system, accidents and poisoning, diseases of liver, and all others). The mortality rates of diseases of circulatory system and all others for general population were 4 to S times higher than those for the teachers. However, mortality rates of neoplasm and diseases of liver were only about 2 times higher than those for teachers. Mortality rate of liver cancer for teachers was higher than gastric cancer mortality rate which is the reverse in general population. The crude death rate was 2.12 per 1,000 person-years for male and 1.00 for female which is one-third of the crude death rate of general population. Crude death rate of study population was higher in rural area than in urban area. However, mortality rate of neoplasm for male was higher in urban area than in rural area while mortality rates of all other causes were higher in rural area. For female, mortality rates of neoplasm and diseases of circulatory system were higher in urban area and the rates for all other causes were higher in rural area. Crude death rate was lowest in Gyeongin area and highest in Yeongnam area. The mortality of neoplasm for male accounted the highest proportion of all death in Gyeongin, Chungcheong and Yeoungnam areas while the mortality of neoplasm and mortality of circulatory system accounted the same proportion in Jeonra area. For female, the mortality of disease of circulatory system accounted the highest proportion in Gyeongin and Yeoungnam and Jeonra areas. Proportion of death due to accidents and poisoning was high in Chungcheong area and death due to all other causes was high in Yeoungnam area. The most common cause of death for male by city and province was neoplasm in Seoul, Busan, Daegu, Gyeonggi, Chungnam, Chungbuk, Gyeongnam and Gyeongbuk. Diseases of circulatory system was the leading cause of death in the rest of city and provinces. The leading cause of death for female was diseases of circulatory system in Seoul, Incheon, Chungbuk, Chungnam, and Gyeongbuk, neoplasm in Busan, and accident and poisons in all other cities and provinces. The mortality rates of male were above 2 per 1,000 person-years in Jeju, Gyeongbuk, Gyeongnam, Daegu, and Chungbuk, and it was below 1.5/l,000 in Seoul, Incheon and Gyeonggi. The mortality rate of female was above 1.2/1,000 person-years in Gyeongnam and Incheon while it was below 0.5/l,000 in Daegu, Geonggi Chungbuk and Jeju. The leading cause for male by school of employment was neoplasm in all levels of school with a remarkably higher rate in the professors of college. Leading cause of death for female was disease of circulatory system in primary schools, high schools and college but neoplasm in middle schools. There was no death due to liver diseases in middle and high school teachers and college professors and no death due to all other category in high school teachers and college professors, in females. High school teachers and the highest mortality rate and college professors showed the lowest mortality rate. Temporal trend of mortality was examined in three periods; period I ($1968{\sim}1974$), period II ($1975{\sim}1979$), and period III ($1980{\sim}1985$). The leading cause of death for male was diseases of circulatory system in period I and II but neoplasm in period III. Such trend of decreasing diseases of circulatory system and increasing neoplasm was observed in female. Overall mortality rate was decreased over the 3 periods. The mortality rates of diseases of circulatory system, liver disease and all others were decreased in male but the mortality rates of neoplasm and accident and posions was increased. Female showed a similar trend to male but the mortality rate of liver diseases was increased. Mortality rates of diseases of circulatory system, neoplasm and liver diseases increased with age of teachers up to 50 years of age but decreased in 60 years of age. Mean age at death due to each cause was higher in male than female by $4{\sim}10$ years. However, the mean age at death of the teachers was $2{\sim}5$ years lower than that of the general population in all causes of death and the sex difference in the mean a2e at death was smaller ($2{\sim}3$ years) in general population. In sex ratio of mortality, male was higher than female in almost all diseases except suicide and maintained a high ratio. The general population showed universally high ratio in male like teachers, and more or less did regular patterns in mortality with ratio smaller.