• Journal of The Korea Institute of Healthcare Architecture
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• v.13 no.3
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• pp.25-33
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• 2007

This study is about change a necessary and natural change from institutionalized hospital based health care to a more patient centered, accessible health care. Rapidly change of social and medical facts such as growing aging population, malady, changing of medical policy are made new paradigm. This paradigm is both required to the hospital ; consolidate department and service; architectural change. Benefit to patient and hospital are many, so there are many challenges in Korean general hospital. The purpose of this study is find architectural design guideline to Korean general hospital which is struggling to change from to functional organization to the patient based care center. As a result, the type is divided into three classes, consultation type(C), some of examinations are added on consultation type(EAC), consultation and examination are fully integrated type(CEI). Each type has different organization and the proportion of area, group unit, process of treatment.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.28 no.1
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• pp.99-115
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• 2002

Tests of stability and toxicity, and clinical evaluation of anti-acne activity suggest that cryptotanshinone, a constituent of the roots of Salvia miltiorrhiza Bunge, is an effective active ingredient for acne vulgaris treatments. Acne vulgaris, called acne or pimples, is the most common disease of the pilosebaceous follicle unit of the skin. It affects nearly 80% of people between the ages of 11 and 30. Approximately 30% of teenagers have acne of sufficient severity to require medical treatment. Acne is a follicular disorder of the skin. It occurs in specialized pilosebaceous units on the face and body. Acne develops when these specialized follicles undergo pathologic alterations that result in the formation of non-inflammatory lesions (comedones) and inflammatory lesions (papules, pustules and nodules). An abnormality of keratinizing epithelium of these follicles, thought to be due to the action of sebum synthesized and secreted by the androgen-sensitive sebaceous glands, leads to inflammation induced by the follicular bacterium Propionibacterium acnes. Therapy involves treatments that modify these pathogenic factors and includes drugs with antikeratinizing, antibacterial and antiseborrheic actions. Acne vulgaris is a very frequent disease, seen primarily in adolescents, involving the sebaceous follicles. Acne vulgaris is characterized by a great variety of clinical inflammatory and non-inflammatory lesions: comedones, papules, pustules, nodules, cysts and scars. Acne vulgaris is a multi-factorial disease. Although its pathogenicity is unclear, extensive studies have shown that hyperseborrhea, superinfection by P. acnes and endocrinologic androgenic changes play a role in the development of acne vulgaris.

• Journal of Science Education
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• v.33 no.2
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• pp.165-172
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• 2009

Korean 7th national curriculum gave the right to elect the advanced subject such as physics II, chemistry II. Students could elect the subject by their aptitude and interest. But, actually, the choice was constrained by school circumstances such as the number of teacher and the number of class. high school students. We investigated the demand about school science and perception about scientifically specialized high school in which the students could have all advanced science subjects by the survey of 336 middle school students including 148 students in the science education center for the gifted, 220 high school students, and 70 science teachers in capital region. As results of this study, most of the high school opened chemistry and biology advanced subjects, but only 37.1% of them opend physics advanced subject. This constrained students' right of elect the subject by their interest. While most of middle school and high school students normally demanded the more experiment in the class and the easier science content, the students in the science education center for the gifted demanded more science class time. The students who wanted to have science career had very positive recognition of scientifically specialized high school and science teachers agreed to running the scientifically specialized high school.

• Korean Institute of Interior Design Journal
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• v.22 no.3
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• pp.108-116
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• 2013

This study has the purpose to review the way of experience element and property of space design appearing in vocational experience space and accumulate basic study material for children's vocational experience space and build systematic and specialized modules. Analysing the marketing elements of experience space through pilot research to arrange frame of analysis, and in a determined range, experimental marketing's property appearing in children's vocational experience center is analysed. This researcher analysed experimental displaying space's function of recognition, emotional, behavior, sense marketing and experimental marketing induced from pilot research on space design expressive elements of experimental marketing when it is applied to spaces through the frame of analysis with the combination of total 8 kind's experience display space function such as investigative, conceptional, aesthetic, entertaining, logical, relative, participating, and comprehensive experience based on 5 vocational experience spaces located in Seoul and Gyeonggi, opened after 2010, being operated at present with more than 500 pyeong (about 1,650 square meter) and targeted for children, after this researcher visited the site directly to make check list with the frame of analysis together with the staff and administrator in charge of vocational experience education. As a conclusion, vocational experience center is a space of edutainment helping children experience various profession more easily to find their interest and to bring up their dream. By analysing current vocational experience center through the element called experimental marketing, current status of vocational experience center could be known. the experience itself in vocational experience center becomes a merchandise. Instead of mere experience, so as to get professional experience and new information, new experiences should be provided by incessant variation and development. This study is to build basic research data for children's vocational experience space, however not only drawing specialty of vocational experience center through the connection of enterprises based on the contents arranged above but also systematic and specialized modules are expected to be built in next researches.

• Journal of the Korea Convergence Society
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• v.12 no.11
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• pp.411-418
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• 2021

The purpose of this study was to identify contents of Taekwon and to improve specialized knowledges and practical abilities for Taekwondo majoring university students. The sample was categorized into college and student. The first round survey was divided into two parts in finding possible ways to improve practical abilities from students and school authority perspectives. The second round was conducted through survey by dividing respondents into students and school authority. The third round was performed to identify the nessessities and problems in relation to specialized knowledge and practical abilities such as sparring, poomsae, and demonstration. Based on the findings, three critical themes were identified: motivating them to accumulate specialized knowledge, providing opportunities to practice, and offering diverse job directions. Students indicated several critical themes such as recognition of job opportunities in different domains, endeavour to increase communication ability with others in different domains, reconsideration to learn things in different domains, and efforts to take an interests in life-time Taekwondo. The findings provide ideas in applying practical knowledge into the field and in changing students' perception in terms of Taekwondo majoring. They are specialized knowledge and practical ability improvement based upon college authority and students (15 college authority items, 9 student items).

• Journal of The Korea Institute of Healthcare Architecture
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• v.12 no.2
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• pp.31-39
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• 2006

Much has changed in the healthcare field since the beginning of the industrial age. In the healthcare field changes are occurring so rapidly and dramatically that yesterday's paradigm will not be tomorrow's paradigm, creating the need above all else to stay fluid and flexible as strategies(included healthcare architecture planning) for the future are developed. The purpose of this study is to analyze the latest architectural trends of general hospital outpatient department based on the healthcare environment changes in Korea. The major healthcare environment change is to change the object of hospital's healthcare services from inpatient to outpatient. In conclusion, the first, medical faculties of outpatient department are subdivided specialized small faculty. The second, clinic systems for medical examination and treatment of specific disease are activated in the most outpatient department. The third, specialized medical centers for chronical disease(Cancer, Cardiac etc.) control are arranged in existed outpatient department or freestanding facility. Specialized medical center for preventive medicine is regionally decentralized for corresponding with the healthcare paradigm shifts.

• IMMUNE NETWORK
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• v.15 no.2
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• pp.91-99
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• 2015

Herpes simplex virus (HSV) is a common causative agent of genital ulceration and can lead to subsequent neurological disease in some cases. Here, using a genital infection model, we tested the efficacy of vinegar-processed flos of Daphne genkwa (vp-genkwa) to modulate vaginal inflammation caused by HSV-1 infection. Our data revealed that treatment with optimal doses of vp-genkwa after, but not before, HSV-1 infection provided enhanced resistance against HSV-1 infection, as corroborated by reduced mortality and clinical signs. Consistent with these results, treatment with vp-genkwa after HSV-1 infection reduced viral replication in the vaginal tract. Furthermore, somewhat intriguingly, treatment of vp-genkwa after HSV-1 infection increased the frequency and absolute number of $CD3^-NK1.1^+NKp46^+$ natural killer (NK) cells producing interferon (IFN)-${\gamma}$ and granyzme B, which indicates that vp-genkwa treatment induces the activation of NK cells. Supportively, secreted IFN-${\gamma}$ was detected at an increased level in vaginal lavages of mice treated with vp-genkwa after HSV-1 infection. These results indicate that enhanced resistance to HSV-1 infection by treatment with vp-genkwa is associated with NK cell activation. Therefore, our data provide a valuable insight into the use of vp-genkwa to control clinical severity in HSV infection through NK cell activation.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6415-6421
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• 2012

Background: Canine mammary gland tumors (CMGTs) are the most common tumor found in bitches. Changes in HER-2/neu genes in human breast cancer (HBC) lead to decrease in disease-free survival (DFS) and overall survival rate (OSR). Previous studies have demonstrated that the biological behavior of malignant mammary gland tumors (MMGTs) is similar to that of HBC. The present study aimed at evaluating the relationship between overexpression of HER-2/neu and clinicopathological features in MMGTs to represent a model of prognostic factors for HBC. Materials and Method: The clinicopathological data of 35 MMGTs were obtained. Immunohistochemical staining with HER-2, Ki-67 and CD34 markers was conducted with sections from paraffin-embedded blocks. According to standard protocols, histological type, grade, margin status, lymphovascular invasion (LVI), HER-2/neu score, proliferation rate and microvessel density (MVD) of tumors were determined and the association of HER-2/neu overexpression with these parameters was assessed statistically. Results: The IHC results showed that 12 (34.3%) cases were HER-2/neu positive. Statistical analyses indicated a significant relationship between HER-2 positivity and tumor grade (p=0.043), which also was demonstrated with cancer stage (p=0.035), tumor margin involvement (p=0.016), proliferation index (p=0.001) and MVD (p=0.001); however, there was no statistical relationship between LVI and tumor size. Overexpression of the HER-2/neu gene in MMGTs results in similar biological behavior as that of HBC; as a result, these tumors have can be considered to have important similarities in clinicopathological characteristics. Conclusions: MMGTs can be regarded as an HBC animal model. Further studies in this field would result in new treatments that could be beneficial for both dogs and humans.

• Journal of Korean Institute of Industrial Engineers
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• v.4 no.1
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• pp.5-10
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• 1978

In this paper it was attempted to design a system for the effective development of electronics industry by use of systems management concept. For the design of this system, current status of electronics industry was analyzed; problem area was derived through this analysis and developmental strategy was determined. As an organization for centeralized coordination, "Electronics Industry Committee" was proposed. The committee controls three specialized organizations such as R&D center, marketing management center, and council for political support. Each function of these special organizations was introduced and special role as a system manager was described.

• Korean Institute of Interior Design Journal
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• v.19 no.2
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• pp.216-224
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• 2010

This study aims to examine a special type of hospital known as Western Oriental medicine treatment designed to provide the best treatment by combining the advantages of Western and Oriental medicine, The actual conditions of the organizations and operations of O.P.D and how the cooperative treatment between Western and Oriental medicine is conducted at general hospitals that operate the cooperative treatment by applying a drawing analysis and an area analysis, and provide materials that help design hospitals that offers the cooperative treatment based on the information. According to the results of this study, the forms of the cooperative treatment between Western and Oriental medicine included several methods; to operate the cooperative center separately between an Oriental hospital and a general hospital, to operate the cooperative hospital, using several floors for an Oriental hospital inside a general hospital, and to operate the cooperative center in specialized centers inside a general hospital and the type of cluster that offers the cooperative treatment in specialized centers is known as the best appropriate treatment.