• 생물정신의학
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• 제27권1호
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• pp.27-35
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• 2020

Objectives Ketamine has been reported to have antidepressant effects or psychotomimetic effects. The aim of this study was to investigate the behavioral effects of ketamine treatment at various sub-anesthetic doses in adolescent and adult naïve mice. Methods In each experiment for adolescent and adult mice, a total of 60 male Institute of Cancer Research mice were randomly divided into 6 groups, which were intraperitoneally treated with physiological saline, 10, 20, 30, 40, and 50 mg/kg ketamine for consecutive 3 days. At 1 day after last injection, the locomotor and depressive-like behaviors were evaluated in mice, using open field test (OFT) and forced swim test (FST), respectively. Results In case of adolescent mice, ketamine dose was negatively correlated with total distance traveled in the OFT (Spearman's rho = -0.27, p = 0.039). In case of adult mice, we found significant positive correlation between ketamine dose and duration of immobility in the FST (Spearman's rho = 0.45, p < 0.001). Immobility time in the 50 mg/kg ketamine-treated mice was significantly higher compared to the saline-treated mice (Dunnett's post-hoc test, p = 0.012). Conclusions We found that the repeated treatment with ketamine could decrease the locomotor or prolong the duration of immobility in mice as the dose of ketamine increased. Our findings suggest that sub-anesthetic doses of ketamine might induce schizophrenia-like negative symptoms but not antidepressant effects in naïve laboratory animals.

• 대한후두음성언어의학회지
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• 제33권2호
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• pp.103-109
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• 2022

Background and Objectives The Voice Perceived Present Control scale (VPPC) has been developed to provide better insight into patients' perceived control over their thoughts or behaviors related to voice disorders. The objective of the present study was to validate the Korean VPPC (K-VPPC) by evaluating its internal consistency and reliability. Materials and Method All items of the English VPPC were translated into Korean. Content validity was analyzed through three Delphi survey rounds by an expert panel (n=44) with active clinical and research experience in treating dysphonic patients. Twenty-three patients with a heterogeneous diagnosis of dysphonia and twenty-three gender-matched vocally normal controls (total n=46) were asked to complete the K-VPPC and the Korean Voice Handicap Index-10 (KVHI-10). Psychometric properties including internal consistency and reliability were evaluated to examine the appropriateness of cross-cultural use of K-VPPC. Results Cronbach's alpha coefficient of K-VPPC was 0.89 for dysphonic patients, indicating good internal consistency in clinical samples. Furthermore, patients with dysphonia scored significantly lower on the total score of K-VPPC and higher on voice handicap than the vocally normal controls. Spearman's correlation coefficients indicated an inverse and moderate association between the K-VPPC and all domains of KVHI-10 (Spearman's r=-0.44- -0.68). Conclusion The findings of the current study indicated that the K-VPPC is a valid and reliable tool for the assessment of perceived control in Korean patients with dysphonia. Therefore, the K-VPPC could be a useful and complementary tool for the comprehensive evaluation of dysphonia, thereby improving care in Korean patients with voice disorders.

• Journal of Acupuncture Research
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• 제26권6호
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• pp.171-178
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• 2009

Objectives : To investigate the correlation between DITI and assessment instruments of knee OA. Methods : Data were obtained from 127 subjects with OA of the knee. They were asked to answer VAS pain scale, LFI, WOMAC and KHAQ. Correlation was assessed by examing the pearson's correlation and spearman's rank correlation coefficients. Results : The thermal difference between the patella of knee was correlated with VAS, LFI and WOMAC. Age, duration, BMI and sex were not correlated with the thermal differences of each region. Conclusions : DITI value was useful for evaluating the severity of OA. And we should find out the standardization of analysis of DITI value for diagnosis of OA.

• Journal of Cardiovascular Imaging
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• 제30권2호
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• pp.125-134
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• 2022

BACKGROUND: To assess the interventricular septum (IVS) volume of fetuses from pre-gestational diabetes mellitus (DM) pregnant women by 3-dimensional ultrasound using spatiotemporal image correlation (STIC) and virtual organ computer-aided analysis (VOCAL) methods. METHODS: This was a prospective cross-sectional study of 45 fetuses from pre-gestational DM and 45 fetuses from healthy pregnant women (controls). Only singleton pregnancies between 20 and 34 + 6 weeks of gestation were included. The fetal IVS volumes were obtained off-line using STIC and VOCAL methods. To analyze differences among variables, the Student's t-test and Mann-Whitney U test were used. The correlation among continuous variables was determine using Spearman's correlation test (r). RESULTS: The median of fetal IVS volume was significantly higher in pre-gestational DM than in healthy pregnant women (0.3 cm³ vs. 0.2 cm³, p = 0.032). A strong positive correlation was observed between fetal IVS volume and gestational age at the time of ultrasound examination (r = 0.75, R² = 0.48, p < 0.0001) and between fetal IVS volume and estimated fetal weight (r = 0.63, R² = 0.37, p < 0.0001). No significant correlation was noted between fetal IVS volume and glycated hemoglobin levels (r = -0.16, R² = 0.01, p = 0.540) in the pre-gestational DM pregnant women. CONCLUSIONS: Significant differences were observed in fetal IVS volumes between pre-gestational and healthy mothers, with higher values in the fetuses of pre-gestational DM pregnant women.

• 한국보건간호학회지
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• 제15권1호
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• pp.172-181
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• 2001

This study was performed to explore the effects of walking exercise on blood glucose level in the diabetes mellitus patients. The design of this study was a equivalent pre-post test experiment. The subjects consisted of eighteen diabetes mellitus patients. The walking exercise consists of 22.5minutes, speed of 120walking per minute. Data were analyzed with mean, standard deviation, Wilcoxon signed rank test, Spearman correlation and percentage using SAS program. The results were as follows. 1. The blood glucose level has significantly decreased after walking exercise. 2. Strength of exercise and change of blood glucose level was revealed correlation. 3. Age and strength of exercise was revealed high correlation. 4. Satisfaction after walking exercise was revealed all patients. In conclusion, the walking exercise can decrease blood glucose level. This exercise was show a positive effect on the exercise compliance.

• 전기학회논문지
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• 제65권7호
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• pp.1257-1262
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• 2016

The purpose of this study is to evaluate whether to take a medicine based on a measuring data using textile proximity sensor. We developed a proximity sensor of ring type using conductive textile, and acquired a data in accordance with the quantity of each pills. To evaluate our approach, we designed an experimental protocol that is counting pills subtracting the one which contains range of 0 T(Tablet, 4,100mg) from 20 T. And, The experiments were performed a nine times in the same way. In order to remove a noise and smoothen data, data preprocessing were performed using resampling method and moving average filter which has ten points. Then, we calculated a linear trend line equation, and analyzed a correlation between pill quantity and trend line equation. As a results, correlation coefficient was shown at 0.833 through using a Spearman's correlation method and we could be determined that data was continuos decreases when take a medicine.

• 응용통계연구
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• 제13권2호
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• pp.525-540
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• 2000

본 논문에서는 측우기 관측자료와 현대 관측자료로 이루어진 서울 강수량 시계열 자료에 나타난 시간에 따른(년도별 및 계절별)변화 및 변동 특성을 파악하고자 한다. 이를 위하여 먼저 200여년 간의 강수량 시계열에 어떤 특정한 증감 추세가 있는지를 알아보는 추세분석을 실시하였다. 그리고 추세뿐만 아니라 시간에 따른 강수량의 주기성 및 변동성을 더 자세히 알기 위하여 파엽 변환(wavelet transform)을 실시하여 여러 진동 모드들의 시간에 따른 변화 양상을 분석하였다.

• 산업경영시스템학회지
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• 제32권3호
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• pp.135-141
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• 2009

A variety of statistical methods are applied to model and optimize responses, related to product or system's quality, in terms of control and noise factors at design and manufacturing stages. Most of them assume continuous response variables but, assessing the performance of a product or system often involves categorical observations, such as ratings and scores. Although most previous works to deal with the categorical data provide sorhisticated response models and ensure unbiased outcomes, they require heavy computation to estimate the model parameters, as well as enough replications. In this study, we present some practical approaches for optimal parameter design with ordered categorical response when only a few or no replication is available. Two real-life examples are given to illustrate the presented methods.

• 대한산업공학회지
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• 제11권2호
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• pp.131-140
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• 1985

This paper analyses the hindrance factors of process capability. The reasons of the products which are out of specification can be accounted on the hindrance factors. An $\hat{e}$nquete which consists of 4 categories such as technical knowledge, work performance, work environment, and human relations at home and office, is prepared and handed out to 1000 works to get information. And Spearman's Correlation Coefficient (${\rho}s$) is adapted as an anaysis and consideration criterion. In consequence, it is revealed the next 4 factors become the vital hindrance factors of process capability: (1) unskillful working (2) over load for operators (3) imperfect work environment (4) incoordination of human relations And the correspondent policy can be summarized as follows: (1) propagation & fixation of I.E. techniques (2) harmonization of human relations (3) improvement of work environment (4) strengthening the T.W.I.

• Clinical and Experimental Pediatrics
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• 제62권7호
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• pp.281-285
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• 2019

Purpose: To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE). Methods: An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE included all children with a history of SE; control included all children with febrile seizure. Blood samples of patients were drawn within 24 hours after admission. SE patients also underwent cranial MRI with additional DTI sequencing. The Mann-Whitney test and Spearman test were used for statistical analysis. Results: Fifty-three patients were enrolled the study. In the 24 children with SE who met the inclusion criteria, serum S100B and cranial MRI findings were assessed. Twenty-two children admitted with febrile seizures became the control group. Most patients were male (66.7%); the mean age was 35.8 months (standard deviation, 31.09). Mean S100B values of the SE group ($3.430{\pm}0.141{\mu}g/L$) and the control group ($2.998{\pm}0.572{\mu}g/L$) were significantly different (P<0.05). A significant difference was noted among each level of encephalopathy based on the cranial MRI results with serum S100B levels and the correlation was strongly positive with a coefficient value of 0.758 (P<0.001). Conclusion: In SE patients, there is an increase of serum S100B levels within 24 hours after seizure, which has a strong positive correlation with brain damage seen in head MRI and DTI.