Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Correlation of serum S100B levels with brain magnetic resonance imaging abnormalities in children with status epilepticus

  • Gunawan, Prastiya Indra (Division of Neurology, Department of Child Health, Airlangga University, Soetomo Hospital) ;
  • Saharso, Darto (Division of Neurology, Department of Child Health, Airlangga University, Soetomo Hospital) ;
  • Sari, Dian Purnama (Division of Neurology, Department of Child Health, Airlangga University, Soetomo Hospital)
  • Received : 2018.09.07
  • Accepted : 2019.05.08
  • Published : 2019.07.15
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Abstract

Purpose: To evaluate the association between elevated S100B levels with brain tissue damage seen in abnormalities of head magnetic resonance imaging (MRI; diffusion tensor imaging [DTI] sequence) in patients with status epilepticus (SE). Methods: An analytical observational study was conducted in children hospitalized at Dr Soetomo Hospital, Surabaya, from July to December 2016. The patients were divided into 2 groups: SE included all children with a history of SE; control included all children with febrile seizure. Blood samples of patients were drawn within 24 hours after admission. SE patients also underwent cranial MRI with additional DTI sequencing. The Mann-Whitney test and Spearman test were used for statistical analysis. Results: Fifty-three patients were enrolled the study. In the 24 children with SE who met the inclusion criteria, serum S100B and cranial MRI findings were assessed. Twenty-two children admitted with febrile seizures became the control group. Most patients were male (66.7%); the mean age was 35.8 months (standard deviation, 31.09). Mean S100B values of the SE group ($3.430{\pm}0.141{\mu}g/L$) and the control group ($2.998{\pm}0.572{\mu}g/L$) were significantly different (P<0.05). A significant difference was noted among each level of encephalopathy based on the cranial MRI results with serum S100B levels and the correlation was strongly positive with a coefficient value of 0.758 (P<0.001). Conclusion: In SE patients, there is an increase of serum S100B levels within 24 hours after seizure, which has a strong positive correlation with brain damage seen in head MRI and DTI.

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References

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