• 구강회복응용과학지
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• 제23권2호
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• pp.179-186
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• 2007

The decrease of masticatory function caused by tooth loss leads to a decrease of cerebral blood flow volume resulting in impairment of cognitive function and learning memory disorder. However, the reduced mastication-mediated morphological alteration in the central nervous system (CNS) responsible for senile deficit of cognition, learning and memory has not been well documented. In this study, the effect of the loss of the molar teeth (molarless condition) on the hippocampal expression of glial fibrillary acidic protein (GFAP) protein was studied by immunohistochemical techniques. The results were as follows : 1. The molarless mice showed a lower density of pyramidal cells in the cornu ammonis 1 (CA1) and dentate gyrus (DG) region of the hippocampus than control mice. 2. Immunohistochemical analysis showed that the molarless condition enhanced the time-dependent increase in the cell density and hypertrophy of GFAP immunoreactivity in the CA1 region of the hippocampus. The molarless condition enhanced an time-dependent decrease in the number of neurons in the hippocampal formation and the time-dependent increase in the number and hypertrophy of GFAP-labeled cells in the same region. The data suggest a possible link between reduced mastication and histological changes in hippocampal formation that may be one risk factor for senile impairment of cognitive function and spatial learning memory.

• Journal of Korean Biological Nursing Science
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• 제18권4호
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• pp.274-279
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• 2016

Purpose: Adolescents who experienced the alcohol consumption have gradually increased. Adolescence is a critical period of the neural plasticity in the brain. Neural plasticity is mediated by neurotrophins and has an impact on cognitive function. Environmental enrichment ameliorates the cognitive function and increases neurotrophins. Thus, we investigated the neuroprotective effect of environmental enrichment on ethanol induced cognitive impairment in adolescent rats. Methods: The ethanol groups and the controls groups were injected with ethanol (0.5g/kg) and phosphate buffered saline, respectively, through intraperitoneal from 28th day of birth for 11 days. The environmental enrichment groups were provided larger cages containing toys than the standard cage. Passive avoidance test and Y-maze test were performed to evaluate the spatial memory. Results: Environmental enrichment+ethanol group showed higher alterations than the standard environment+ethanol group in Y-maze test (p<.05). In hippocampus, The environmental enrichment+ethanol group showed significantly higher level of the number of c-fos positive celsl and density of tropomyosin receptors kinase B receptor than the standard environment+ethanol group (p<.05). Conclusion: So, we suggested that the environmental enrichment played a role as a prophylaxis for prevention of memory impairment induced by ethanol exposure in adolescence.

• 한국가구학회지
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• 제26권4호
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• pp.346-355
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• 2015

It suggests a closet design for infants in consideration of space utilization, furniture arrangement, and goods storage by integrating a baby's closet and toy chest, which was used for storage of baby's toys and play instrument. For this, it conducted and analyzed data research on the infants' toy chests in the domestic and overseas market and based on such approach, the colors that helped development of infants' cognition and emotion were selected while suggesting familiar animal characters for infants. Without considering separate arrangement of furniture and toy chest within limited space, it allowed space utilization and provided enough storing space. Also, the attached ball casters enabled easy carry of the closet and with this function, it helps infants arrange and store goods by themselves so that making them feel a sense of accomplishment. For effective spatial utilization as well as security of its genuine storage function, the closet and toy chest were combined in this study. Thus, it is believed that development of such multifunctional furniture will suggest the direction of researches on domestic furniture development that are conducted to maximize utilization of residential space for the people living today.

• Archives of Pharmacal Research
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• 제24권3호
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• pp.234-239
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• 2001

Three types of learning and memory tests (Morris water maze, active and passive avoidance) were performed in rats following intracerebroventricular infusion of ethylcholine aziridium (AF64A). In Morris water maze, AF64A-treated rats showed the delayed latencies to find the platform iron 6th day after the infusion. In pretrained rats, AF64A caused the significant delay of latency at 7th days but not 8th day. In the active avoidance for the pretrained rats, the escape latency was significantly delayed in AF64A-treatment. The percentages of avoidance in AF64A-treated rats were less increased than those in the control. Especially, the percentage of no response in the AF64A-treated rats was markedly increased in the first half trials. In the passive avoidance, AF64A-treated rats shortened the latency 1.5 h after the electronic shock, but not 24 h. AF64A also caused the pretrained rats to shorten the latency 7th day after the infusion, but not 8th day. These results indicate that AF64A might impair the learning and memory. However, these results indicate that the disturbed memory by AF64A might rapidly recover after the first retrain. Furthermore, these results suggest that AF64A may be a useful agent for the animal model of learning for Spatial cognition .

• 교육시설
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• 제15권5호
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• pp.13-20
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• 2008

The sense of place at school environment becomes more important as children increasingly spend more time in school and children's attachment to the environment affects the cognition development of children. The goal of this research is to identify characteristics that enhance the sense of place for children in outdoor space and check the possibilities of forming it in the school environments. Through the analysis of design document and design report for schematic design of elementary school which is executed through Korean Institute of Educational Facilities between 2002-2005, 47cases from 32elementary schools are analyzed. As a result it is found that designers tend to orient towards the visual aspects compared to other invisible aspects such as thermal comfort and participation of children, which is extracted as a key characteristics of forming a sense of place for children. More attention is required to enhance the sense of place in school environment to support the child development in everyday space.

• 한국조경학회지
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• 제23권1호
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• pp.95-109
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• 1995

All human spatial behavior and psychological stress are affected by the 'Privacy'of each space. This Paper deals with the theoretical review of 'privacy'concept and establishment of 'Privacy Model' that can be a useful design tool. 'Privacy Index(Pl)' model of 10 point scale, which is based on 'Hierarchic system of Privacy' in urban spaces by Chermeyeff and Alexander(1963), was established as a hypothetical model in this study. And'Activity Suitability', based on each hierarchy of primacy level, was investigated at each site to construct the validity of 'Privacy Model'. Total 67 sites were investigated by on.-site questionnaire in 3 types of outdoor spaces, (Park), (Campus), and (Garden) respectively. The major results are as follows; 1. The P7rivacy level of earth spaces, distributed from to in and . and (Groun Private> spaces are dominant In , spaces are dondnant 2, Privacy level, based on , showed higher privacy level than that of . This means the criteria of each privacy level should be modified for more specific space. The . could be derived from the (Activity Suitability) of each space. 3.The cognition of privacy level. by user group, showed no significant difference in dach group by sex, age, education, and job, respectively.

• 한국실내디자인학회논문집
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• 제18호
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• pp.103-109
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• 1999

The purpose of this research is to suggest the ultimate solution to the interior elements and ways to express specific function within interior design of the new high-speed train station in Korea through careful studies based on the characteristics of each areas in the stations. During the research, it became very clear that the most important points in designing of the high speed train station's interior space can be found from close examination on whether each space allocation was thoughtfully organized to provide enough space to accommodate various activities of the users. Another point is to realize, within the space program, that there should be a clear understanding of the future expansion plan and reserving sufficient areas for the future growth. Also the problem of requiring larger floor areas to accommodate various functions divided by separate units must be recognized simultaneously during the programming. The new high-sped train must be able to function as a multi service facility of the future. In summary this research is to present datas and suggestion to various areas in the station and redefine its new meaning of train station space program with much borader concept which can be adopted to the process of better space programing.

• 대한건축학회논문집:계획계
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• 제35권9호
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• pp.101-108
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• 2019

Chinese ethnic minorities are inheriting their own traditions based on thousands of years of community life. Yunnan province in china is a castle in which many ethnic minorities have been living on the basis of various natural environments. Their traditional village can be regarded as a place reflecting minorities' thousands year of history and culture, and elements of positive social spaces are seen from the old village. Streets and places of the village are accumulated as images for residents. Based on their imagination-concept, sketch maps, reflecting residents' cognitive perception were collected. Analysis of 21 sketch maps shows that architectural elements, forming a unique landscape and community life contribute to establish a unity of one nation. the oldest tree in the village has a strong specificity as a place with the belief that the tree protects all residents in the village. Space in the head of the residents and Social spaces, embedded in the memories of the residents living in the community continued organically and the roads of the village showed clear recognition. Following this, the analysis methodology of social spaces and sketch will be examined in depth.

• Journal of Korean Biological Nursing Science
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• 제24권2호
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• pp.77-85
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• 2022

Purpose: Aging process comes with cognitive impairment due to decreased neuronal cell number, activity, and neuronal circuit. Alteration of inhibitory neurons contributes to cognitive impairment in normal aging and is responsible for disrupting the excitation/inhibition balance by reducing the synthesis of gamma-aminobutyric acid (GABA). Morus nigra (Mulberry) is a natural physiologically active substance that has been proven to have anti-oxidant, anti-diabetic, and anti-inflammatory effects through many studies. This study aimed to evaluate the effects of the mulberry extract (ME) on cognitive function through anti-oxidant enzyme and GABAergic neuronal activity in aged rat brain. Methods: Sprague Dawley rats were randomly assigned as the young group (8 weeks, n= 8), aging group (67 weeks, n= 8), and aging+ mulberry extract group (67 weeks, n= 8). The aging+ mulberry extract group was orally administered 500 mg/kg/d mulberry extract for 6 weeks. Results: The aging+ mulberry extract group improved spatial and short-term memory. The antioxidant potential of ME increased the expression of superoxide dismutase-1 (SOD-1) and decreased inducible nitric oxide synthase (iNOS). Also, the aging+ mulberry extract group significantly increased the expression of GABAergic interneuron in hippocampus cornu ammonis1 (CA1) compared to the aging group. Conclusion: The number of GABAergic inhibitory interneurons was deceased and memory functions in the aging process, but those symptoms were improved and restored by mulberry extract administration.

• Biomolecules & Therapeutics
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• 제32권3호
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• pp.309-318
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• 2024

Compared to other organs, the brain has limited antioxidant defenses. In particular, the hippocampus is the central region for learning and memory and is highly susceptible to oxidative stress. Glial cells are the most abundant cells in the brain, and sustained glial cell activation is critical to the neuroinflammation that aggravates neuropathology and neurotoxicity. Therefore, regulating glial cell activation is a promising neurotherapeutic treatment. Quinic acid (QA) and its derivatives possess anti-oxidant and anti-inflammatory properties. Although previous studies have evidenced QA's benefit on the brain, in vivo and in vitro analyses of its anti-oxidant and anti-inflammatory properties in glial cells have yet to be established. This study investigated QA's rescue effect in lipopolysaccharide (LPS)-induced behavior impairment. Orally administering QA restored social impairment and LPS-induced spatial and fear memory. In addition, QA inhibited proinflammatory mediator, oxidative stress marker, and mitogen-activated protein kinase (MAPK) activation in the LPS-injected hippocampus. QA inhibited nitrite release and extracellular signal-regulated kinase (ERK) phosphorylation in LPS-stimulated astrocytes. Collectively, QA restored impaired neuroinflammation-induced behavior by regulating proinflammatory mediator and ERK activation in astrocytes, demonstrating its potential as a therapeutic agent for neuroinflammation-induced brain disease treatments.