Journal of Dental Rehabilitation and Applied Science (구강회복응용과학지)

Korean Academy of Stomatognathic Function and Occlusion (대한턱관절교합학회)
권호 표지

Influence of Molarless Condition on the Hippocampal Formation in Mouse: a Histological Study

구치부 치관삭제가 생쥐 해마복합체에 미치는 영향에 관한 조직학적 연구

  • Kim, Yong-Chul (Department of Prothodontics, College of Dentistry, Chosun University) ;
  • Kang, Dong-Wan (Department of Prothodontics, College of Dentistry, Chosun University)
  • 김용철 (조선대학교 치과대학 보철학 교실) ;
  • 강동완 (조선대학교 치과대학 보철학 교실)
  • Published : 2007.06.30
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Abstract

The decrease of masticatory function caused by tooth loss leads to a decrease of cerebral blood flow volume resulting in impairment of cognitive function and learning memory disorder. However, the reduced mastication-mediated morphological alteration in the central nervous system (CNS) responsible for senile deficit of cognition, learning and memory has not been well documented. In this study, the effect of the loss of the molar teeth (molarless condition) on the hippocampal expression of glial fibrillary acidic protein (GFAP) protein was studied by immunohistochemical techniques. The results were as follows : 1. The molarless mice showed a lower density of pyramidal cells in the cornu ammonis 1 (CA1) and dentate gyrus (DG) region of the hippocampus than control mice. 2. Immunohistochemical analysis showed that the molarless condition enhanced the time-dependent increase in the cell density and hypertrophy of GFAP immunoreactivity in the CA1 region of the hippocampus. The molarless condition enhanced an time-dependent decrease in the number of neurons in the hippocampal formation and the time-dependent increase in the number and hypertrophy of GFAP-labeled cells in the same region. The data suggest a possible link between reduced mastication and histological changes in hippocampal formation that may be one risk factor for senile impairment of cognitive function and spatial learning memory.

Keywords

Acknowledgement

Supported by : 조선대학교

References

  1. Isse K, Kanamori M, Uchiyama M. A case-control study of risk factors associated with alzheimer type dementia in Japan. In: studies in Alzheimer disease:Epidemiology and Risk factors. Edited by Satoshi. National center of Neurology and Psychiatry, Tokyo. pp. 63-67, 1991
  2. Kang H, Sun LD, Atkins CM. An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term Memory. Cell 2001;106: 71-783 https://doi.org/10.1016/S0092-8674(01)00417-2
  3. Kondo K, Niino M, Shido K. A case control study of Alzheimer's disease in Japan: signiticance of life-styles. Dementia 1995;5:314-326
  4. Nishiura H, Tabata T, Watanabe M. Response properties of slowly and rapidly adapting periodontal mechanosensitive neurons in the primary somatosensory cortex of the cat. Arch Oral BioI 2000;45:833-842 https://doi.org/10.1016/S0003-9969(00)00054-6
  5. Sulliven AM, Reynolds DS, Thomas KL. Cortical induction of c-fos by interastriatal endothelin-l is mediated vis NMDA receptors. Neuroreport 1996;8: 11-216 https://doi.org/10.1097/00001756-199612200-00003
  6. Fujisawa H. The effect of mastication on post-natal development of the rat brain with a histological and behavioral study. J Jpn Oral BioI 1990;32:495-508 https://doi.org/10.2330/joralbiosci1965.32.495
  7. Kato T, Usami T, Noda Y, Hasegawa M, Ueda M, Nabeshima T. The effect of the loss of molar teeth on spatial memory and acetylcholine release from the parietal cortex in aged rats. Behav Res 1997;83:39-242 https://doi.org/10.1016/S0166-4328(97)86043-3
  8. Kawamura S. The effect of food consistency on conditioned avoidance response in mice and rats. J Jpn Oral BioI 1993; 9:227-237
  9. Amaral DG, Witter MP, The rat nervous system. In:hippocampal formation. Academic press, pp.443-93,1995
  10. Yamashita K, Kataoka Y, Niwa M. Increased production of endothelins in the hippocampus of stroke-prone spontaneously hypertensive rats following transient forebrain ischemia: histochemical evidence. Cell Mol Neurobiol 1993;13:15-23 https://doi.org/10.1007/BF00712986
  11. Makiura T, Ikeeda Y, Hirai T. Influence of diet and occlusal support on learning memory in rats behavioral and biochemical studies. Res Comm Mol Pathol Pharmacol 2000;107:269-277
  12. Senda M, Ishiyama N, Ishii K. Changes in regional cerebral blood flow during mastication in young and old normal subjects measured with positronemission tomography. J Mastication & Health Society 1992;2:49-54
  13. Monose I, Nishikawa J, Watanabe Y. Effect of mastication on regional cerebral blood flow in humans examined by positron on regional cerebral blood flow in humans examined by positron emission tomography with $^{15}O$-labelled water and magnetic resonance imaging. Arch Oral BioI 1997;42:57-61 https://doi.org/10.1016/S0003-9969(96)00081-7
  14. Hinton RJ, Carlson DS. Response of the mandibular joint to loss of incisal function in the rat. Acta Anat 1986;125: 145-151 https://doi.org/10.1159/000146153
  15. Hinton RJ. Effect of dietary consistency on matrix synthesis and composition in the rat condylar cartilage. Acta Anat 1993;147:97-104 https://doi.org/10.1159/000147488
  16. Li J, Shen H, Naus C. Upregulation of gap junction connexin 32 with epileptiform activity in isolated mouse hippocampus. Neuroscience 2001;105:589-598 https://doi.org/10.1016/S0306-4522(01)00204-4
  17. Olton DS, Becker JT, Handelmann GE. Hippocampus space and memory. Brain Science 1979;2:313-365 https://doi.org/10.1017/S0140525X00062713
  18. Hidehiko S, Anthony HF. Cholera toxin is found in detergent-insoluble rafts/domains at the cell surface of hippocampal neurons but is internalized via a raft-independent mechanism. J Bioi Chem 2001;276:182-9188
  19. Oozuka M, Watanabe K, Mirbod SM. Reduced mastication stimulates impairment of spatial memory and degeneration of hippocampal neurons in aged SAMP8 mice. Brain Res 1999;826:148-153 https://doi.org/10.1016/S0006-8993(99)01255-X
  20. Willmott NJ, Wong K, Strong AJ. Intercellualr $Ca^{2+}$ waves in rat hippocampal slice and dissociated glial-neuron cultures mediated by nitric oxide. FEBS 2000;487:239-347 https://doi.org/10.1016/S0014-5793(00)02359-0
  21. Salo LA, Hoyland J, Ayad S. The expression of types X and VI collagen and fibrillin in rat mandibular condylar cartilage: Response to mastication forces. Acta Odontol Scand 1996;54:295-302 https://doi.org/10.3109/00016359609003541
  22. Sasaguri K, Jiang H, Chen J. The effect of altered functional forces on the expression of bone-matrix proteins in developing mouse mandibular condyle. Archs Oral BioI 1998;43:83-92 https://doi.org/10.1016/S0003-9969(97)00075-7
  23. Smith OM, Mclachlan KR, Mccall WD. A numerical model of temporomandibular joint loading. J Dent Res 1986; 65:1046-1052 https://doi.org/10.1177/00220345860650080201
  24. Yamada K. Kimmel DB. The effect of dietary consistency on bone mass and turnover in the growing rat mandible. Archs Oral Biol 1991;36:129-138 https://doi.org/10.1016/0003-9969(91)90075-6
  25. Smith DR, Hoyt EC, Gallagher M. Effect of age and cognitive status on basal level AP-l activity in rat hippocampus. Neurobiol Aging 2001;22:773-786 https://doi.org/10.1016/S0197-4580(01)00240-8
  26. Yamashita K, Kataoka Y, sokurai- Yamashita Y. Involvement of glial Endothelin/Nitric Oxide in delayed neuronal death of rat hippocampus after transient forebrain ischemia. Cell Mol Neurobiol 2000;20: 541-551 https://doi.org/10.1023/A:1007007710703
  27. Watanabe K, Tonosajas K, Kawase T. Evidence for involvement of dysfunctional teeth in the senile process in the hippocampus of SAMP8 mice. Exp Gerontol 2001;36:283-295 https://doi.org/10.1016/S0531-5565(00)00216-3
  28. Oozuka M, Watanabe K, Nagasaki S. Impirment of spatial memory and changes in astroglial responsiveness following loss of molar teeth in aged SAMP8 mice. Behav Brain Res 2000;108:145-155 https://doi.org/10.1016/S0166-4328(99)00145-X
  29. Drew GM, Christine MC, Abraham We. Effects of endothelin-l on hippocampal synaptic plasticity. Neuro Report 1998;9:1827-1830
  30. Zhow XH, Brakebusch C, Matthies H. Neurocan is dispensable for brain development. Mol Cell Biol 2001;21 :5970-5978 https://doi.org/10.1128/MCB.21.17.5970-5978.2001
  31. Schuster T, Krug M, Stalder M. Immunoelectron microscopic localization of the neural recognition molecules Ll, NCAM, and its isoform NCAM-associated polysialic acid, beta-1 integrin and the extracellular matrix molecule Tenascin-R in synpses of the adult aat hippocampus. J Neurobiol 2001;49: 142-158 https://doi.org/10.1002/neu.1071