• The Korean Journal of Pain
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• v.35 no.3
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• pp.261-270
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• 2022

Background: The rostral ventromedial medulla (RVM) is a critical region for the management of nociception. The RVM is also involved in learning and memory processes due to its relationship with the hippocampus. The purpose of the present study was to investigate the molecular mechanisms behind orexin-A signaling in the RVM and hippocampus's effects on capsaicin-induced pulpal nociception and cognitive impairments in rats. Methods: Capsaicin (100 g) was applied intradentally to male Wistar rats to induce inflammatory pulpal nociception. Orexin-A and an orexin-1 receptor antagonist (SB-334867) were then microinjected into the RVM. Immunoblotting and immunofluorescence staining were used to check the levels of cyclooxygenase-2 (COX-2) and brain-derived neurotrophic factor (BDNF) in the RVM and hippocampus. Results: Interdental capsaicin treatment resulted in nociceptive responses as well as a reduction in spatial learning and memory. Additionally, it resulted in decreased BDNF and increased COX-2 expression levels. Orexin-A administration (50 pmol/1 µL/rat) could reverse such molecular changes. SB-334867 microinjection (80 nM/1 µL/rat) suppressed orexin's effects. Conclusions: Orexin-A signaling in the RVM and hippocampus modulates capsaicin-induced pulpal nociception in male rats by increasing BDNF expression and decreasing COX-2 expression.

• The Korea Journal of Herbology
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• v.21 no.2
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• pp.63-75
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• 2006

Objectives : We investigated the effects of Liriopis Tuber on the nervous protection. Methods : We measured the reaction behavior with EPM(Elevated Plus Maxe) and MWM(Morris Water Maze) after applying restraint stress to rats. Also, the degrees of AchE generation were measured with immunohistochemical method in the regions of hippocampus, and the degree of TH generation in the regions of VTA and LC, respectively. Results : 1. As the results of measuring how long EPM which reflects anxiety reaction stayed in the open arm, there was the trend which can suppress anxiety reaction in the MMD+stress group(Liriopis Tuber+stress) but no statistical significance. The counting results how many EPM passed between opened and closed arm showed suppression trend against a physical activity in the saline+stress group but there was no statistical significance. 2. According to the result of MWM, the saline+stress group showed the learning retardation which means increased time arriving at goal compared to ti1e normal group at the second and third day of measurement. On the contrary, a learning retardation was significantly decreased in the MMD+stress group. Among the probe trial test a memory loss occurred in the saline+stress group, meanwhile memory ability was notably increased in the saline-stress group. 3. The degree of TH generation was investigated at the VTA and LC respectively after test animals treated with drug. In the saline+stress group, TH-immunoreactive cells were significantly increased, and these stress-induced TH increases were suppressed in the saline+stress group at the VTA region. However, the saline+stress group did not show any significant difference. 4. the degree of AchE generation was investigated at the CA3 of hippocampus. The saline+stress group showed that AchE-immunoreactive cells were significantly decreased. Those stress-induced reductions of AchE cells were meaningfully recovered in the saline+stress group. Although the cells showed recovery trend in the region of CA1 of hippocampus, statistical significance was not observed. Conclusion : The results of our study indicate that Liriopis Tuber can improve spatial memory ability of rats applied a restraint stress. This improvement of the spatial memory ability is considered to have an efficacy of nervous protection that Liriopis Tuber suppresses the generation of AchE in the hippocampus region and enhances the generation of TH in the VTA.

• Journal of The Korean Association For Science Education
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• v.26 no.3
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• pp.367-375
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• 2006

This study investigated the effects of varying visuals in drawing and writing as methods to assist students in connecting and integrating multiple external representations provided in learning the particulate nature of matter. Seventh graders (N=233) at a coed middle school were assigned to control, static drawing (SO), dynamic drawing (DD), static writing (SW), and dynamic writing (DW) groups. The students were taught about "Boyle's Law" and "Charles's Law" for two class periods. Two-way ANCOVA results revealed that the scores of a conception test for the two drawing (SD, DD) groups and the two writing (SW, DW) groups were significantly higher than those for the control group. Within the writing groups, students of lower spatial visualization ability in the DW group scored significantly higher than those in the SW group. However, no significant differences were found in the scores of the conception test for the two drawing (SD, DD) groups regardless of students' visualization ability. Researchers also found that most students in both DD and DW groups had respectively positive perceptions of dynamic visuals in drawing or writing.

• Science of Emotion and Sensibility
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• v.22 no.4
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• pp.31-44
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• 2019

This study intended to investigate the effects of the subtitle location on the decreased working memory abilities caused by aging. A junior group (average age: 26, SD: 3.06, N=27) and a senior group (average age: 61.69, SD=4.18, N=26) participated in this study and they all performed N-back tasks which measured the working memory ability of the participants and video subtitle recognition tasks that assessed the most effectively recognized subtitle locations in the video. The results of the N-back task revealed slower response times and low accuracy rates in the senior group in comparison to the junior group, suggesting lower working memory abilities in the senior group vis-à-vis the junior group. The deterioration of working memory due to aging also negatively influenced the 'left-bottom' subtitle location in the video subtitle recognition task and positively influenced the 'left-center' location of the screen. The deterioration of working memory ability did not affect other subtitle locations. By examining the positive or negative effects of the deterioration of working memory ability as a function of age on subtitle locations, the present study suggests that the selection of suitable subtitle locations taking into account the ages of video viewers would cause information to be more effectively displayed on screen.

• Physical Therapy Korea
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• v.25 no.2
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• pp.30-43
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• 2018

Background: Hemispatial neglect is defined as the failure to attend, report, respond, or orient toward meaningful stimuli provided in the contralateral side of a brain lesion. Objects: This study was conducted to find out the effect of dynamic trunk equilibirum exercise for stroke patients with hemi-spatial neglect. Methods: This study included 21 stroke subjects, randomly assigned to either the experimental group or the control group. The exercise program consisted of 5 sessions of 20 minutes per week during 4 weeks. The line-bisection test, the Albert test, the balance function score, the Berg balance scale, the postural assessment scale for stroke and the modified Barthel index were measured before and after training. All data were analyzed using SPSS 12.0 for Windows. Between-group and within-group comparison was analyzed by using Independent t-test and Paired t-test respectively. Results: The results of study were as follows: There were significant differences between before and after intervention in both group (p<.05). There were significant differences in the line-bisection test, Albert test, balance function score, Berg balance scale, postural assessment scale for stroke and modified Barthel index between the experimental group and the control group (p<.05). Conclusion: Dynamic trunk equilibrium exercise had a positive effect on patients' neglect, balance ability and activities of daily living. Further studies are required to generalize the results of this study.

• The Journal of the Korea Contents Association
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• v.11 no.1
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• pp.396-403
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• 2011

According to the development of information and the possibility of utilizing the most effective were high hopes that a plan is in the area have. Planning process of data collection and analysis and forecasts necessary, because even before the introduction of information, logical reasoning and objectivity of the plan to increase the variety of efforts have been made at an early age. This research try to offer a foundation for the future direction of research. Firstly, land use information systems and related legal issues and sought to review the status. Second, the information system of land use and spatial planning and diagnosing the problem was related to the status of the system. This desirable to propose the development of informatization. Finally, the purpose and the information derived legal system's ability to exert maximum legal system of the maintenance and development of information systems is to propose.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.10
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• pp.77-83
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• 2020

The technologies of 3D spatial information, such as Smart City and Digital Twins, are developing rapidly for managing land and solving urban problems scientifically. In this construction of 3D spatial information, an object using aerial photo images is built as a digital DB. Realistically, the task of extracting a texturing image, which is an actual image of the object wall, and attaching an image to the object wall are important. On the other hand, occluded areas occur in the texturing image. In this study, the ResNet algorithm in deep learning technologies was tested to solve these problems. A dataset was constructed, and the street tree was detected using the ResNet algorithm. The ability of the ResNet algorithm to detect the street tree was dependent on the brightness of the image. The ResNet algorithm can detect the street tree in an image with side and inclination angles.

• Imaging Science in Dentistry
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• v.47 no.3
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• pp.199-207
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• 2017

Purpose: Evaluation of alveolar bone is important in the diagnosis of dental diseases. The periodontal ligament space is difficult to clearly depict in cone-beam computed tomography images because the reconstruction filter conditions during image processing cause image blurring, resulting in decreased spatial resolution. We examined different reconstruction filters to assess their ability to improve spatial resolution and allow for a clearer visualization of the periodontal ligament space. Materials and Methods: Cone-beam computed tomography projections of 2 skull phantoms were reconstructed using 6 reconstruction conditions and then compared using the Thurstone paired comparison method. Physical evaluations, including the modulation transfer function and the Wiener spectrum, as well as an assessment of space visibility, were undertaken using experimental phantoms. Results: Image reconstruction using a modified Shepp-Logan filter resulted in better sensory, physical, and quantitative evaluations. The reconstruction conditions substantially improved the spatial resolution and visualization of the periodontal ligament space. The difference in sensitivity was obtained by altering the reconstruction filter. Conclusion: Modifying the characteristics of a reconstruction filter can generate significant improvement in assessments of the periodontal ligament space. A high-frequency enhancement filter improves the visualization of thin structures and will be useful when accurate assessment of the periodontal ligament space is necessary.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.6
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• pp.101-115
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• 2021

The purpose of this study is to evaluate the compatibility of the vegetation index between the two satellites and the applicability of agricultural monitoring by comparing and verifying NDVI (Normalized Difference Vegetation Index) based on Sentinel-2 and Terra MODIS (Moderate Resolution Imaging Spectroradiometer). Terra MODIS NDVI utilized 16-day MOD13Q1 data with 250 m spatial resolution, and Sentinel-2 NDVI utilized 10-day Level-2A BOA (Bottom Of Atmosphere) data with 10 m spatial resolution. To compare both NDVI, Sentinel-2 NDVIs were reproduced at 16-day intervals using the MVC (Maximum Value Composite) technique. As a result of time series NDVIs based on two satellites for 2019 and compare by land cover, the average R² (Coefficient of determination) and RMSE (Root Mean Square Error) of the entire land cover were 0.86 and 0.11, which indicates that Sentinel-2 NDVI and MODIS NDVI had a high correlation. MODIS NDVI is overestimated than Sentinel-2 NDVI for all land cover due to coarse spatial resolution. The high-resolution Sentinel-2 NDVI was found to reflect the characteristics of each land cover better than the MODIS NDVI because it has a higher discrimination ability for subdivided land cover and land cover with a small area range.

• Journal of the Korean Society of Physical Medicine
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• v.14 no.2
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• pp.107-115
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• 2019

PURPOSE: This study examined the effects of the chopping pattern of proprioceptive neuromuscular facilitation (PNF) on the neglect, balance ability, and activities of daily living in stroke patients with hemi-spatial neglect. METHODS: Twenty stroke patients with neglect volunteered for this study. The subjects were assigned randomly to either the experimental group (EG, n=10) or control group (CG, n=10). The chopping pattern of PNF and exercise therapy were applied in the EG and CG, respectively, for four weeks. Neglect, balance, and activities of daily living were evaluated at the pre-and post-intervention. The assessment tools included a line-bisection test, balance test using Space balance 3D, and modified Barthel index. The pre-and post-intervention values were compared in each group using a paired t-test and the between-group differences were assessed using an independent t-test. Statistical significance was set to ${\alpha}=.05$ for all variables. RESULTS: Significant differences were observed between the EG and CG in terms of neglect, balance, and activities of daily living (p<.05). Both groups showed significant improvement in neglect, balance, and activities of daily living (p<.05). CONCLUSION: These results suggest that the chopping pattern of PNF is effective in improving the hemi-spatial neglect, balance, and activities of daily living in stroke patients with neglect.