• Korean journal of applied entomology
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• v.22 no.2 s.55
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• pp.52-66
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• 1983

The brown planthopper, N. lugens (Stal), has become a serious pest of rice in tropical Asia during the last decade. At high pest density, its feeding damage causes 'hopperburn' or complete wilting and drying of the rice plant. It also transmits grassy and ragged stunt virus diseases. The estimated losses caused by the pest in tropical Asia exceed $US\$300$ millions. While cultivation of resistant rice varieties has proved to be highly effective against the pest, their long-term stability is threatened because of the evolution of prolific biotypes which can destroy these varieties. At present, identification of biotypes is based principally on the differential reactions of host rice varieties to the pest and on host-mediated behavioral and physiological responses of the pest. Recent findings of morphological differences in adult rostrum, legs, and antennae, body parts that possess receptors for host plant location and discrimination, and cytological differences in N. lugens populations maintained as stock cultures strongly complement other biotype studies. So far, three N. lugens biotypes have been identified in the Philippines. Biotype I can survive on and damage varieties that do not carry and genes for resistance, while Biotype 2 survives on resistant varieties carrying Bph 1 gene and Biotype 3 on varieties carrying gene bph 2. However, none of these biotypes can survive on varieties with genes Bph 3 or bph 4. Several varieties which are resistant in the Philippines are susceptible in India and Sri Lanka as the South Asian biotypes of N. lugens are more virulent than Southeast Asian biotypes. To monitor the pest biotypes in different geographical regions and to identify new sources of resistance, an International Brown Planthopper Nursery has been established in many cooperating countries. The evolution of biotypes is an exceedingly complex process which is governed by the interactions of genetic and biological factors of the pest populations and the genetic makeup of the cultivated varieties. While the strategy for sequential release of varieties with major resistance genes has been fairly successful so far, the monegenic resistance of these varieties makes them vulnerable to the development of the pest biotypes. Therefore, present breeding endeavors envisage utilizing both major and minor resistance genes for effective control of the pest.

• Journal of Environmental Impact Assessment
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• v.26 no.5
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• pp.376-384
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• 2017

Bangladesh is a South Asian country with subtropical monsoonal climate between the intersection of the Indo-Himalayan and Indo-Chinese sub-regions, is known as biodiversity hotspot of the Asian region. The country has different types of forest like deciduous forest, evergreen forest, mixed forest, haor (wetlands) and mangrove forest. The natural beauty of the country is increased with the presence of so many rivers, longest sea beach of the world, green plants, critical hilly regions and green agricultural forest widely spread here and there. Sundarbans is the world largest mangrove forest and world natural heritage site declared by UNESCO in 1999 situated in Bangladesh and India. About 62 percent of this mangrove forest is situated in Bangladesh and there are so many plants and animals are found in this forest. To meet the increasing demand of the large population most of the natural ecosystem is now altered, deforestation rate is increased, natural habitat of the species is disturbed. Due to the imbalance of the climate and natural system many of the rare species of the world found this region is now endangered and some of the species are extinct. Directly or indirectly they are benefited from natural resources. At present time community, based ecotourism is also an important source of income for rural poor peoples. To protect the natural resources the government is now developed so many conservation acts and policy as well NGOs are also doing work for the conservation of ecosystem and biodiversity. At present transboundary pollutants and so many natural disasters also destruct the natural resources of Bangladesh.

• The Journal of the Petrological Society of Korea
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• v.21 no.2
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• pp.193-202
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• 2012

There were three cycles of igneous activities from the late Paleozoic to early Cenozoic; Permian to Triassic, Jurassic, and Cretaceous to Paleogene. After the beginning of each igneous activity cycle, igneous activity became more frequent until its climax. It is noteworthy that A-type magmatisms are reported from near the ends of the all three igneous activity cycles. In addition, adakitic magmatisms occurred at the beginning of both the Permian-Triassic and the Cretaceous-Paleogene cycles. Most of the igneous activities during the late Paleozoic to early Cenozoic period were subduction-related. Therefore, transitions among beginning, proceeding, and closing of the igneous activity cycles would be intimately related with changes in directions of plate movements. In this context, I suggest following hypotheses. The closing of the Permian-Triassic igneous cycle was possibly a consequence of radical adjustment of plate motion occurred due to continental collision between north and south China blocks. Considering that no appreciable tectonic activities were recognized from the east Asian continent at the closing of the Jurassic igneous cycle, it seems that one of the strong events related with Gondwanaland-breakup and subsequent birth of the new oceans, which might cause sudden adjustments of plate motions. The closing of the Cretaceous-Paleogene igneous cycle seems to be caused as a consequence of the collision between India and Asia continents. Meanwhile, adakitic igneous bodies emplaced at the beginnings of the Permian-Triassic and Cretaceous-Paleogene cycles could be products of slab-melting during the early stages of the subduction.

• Acta Via Serica
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• v.1 no.1
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• pp.95-104
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• 2016

The Silk Route in ancient times served as a link between the World's greatest civilizations and as a source of knowledge, art, religion and philosophy. This network of ancient caravan paths formed the first bridge between East and West, where two different civilizations came in contact with their respective cultural traditions and religious beliefs, as well as their scientific and technological achievements. One of the main routes of the Great Silk Route passed through the Karakoram, linking Kashgar with Kashmir and the Gandhara regions. The Karakoram Highway connects the Chinese province with Pakistan and follows the ancient Silk Route, which connected the Heartlands of Asia with the Western fringes and further beyond the entire continent of Europe. Evidences of the history of humankind, ranging from Pre-historic times to the spread of Buddhism from South Asia to China and the Far East, is depicted in the rocky cliffs on the waysides and on rough boulders scattered in the upper valley of the Indus River and its tributaries. The ancient trade routes also carried scholars, teachers, missionaries and monks of different beliefs and practices, who met and exchanged ideas. The Buddhists as well as Zoroastrians and other missionaries all followed the Silk Route, leaving permanent footprints of their passage. The ancient greater Gandhara is situated in the North-West of the Indian Sub-continent, with the steep mountain ranges of the Karakoram, the Pamir and the Hindu-Kush bordering it and the dry areas of Central Asia to its rear. A number of races from Central Asia migrated to Gandhara because of its mild climate and plentiful farm products and fruits. This area was an entry point of Western Culture into India and at the same times the exit point of Indian Culture, including Buddhism, to the West. In Gandhara, the diffusion of different cultures developed an art form, during the 1-7th centuries CE commonly known after its geographic name as "Gandhara Art". The Buddhism's route of introduction into China originated in Gandhara, then reached in Korea and Japan and other countries. The fame of Gandhara however, rested on its capital, "Taxila" which was a great centre of learning. From the time of the Achaemenians, down through Muslim period, Gandhara continued to establish and maintain a link between East & West, as shown by material evidences recovered from Taxila and other Buddhist centres of Gandhara during the course of archaeological excavations.

• Journal of the korean academy of Pediatric Dentistry
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• v.47 no.3
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• pp.352-358
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• 2020

Glanzmann's thrombasthenia (GT) is a rare, autosomal recessive inherited congenital disorder, characterized by impaired blood coagulation due to platelet dysfunction. It was first reported by the pediatrician Glanzmann in 1918. GT affects both males and females, and it is more common in regions of the Middle East, India, and France, where intermarriage is common. It has an incidence of about 1 in 1,000,000 people. In South Korea, according to the Division of Rare Diseases, Korea Centers for Disease Control and Prevention, around 200 cases have been reported in 2018. Clinical symptoms include petechia, ecchymosis, epistaxis, and gingival bleeding. The spontaneous loss of deciduous teeth can result in excessive bleeding with that blood transfusion should be considered. Preventing hemorrhages and hemostasis are most important factors in dental treatment. Local bleeding can be controlled by compression, but platelet transfusion can be required by prolonged bleeding. Pediatric dentists can minimize the gingival bleeding by control of the oral hygiene to prevent gingivitis and dental caries. The importance of oral hygiene and periodic recall check-up should be emphasized. During dental treatment, the examination and the treatment plan of patient should be modified to prevention of hemorrhages carefully. A 6-year-old girl with GT was referred for the treatment of dental caries, and resin restoration was performed under nitrous oxide inhalation sedation. After treatment, compression was required for the bleeding control.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3785-3792
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• 2015

The CCAAT/enhancer-binding protein-alpha (CEBPA) is a transcriptional factor that plays a crucial role in the control of proliferation and differentiation of myeloid precursors. This gene was recognized as the target of genetic alterations and were associated with clinical complexity among AML. We here analyze the frequency and types of CEBPA mutations and polymorphisms in a de novo AML patients from South India and tried to find out associations of these variations with different clinical parameters and the prognostic significance in AML. Study was carried out in 248 de novo AML patients, cytogenetic analysis was performed from the bone marrow samples and was karyotyped. PCR-SSCP analysis and sequencing was performed for the detection of CEBPA gene variations. All the statistical analysis was performed using SPSS 17 (statistical package for social sciences) software. Pearson Chi-square test, Mann-Whitney U test, Kaplan-Meier survival analysis and log rank tests were performed. CEBPA mutations were detected in 18% and CEBPA polymorphisms were detected in 18.9% of AML cases studied. Most of the mutations occured at the C terminal region. Polymorphisms were detected in both N and C terminal region. with most common being, c.584_589dup ACCCGC and c.690G>T. A significant association was not observed for the mutation and polymorphism with respect to clinical and laboratory parameters. Survival advantage was observed for the mutated cases compared to non mutated cases, especially for the normal karyotype groups. Polymorphisms has no effect on the survival pattern of AML patients. CEBPA mutation and polymorphisms were observed with similar frequency and was identified in all the FAB subtypes as well as in cytogenetic risk groups in our study population, but CEBPA mutations alone confer a prognostic value for NK AML patients.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3335-3340
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• 2016

Background: Oral submucous fibrosis (OSF) is a precancerous condition with a 4 to13% malignant transformation rate. Related to the habit of areca nut chewing it is mainly prevalent in South-east Asian countries where the habit of betel quid chewing is frequently practised. On chewing, alkaloids and polyphenols are released which undergo nitrosation and give rise to N-nitrosamines which are cytotoxic agents. CYP450 is a microsomal enzyme group which metabolizes various endogenous and exogenous chemicals including those released by areca nut chewing. CYP1A1 plays a central role in metabolic activation of these xenobiotics, whereas CYP2E1 metabolizes nitrosamines and tannins. Polymorphisms in genes that code for these enzymes may alter their expression or function and may therefore affect an individuals susceptibility regarding OSF and oral cancer. The present study was therefore undertaken to investigate the association of polymorphisms in CYP1A1 m2 and CYP2E1 (RsaI/PstI) sites with risk of OSF among areca nut chewers in the Northern India population. A total of 95 histopathologically confirmed cases of OSF with history of areca nut chewing not less than 1 year and 80, age and sex matched controls without any clinical signs and symptoms of OSF with areca nut chewing habit not less than 1 year were enrolled. DNA was extracted from peripheral blood samples and polymorphisms were analyzed by PCR-RFLP method. Gene polymorphism of CYP1A1 at NcoI site was observed to be significantly higher (p = 0.016) in cases of OSF when compared to controls. Association of CYP1A1 gene polymorphism at NcoI site and the risk of OSF (Odd's Ratio = 2.275) was also observed to be significant. However, no such association was observed for the CYP2E1 gene polymorphism (Odd's Ratio = 0.815). Our results suggest that the CYP1A1 gene polymorphism at the NcoI site confers an increased risk for OSF.

• Journal of Life Science
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• v.28 no.5
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• pp.540-546
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• 2018

Annona muricata, generally known as soursop, graviola, or sirsak, is native to the warmest tropical areas of North and South America and is now widely distributed throughout tropical and subtropical parts of the world, including India and Nigeria. This study tested the contents of polyphenolic compounds, flavonoids, and minerals, as well as the antioxidative effects of DPPH radical-scavenging activity, Fe/Cu-reducing power, linoleic-acid peroxidation using thiobarbituric-acid (TBA) methods and peroxidation of rat-hepatocyte microsomes, and ${\beta}$-carotene bleaching assay. These were tested with in-vitro experimental models using water, ethanol, and methanol extracts of the Annona muricata leaf (AMl). Water extracts of AMl showed the highest extraction yield (1.76%). The total polyphenol-compound concentration was the highest in the methanol extract of AMl. However, the flavonoids concentration was the highest in the ethanol extracts of AMl. AMlMl major minerals were Ca, K, and Mg. In DPPH radical-scavenging activity, the contents exhibited a strong scavenging effect on the ethanol and methanol extracts of AMl. Additionally, the Fe/Cu-reducing power was strong in ethanol and methanol extracts of AMl. $Fe^{2+}$/ascorbate-induced linoleic-acid peroxidation using TBA methods and auto-oxidation of rat-hepatic microsomes showed strong antioxidative activities in ethanol extracts of AMl. ${\beta}$-Carotene bleaching was also highest in the ethanol extracts of AMl. These results may provide the basic data to understand the chemical characteristics and antioxidative effects of Annona muricata leaf extract for the development of functional foods.

• Journal of Korea Port Economic Association
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• v.32 no.4
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• pp.193-209
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• 2016

The Mekong River is a river in the south-eastern part of the continent of Aisa. It flows through the countries of Thailand, Lao PDR, Cambodia, Myanmar, and Vietnam that are located in Indochina and are members of ASEAN. These countries are growing rapidly and many others have entered into these markets. As the number of manufactures has increased, logistics markets become very attractive to our logistics companies that want to expand their business. This study focuses on four countries, Lao PDR, Cambodia, Myanmar, and Vietnam, which have potential economic growth and shows the environment of logistics with current logistics infrastructure and related investment law and system. The goal of this study to provide, with strength, weakness, opportunities, and threats(SWOT) analysis, some strategies to enter 4 countries' logistics market with SWOT and the strategies are as follows; First, foreign direct investment in logistics is linked with logistics infrastructure projects. Our government should strengthen its role to find cooperation programs that make connect with logistics business. Second, a logistics company is better off in a consortium with other manufacturers or other logistics companies to ensure minimum cargo and reduce entry risks. Finally, the four countries' roles as a logistics bases need to divided according to their environments, to benefits of logistics connecting between India and China.

• Journal of Korea Water Resources Association
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• v.53 no.spc1
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• pp.719-730
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• 2020

Recognizing a complexity of global water challenges, such as water shortage, water pollution, water-related disasters, and degradation of water environments, this study introduces the newly established concept and definition of water security and water security assessment framework based on the review of previous works on water security. In order to critically assess the situations of water security of each country, an water security assessment framework is employed highlighting the four core areas: 1) social equity; 2) economic efficiency; 3) environmental sustainability; and 4) resilience to water-related disasters. 28 Asian countries have been selected and evaluated for the level of water security, and as a consequence, Japan, Malaysia and South Korea demonstrate a high degree of water security whereas India, Pakistan and the Philippines show a relatively low level of water security. The significance of this study lies in clarifying weak areas in water security as well as suggesting the areas that should be improved for achieving sustainable water management.