• BMB Reports
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• 제42권12호
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• pp.829-833
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• 2009

Angiogenin is a member of the ribonuclease superfamily that induces the formation of new blood vessels. It has been suggested that the surface loop of angiogenin defined by residues 59-71 plays a special role in angiogenic function (1); however, the mechanism of action is not clearly defined. To elucidate the role of the surface loop on the structure, function and stability of angiogenin, three surface loop mutants were produced in which 14 amino acids in the surface loop of RNase A were substituted for the 13 amino acids in the corresponding loop of angiogenin. The structure, stability and biological functions of the mutants were then investigated using biophysical and biological approaches. Even though the substitutions did not influence the overall structure of angiogenin, they affected the stability and angiogenic function of angiogenin, indicating that the surface loop of angiogenin plays a significant role in maintaining the stability and angiogenic function of angiogenin.

• 전기학회논문지
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• 제66권10호
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• pp.1454-1459
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• 2017

In spite of continuous increase of electric power demand and new generation plants, it is very difficult to install new transmission line. Therefore, it comes to be difficult to operate the power system stable, so it is required to find another way to get new transmission capacity. Because HVDC transmission system installation is the one of the best option for us, we have undertake the HVDC project in mainland. Buckdangjin-Goduck HVDC project(500kV, 3GW) is currently under construction and Eastern Power HVDC project(500kV, 8GW) is under the study for technical specification. Both of them have the Run-up SPS function for taking action of 765kV Transmission line fault. The Run-up SPS function increases the active power output of the HVDC rapidly when the transmission line between the power plant and network is tripped, thereby preventing the generator from overspeed and improving the power system stability. In this paper, we propose MEAC(Modified Equal Area Criteria) method based on traditional EAC method to quantitatively evaluate the effect of the HVDC run-up SPS function on the power system stability improvement.

• 대한한의학회지
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• 제30권3호
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• pp.28-38
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• 2009

Background : Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. Objective : The aim of this study was to evaluate the effects of Gentianae Macrophyllae Radix (G. M. Radix) on the pain control and the recovery of the locomotor function that results from the sciatic crushed nerve injury in rats. Method : Using rats, we crushed their sciatic nerve, and then orally administered the aqueous extract of G. M. Radix. The effects of G. M. Radix on the recovery locomotor function were investigated by walking track analysis. The effects of G. M. Radix on pain control were investigated by brain-derived neurotrophic factor (BDNF) expression in the sciatic nerve, and c-Fos expression in the paraventricular nucleus (PVN) of the hypothalamus and in the ventrolateral periaqueductal gray (vlPAG). Result : G. M. RADIX facilitates motor function from the locomotor deficit, and thereby increased BDNF expression and suppressed painful stimuli in the PVN and vlPAG after sciatic crushed nerve injury. Conclusion : It is suggested that G. M. Radix might aid recovery locomotor function and control pain after sciatic crushed nerve injury. Further studies on identifying specific the component in G.M. Radix associated with enhanced neural activity in the peripheral nerve injury may be helpful to develop therapeutic strategies for the treatment of peripheral nerve injury.

• 대한기계학회논문집
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• 제14권6호
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• pp.1464-1473
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• 1990

Optimal design parameters are estimated from the sensitivity function and performance index variation. Suspension design modification for performance improvement and basic materials for practical applications are presented. The linear quarter model of a vehicle suspension is analyzed in order to represent the utilities of sensitivity analysis, and sensitivity function is determined in the frequency domain. The change of frequency response function is predicted, which depends on the design parameter variation and the property is verified by computer simulation. As an investigation results of sensitivity function for the vibrational amplitude of sprung mass to road profile input, it is shown that the most sensitive parameters are the suspension damping and the suspension stiffness. In order to identify the effects of these two parameters to the performance of suspension system, the performance index variation according to the changes of parameters is considered and then optimal design parameters are determined. It is verified that the system response is improved noticeably in the both of frequency and time domain after the design modification with the optimal parameters.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 추계종합학술대회 B
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• pp.195-198
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• 2008

최근 태양광 발전시스템 등 낮은 전압을 발생하는 전원소스를 이용하여 높은 승압효과를 얻기 위한 멀티레벨 인버터에 대한 관심이 높아지고 있다. 본 논문은 FPGA 기반 멀티레벨 인버터용 스위칭 함수를 구현하고자 한다. FPGA는 프로그램 가능한 로직 디바이스로써 풀 디지털 스위칭함수를 구현하는 효율적이다. 본 논문에서는 FPGA 기반 스위칭 함수를 구현하기 위해서 마이크로프로세서로부터 출력되는 클럭과 동기신호로 독립적으로 구동이 되도록 하였다.

• 정보처리학회논문지B
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• 제12B권5호
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• pp.513-520
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• 2005

본 논문에서는 인덱스 변환 함수를 이용한 벡터양자화 기반의 견고한 다중 워터마킹 방법을 제안한다. 기존의 워터마크 삽입 방법들은 단지 하나의 워터마크를 원영상에 삽입하는데 비해 제안한 방법에서는 저작권 보호를 위하여 여러 개의 워터마크를 삽입한다. 제안한 방법은 다양한 공격에서도 벡터양자화 인덱스들의 변화를 최소화시키는 인덱스 변환 함수를 사용하여 견고성을 효과적으로 개선시킨다. 실험을 통하여 제안한 방법이 기존의 벡터양자화 기반의 다중 워터마킹 방법과 비교하여 다양한 공격에서도 견고성이 우수함을 확인하였다.

• 한국압력기기공학회 논문집
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• 제8권2호
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• pp.26-32
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• 2012

The systems of the nuclear power plant are designed based on the User Requirement Document, and Korea Hydro & Nuclear Power Co. (KHNP) implements preventive maintenance activities to keep the specific design function of the system consistently. To monitor the preventive maintenance effectiveness, KHNP has also developed maintenance effectiveness monitoring (MR) program based on NUMARC 93-01 since 2003, and has implemented the program in all operating plants. Recently, KHNP has upgraded MR programs by reflecting implementing experiences ; reestablishing the performance monitoring level, improving analysis for standby function and performance criteria for passive components, reestablishing the availability performance criteria and the performance criteria for the same type of components. These upgraded MR programs will contribute to enhance safety and improve equipment reliability through monitoring maintenance effectiveness.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2008년도 춘계학술대회 논문집
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• pp.158-163
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• 2008

In inverse synthetic aperture radar (ISAR) imaging, An ISAR autofocusing algorithm is essential to obtain well-focused ISAR images. Traditional methods have relied on the approximation that the phase error due to target motion is a function of the cross-range dimension only. However, in the stepped-frequency radar system, it tends to become a two-dimensional function of both down-range and cross-range, especially when target's movement is very fast and the pulse repetition frequency (PRF) is low. In order to remove the phase error along down-range, this paper proposes a method called SAEM (subarray averaging and entropy minimization) [1] that uses a subarray averaging concept in conjunction with the entropy cost function in order to find target motion parameters, and a novel 2-D optimization technique with the inherent properties of the proposed entropy-based cost function. A well-focused ISAR image can be obtained from the combination of the proposed method and a traditional autofocus algorithm that removes the phase error along the cross-range dimension. The effectiveness of this method is illustrated and analyzed with simulated targets comprised of point scatters.

• 사상체질의학회지
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• 제22권4호
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• pp.113-123
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• 2010

1. Objectives This study is about three cerebellar infarction patients with dizziness and ataxia. In this study, we evaluated the effects of Sasang constitutional treatment and suggested using the 'Equilibrium Function Test' as scale. 2. Methods These three patients were treated by Sasang constitutional herbal medications based on "Donguisusebowon". Acupuncture & moxa therapy and west medications were limited as much as possible. We evaluated the symptoms through two methods, the Visual Analogue Scale and the Equilibrium Function Test. 3. Results and Conclusions Dizziness and ataxia that were these three patients' chief complaints were improved. This case study shows that Sasang constitutional herbal medications are an effective treatment for cerebellar infarction patients.

• 한국해양공학회지
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• 제26권6호
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• pp.80-85
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• 2012

The methods of robust design optimization (RDO) and reliability-based robust design optimization (RBRDO) were implemented in the present study. RBRDO is an integrated method that accounts for the design robustness of an objective function and for the reliability of constraints. The objective function in RBRDO is expressed in terms of the mean and standard deviation of an original objective function. Thus, a multi-objective formulation is employed. The regressive approximate models are generated via the moving least squares method (MLSM) and constraint-feasible moving least squares method (CF-MLSM), which make it possible to realize the feasibility regardless of the multimodality/nonlinearity of the constraint function during the approximate optimization processes. The regression model based RBRDO is newly devised and its numerical characteristics are explored using the design of an actively controlled ten bar truss structure.