• Journal of Korean Neurosurgical Society
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• v.29 no.11
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• pp.1429-1436
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• 2000

Objectives : This study was performed in cultured rat hippocampal neurons to investigate the acute electrophysiological features of ionotropic glutamate receptors which act as a major excitatory neurotransmitter in mammalian brain. Method : Glutamate receptor agonists were applied into the bath solution embedding in whole-cell patch-clamp recording of single hippocampal neuron. Results : In voltage-clamped at -60mV and the presence of 1mmol $Mg^{2+}$, extracellulary applied NMDA did not induce any inward current. Both the elimination of $Mg^{2+}$ and addition of glycine in bath, however, elicited a NMDAinduced inward current. $Mg^{2+}$ block current was increased gradually in more negative potentials from -30mV, showing a negative slope in I-V plot with $Mg^{2+}$. Glutamate-induced current represented an outward rectification. A non-NMDA receptor component occupied about 40% of glutamate-induced current in the voltage range of -80mV to +60mV. Conclusion : Present study suggests that glutamate activates acutely the non-NMDA receptors which induces an inward current in the level of resting membrane potential. This makes the membrane potential increase and can activate the NMDA receptors that permit calcium influx against $Mg^{2+}$ block. At the depolarized state of neuron, there may be recovery mechanisms of membrane potential to repolarize irrespective of voltage-dependent potassium channels in the hippocampal neurons.

• Journal of the Korean Society for information Management
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• v.35 no.2
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• pp.63-88
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• 2018

This research evaluated differences of classification performance for feature selection methods using LDA topic model and Doc2Vec which is based on word embedding using deep learning, feature corpus sizes and classification algorithms. In addition to find the feature corpus with high performance of classification, an experiment was conducted using feature corpus was composed differently according to the location of the document and by adjusting the size of the feature corpus. Conclusionally, in the experiments using deep learning evaluate training frequency and specifically considered information for context inference. This study constructed biomedical document dataset, Disease-35083 which consisted biomedical scholarly documents provided by PMC and categorized by the disease category. Throughout the study this research verifies which type and size of feature corpus produces the highest performance and, also suggests some feature corpus which carry an extensibility to specific feature by displaying efficiency during the training time. Additionally, this research compares the differences between deep learning and existing method and suggests an appropriate method by classification environment.

• Journal of Biomedical Engineering Research
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• v.31 no.3
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• pp.234-239
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• 2010

We have developed and reported several micro-spikes for minimally invasive biopsy. This paper presents a diagnosis protocol for micro-spike biopsy using paraffin-based tissue collecting tool. Using the proposed tissue collecting tool, which has a negative micro-spike structure in a porous chamber, the biopsied tissue in a micro-spike is effectively detached. The proposed diagnosis protocol prevents the loss of tissues in a paraffin embedding and sectioning process. Hence, it is compatible with conventional histopathology without additional reagents and processes. The gastro-intestinal tissue of a pig is biopsied in an in vivo environment, and then it is detached from a micro-spike using the paraffin-based tissue collecting tool. A histopathological photomicrograph of the detached tissue is acquired with the proposed diagnosis protocol. The acquired image offers clinical quality. This result shows that the paraffin-based tissue collecting tool is applicable to the medical practice.

• Journal of Korea Multimedia Society
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• v.11 no.10
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• pp.1347-1358
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• 2008

A blind video watermarking scheme for providing safety, authenticity, and copyright protection is proposed in this paper, which is robust to MPEG-4 SVC and multimedia transcoding. In proposed method, embedding and detecting of watermark is performed based on base layer with considering spatial SVC. To be robust from temporal SVC, our method embeds repeatedly a permutated character with ordering number per one frame. Also for robustness from multimedia transcoding and FGS, the method is embedded watermark in low middle frequency of each frame adaptively based on DCT in ROI. Through experimental results, invisibility of the watermark is confirmed and robustness of the watermark against the spatial SVC, temporal SVC, FGS and video transcoding between MPEG-2 and MPEG-4 SVC is also verified.

• The Korea Journal of Herbology
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• v.30 no.4
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• pp.65-69
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• 2015

Objectives : The root ofCyanchum wifordii(CW) had been used as herbal medicine, 'Baeksuo', in Korea. However, the root ofCynanchum auriculatum(CA) had also been mis-used as 'Baeksuo' in herbal markets, due to its morphological similarity with CW. This study aimed to compare discriminative features and establish the identification-keys between two herbal medicines using microscopic methods.Methods : Microscopic preparations including fixation, rapid dehydration, paraffin infiltration, paraffin embedding, sectioning, mounting, and staining, were performed and the microscopic features between CW and CA samples were compared.Results : The starch grain of parenchymal cells, the amounts of calcium oxalate crystals, cell sizes, and the shape of phloem were not different between CW and CA samples. However, the clusters of stone cells which were conglomerated at outer cortex were apparently observed in CA sample (4~8 layers of stone cells), but not in CW sample (2~4 layers of stone cells, or not). Xylem of CW consisted of several vessels and fiber bundles which were formed as linear shapes and discontinuous radial lines, while that of CA, in which radial lines was not observed, were shaped as a wedge and scattered near cambium with comparatively few fiber bundles enclosed vessels. Especially, in the xylem of CA, fiber bundles located towards cambium were relatively more developed than those located outward cambium.Conclusions : The identification-keys established in this study would be helpful to discriminate microscopic features between CW and CA.

• The KIPS Transactions:PartB
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• v.8B no.5
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• pp.579-586
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• 2001

Digital watermarking is to embed imperceptible mark into image, video, audio, and text data to prevent the illegal copy of multimedia data. arbitrary modification, and also illegal sales of the copies without agreement of copyright ownership. In this paper, we study for the embedding and extraction of watermark key using wavelet in the luminance signal in order to implement the system to protect the copyright for image MPEG. First, the original image is analyzed into frequency domain by discrete wavelet transform. The RSA(Rivest, Shamir, Aldeman) public key of the coded target is RUN parameter of VLD(variable length coding). Because the high relationship among the adjacent RUN parameters effect the whole image, it prevents non-authorizer not to possess private key from behaving illegally. The Results show that the proposed method provides better moving picture and the distortion more key of insert than direct coded method on low-frequency domain based DCT.

• Textile Coloration and Finishing
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• v.30 no.3
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• pp.190-198
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• 2018

We fabricated high transmission and high scattering poly(ethylene-co-vinyl acetate)(EVA) films embedding $SiO_2$ nanoparticles to improve outcoupling efficiency in organic display. The 800nm diameter $SiO_2$ nanoparticles aggregated and formed $1.56{\mu}m$ (with ${\pm}0.853{\mu}m$ standard deviation) diameter microparticles in EVA. The total transmission of scattering film was 83.3% on Polyethylene terephthalate(PET), which was higher than reference 82.8% PET substrate. The diffuse transmission and haze of the $SiO_2$ embedded EVA film were 76.1% and 91.4%, respectively. The optimized condition was 1:1 weight ratio of $SiO_2$ nanoparticles to EVA in Tetrahydrofuran(THF) solution. When the ratio of $SiO_2$ was larger than 1, the total transmission decreased by the increase in backscattering of light due to high scattering. With the optimized condition, we could succeed to fabricate a large scale film(35m in length) with a roll-to-roll process.

• Journal of KIISE
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• v.43 no.8
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• pp.902-909
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• 2016

Question answering system (QA system) is a system that finds an actual answer to the question posed by a user, whereas a typical search engine would only find the links to the relevant documents. Recent works related to the open domain QA systems are receiving much attention in the fields of natural language processing, artificial intelligence, and data mining. However, the prior works on QA systems simply replace all words that are not in the training data with a single token, even though such unseen words are likely to play crucial roles in differentiating the candidate answers from the actual answers. In this paper, we propose a method to compute vectors of such unseen words by taking into account the context in which the words have occurred. Next, we also propose a model which utilizes inverse document frequencies (IDF) to efficiently process unseen words by expanding the system's vocabulary. Finally, we validate that the proposed method and model improve the performance of a QA system through experiments.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.45.1-45.1
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• 2016

Spatially rotating magnetic fields have been observed in the solar wind and in the Earth's magnetopause as well as in reversed field pinch (RFP) devices. Such field configurations have a similarity with extended current layers having a spatially varying plasma pressure instead of the spatially varying guide field. It is thus expected that magnetic reconnection may take place in a rotating magnetic field no less than in an extended current layer. We have investigated the spontaneous evolution of a collisionless plasma system embedding a rotating magnetic field with a two-and-a-half-dimensional electromagnetic particle-in-cell (PIC) simulation. In magnetohydrodynamics, magnetic flux can be decreased by diffusion in O-lines. In kinetic physics, however, an asymmetry of the velocity distribution function can generate new magnetic flux near O- and X-lines, hence a dynamo effect. We have found that a magnetic-flux-reducing diffusion phase and a magnetic-flux-increasing dynamo phase are alternating with a certain period. The temperature of the system also varies with the same period, showing a similarity to sawtooth oscillations in tokamaks. We have shown that a modified theory of sawtooth oscillations can explain the periodic behavior observed in the simulation. A strong guide field distorts the current layer as was observed in laboratory experiments. This distortion is smoothed out as magnetic islands fade away by the O-line diffusion, but is soon strengthened by the growth of magnetic islands. These processes are all repeating with a fixed period. Our results suggest that a rotating magnetic field configuration continuously undergoes deformation and relaxation in a short time-scale although it might look rather steady in a long-term view.

• Journal of Pharmacopuncture
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• v.12 no.1
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• pp.53-65
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• 2009

Objectives : This study was to investigate the effect of Oriental medical treatment on ALS. Methods : We investigated 12 ALS patients which were admitted to Gwang-Ju O.M. hospital from Oct. 14, 2008 to Nov. 14, 2008. All patients were treated by SAAM-acupuncture, herb medication, Bee venom Pharmacopuncture therapy, Needle-embedding therapy, etc. We evaluated patients using the Amyotrophic lateral sclerosis Functional Rating Scale-Revised(ALSFRS-R), Medical Research Council (MRC) Scale. Results : After 30 days, mean ALSFRS-R score of patients was improved from $28.42{\pm}7.83$ to $29.08{\pm}7.99$, and mean MRC Scale of patients was improved from $24.79{\pm}8.37$ to $25.34{\pm}8.45$. But in both cases, the variation was not statistically significant. After 30 days, mean ALSFRS-R score and mean MRC Scale of patients was more improved in subjects with bulbar-onset, onset age: 51-60yrs., disease duration: 24-48mo. And the results showed partially significant difference. Conclusions : We think that the results of this case be a pilot study that proves the effect of Oriental Medical treatment on ALS.