• Journal of the Korean Magnetic Resonance Society
• /
• v.14 no.2
• /
• pp.88-104
• /
• 2010

Human melanocortin-4 receptor (hMC4R) has a critical role in part of energy homeostasis, and their heterozygous mutations related in genetic cause of severe human obesity. In order to study the structure and function of these membrane proteins, it is important to prepare the samples. However, the preparation of transmembrane peptide is seriously difficult and time-consuming. Overexpression and purification of membrane proteins was reported to be difficult due to their innate insoluble and toxic properties. Among the many difficulties, the most important is the difficulty in obtaining sufficient quantities of purified protein. Recently, we succeed to produce large amounts of the second transmembrane domain from the wild-type hMC4R (wt-TM2) and D90N mutant hMC4R (m-TM2) and proposed the structural difference of them in membrane-like environments. In this paper, we demonstrate the optimization procedures to express and purify wt-TM2 or m-TM2 peptides, and solution NMR studies in different detergents to get high-resolution spectra were also described.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2002.07b
• /
• pp.723-726
• /
• 2002

We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is 10[mN/m]. In processing of a device manufacture, we can see the process is good from the change of a surface pressure for organic thin films and transfer ratio of area per molecule. The structure of manufactured device is Au/Poly-$\gamma$ Benzyl $_D$-Glutamate/Al; the number of accumulated layers is 1, 3, 5 and 7. Also, we then examined of the MIM device by means of I-V. The I-V characteristic of the device is measured from 0 to +2[V]. We determined electrochemical measurement by using cyclic voltammetry with a three-electrode system. LB film accumulated by monolayer on an ITO. In the cyclicvoltammetry, An Ag/AgCl reference electrode, a platinum wire counter electrode and LB film-coated ITO working electrode measured in $LiBF_4$ solution, stable up to 0.9V vs. Ag/AgCl.

• Journal of Institute of Control, Robotics and Systems
• /
• v.11 no.1
• /
• pp.77-83
• /
• 2005

This paper deals with determination of motions of a humanoid robot using genetic algorithm. A humanoid robot has some problems of the structural instability basically. So, we have to consider the stable walking gait in gait planning. Besides, it is important to make the smoothly optimal gait for saving the electric power. A mobile robot has a battery to move autonomously. But a humanoid robot needs more electric power in order to drive many joints. So, if movements of walking joints don't maintain optimally, it is difficult for a robot to have working time for a long time. Also, if a gait trajectory doesn't have optimal state, the expected life span of joints tends to be decreased. To solve these problems, the genetic algorithm is employed to guarantee the optimal gait trajectory. The fitness functions in a genetic algorithm are introduced to find out optimal trajectory, which enables the robot to have the less reduced jerk of joints and get smooth movement. With these all process accomplished by a PC-based program, the optimal solution could be obtained from the simulation. In addition, we discuss the design consideration for the joint motion and distributed computation of the humanoid, ISHURO, and suggest its result such as the structure of the network and a disturbance observer.

• Journal of Hydrogen and New Energy
• /
• v.16 no.2
• /
• pp.130-135
• /
• 2005

Cadmium selenide is one of the group IIb-VI compounds, which is the promising semiconductor material due to its wide range of technological applications in optoelectronic devices such as photoelectrochemical cells, solid state solar cells, thin film photoconductors etc. CdSe has optical band gap of 1.7-1.8eV and proper conduction band edge for water splitting. CdSe films are coated with small thickness(20-50nm) nanocrystalline $TiO_2$ film by electrodeposition or chemical bath deposition methods and PEC properties of CdSe and CdSe/$TiO_2$ sandwich structure are studied. The photoactivity of CdSe and CdSe/$TiO_2$ films deposited on titanium substrate is studied in aqueous electrolyte of 1M NaOH solution. Photocurrent and photovoltage obtained were of the order of 2-4 mA/$cm^2$ and 0.5V, respectively, under the intensity of illumination of 100 mW/$cm^2$.

• Computers and Concrete
• /
• v.2 no.2
• /
• pp.125-146
• /
• 2005

The objective of this paper is setting out, for a cable-stayed bridge with a curtain suspension, a method to determine the modes of vibration of the structure. The system of differential equations governing the vibrations of the bridge, derived by means of a variational formulation in a nonlinear field, is reported in Appendix C. The whole analysis results from the application of Hamilton's principle, using the expressions of potential and kinetic energies and of the virtual work made by viscous damping forces of the various parts of the bridge (Monaco and Fiore 2003). This paper focuses on the equation concerning the transversal motion of the girder of the cable-stayed bridge and in particular on its final form obtained, restrictedly to the linear case, neglecting some quantities affecting the solution in a non-remarkable way. In the hypotheses of normal mode of vibration and of steady-state, we propose the resolution of this equation by a particular method based on a numerical approach. Respecting the boundary conditions, we derive, for each mode of vibration, the corresponding frequency, both natural and damped, the shape-function of the girder axis and the exponential function governing the variability of motion amplitude in time. Finally the results so obtained are compared with those deriving from the dynamic analysis performed by a finite elements calculation program.

• Structural Engineering and Mechanics
• /
• v.36 no.3
• /
• pp.301-319
• /
• 2010

The paper seeks to explore some aspects of the current state of knowledge on progressive collapse in the technical literature covering blast loads and structural analysis procedure applicable to reinforced concrete (RC) buildings. The paper describes the progressive collapse analysis of a commercial RC building located in the city of Riyadh and subjected to different blast scenarios. A 3-D finite element model of the structure was created using LS-DYNA, which uses explicit time integration algorithms for solution. Blast loads were treated as dynamic pressure-time history curves applied to the exterior elements. The inherent shortcomings of notional member removal have been taken care of in the present paper by simulating the damage of structural elements through the use of solid elements with the provision of element erosion. Effects of erosion and cratering are studied for different scenarios of the blast.

• Earthquakes and Structures
• /
• v.7 no.6
• /
• pp.1119-1139
• /
• 2014

A damage-based seismic design procedure for steel frame structures is formulated as an optimization problem, in which minimization of the initial construction cost is treated as the objective of the problem. The performance constraint of the design procedure is to achieve "repairable" damage state for earthquake demands that are less severe than the design ground motions. The Park-Ang damage index is selected as the seismic damage measure for the quantification of structural damage. The charged system search (CSS) algorithm is employed as the optimization algorithm to search the optimum solutions. To improve the time efficiency of the solution algorithm, two simplifying strategies are adopted: first, SDOF idealization of multi-story building structures capable of estimating the actual seismic response in a very short time; second, fitness approximation decreasing the number of fitness function evaluations. The results from a numerical application of the proposed framework for designing a twelve-story 3D steel frame structure demonstrate its efficiency in solving the present optimization problem.

• Proceedings of the KIEE Conference
• /
• 2008.07a
• /
• pp.1959-1960
• /
• 2008

The Logic Built In Self Test (LBIST) technique is substantially applied in chip design in most many semiconductor company in despite of unavoidable overhead like an increase in dimension and time delay occurred as it used. Currently common LBIST software uses the MISR (Multiple Input Shift Register) However, it has many considerations like defining the X-value (Unknown Value), length and number of Scan Chain, Scan Chain and so on for analysis of result occurred in the process. So, to solve these problems, common LBIST software provides the solution method automated. Nevertheless, these problems haven't been solved automatically by Tri-state Bus in logic circuit yet. This paper studies the algorithm that it also suggest algorithm that reduce additional circuits and time delay as matching of pattern about 2-type circuits which are CUT(circuit Under Test) and additional circuits so that the designer can detect the wrong location in CUT: Circuit Under Test.

• Korean Institute of Interior Design Journal
• /
• no.23
• /
• pp.116-123
• /
• 2000

The importance of evaluation in design activity has been increased. Specially, it is necessary to take into consideration of user's needs as design criteria nowadays. Through these evaluations, the comprehensive quality of architectural design could be substantially improved and play the part of recycling at least in cases of theme similar structures. By a viewpoint of library patrons, there have increased many problems In library environment because more library patrons use the reference room for their study since reform of university education was carried out In 1981. Therefore, after post occupancy evaluation and spatial-planning matters of architecture are taken into consideration in this study, the problems of the plan-composition on the existing structure is pointed out and introduced the concept of post occupancy evaluation to grope the solution. With the question about users's needs and the state of use in the K-University Library, this study aims to investigate the actual use circumstance of space and maintenance of facilities as well as giving the most relevant alternatives instead of already existing one. This also intends to propose the essential date to meet the users' sociopsychological needs and environment innovation when planning the university library.

• Journal of Korean Academy of Nursing
• /
• v.37 no.3
• /
• pp.353-364
• /
• 2007

Purpose: This study is aimed to analyze and clarify the ambiguous concept of insight. Method: This study used the process of Walker & Avant's concept analysis. Results: Insight can be defined in terms of its attributes as follows: Insight 1) comes as a release to the tension of inquiry, (2) is the outcome of the process to discover the overall structure of the problem situation and psychologically restructurize it, (3) comes suddenly and unexpectedly, (4) is to clearly perceive the solution of the abstract problem, and (5) promotes obtaining another new insight. The antecedents of insight include inquiry that can not be resolved easily and also a state where basic knowledge related to the inquiry can be utilized. The consequence of the insight is (1) a new judgement is made, (2) the problem is solved, (3) previous insight is retained and transferred, and it also facilitates the generation of fresh insight, and (4) it passes into the habitual texture of one's mind. Conclusion: Nurse educators need to facilitate nursing students and nurses to accumulate systematically, various information that can become the basis of insight and provide them with an opportunity to experience a variety of problems. In addition, it is important to provide questions to learners as an education strategy to allow them to gain insight into problem solving. From now on, insight needs to be studied in conjunction with critical thinking and questioning in order to enhance nurses' ability to resolve problems.