• Journal of Animal Science and Technology
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• v.53 no.3
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• pp.269-274
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• 2011

DNA methyltransferases (DNMTs) are closely associated with the epigenetic change and the gene silencing through the regulation of methylation status in animal genome. But, the role of DNMTs in transgene silencing has remained unclear. So, we examined whether the knockdown of DNMT influences the reactivation of transgene expression in the transgenic quails. In this study, we investigated the expression of DNMT3a, and DNMT3b in blastoderm, quail embryonic fibroblasts (QEFs) and limited embryonic tissues such as gonad, kidney, heart and liver of E6 transgenic quails (TQ2) by RT-PCR. We further analyzed the expression of DNMT3a at different stages of whole embryos during early embryonic development by qRT-PCR. DNMT3a expression was detected in all test samples; however, it showed the highest expression in E6 whole embryo. Embryonic fibroblasts collected from TQ2 quails were treated with two DNMT3a-targeted siRNAs (siDNMT3a-51 and siDNMT3a-88) for RNA interference assay, and changes in expression were then analyzed by qRT-PCR. The siDNMT3a-51 and siDNMT3a-88 reduced 53.34% and 64.64% of DNMT3a expression in TQ2 QEFs, respectively. Subsequently the treatment of each siRNA reactivated enhanced green fluorescent protein (EGFP) expression in TQ2 (224% and 114%). Our results might provide a clue for understanding the DNA methylation mechanism responsible for transgenic animal production and stable transgene expression.

• Korean Journal of Clinical Laboratory Science
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• v.40 no.2
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• pp.98-105
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• 2008

Colorectal carcinoma from various cancers is fourth ranked occurred to Korean. Due to western dietary life, this cancer has been increased continuously. Therefore, the further study will be needed to find a candidate gene involved in the development and progression of colorectal carcinoma as well as to diagnose and treatment helpfully. The purpose of this study was designed to find a carcinogenesis gene using microsatellite marker on chromosomes 7th and 20th from 30 colon cancer patients. The amplification was investigated in order of D20S97 57% (17/30), D20S101 57% (17/30), D20S119 53% (16/30), D7S483 50% (15/30), D7S495 47% (14/30), D7S498 47% (14/30). The genetic mutation pattern depends on loci of colorectal carcinoma was shown highly amplified with 3.77 from colon cancer than with 2.08 from right colorectal carcinoma (P<0.018). The genetic mutation with lymph nodes was investigated higher with 4.13 at metastasized group than with 1.93 at non-metastasized group (P<0.001). There was no difference at comparison between histological classfication and serological CEA increase as well as on genetic mutated pattern depends on disease stage. It is suggested that the amplification on chromosomes 7q and 20q determines a pivotal role from first stage to metastasis cancer and also functions as an useful marker on diagnosis and treatment of colorectal carcinoma patients as well as follow-up checkup. Recently, the diagnosis and study using genetic analyzer are necessary for efficient application. Fortunately, several university hospitals run this genetic analyzer currently so it is expected that this method makes full use of clinical application.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.6
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• pp.558-566
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• 2003

We fabricated thick film monopole antennas using Li-doped BiNbO$_4$ ceramics and investigated their electrical properties as a function of the Li-doping concentration. Compared with undoped BiNbO$_4$ ceramics, addition of Li$_2$CO$_3$ improved dielectric constant by increasing of ionic polarization, but reduced quality value by increasing of lattice distortion. Antenna properties like gain, bandwidth and radiation patterns were also greatly affected by the addition of Li$_2$CO$_3$. With increasing amount of Li$_2$CO$_3$, the bandwidth of ceramic monopole antenna was increased to 81.7 %, but the gain was reduced to -10.03 dBi. Also radiation patterns were so distorted and showed low dB value by increasing of dielectric loss.

• The Transactions of the Korea Information Processing Society
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• v.2 no.1
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• pp.55-65
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• 1995

Existing multiple-row downdating algorithms have adopted a CFD(Cholesky Factor Downdating) that recursively downdates one row at a time. The CFD based algorithm requires 5/2p $n^{2}$ flops(floating point operations) downdating a p$\times$n observation matrix $Z^{T}$ . On the other hands, a HCFD(Hybrid CFD) based algorithm we propose in this paper, requires p $n^{2}$＋6/5 $n^{3}$ flops v hen p$\geq$n. Such a HCFD based algorithm factorizes $Z^{T}$ at first, such that $Z^{T}$ = $Q_{z}$ RT/Z, and then applies the CFD onto the upper triangular matrix Rt/z, so that the total number of floating point operations for downdating $Z^{T}$ would be significantly reduced compared with that of the CFD based algorithm. Benchmark tests on the Sun SPARC/2 and the Tolerant System also show that performance of the HCFD based algorithm is superior to that of the CFD based algorithm, especially when the number of rows of the observation matrix is large.rge.

• Journal of Power Electronics
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• v.10 no.5
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• pp.548-554
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• 2010

In this paper, a 1.5 kW Interior Permanent Magnet Synchronous Generator (IPMSG) with a power conditioner for the grid integration of a variable-speed wind turbine is developed. The power-conditioning system consists of a series-type 12-pulse diode rectifier powered by a phase shifting transformer and then cascaded to a PWM voltage source inverter. The PWM inverter is utilized to supply sinusoidal currents to the utility line by controlling the active and reactive current components in the q-d rotating reference frame. While the q-axis active current of the PWM inverter is regulated to follow an optimized active current reference so as to track the maximum power of the wind turbine. The d-axis reactive current can be adjusted to control the reactive power and voltage. In order to track the maximum power of the wind turbine, the optimal active current reference is determined by using a simple MPPT algorithm which requires only three sensors. Moreover, the phase angle of the utility voltage is detected using a simple electronic circuit consisting of both a zero-crossing voltage detecting circuit and a counter circuit employed with a crystal oscillator. At the generator terminals, a passive filter is designed not only to decrease the harmonic voltages and currents observed at the terminals of the IPMSG but also to improve the generator efficiency. The laboratory results indicate that the losses in the IPMSG can be effectively reduced by setting a passive filter at the generator terminals.

• Journal of KIISE
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• v.42 no.10
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• pp.1247-1253
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• 2015

An inverted index structure is widely used for efficient string similarity search. One of the main requirements of similarity search is a fast response time; to this end, most techniques use an in-memory index structure. Since the size of an inverted index structure usually very large, however, it is not practical to assume that an index structure will fit into the main memory. To alleviate this problem, we propose a novel technique that reduces the size of an inverted index. In order to reduce the size of an index, the proposed technique rearranges data strings so that the data strings containing the same q-grams can be placed close to one other. Then, the technique encodes those multiple strings into a range. Through an experimental study using real data sets, we show that our technique significantly reduces the size of an inverted index without sacrificing query processing time.

• Journal of Broadcast Engineering
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• v.15 no.6
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• pp.749-756
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• 2010

The signal space diversity is one of the promising transmission techniques in next generation mobile TV service. However, DVB-T2 does not consider the multiple antennas (MIMO) so that the cyclic Q-delay method, a component interleaver in DVB-T2, causes a critical issue in detecting symbols at the receiver side by increasing the inter-symbol dependency. To solve this problem, the component-swapping technique is proposed, which limits the inter-symbol dependency in order to reduce detection complexity. In this paper, the achievable gain of a component-swapping technique combined with 16K LDPC code defined in DVB-T2 is evaluated by computer simulations. From the results, the gain is confirmed in terms of BER and receive complexity compared to legacy component interleaver methods.

• Journal of KIISE:Computer Systems and Theory
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• v.27 no.5
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• pp.529-539
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• 2000

This paper proposes a prefetch-based disk buffer management algorithm, which we call W2R (Veighingjwaiting Room). Instead of using elaborate prefetching schemes to decide which blockto prefetch and when, we simply follow the LRU-OBL (One Block Lookahead) approach and prefetchthe logical next block along with the block that is being referenced. The basic difference is that theW2R algorithm logically partitions the buffer into two rooms, namely, the Weighing Room and theWaiting Room. The referenced, hence fetched block is placed in the Weighing Room, while theprefetched logical next block is placed in the Waiting Room. By so doing, we alleviate some inherentdeficiencies of blindly prefetching the logical next block of a referenced block. Specifically, a prefetchedblock that is never used may replace a possibly valuable block and a prefetched block, thoughreferenced in the future, may replace a block that is used earlier than itself. We show through tracedriven simulation that for the workloads and the environments considered the W2R algorithm improvesthe hit rate by a maximum of 23.19 percentage points compared to the 2Q algorithm and a maximumof 10,25 percentage feints compared to the LRU-OBL algorithm.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.10
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• pp.2639-2645
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• 2009

This paper describes a CPW oscillator using a spiral resonator. Spiral resonators are very useful in design CPW oscillators since they show a relatively higher Q than CPW hairpin and helical resonators. Prior to the design of oscillators, three CPW resonators are designed and compared. Electromagnetic (EM) simulation are performed for an improved design in design the CPW resonators and oscillators. Three oscillators are designed at 5.7 GHz using the mentioned CPW resonators. The measured output power of three CPW oscillators using the helical, hairpin, and spiral resonators are 2.55 dBm, 2.64 dBm, and 4.98 dBm, respectively. In addition, the size of three resonators are $102.15mm^2,\;130.05mm^2,\;80.625mm^2$, respectively, so it is proven that the proposed CPW oscillator using the spiral resonator has a smaller size than the others.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.05a
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• pp.652-654
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• 2018

Recently there are many people who suffer from a mental problem like depression or anxiety caused by the stress of employment or school works. Some mental care agencies serve a campaign for them, but it's less accessible due to the geographic distance. And before taking the service, people should find out what is a better psychological test for them to diagnose the problem. Furthermore, it is inconvenient that keeping the diagnosis which is written in some papers. In his paper, in order to solve these problems, suggests the novel platform that serves psychological tests to users and stores results into database so that involved agencies could contact quickly. The psychological tests BAI, BDI, PHQ-15, and Q-15 were used to verify the reliability and effectiveness of the platform.