• Journal of Pharmaceutical Investigation
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• 제32권3호
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• pp.209-213
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• 2002

Diltiazem inhibits calcium channels and Iεads to vascular smooth muscle rεlaxation and negative inotropic and chronotropic effects in the hεart. Diltiazem is almost completely absorbεd after oral administration, but its extent of absolute oral bioavailability is reduced because of considerable first-pass hepatic metabolism. Diltiazem is able to dilate renal vasculature and can increase the glomerular filtration rate and renal sodium excretion. The purpose of this study was to report the pharmacokinetic changes of diltiazem after oral administration of diltiazem, 20 mg/kg, in rabbits coadministered with cimetidine, 20 mg/kg and pretreated twice per day for 3 days at cimetidine dose of 20 mg/kg. The area under the plasma concentration-time curve (AUC) of diltiazem was significantly higher in rabbits pretreated with cimetidine than that in control rabbits (p<0.01), showing about 149% increased relative bioavailability. The peak plasma concentration $(C_{max})$ and elimination half-life of diltiazem were increased significantly (p<0.05) in rabbits pretreated with cimetidine compared with those in control rabbits. This findings could be due to significant reduction of elimination rate constant by pretreated with cimetidine. The effects of cimetidine on the pharmacokinetics of oral diltiazem were more considerable in rabbits pretreated with cimetidine compared with those in control rabbits. The results suggest that the dosage of diltiazem should be adjusted when the drug would be co-administerεd chronically with cimetidine in a clinical situation.

• 한국수산과학회지
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• 제42권6호
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• pp.683-694
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• 2009

High-resolution (Chirp and Sparker system) seismic profiles were analyzed to investigate the sedimentary sequence and distribution pattern of the late Holocene deposits in Gyunggi Bay, the Yellow Sea. The bay is located in the western part of Korea, east of the Yellow Sea. The sedimentary sequence divided into three units bounded by erosional bounding surface: (1) acoustically parallel to subparallel reflectors with cross bedding structures (Unit 1); (2) confused inner reflectors and top of unit exposed partially at the seafloor (Unit 2); and (3) approximately parallel reflections and regressive to transgressive incision-fills (Unit 3). On the basis of seafloor morphology, surface bedforms, and subbotom acoustic characters, echo types in the study area were identified following the schemes of Chough et al. (2002); (1) flat seafloor with sharp bottom echoes (echo types 1-1, 1-2 and 1-3; transgressive sediment sheets or relict sands), (2) mounded seafloor with either smooth surface or superposed bedforms (echo types 2-1 and 2-2; tidal ridges), and (3) various-scale eroded seafloor (echo types 3-1 and 3-2; channels). Suspect features of acoustic turbid zones which is related to gas charged sediment are reported.

• 한국수산과학회지
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• 제42권6호
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• pp.585-590
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• 2009

The purpose of this study was to examine the effects of oral-administered sex hormone for hybrid sturgeon, bester juvenile. The bester juveniles (2 months after hatching) were received a diet containing various doses of $17\alpha$-methyltestosterone (MT) or estradiol-$17\beta$ ($E_2$) for 6 months. Somatic growth of bester sturgeon juvenile did not show significant differences between experimental and control groups (27.9-30.5 cm; 125.1-161.7 g), although survival percentages showed a decreasing tendency in MT-treated animals. By histological examination, germ cells were recorded as smooth type in MT-treated fish and uneven type of germinal epithelium in $E_2$-treated animals. Their sex ratios were 5:4:1 (male: female: undifferentiation) in control and low dose of MT-treated fish (1 mg/kg), and 9:1:0 in fish treated with high dose of MT (10 mg/kg), whereas the ratios were reversed by both low and high doses of $E_2$ treatment, recorded as 2:8:0. Gonadal areas were not significantly differed in all trials (424,600.4 - 1,039,656.3 ${\mu}m^2$). Total number of germ cells, number of germ cells per gonadal areas and number of germ cells per area were significantly higher to 144.7-148.7 cells/section, 374.0-408.5 $cells/mm^2$ and 1,599.5-1,670.9 $cells/mm^2$ in $E_2$ treatment than those of others (30.4-63.9 cells/section, 148.4-226.9 $cells/mm^2$ and 850.0-1,050.6 $cells/mm^2$), respectively. And somatic growth according to their gender was not significantly differed between male and female.

• 대한한의학원전학회지
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• 제33권4호
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• pp.167-182
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• 2020

Objectives : The relationship between the Lungs, Stomach and Kidneys were examined in relation to their pulses continuously beating without rest as discussed in the 『Lingshu·Dongshu』, with other chapters in the 『Huangdineijing』. Methods : Chapters in the 『Huangdineijing』 and annotations were referenced in relation to the contents in question of the 『Lingshu·Dongshu』. Results & Conclusions : In 『Lingshu·Dongshu』, the Stomach of the Zuyangming is central. In the flow of Qi that is produced and circulated from the Stomach, we can see that Ancestral qi that is created in the Stomach ascends and accumulates in the chest area to disperse Qi throughout the entire body according to breathing and pulsation, while Nutrient qi exits from the middle energizer and ascends to the Lungs, circulates the entire body and Qi that is partially similar to Defense qi moves upwards to the head and circulates. In the lower part of the body, Qi flows to the Zushaoyin that is associated with Jing qi to assist with actions of the Extra meridians, while it connects to the Ancestral sinew through Zujueyin allowing for smooth movement of the muscles and joints. The special emphasis on the pulsation points of the three meridians, Shoutaiyin, Zuyangming and Zushaoyin, is based on the Qi thoroughfare[氣街] theory, where production and circulation of all Qi in the upper, middle, and lower energizers of the body manifest as pulse movement of the three meridians, which are the fundamental rhythms and movements of life.

• 한국항행학회논문지
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• 제20권1호
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• pp.37-44
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• 2016

한국은 성능기반항행 (PBN; performance-based navigation)으로 전환하기 위한 단계적 PBN 이행계획을 2010년에 수립하고 로드맵에 따른 새로운 비행절차를 개발 중에 있다. PBN 비행절차에는 GNSS (global navigation satellite systems), DME (distance measuring equipment), VOR (VHF omnidirectional range), INS (inertial navigation system) 등의 항행시설 (NAVAID; navigation aid)이 활용되는 것으로 되어있다. 그 중에서 GNSS를 이용한 PBN 업무제공이 중심을 이루고 있는 실정이다. 그러나 위성항법신호의 인위적, 자연적 간섭에 의한 취약성이 발견됨에 따라 세계 각국은 다양한 대안항법(APNT; alternative positioning, navigation and timing) 기술을 연구하고 있다. 본 논문에서는 GNSS 신호가 가용하지 않을 경우 기존의 항행시스템으로 지속적인 PBN 운항이 가능한지를 분석하였으며, 결과적으로 국내 일부 공항은 접근 단계 구역에서 대안항법의 구축이 필요한 것으로 나타났다.

• Journal of Chest Surgery
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• 제42권4호
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• pp.540-542
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• 2009

사구종양은 정상 사구체에서 볼 수 있는 특화된 평활근 세포를 닳은 세포로 이루어진 종양으로 손가락의 손톱 아래 부위가 호발 부위이지만, 손바닥, 팔, 다리에도 잘 생기며 이외에도 무릎골, 흉벽, 골, 위, 대장, 신경 등에도 드물게 생긴다. 그러나, 기관에 생긴 사구 종양은 매우 드문데, 저자들은 기관에 생긴 1예의 사구 종양을 경험하였기에 이를 문헌 고찰과 함께 보고하고자 한다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권3호
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• pp.397-418
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• 1994

Microvascular surgery has been widely used in the clinical field of replantation and reconstructive surgery. Since the last 20 years, microsurgical techniques and instruments have been rapidly developed and the success rate is remarkably increased. But thrombotic occlusion of vessels remains the major reason for clinical failure. The change of vessel wall is the most important factor in thrombus formation. If we can reduce the traumatic changes in the vessel walls during surgery, the success rate can be markedly increased. For this study, femoral arteries and veins of 36 Sprague-Dawley rats with average weights of 300gm were used. The author observed the histological changes and healing process in the anastomostic site after 1 hour, 24 hours, 1, 2, 3 and 4 weeks under light microscopy and scanning electron microscopy. The results were as follows : 1. The patency rate was 100% in femoral arteries and 85% in femoral vein. 2. At the early stages after microvascular anastomosis, the loss of endothelial cell in the vessel walls was observed in the wide area including anastomotic site. In scanning electron microscopic finding the anastomotic site was covered with much fibrin, many red blood cells and some platelets. 3. At 1st week, new endothelial cells were formed toward anastomotic site and at 3rd week, the anastomotic site was completely covered by new endothelial cells. At 4th week, the complete endothelialization over the threads was observed. 4. The media extended from the anastomotic site toward the end of the specimen. At later stages, the extent of media necrosis was markedly decreased. But the media necrosis of anastomotic site was not regenerated till 4th week. 5. Intimal hyperplasia appeared at 1st week and increased till 4th week. The layer consisted of endothelialization the most luminal layers and smooth muscle in the deeper layers. But in veins, the response was less pronounced than in arteries. 6. Foreign body granuloma remained during 4 weeks and aneurysm was observed at 3rd week in artery. In aneurismal wall, media necrosis, loss of elastic lamina and intimal hyperplasia were seen.

• 전자공학회논문지C
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• 제36C권5호
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• pp.57-66
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• 1999

본 논문에서는 50 MHz 수준의 고속 신호 샘플링을 위해 정착시간 최소화 기법을 적용한 12 비트 50 MHz CMOS A/D 변환기(analon-to-digital-converter : ADC) 회로를 제안한다. 제안하는 ADC는 0.35㎛ double-poly five-metal n-well CMOS 공정을 사용하여 설계 및 레이아웃되었으며, 응용되는 시스템의 속도, 해상도 및 면적 등의 사양을 고려하여 다단 파이프라인 구조가 적용되었다. 기존의 파이프라인 구조를 가진 ADC의 경우, 동작속도를 제한하는 결정적인 회로 불럭은 잔류전압 증폭기이나, 제안하는 정착 시간 최소화 기법은 이러한 잔류전압 증폭기의 동작 전류 제어를 통해 정착시간 단축 및 출력신호의 불규칙성을 최소한으로 줄인다. 3 V 전원전압에서 50 MHz 클럭 주파수를 사용하여 모의실험한 결과, 입출력단을 포함한 전체 ADC는 197mW의 전력소모를 나타내었고, 입출력단의 패드를 포함한 전체 칩면적은 3.2mm×3.6mm이다.

• Strategy21
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• 통권41호
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• pp.5-29
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• 2017

The Mahan's seapower theory has been the basis of US Navy to date as it can enjoy the supremacy status in all of the seas of the world. His theory is very straightforward. A nation can be a great country in the world just through the use of maritime commerce that could be protected by a strong and powerful navy. Mahan's theory on seapower was substantiated in the Spanish-American War with respect to how important the naval power is. The best thing to make US a great nation was to make sure that flow of international trade is smooth, and the unhindered trade could be made possible only by the destruction of enemy's fleet that may obstruct the SLOCs. That's why Mahan insisted that a strong navy was needed and a decisive battle by the navy's fleet at sea should be encouraged as a way of ensuring the safety of the SLOCs. The newly-arrived Trump administration seems to be in line with the Mahan's theory seapower in its policy on naval forces structure. It is expected that US will continue to support the Pivot to Asia policy that has been adopted by the previous administration through an increase in its naval fleet forces. The number of US navy ships will be 355 in 2030, rendering it much more powerful navy than before. The catch phrase "3rd Fleet Forward" proposed by the president Trump indicates that two carrier strike groups will be present in the Asia Pacific region, being able to make the confrontation between US and China more tense than before. The presence of the US naval forces in the area may function as some sort of pressure against China that Trump insisted had been responsible for the closure of 60,000 factories and the loss of 3,000,000 jobs in the United States.

• 한국HCI학회논문지
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• 제12권1호
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• pp.25-32
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• 2017

본 연구의 목적은 대화면 스마트폰을 한 손으로 조작 시 터치가 어려운 사각영역의 효율적인 터치를 지원하는 한 손 모드 인터랙션의 유용성을 평가하는 것이다. 이를 위해 아이폰과 안드로이드 스마트폰 내 두 종류의 기존 한손 모드들을 분석하였고, 보다 유용할 것으로 기대되는 두 개 유형의 한 손 모드들을 추가적으로 제안하고 구현하였다. 기존 및 제안한 한 손 모드들의 유용성을 검증하기 위해, 네 개의 한 손 모드들과 일반터치를 비교하는 실험을 수행하였다. 실험 결과, 일반터치에 비해 한 손 모드로 사각영역을 터치하는데 오히려 더 긴 시간이 걸렸다. 이는 한손 모드의 경우 모드진입 조작 및 모드전환 애니메이션 시간이 기본적으로 필요했기 때문이었다. 그러나 실험참여자들이 일반터치로 사각영역을 터치 시에는 엄지를 많이 뻗어서 터치해야 해서 손의 위치변화가 커지고 연속된 조작을 어려워하였다. 또한 한 손 모드로의 전환효과와 터치 조작반경의 축소로 인하여 주관적 만족도는 한 손 모드를 사용하는 것이 더 높았다. 한편, 한 손 모드들 중에서는 아이폰의 하단이동 한 손 모드가 가장 좋은 것으로 평가되었다.