• Journal of the Korean Magnetics Society
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• v.23 no.4
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• pp.135-143
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• 2013

The clip-type pulsimeter equipped with a Hall sensor has a permanent magnet attached in the "Chwan" position to the center of a radial artery. The clip-type pulsimeter is composed of a hardware system measuring voltage signals. These electrical bio-signals display pulse rate, non-invasive blood pressure, respiratory rate, pulse wave velocity (PWV), and spatial pulse wave velocity (SPWV) simultaneously measured by using the radial artery pulsimeter, the electrocardiograph (ECG), and the photoplethysmograph (PPG). The findings of this research may be useful for developing a oriental-western biomedical signal storage device, that is, the new and fusion patient monitor, for a U-health-care system.

• IMMUNE NETWORK
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• v.14 no.6
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• pp.321-327
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• 2014

TGF-${\beta}$ induces IgA class switching by B cells. We previously reported that Smad3 and Smad4, pivotal TGF-${\beta}$ signal-transducing transcription factors, mediate germline (GL) ${\alpha}$ transcription induced by TGF-${\beta}1$, resulting in IgA switching by mouse B cells. Post-translational sumoylation of Smad3 and Smad4 regulates TGF-${\beta}$-induced transcriptional activation in certain cell types. In the present study, we investigated the effect of sumoylation on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ transcription and IgA switching by mouse B cell line, CH12F3-2A. Overexpression of small ubiquitin-like modifier (SUMO)-1, SUMO-2 or SUMO-3 did not affect TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity, expression of endogenous $GL{\alpha}$ transcripts, surface IgA expression, and IgA production. Next, we tested the effect of the E3 ligase PIASy on TGF-${\beta}1$-induced, Smad3/4-mediated $GL{\alpha}$ promoter activity. We found that PIASy overexpression suppresses the $GL{\alpha}$ promoter activity in cooperation with histone deacetylase 1. Taken together, these results suggest that SUMO itself does not affect regulation of $GL{\alpha}$ transcription and IgA switching induced by TGF-${\beta}1$/Smad3/4, while PIASy acts as a repressor.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.38 no.4
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• pp.38-44
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• 2001

In this paper, for the microwave level meter based on the FM-CW radar, we analyze the spectrum correlation of beat signals and propose a measurement algorithm using the theory. For industrial applications, level meters must have high precision, which requires a good linearity of VCO. But, in practice, it is very complicated or very expensive to make VCO linear enough to be acceptable in the industrial field. We propose a measurement algorithm using the fact that there exists a peak in the spectrum correlation of beat signals when range difference is sufficiently small. This makes it possible to determine the range difference in a precise manner even using a practical VCO. We present some experimental results to show the validity of this algorithm.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.46 no.6
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• pp.38-43
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• 2009

We provide a method to infer finger flexing motions using a 4-channel surface electromyogram (sEMG). Surface EMGs are harmless to the human body and easily acquired. However, they do not reflect the activity of specific nerves or muscles, unlike invasive EMGs. On the other hand, the non-invasive type is difficult to use for discriminating various motions while using only a small number of electrodes. Surface EMG data in this study were obtained from four electrodes placed around the forearm. The motions were the flexion of the thumb, index, middle, ring, and little linger. One subject was trained with these motions and another left was untrained. The maximum likelihood estimation was used to infer the finger motion. Experimental results have showed that this method could be useful for recognizing finger motions. The average accuracy was as high as 95%.

• Journal of IKEEE
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• v.17 no.1
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• pp.77-82
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• 2013

In this paper, dc-dc buck converter controled by the peak current-mode pulse-width-modulation (PWM) presented. Based on the small-signal model, we propose the novel methods of the power stage and the systematic stability designs. To improve the reliability and performance, over-temperature and over-current protection circuits have been designed in the dc-dc converter systems. To prevent electrostatic An electrostatic discharge (ESD) protection circuit is proposed. The proposed dc-dc converter circuit exhibits low triggering voltage by using the gate-substrate biasing techniques. Throughout the circuit simulation, it confirms that the proposed ESD protection circuit has lower triggering voltage(4.1V) than that of conventional ggNMOS (8.2V). The circuit simulation is performed by Mathlab and HSPICE programs utilizing the 0.35um BCD (Bipolar-CMOS-DMOS) process parameters.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.4
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• pp.33-38
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• 2009

Recently most of A/V devices are being adopted hi-tech of A VRCP and changed to mobile environment. AVRCP is designed to provide a standard interface to control A/V devices, hi-fi equipment, or others to allow a single remote control or other device to control all the A/V equipment to which a user has access. It may be used in concert with A2DP or VDP. The AVRCP defines two roles, that of a controller and target device. In AVRCP, the controller translates the detected user action to the A/V control signal, and then transmits it to a remote Bluetooth enabled device. It can be small and mixed mobile devices using bluetooth technologies. The functions available for a conventional infrared remote controller can be realized in this protocol. The remote control described in this protocol is designed specifically for A/V control only. We designed new DSP using Adaptive Acoustic Echo Canceller for bluetooth hands free based this AVRCP standard specifications.

• Journal of the Korea Society of Computer and Information
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• v.12 no.1 s.45
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• pp.155-160
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• 2007

Because output of multi-code CDMA system adapted high speed data transmission becoming multi-level system use linear amplifier in output stage and complex output signal. Therefore, Multi-Code CDMA system has shortcoming of high price, high complexity etc.. Binary CDMA technology that allow fetters in existing CDMA technology to supplement this shortcoming proposed. In binary CDMA system When correlator process high speed data, bottle-neck phenomenon is happened on synchronization acquisition process, it is very important parameter. Because existent correlator must there be advantage that power consumption is small but flow addition of several stages to receive correlation's value, the processing speed has disadvantage because the operation amount is much. Therefore in this paper, proposed correlator has characteristic such as data is able to high speed processing, chip area is independent and power consumption is constant in structure in binary CDMA system.

• Korean Journal of Agricultural Science
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• v.47 no.2
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• pp.361-373
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• 2020

Integrins such as lymphocyte function-associated antigen -1 (LFA-1) have an essential role in T cell immunity. Integrin activation, namely, the transition from the inactive conformation to the active one, takes place when an intracellular signal is generated by specific receptors such as T cell receptors (TCRs) and chemokine receptors in T cells. In an effort to explore the molecular mechanisms underlying the TCR-mediated LFA-1 activation, we had previously established a high-throughput cell-based assay and screened a chemical library deposited in the National Institute of Health in the United States. As a result, several hits had been isolated including HIKS-1 (Benzo[b]thiophene-3-carboxylic acid, 2-[3-[(2-carboxyphenyl) thio]-2,5-dioxo-1-pyrrolinyl]-4,5,6,7-tetrahydro-,3-ethyl ester). In an attempt to reveal the mode of action of HIKS-1, in this study, we did drug affinity responsive target stability (DARTS) assay finding that HIKS-1 interacted with the IQ motif containing GTPase activating protein 1 (IQGAP1), a 189 kDa multidomain scaffold protein critically involved in various signaling mechanisms. Furthermore, the cellular thermal shift assay (CETSA) provided compelling evidence that HIKS-1 also interacted with IQGAP1 in vivo. Taken together, it can be concluded that HIKS-1 interferes with the TCR-mediated LFA-1 activation by interacting with IQGAP1 and thereby disrupting the signaling pathway for LFA-1 activation.

• The Journal of the Acoustical Society of Korea
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• v.34 no.4
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• pp.295-302
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• 2015

Acoustic channels are characterized by long multipath spreads that cause inter-symbol interference. The way in which this fact influences the design of the receiver structure is considered. To satisfy performance and throughput, we presented consecutive iterative BCJR (Bahl, Cocke, Jelinek, Raviv) equalization to improve the performance and throughput. To achieve low error performance, we resort to powerful BCJR equalization algorithms that iteratively update probabilistic information between inner decoder and outer decoder. Also, to achieve high throughput, we divide long packet into consecutive small packets, and the estimate channel information of previous packets are compensated to next packets. Based on experimental channel response, we confirmed that the performance is improved for long length packet size.

• International Journal of Precision Engineering and Manufacturing
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• v.8 no.2
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• pp.54-58
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• 2007

This paper describes an atomic force microscope (AFM)-based instrument for measuring the nanoscale cutting edge profiles of diamond cutting tools. The instrument consists of a combined AFM unit and an optical sensor to align the AFM tip with the top of the diamond cutting tool edge over a submicron range. In the optical sensor, a aser beam is emitted from a laser diode along the Y-axis and focused to a small beam spot with a diameter of approximately $10{\mu}m$ at the beam waist, which is then received by a photodiode. The top of the tool edge is first brought into the center of the beam waist by adjusting it in the X-Z-plane while monitoring the variation in the photodiode output. The cutting tool is then withdrawn and its top edge position at the beam center is recorded. The AFM tip can also be positioned at the beam center in a similar manner to align it with the top of the cutting edge. To reduce electronic noise interference on the photodiode output and thereby enhance the alignment accuracy, a technique is applied that can modulate the photodiode output to an AC signal by driving the laser diode with a sinusoidal current. Alignment experiments and edge profile measurements of a diamond cutting tool were carried out to verify the performance of the proposed system.