• 한국멀티미디어학회논문지
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• 제9권12호
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• pp.1669-1680
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• 2006

This paper explains that the RF systems for hi-directional wireless capsule endoscopes were designed and implemented. The designed RF systems for a capsule endoscope can transmit the images of intestines from the inside to the outside of a body and the behavior of the capsules can be controlled by an external controller simultaneously. The hi-directional wireless capsule endoscope consists of a CMOS image sensor, FPGA, LED, battery, DC to DC Converter, transmitter, receiver, and antennas. The transmitter and receiver which were used in the hi-directional capsule endoscope, were designed and fabricated with $10mm(diameter){\times}3.2mm(thickness)$ dimensions taking into the MPE, power consumption, system size, signal to noise ratio and modulation method. The RF systems designed and implemented for the hi-directional wireless capsule endoscopes system were verified by in-vivo experiments. As a result, the RF systems for the hi-directional wireless capsule endoscopes satisfied the design specifications.

• 한국전자통신학회논문지
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• 제11권11호
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• pp.1039-1046
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• 2016

논문에서는 야생동물의 생활 패턴과 습성을 연구하기 위해 Yagi-Antenna, Low Pass Filter, Angle 추적기술 등을 이용한 야생동물 위치추적 시스템을 연구하였다. 현재 일반적으로 VHF 라디오식 위치측위 기술을 사용하여 야생동물 위치추적 시스템에 사용되고 있다. 기존 Yagi-Antenna는 이동성을 고려하여 4-element가 사용되며, 휴대성에 대한 장점이 있지만 이득이 낮고 지향성이 약하다. 제안된 기술은 이득을 높이기 위해 6-element를 채택하여 Narrow Space Yagi-Antenna 기술을 구현 하였다. 또한 수신 신호의 정밀한 방향 검출 기술과 3대의 수신기를 이용한 AOA(:Angle Of Arrival) 위치측위 기술을 적용하였다. 이를 바탕으로 본 연구에서는 공간적으로 특정한 서식영역에서 활동하는 야생동물 생활패턴과 습성을 파악하기 위한 위치추적 기술을 개발하여 검증 하였다.

• 항공우주기술
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• 제8권2호
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• pp.105-112
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• 2009

위성발사체(KSLV)발사에 있어서 Telemetry data는 발사임무수행 및 비행안전통제를 위해서 매우 중요한 자료이다. 따라서 발사체의 전체 비행구간 동안에 Telemetry 신호를 안정적으로 수신하는 것은 매우 중요하며, 이를 위하여 우주센터에서는 고흥 센터, 제주추적소 및 해상의 다운레인지를 운용하고 있다. 본 문서에서는 발사임무설계에 따른 예상비행궤적 및 발사체 자세, 추적소 위치를 고려하여 각 추적소의 임무구간에 신호를 안정적으로 수신할 수 있는지를 판단하는 Link Margin 및 통신신뢰도를 분석한다. 보다 정확한 분석을 위해서는 예상비행궤적 및 추적소 위치를 고려하여 발사체기준의 추적소방향(Aspect angle 및 roll angle)에 대한 탑재송신부 유효방사전력(EIRP: Effective Isotropic Radiation Power) 특성을 사용하여야 하나, 본 분석에서는 가용자료의 한계로 95% spatial coverage 유효방사전력을 사용하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제29권11호
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• pp.1664-1674
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• 2016

This research analyzed the effect of ${\beta}$-glucan that is expected to alleviate the production of the inflammatory mediator in macrophagocytes, which are processed by the lipopolysaccharide (LPS) of Escherichia. The incubated layer was used for a nitric oxide (NO) analysis. The DNA-binding activation of the small unit of nuclear factor-${\kappa}B$ was measured using the enzyme-linked immunosorbent assay-based kit. In the RAW264.7 cells that were vitalized by Escherichia coli (E. coli) LPS, the ${\beta}$-glucan inhibited both the combatant and rendering phases of the inducible NO synthase (iNOS)-derived NO. ${\beta}$-Glucan increased the expression of the heme oxygenase-1 (HO-1) in the cells that were stimulated by E. coli LPS, and the HO-1 activation was inhibited by the tin protoporphyrin IX (SnPP). This shows that the NO production induced by LPS is related to the inhibition effect of ${\beta}$-glucan. The phosphorylation of c-Jun N-terminal kinases (JNK) and the p38 induced by the LPS were not influenced by the ${\beta}$-glucan, and the inhibitory ${\kappa}B-{\alpha}$ ($I{\kappa}B-{\alpha}$) decomposition was not influenced either. Instead, ${\beta}$-glucan remarkably inhibited the phosphorylation of the signal transducer and activator of transcription-1 (STAT1) that was induced by the E. coli LPS. Overall, the ${\beta}$-glucan inhibited the production of NO in macrophagocytes that was vitalized by the E. coli LPS through the HO-1 induction and the STAT1 pathways inhibition in this research. As the host immune response control by ${\beta}$-glucan weakens the progress of the inflammatory disease, ${\beta}$-glucan can be used as an effective immunomodulator.

• Ocean and Polar Research
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• 제27권2호
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• pp.189-195
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• 2005

Several models predict large and potentially abrupt ocean circulation changes due to anthropogenic greenhouse-gas emissions. These circulation changes drive-in the models-considerable oceanic oxygen trend. A sound estimate of the observed oxygen trends can hence be a powerful tool to constrain predictions of future changes in oceanic deepwater formation, heat and carbon dioxide uptake. Estimating decadal scale oxygen trends is, however, a nontrivial task and previous studies have come to contradicting conclusions. One key potential problem is that changes in the historical observation network might introduce considerable errors. Here we estimate the likely magnitude of these errors for a subset of the available observations in the Southern Ocean. We test three common data analysis methods south of Australia and focus on the decadal-scale trends between the 1970's and the 1990's. Specifically, we estimate errors due to sparsely sampled observations using a known signal (the time invariant, temporally averaged, World Ocean Atlas 2001) as a negative control. The crossover analysis and the objective analysis methods are for less prone to spatial sampling location biases than the area averaging method. Subject to numerous caveats, we find that errors due to sparse sampling for the area averaging method are on the order of several micro-moles $kg^{-1}$. for the crossover and the objective analysis method, these errors are much smaller. For the analyzed example, the biases due to changes in the spatial design of the historical observation network are relatively small compared to the tends predicted by many model simulations. This raises the possibility to use historic oxygen trends to constrain model simulations, even in sparsely sampled ocean basins.

• Tribology and Lubricants
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• 제36권5호
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• pp.253-261
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• 2020

In this paper, we present an experimental investigation of the frequency characteristics and a visual inspection of an oxidizer pump with a modified rear-floating ring seal for a 7-tonf turbopump. An oxidizer pump typically operates at high rotational speeds and under cryogenic conditions. Despite its low hydraulic efficiency, the floating ring seal is frequently employed as a leakage control solution for turbomachinery because it effectively reduces abrasion by friction. When the oxidizer pump starts up, the floating ring moves excursively but locks up stably against the pump casing when the contact pressure increases. The compressive force on the floating ring depends on the hydrodynamic forces induced by the flow through the floating ring. This force is controlled by the nose position of the floating ring. Based on a validation test for a 7-tonf turbopump with two types of floating rings, we concluded that the floating ring with a small diameter nose can move easily with a low contact pressure in the cooling path. This leads to instability of the pressure fluctuation around the floating ring. In contrast, a floating ring with a large diameter nose has a high contact pressure and attaches strongly to the casing, which causes wear and frictional oxidation between the contact surfaces of the impeller and the floating ring.

• 동의생리병리학회지
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• 제19권6호
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• pp.1666-1672
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• 2005

Oriental medicinal drugs have a broad spectrum of clinical use for the cure of nervous system diseases including brain ischemic damages or neuropathies. Yet, specific drugs or drug components used in the oriental medicine in relation to none fiber regeneration are not known. In the present study, possible growth promoting effects of oriental medicinal drugs were investigated in the injured sciatic nerve system in the rat. By immunofluorescence staining, we found that Jahageo (JHG, Hominis placenta) increased Induction levels of axonal growth associated protein GAP-43 in the rat sciatic none. Small growth promoting activity was found in Golsebo (GSB, Drynariae rhizoma) and Baikhasuo (BHSO, Polygoni multiflori radix) drugs. JHG also increased cell cycle protein Cdc2 levels in the injured area of the sciatic nerves. Immunofluorescence staining indicated that induced Cdc2 protein was mostly localized in the Schwann cells in the injury area, implying that JHG activity might be related to increased Schwann cell proliferation during axonal regeneration. Moreover, levels of phospho-extracellular signal-regulated (ERK) pathway in the injured neNes were elevated by JHG treatment while levels of total ERK were unaltered. In vivo measurement of axonal regeneration using retrograde tracer showed that JHG, GSB and BHSO significantly enhanced Dil-labeled regenerating motor neurons compared with saline control. The present data suggest that oriental medicinal drugs such as JHG, GSB, and BHSO may be a useful target for developing specific drugs of axonal regeneration.

• 한국정보전자통신기술학회논문지
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• 제10권2호
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• pp.141-146
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• 2017

본 논문에서는 저전력 영상 특징 추출 하드웨어 설계를 위한 하드웨어 폴딩 기법 기반 저면적 Gradient magnitude 연산기 구조를 제안한다. 하드웨어 복잡도를 줄이기 위해 Gradient magnitude 벡터의 특징을 분석하여 기존 알고리즘을 하드웨어를 공유하여 사용할 수 있는 알고리즘으로 변경하여 Folding 구조가 적용될 수 있도록 했다. 제안된 하드웨어 구조는 기존 알고리즘의 특징을 최대한 이용했기 때문에 데이터 품질의 열화가 거의 없이 구현될 수 있다. 제안된 하드웨어 구조는 Altera Quartus II v16.0 환경에서 Altera Cyclone VI (EP4CE115F29C7N) FPGA를 이용하여 구현되었다. 구현 결과, 기존 하드웨어 구조를 이용하여 구현한 연산기와의 비교에서 41%의 logic elements, 62%의 embedded multiplier 절감 효과가 있음을 확인했다.

• 한국정보통신학회논문지
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• 제13권10호
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• pp.2066-2070
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• 2009

본 논문에서는 한 개 PIN 다이오드와 두 개 저항을 이용하여 $\pi$-형 고정 감쇠기 구조 형태의 전압 제어 방식의 가변 감쇠기를 설계 및 제작하였다. 제안된 가변 감쇠기는 저항과 외부 인가 전압에 따른 PIN 다이오드의 저항 값의 변화에 따라 원하는 일정 감쇠 범위에서 동작하며, 작은 크기의 회로로 낮은 입력 VSWR 특성과 혼변조 발생 특성을 갖는다. 또한, 제안된 가변 감쇠기에서는 PIN 다이오드에 추가적인 개방 선로를 연결하여 감쇠량의 변화에 따른 위상 변화량을 적게 하였다. 추가적인 개방 선로의 길이는 Deloach 방법과 초고주파 회로 특성을 이용하여 계산하였다. 제안된 가변 감쇠기의 특성을 살펴보기 위하여 2110~2170 MHz 주파수 대역에서 마이크로스트립 기판을 이용하여 가변 감쇠기를 제작하였다. 제작된 감쇠기는 0~2.7 V의 전압 범위에서 4 dB의 감쇠량의 변화를 가졌으며, 이 때 위상 변화량은 2도 이내, 반사계수(S11)는 -20 dB 이하의 값을 가졌다.

• Molecules and Cells
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• 제44권10호
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• pp.710-722
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• 2021

Hypoxia, or low oxygen tension, is a hallmark of the tumor microenvironment. The hypoxia-inducible factor-1α (HIF-1α) subunit plays a critical role in the adaptive cellular response of hypoxic tumor cells to low oxygen tension by activating gene-expression programs that control cancer cell metabolism, angiogenesis, and therapy resistance. Phosphorylation is involved in the stabilization and regulation of HIF-1α transcriptional activity. HIF-1α is activated by several factors, including the mitogen-activated protein kinase (MAPK) superfamily. MAPK phosphatase 3 (MKP-3) is a cytoplasmic dual-specificity phosphatase specific for extracellular signal-regulated kinase 1/2 (Erk1/2). Recent evidence indicates that hypoxia increases the endogenous levels of both MKP-3 mRNA and protein. However, its role in the response of cells to hypoxia is poorly understood. Herein, we demonstrated that small-interfering RNA (siRNA)-mediated knockdown of MKP-3 enhanced HIF-1α (not HIF-2α) levels. Conversely, MKP-3 overexpression suppressed HIF-1α (not HIF-2α) levels, as well as the expression levels of hypoxia-responsive genes (LDHA, CA9, GLUT-1, and VEGF), in hypoxic colon cancer cells. These findings indicated that MKP-3, induced by HIF-1α in hypoxia, negatively regulates HIF-1α protein levels and hypoxia-responsive genes. However, we also found that long-term hypoxia (>12 h) induced proteasomal degradation of MKP-3 in a lactic acid-dependent manner. Taken together, MKP-3 expression is modulated by the hypoxic conditions prevailing in colon cancer, and plays a role in cellular adaptation to tumor hypoxia and tumor progression. Thus, MKP-3 may serve as a potential therapeutic target for colon cancer treatment.