• Journal of the Korea Society for Simulation
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• v.10 no.4
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• pp.11-20
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• 2001

In the IMT-2000 networks, the model of micro/pico cell is suggested for transmission of multimedia service. Hence, the efficient method is required for processing of mobile calls in micro/pico cell. In the central urban area, mobile calls may be dynamically increased because of many mobile users. And microcel]/picocell size has small size, handover calls will be more increased. Therefore, many of mobile calls is occurred at a cell in the central urban area, so channel requests for these calls will be increased in the call. In this paper, we propose a scheme, FTC(Fault Tolerant Channel allocation) which is the channel management method for hard handover and new call in a mobile cell of central urban area. When available channels in the cell are consumed, the FTC investigates channel states of neighbor cells in the RNC(Radio Network Controller) or BSC (Base Station Center), and provide available channel for mobile call. The ]no scheme is analyzed and compared with existing channel management method by simulation.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.5
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• pp.19-24
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• 2016

In Long Term Evolution-Advanced (LTE-A), small cell enhancement(SCE) has been developed as a cost-effective way of supporting exponentially increasing demand of wireless data services and satisfying the user quality of service(QoS). However, due to the dense and irregular distribution of a large number of small cells, the offloading scheme should be applied in the small cell network. In this paper, we propose an user offloading scheme for SCE in LTE-Advanced system. We divide the small cells into different clusters according to the reference signal received power(RSRP) from user equipment(UE). Within a cluster, We apply the user offloading scheme with the consideration of the number of users and interference conditions. Simulation results show that proposed scheme can improve the throughput, and spectral efficiency of small cell users. Eventually, proposed scheme can improve overall cell performance.

• The Transactions of the Korea Information Processing Society
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• v.3 no.4
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• pp.947-960
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• 1996

The primary goal for developing high performance ATM switching systems is to minimized the probability of cell loss, cell delay and deterioration of throughput. ATM switching element that is the most suitable for this purpose is the shared buffer memory switch executed by common random access memory and control logic. Since it is difficult to manufacture VLIS(Very Large Scale Integrated circuit) as the number of input ports increased, the used of switching module method the realizes 32$\times$32, 150 Mb/s switch utilizing 8$\times$8, 600Mb/s os 16$\times$16, 150Mb/s unit switch is latest ATM switching technology for small and large scale. In this paper, buffer capacity satisfying total-memory-reduction effect by buffer sharing in a shared buffer memory switch are analytically evalu ated and simulated by computer with cell loss level at traffic conditions, and also features of switching network utilizing the switching module methods in small and large-capacity ATM switching system is analized. Based on this results, the structure in outline of 32$\times$32(4.9Gb/s throughput), 150Mb/s switches under research in many countries is proposed, and eventually, switching-network structure for ATM switching system of small and large and capacity satisfying with above primary goals is suggested.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39B no.10
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• pp.664-673
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• 2014

This paper analyzes the power allocation scheme to maximize the sum-rate for heterogeneous networks based on asynchronous time division duplex. We consider heterogeneous networks where a small cell exists in the macro cell coverage and the small cell and the macro cell share the same time-frequency resources. We formulate the optimization problem which maximizes the sum-rate of the heterogeneous network subject to the target signal-to-interference-plus-noise ratio. We analyze the feasible region in order for the optimal solution to exists and the optimal power allocation scheme for maximizing the sum-rate. Simulation results show that the proposed power allocation schemes outperform the maximum power transmission scheme.

• ETRI Journal
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• v.35 no.5
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• pp.775-785
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• 2013

Because of their exclusive features, millimeter wave directive mesh networks can be considered for small cell backhaul support in urban environments. For this purpose, a network of closely spaced stations has been considered with very directive line-of-sight links operating in the 60-GHz band. An attempt is made to evaluate channel response and interference behavior in such a network, taking into account the effect of building blockage. A simple grid of building blocks is considered as the propagation environment, and wave propagation is simulated using 2.5-dimensional (2.5D) ray tracing (2D with ground effect) to calculate the received signal at different nodes in the network. The results are compared with free space predictions and used to evaluate interference at all nodes in the channel and describe certain characteristics of links, such as the delay profile and the correlation length.

• IMMUNE NETWORK
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• v.6 no.1
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• pp.1-5
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• 2006

Background: B cell subset has been divided into B-1 cells and B-2 cells. B-1 cells are found most prominently in the peritoneal cavity, as well as constituting a small pro portion of splenic B cells and they are larger and less dense than B-2 cells in morphology. This study was designed to compare the differences in their proliferation and differentiation between B-1 and B-2 cell. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. Secreted IgM was measured by enzyme-linked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Cell cycle analysis by propidium iodide was performed. p21 expression was assessed by real time PCR. Results: Cell proliferation and cell cycle progression in B-1 and B-2 cells, which did not occur in the absence of LPS, required LPS stimulation. After LPS stimulation, B-1 and B-2 cells were shifted to Sand G2/M phases. p21 expression by resting B-1 cells was higher than that of resting B-2 cells. Conclusion: B-1 cells differ from conventional B-2 cells in proliferation, differentiation and cell cycle.

• Interdisciplinary Bio Central
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• v.5 no.1
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• pp.1.1-1.8
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• 2013

High quality publicly-available transcriptomic data representing relationships in gene expression across a diverse set of biological conditions is used as a context network to explore transcriptomics of the CNS. The context network, 18367Hu-matrix, contains pairwise Pearson correlations for 22,215 human genes across18,637 human tissue samples1. To do this, we compute a network derived from biological samples from CNS cells and tissues, calculate clusters of co-expressed genes from this network, and compare the significance of these to clusters derived from the larger 18367Hu-matrix network. Sorting and visualization uses the publicly available software, MetaOmGraph (http://www.metnetdb.org/MetNet_MetaOm-Graph.htm). This identifies genes that characterize particular disease conditions. Specifically, differences in gene expression within and between two designations of glial cancer, astrocytoma and glioblastoma, are evaluated in the context of the broader network. Such gene groups, which we term outlier-networks, tease out abnormally expressed genes and the samples in which this expression occurs. This approach distinguishes 48 subnetworks of outlier genes associated with astrocytoma and glioblastoma. As a case study, we investigate the relationships among the genes of a small astrocytoma-only subnetwork. This astrocytoma-only subnetwork consists of SVEP1, IGF1, CHRNA3, and SPAG6. All of these genes are highly coexpressed in a single sample of anaplastic astrocytoma tumor (grade III) and a sample of juvenile pilocytic astrocytoma. Three of these genes are also associated with nicotine. This data lead us to formulate a testable hypothesis that this astrocytoma outlier-network provides a link between some gliomas/astrocytomas and nicotine.

• IMMUNE NETWORK
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• v.12 no.6
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• pp.223-229
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• 2012

Clinical and preclinical in vivo immune cell imaging approaches have been used to study immune cell proliferation, apoptosis and interaction at the microscopic (intra-vital imaging) and macroscopic (whole-body imaging) level by use of ex vivo or in vivo labeling method. A series of imaging techniques ranging from non-radiation based techniques such as optical imaging, MRI, and ultrasound to radiation based CT/nuclear imaging can be used for in vivo immune cell tracking. These imaging modalities highlight the intrinsic behavior of different immune cell populations in physiological context. Fluorescent, radioactive or paramagnetic probes can be used in direct labeling protocols to monitor the specific cell population. Reporter genes can also be used for genetic, indirect labeling protocols to track the fate of a given cell subpopulation in vivo. In this review, we summarized several methods dealing with dendritic cell, macrophage, and T lymphocyte specifically labeled for different macroscopic whole-body imaging techniques both for the study of their physiological function and in the context of immunotherapy to exploit imaging-derived information and immune-based treatments.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.9.1-9.23
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• 2022

In the past few decades, biological drugs and small molecule inhibitors targeting inflammatory cytokines, immune cells, and intracellular kinases have become the standard-of-care to treat autoimmune diseases. Inhibition of TNF, IL-6, IL-17, and IL-23 has revolutionized the treatment of autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, and psoriasis. B cell depletion therapy using anti-CD20 mAbs has shown promising results in patients with neuroinflammatory diseases, and inhibition of B cell survival factors is approved for treatment of systemic lupus erythematosus. Targeting co-stimulatory molecules expressed on Ag-presenting cells and T cells is also expected to have therapeutic potential in autoimmune diseases by modulating T cell function. Recently, small molecule kinase inhibitors targeting the JAK family, which is responsible for signal transduction from multiple receptors, have garnered great interest in the field of autoimmune and hematologic diseases. However, there are still unmet medical needs in terms of therapeutic efficacy and safety profiles. Emerging therapies aim to induce immune tolerance without compromising immune function, using advanced molecular engineering techniques.

• IMMUNE NETWORK
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• v.11 no.5
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.