• Molecules and Cells
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• v.41 no.12
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• pp.1072-1080
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• 2018

A plant-specific B3 domain and AP2 domain-containing transcription factor, RAV1 acts as a negative regulator of growth in many plant species and its transcription was down-regulated by BR and ABA. In this study, we found that RAV1-overexpressing transgenic plants showed abnormally developed ovules, resulting in reduced seed size, weight, and number in a silique. Interestingly, the endogenous expression of RAV1 fluctuated during seed development; it remained low during the early stage of seed development and sharply increased in the seed maturation stage. In plants, seed development is a complex process that requires coordinated growth of the embryo, endosperm, and maternal integuments. Among many genes that are associated with endosperm proliferation and embryo development, three genes consisting of SHB1, MINI3, and IKU2 form a small unit positively regulating this process, and their expression was regulated by BR and ABA. Using the floral stage-specific RNAs, we found that the expression of MINI3 and IKU2, the two downstream genes of the SHB1-MINI3-IKU2 cascade in the seed development pathway, were particularly reduced in the RAV1-overexpressing transgenic plants. We further determined that RAV1 directly binds to the promoter of MINI3 and IKU2, resulting in their repression. Direct treatment with brassinolide (BL) improved seed development of RAV1-overexpressing plants, but treatment with ABA severely worsened it. Overall, these results suggest that RAV1 is an additional negative player in the early stages of seed development, during which ABA and BR signaling are coordinated.

• Journal of Fashion Business
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• v.23 no.4
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• pp.13-23
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• 2019

This study aims to understand the concept of pixel, the most important factor in constituting a digital image, draw the formative characteristics of pixelation image expressed through non-digital media, and develop fashion design reflecting the characteristics. As a research method, the literature review was conducted in the present study by involving domestic and foreign publications, related academic journals, and theses and dissertations on the pixel and pixelation image based on a qualitative research process. In addition, through an analysis of the cases that borrowed pixelation images in non-digital media like contemporary art and design, etc., an attempt was made to draw the formative characteristics of the pixelation image. Apparently, six fashion design looks are presented in the present study. The formative characteristics of the pixelation image include: first, the repeatability that repeats the minimum unit; second, the incompleteness of the shape appearing through the phenomenon of aliasing due to the characteristics of the pixel; and third, the combination that completes the shape through the combination of individual independent pixels. The results of the expression through reflecting them in fashion design are as follows: first, this study chose one small geometric formative element and presented repeatability by repetitively expressing that element in a textile pattern; second, for incompleteness, this study expressed an incomplete form, handling the edge part of the shape with the method of disentangling the strand; and third, the combination by completing a single look through overlapping of independent textiles and the combination of different independent individuals is expressed.

• Journal of Korean Society of Forest Science
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• v.70 no.1
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• pp.28-37
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• 1985

In order to estimate breast-height form factors of Pinus thunbergii and Cryptomeria japonica, 8 models based on tree age, diameter at breast height and tree height were suggested and evaluated. It was the following equations that turned out to be most fit for estimating them; for Pinus thunbergii, $F=0.553-4.567\;1/A+71.409\;1/A^2$ ($R^2=0.928$), based on tree age, ($6.727^{**}$) ($14.100^{**}$) $F=0.356+1.774\;1/D-0.770\;1/D^2$ ($R^2=0.944$), based on diameter at breast height, ($15.102^{**}$) ($2.908^{**}$) $F=0.316+1.546\;1/H+0.397\;1/H^2$ ($R^2=0.941$), based on tree height, ($8.380^{**}$) ($3.896^{**}$) for Cryptomeria japonica, $F=0.400+2.348\;1/A+17.053\;1/A^2$ ($R^2=0.889$), based on tree age, ($3.501^{**}$) ($3.298^{**}$) $F=0.353+2.118\;1/D-1.462\;1/D^2$ ($R^2=0.923$), based on diameter at breast height, ($14.873^{**}$) ($3.545^{**}$) $F=0.403+0.427\;1/H+2.843\;1/H^2$ ($R^2=0.887$), based on tree height. ($3.254^{**}$) ($5.742^{**}$) The above estimated breast-height form factors proved to be overestimated for young trees and small diameter trees, and to be underestimated for old trees and large diameter trees, in comparison to generally accepted figure in Korea, that is, the form factor of 0.45.

• Journal of Life Science
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• v.25 no.9
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• pp.1007-1013
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• 2015

A COG (Cluster of Orthologous Groups of proteins) algorithm was applied to detect conserved genes in 711 prokaryotes. Only COG0080 (ribosomal protein L11) was common among all the 711 prokaryotes analyzed and 58 COGs were common in more than 700 prokaryotes. Nine COGs among 58, including COG0197 (endonuclease III) and COG0088 (ribosomal protein L4), were conserved in a form of one gene per one organism. COG0008 represented 1356 genes in 709 of the prokaryotes and this was the highest number of genes among 58 COGs. Twenty-two COGs were conserved in more than 708 prokaryotes. Of these, two were transcription related, four were tRNA synthetases, eight were large ribosomal subunits, seven were small ribosomal subunits, and one was translation elongation factor. Among 58 conserved COGs in more than 700 prokaryotes, 50 (86.2%) were translation related, and four (6.9%) were transcription related, pointing to the importance of protein-synthesis in prokaryotes. Among these 58 COGs, the most conserved COG was COG0060 (isoleucyl tRNA synthetase), and the least conserved was COG0143 (methionyl tRNA synthetase). Archaea and eubacteria were discriminated in the genomic analysis by the average distance and variation in distance of common COGs. The identification of these conserved genes could be useful in basic and applied research, such as antibiotic development and cancer therapeutics.

• Journal of Life Science
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• v.24 no.5
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• pp.588-593
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• 2014

Tumor angiogenesis is important in tumorigenesis and therapeutic interventions in cancer. To know inhibitor and effector of tumor angiogenesis in cancer, the specific gene of tumor and angiogenesis may develop the mechanisms of cancer suppression and therapy. Recently, we described the role of RalA-binding protein 1 (RLIP76) in tumor angiogenesis. Tumor vascular volumes were diminished, and vessels were fewer in number, shorter, and narrower in RLIP76 knockout mice than in wild-type mice. Moreover, angiogenesis in basement membrane matrix plugs was blunted in the knockout mice in the absence of tumor cells, with endothelial cells isolated from the lungs of these animals exhibiting defects in migration, proliferation, and cord formation in vitro. RLIP76 is expressed in most human tissues and is overexpressed in many tumor types. In addition, the protein regulates tumorigenesis and angiogenesis in vivo and in vitro. As the export of chemotherapy agents is a prominent cellular function of RLIP76, it is a major factor in mechanisms of drug resistance. Moreover, RLIP76 acts as a selective effector of the small GTPase, R-Ras, and regulates R-Ras signaling, leading to cell spreading and migration. Furthermore, in skin carcinogenesis, RLIP76 knockout mice are resistant, with tumors that form showing diminished angiogenesis. Thus, RLIP76 is required for efficient endothelial cell function and angiogenesis in solid tumors.

• The Journal of the Korea Contents Association
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• v.18 no.2
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• pp.468-475
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• 2018

The current system of making course evaluations mandatory in universities in Korea in order to supplement low participation levels is a major hindering factor for the validity of the evaluation results due to students' insincere responses. This study points out the problems in course evaluations that are in the form of surveys and instead proposes a sample course evaluation system that utilizes a sample mean to deduce a population mean, attempting to prove through simulation that this is statistically significant. Thus, small, medium, and large scale courses as well as cyber courses that were available in S University in the fall 2016 semester were set as the population, and each course's evaluation average grade was set as the population mean. Furthermore, we used the average grade and standard deviation of the same courses from the previous year in order to decide the sample number, the reliability level was set as 95%, and the margin of error was set as ${\pm}0.25$. As a result of carrying out a simulation using the data analysis tool R, all the courses (small scale, medium scale, large scale, and cyber) showed to have a reliability level close to 95% including the population mean, and consequently practicality of the representative sample course evaluation system was proven.

• 한국신재생에너지학회:학술대회논문집
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• 2011.11a
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• pp.39.2-39.2
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• 2011

The new and renewable energy today has a great interest in all countries around the world. In special it has need more limit of the fossil fuel that needs of low carbon emission among the social necessary conditions. Recently, the high-rise building demand the structural safety, the economic feasibility and the functional design. The high-rise building spends enormous energy and it satisfied the design in solving energy requirements. The requirements of energy for the building depends on the partly form wind energy due to the cladding of the building that came from the surroundings of the high-rise building. In this study of the wind energy, the cladding of the building was assessed a tentative study. The wind energy obtains from several small wind powers that came from the building or the surrounding of the building. In making a cladding the wind energy forms with wind pressure by means of energy transformation methods. The assessment for the building cladding was surrounded of wind speed and wind pressure that was carried out as a result of numerical simulation of wind environment and wind pressure which is coefficient around the high-rise building with the computational fluid dynamics. In case of the obtained wind energy from the pressure of the building cladding was estimated by the simulation of CFD of the building. The wind energy at this case was calculated by energy transform methods: the wind pressure coefficients were obtained from the simulated model for wind environment using CFD as follow. The concept for the factor of $E_f$ was suggested in this study. $$C_p=\frac{P_{surface}}{0.5{\rho}V^{2ref}}$$ $$E_c=C_p{\cdot}E_f$$ Where $C_p$ is wind pressure coefficient from CFD, $E_f$ means energy transformation parameter from the principle of the conservation of energy and $E_c$ means energy from the building cladding. The other wind energy that is $E_p$ was assessed by wind power on the building or building surroundings. In this case the small wind power system was carried out for wind energy on the place with the building and it was simulated by computational fluid dynamics. Therefore the total wind energy in the building was calculated as the follows. $$E=E_c+E_p$$ The energy transformation, which is $E_f$ will need more research and estimation for various wind situation of the building. It is necessary for the assessment to make a comparative study about the wind tunnel test or full scale test.

• Korean Journal of Ichthyology
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• v.22 no.4
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• pp.230-237
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• 2010

Histological observation on the seasonal variation of mucus cells of the mud loach Misgurnus mizolepis inhabiting a natural stream was carried out on three skin regions (dorsal, lateral and occiput) from March 2008 to February 2009. Our results showed no differences in general morphology by season, but the mucus cells of the epidermis showed significant seasonal change in their size and number as the water temperature changed. The ratio of surface area of the mucus cell layer and mucus cells, and the number of mucus cells in surface area of the epidermis were the greatest in the cold winter and the least in the hot summer in all regions of the epidermis. In particular, the occiput seemed to be a very sensitive region in response to environmental change, showing wide fluctuations in the size of mucus cells throughout the year and a great change in between seasons, especially from late autumn to early winter when the temperature decreased. As the temperature became colder, a small and spherical-shaped mucus cell was transformed into a large and elongated columnar form with a lot of secreted mucus material in a superficial layer of the epidermis. From our results, we can safely surmise that cold temperature is an important environmental factor having a close relationship with the modification of mucus cells of M. mizolepis in winter.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.925-928
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• 2014

Background: Gestational trophoblastic neoplasia (GTN) is a spectrum of disease with abnormal trophoblastic proliferation. Treatment is based on FIGO stage and WHO risk factor scores. Patients whose score is 12 or more are considered as at extremely high risk with a high likelihood of resistance to first line treatment. Optimal therapy is therefore controversial. Objective: This study was conducted in order to summarize the regimen used for extremely high risk or resistant GTN patients in our institution the in past 10 years. Materials and Methods: All the charts of GTN patients classified as extremely high risk, recurrent or resistant during 1 January 2002 to 31 December 2011 were reviewed. Criteria for diagnosis of GTN were also assessed to confirm the diagnosis. FIGO stage and WHO risk prognostic score were also re-calculated to ensure the accuracy of the information. Patient characteristics were reviewed in the aspects of age, weight, height, BMI, presenting symptoms, metastatic area, lesions, FIGO stage, WHO risk factor score, serum hCG level, treatment regimen, adjuvant treatments, side effects and response to treatment, including disease free survival. Results: Eight patients meeting the criteria of extremely high risk or resistant GTN were included in this review. Mean age was 33.6 years (SD=13.5, range 17-53). Of the total, 3 were stage III (37.5%) and 5 were stage IV (62.5%). Mean duration from previous pregnancies to GTN was 17.6 months (SD 9.9). Mean serum hCG level was 864,589 mIU/ml (SD 98,151). Presenting symptoms of the patients were various such as hemoptysis, abdominal pain, headache, heavy vaginal bleeding and stroke. The most commonly used first line chemotherapeutic regimen in our institution was the VAC regimen which was given to 4 of 8 patients in this study. The most common second line chemotherapy was EMACO. Adjuvant radiation was given to most of the patients who had brain metastasis. Most of the patients have to delay chemotherapy for 1-2 weeks due to grade 2-3 leukopenia and require G-CSF to rescue from neutropenia. Five form 8 patients were still survived. Mean of disease free survival was 20.4 months. Two patients died of the disease, while another one patient died from sepsis of pressure sore wound. None of surviving patients developed recurrence of disease after complete treatment. Conclusions: In extremely high risk GTN patients, main treatment is multi-agent chemotherapy. In our institution, we usually use VAC as a first line treatment of high risk GTN, but since resistance is quite common, this may not suitable for extremely high risk GTN patients. The most commonly used second line multi-agent chemotherapy in our institution is EMA-CO. Adjuvant brain radiation was administered to most of the patients with brain metastasis in our institution. The survival rate is comparable to previous reviews. Our treatment demonstrated differences from other institutions but the survival is comparable. The limitation of this review is the number of cases is small due to rarity of the disease. Further trials or multicenter analyses may be considered.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1972.03a
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• pp.17.1-17
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• 1972

Hemophilia B is hereditary disorder of blood coagulation known as a deficiency of P.T.C. or Christmas factor. Anyway it's indistinguishable clinically with hemophia A and C. Here's one of most interesting problems gave us because we could only find it out as a hemophilia B. when we stood a situation to be met continuous bleeding from the operative wound of tonsillectomy and Adenoidectomy. Wintrobe proposed that easy bruising, difficulty in stopping the bleeding from razor cuts, and prolonged bleeding after tonsillectomy or tooth extraction usually are the major manifestations. For a long time little attention was paid to reports of a milder form of the diseases. In such cases coagulation time, and even prothrombin consumption were normal and the symptoms were correspondinly mild, small wounds as a rule giving little trouble and hemoarthrosis being uncommon. In our cases, there's no specific contributory history except nasal bleeding intermittently and also no specific contributory laboratory data before the operation. After the T. & A., there's continuous bleeding from nasopharynx and the coagulas on the both tonsilar fossas being grown day by day. Therefore we suspected some abnormality of coagulation mechanism and then we could get conclusion of hemophilia B. after various laboratory tests including T.G.T., As I know, this case, hemophilia B. is 3rd one as a report in Korea. We have no data of hemophilia family at present time, so that I propose that we have to make system of hemophilia family in Korea. In a next, we have to make routinely complete laboratory test, ego routine C.B.C., bleeding time, coagulation time, prothrombine time, partial thromboplastine time, before operation of T.& A. If we can solve these problems we can get the T. & A. without any problems of bleeding according to get the operation of T. & A.