• Biomolecules & Therapeutics
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• 제28권3호
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• pp.267-271
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• 2020

Gut microbiota produce dietary metabolites such as short-chain fatty acids, which exhibit anti-inflammatory effects. Free fatty acid receptor 2 (FFA2, formerly known as GPR43) is a specific receptor for short-chain fatty acids, such as acetate that regulates inflammatory responses. However, the therapeutic potential of FFA2 agonists for treatment of atopic dermatitis has not been investigated. We investigated the efficacy of the FFA2 agonist, 4-chloro-α-(1-methylethyl)-N-2-thiazoylylbenzeneacetanilide (4-CMTB), for treatment of atopic dermatitis induced by 2,4-dinitrochlorobenzene (DNCB). Long-term application of DNCB to the ears of mice resulted in significantly increased IgE in the serum, and induced atopic dermatitis-like skin lesions, characterized by mast cell accumulation and skin tissue hypertrophy. Treatment with 4-CMTB (10 mg/kg, i.p.) significantly suppressed DNCB-induced changes in IgE levels, ear skin hypertrophy, and mast cell accumulation. Treatment with 4-CMTB reduced DNCB-induced increases in Th2 cytokine (IL-4 and IL-13) levels in the ears, but did not alter Th1 or Th17 cytokine (IFN-γ and IL-17) levels. Furthermore, 4-CMTB blocked DNCB-induced lymph node enlargement. In conclusion, activation of FFA2 ameliorated DNCB-induced atopic dermatitis, which suggested that FFA2 is a therapeutic target for atopic dermatitis.

• 한방안이비인후피부과학회지
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• 제28권2호
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• pp.75-84
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• 2015

Objectives : The purpose of this study is to report the oriental medical treatment on erythema multiforme caused by acute tonsillitis. Methods : Patient who has been ill Acute tonsillitis suffers from erythema, edema, pruritus, burning sensation of systemic skin. The patient was admitted to Dunsan oriental hospital for 7 days and was treated with oriental medicine(acupuncture, herbal-medicine, and vapor treatment). To evaluate the results of this treatment, the improvement of symptoms(erythema, pruritus, burning sensation) was identified by patient's subjective expression and in lesion-symptom improvement. Results : The symptoms caused by acute tonsillitis on total skin were improved. Conclusions : This study shows that the oriental medical treatment effects on the erythema multiforme caused by acute tonsillitis. Also, the public suggests that the correlation between the skin and tonsil.

• 사상체질의학회지
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• 제26권2호
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• pp.180-193
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• 2014

Objectives The present study was carried out to investigate effects of HBPDS on allergic contact dermatitis (ACD) induced by 2,4-Dinitro-1-fluorobenzene (DNFB) in mice. Methods In this experiment, effects of HBPDS on body weights, skin thicknesses, skin weights, histopathological changes, clinical aspects, erythema index, melanin index, production levels of cytokines in ACD mice were investigated. In addition, effects on proliferation rates, release of ${\beta}$-hexosaminidase and histamine were also investigated in vitro. Results & Conclusions 1) HBPDS inhibited enlargement of skin thickness and weight significantly (P < 0.05). 2) HBPDS treatment prevented spongiosis, edema and immune cell infiltrations. 3) Erythema, desquamation and keratosis were diminished by oral administration of HBPDS. 4) Production levels of TNF-alpha and IFN-gamma in serum were decreased by HBPDS treatment in vivo. 5) More than 200 ${\mu}g/ml$ of HBPDS treatment decreased ${\beta}$-hexosaminidase release and more than 400 ${\mu}g/ml$ of HBPDS treatment also decreased histamine release in vitro.

• 한방안이비인후피부과학회지
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• 제34권2호
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• pp.86-90
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• 2021

Objectives : The purpose of this study is to report the treatment of the Tinea corporis treated by Korean medicine. Methods : The skin lesion with keratin were scraped and placed on a slide glass, and the KOH solution was dropped and observed under a microscope. After the hyphae was confirmed, a ChoPho-bang was prescribed and applied twice a day. Results : In the KOH test performed again 3 weeks after treatment, no hyphae was found and the skin lesion was completely disappeared. Conclusions : For Tinea Corporis, the KOH test is recommended to distinguish it from other skin diseases, and application of ChoPho-bang is effective for treatment.

• 패션비즈니스
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• 제25권2호
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• pp.51-62
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• 2021

This study evaluated the cosmetic effects of a far-infrared hot and cool mask (BBSkinplus) on face skin moisturization, whitening, and wrinkles using a randomized clinical trial. Forty female participants (mean age 47.7 ± 4.6 years) were allocated into the treatment group (BBSkinplus treatment and lotion application twice a day) or the control group (only lotion application twice a day), and moisture, brightness, and wrinkles were measured at 0, 1 and 2 weeks. The average values of each measurement were changed significantly by BBSkinplus treatment compared to the control group. At the 2-week treatment time point, the statistical differences in improvement rates between the two groups were significant at 8.7% vs. 3.9% for moisture (p < 0.01), 0.7% vs. 0.4% for brightness (p < 0.01), and -3.1% vs. 0.0% as Ra and -6.3% vs. 1.5% as R3z for wrinkles (p < 0.05), respectively. No notable complaint was reported regarding any kind of adverse effects such as erythema, itching, or burning. This clinical data support the potential of BBSkinplus as a home beauty device providing moisturizing, whitening, and anti-wrinkle effects on the face.

• 대한한의학회지
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• 제25권1호
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• pp.161-171
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• 2004

Objectives: Sasang Constitutional Medicine is popularly appliedto treatment in Korea. Constitution is a holistic concept contained internal and external characteristics, and physical traits including ordinary symptoms. Skin is one of constitutional property elements. So we researched a correlation female facial skin and sasang constitution. This is a basic study to find constitution can be a major factor to care and manage skin. Methods: We examined sasang constitution and facial skin condition of 100 healthy women who aged from 30 to 59. Hydration and sebum of facial skin was measured by skin diagnostic instrument and skin type was calculated from the data. Keratin, pore size, acne, and brightness of face was measured by skin magnifying lens and subjective skin troubles in ordinary times was also investigated. Constitution diagnosis and Skin diagnosis was investigated separately as a blind test andthe data was statistically analyzed with chi-square test, Correlation analysis, One-way analysis of variance. Results: 1. In sasang constitution, Taeeumingroup bad significant tendencies of larger hydration and sebum amount, combination degree of forehead and cheek was also higher than other constitutions(p<0.05). 2. Facial skin type was significantly different according to Sasang Constitution, Soeumin and Soyangin had a tendency of dry skin comparatively, but Taeeumin had mainly a tendency of combination skin and secondly dry skin(p<0.05). On the other hand, there was no correlation between age and skin type. 3. In subjective skin trouble, Soeumin group had less acne trouble than Soyangin and Taeeumin group(p<0.1). Pore size trouble was more frequent in Soyangin group than Soeumin group(p<0.05). Keratin trouble was more frequent in Soeumin group than Soyangin and Taeumin group(p<0.1). Conclusions: Korean healthy women's skin condition was different according to sasang constitution.

• Nutrition Research and Practice
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• 제4권5호
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• pp.369-374
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• 2010

Grape is one of the most popular and widely cultivated fruits in the world. Although grape skin and seeds are waste product of the winery and grape juice industry, these wastes contain large amounts of phytochemicals such as flavonoids, phenolic acids, and anthocyanidins, which play an important role as chemopreventive and anticancer agents. We evaluated efficacies of grape skin and seeds on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN significantly increased levels of serum alanine transaminase, aspartate transaminase, alkaline phosphatase, and bilirubin. Diet supplementation with grape skin or seeds (10% daily for 4 weeks) prevented these elevations. The grape skin and seeds also restored serum albumin and total protein levels, and reduced the hepatic level of hydroxyproline and malondialdehyde. Furthermore, grape skin and seeds reduced DMN-induced collagen accumulation, as estimated by histological analysis of liver tissue stained with Sirius red. Grape skin and seeds also reduced hepatic stellate cell activation, as assessed by ${\alpha}$-smooth muscle actin staining. In conclusion, grape skin and seeds exhibited in vivo hepatoprotective and antifibrogenic effects against DMN-induced liver injury, suggesting that grape skin and seeds may be useful in preventing the development of hepatic fibrosis.

• Korean Journal of Acupuncture
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• 제20권3호
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• pp.29-34
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• 2003

Objectives : The purpose of this study was to investigate the Effect of Acupuncture Chok-samni(ST36) on Skin temperature(ST), Galvanic skin response(GSR) and Heart rate(HR) in humans. ST36 is used in uneasiness, high fever, stroke, paralysis on oriental medicine. Methods : Subjects were 18 healthy oriental medical students volunteers(15male, 3female, mean age-28). Under sequence of ST36 acupuncture, the first group was observed ST, the second group was observed GSR and the third group was observed HR. Skin temperature was measured on Haegye acupoint(ST41) before and after acupuncture stimulation. Each test took 15minutes. This test was performed twice in order to increase the statistical authenticity. Results : Our result indicates that acupuncture stimulation of ST36 statistically decreased skin temperature on ST41. Also statistically decreased in HR. The change of GSR after ST36 acupuncture was decreased, but there is no statistical. Conclusions : These results suggested that acupuncture stimulation of ST 36 has effect on ST and HR in human body, and may be used by treatment as control the nerve system.

• 셀메드
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• 제9권4호
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• pp.2.1-2.4
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• 2019

With the improvement of economic status and the desire for beauty, the interest in health and skin care is increasing. For these demands, since ages medicinal plants are in vogue. A variety of plants, cosmetics and foods with novel bioactive ingredients for skin care and beauty are under constant research and development. Skin is influenced by various factors such as Ultra-violet rays, stress, hormones and aging which together lead skin to lose elasticity, changes in pigmentation and wrinkle formation. Many medicinal plants have proven effects in skin care and beauty treatment. From this list of medicinal plants, one which is famous for its beauty, flavor and fragrance is Rosa damascene. Rosa damascene has many therapeutic action and postulated pharmacological studies such as anti-arthritic, anti-microbial, cardio protective, anti-inflammatory, antioxidant, analgesic, immune-modulator, gastro-protective, and skin ameliorative effect. Research in the field of Cosmetology has proven the effect of Rosa damascene in rehydrating skin, reducing scars and stretches, acne management, lowering skin pigmentation, delaying wrinkling and is recommended as a skin vitalizing agent. In this review, the morphology, chemical constituents, and some pharmacological activity are discussed.

• Nuclear Engineering and Technology
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• 제55권1호
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• pp.215-221
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• 2023

Proton treatment may deliver a larger dose to a patient's skin than traditional photon therapy, especially when a range shifter (RS) is inserted in the beam path. This study investigated the effects of an RS on skin dose while considering RS with different thicknesses, airgaps and materials. First, the physical model of the scanning nozzle with RS was established in the TOol for PArticle Simulation (TOPAS) code, and the effects of the RS on the skin dose were studied. Second, the variations in the skin dose and isocenter beam size were examined by reducing the air gap. Finally, the effects of different RS materials, such as polymethylmethacrylate (PMMA), Lexan, polyethylene and polystyrene, on the skin dose were analysed. The results demonstrated that the current RS design had a negligible effect on the skin dose, whereas the RS significantly impacted the isocenter beam size. The skin dose was increased considerably when the RS was placed close to the phantom. Moreover, the magnitude of the increase was related to the thickness of the inserted RS. Meanwhile, the results also revealed that the secondary proton primarily contributed to the increased skin dose.