• Journal of Pharmaceutical Investigation
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• 제24권4호
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• pp.281-287
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• 1994

The effects of oleic acid, propylene glycol and 5% (w/w) oleic acid in propylene glycol on the electrical properties of hairless mouse skin were studied and the results were compared. The complex electrical impedance was measured as a function of frequency, and resistance and capacitance were determined from the Nyquist plot. Immediately after the treatment with oleic acid, resistance was 145% of the pretreatment value. However it decreased with time and, after 20 hours, it was about 25% of its pretreatment value. Capacitance increased; immediately after the treatment, it was about 125% of pretreatment value and it seemed to increase slowly with time. When the skin was treated with propylene glycol, resistance decreased about 5O% and capacitance increased about 65%. Similar results were observed when the skin was treated with 5% (w/w) oleic acid in propylene glycol, except that the magnitude of resistance drop was much larger. Oleic acid acted synergistically with propylene glycol. Together with the flux data in the literature, the results obtained in this work indicate that electrical resistance is closely related to the permeability of drug molecules through the skin. The results are discussed in terms of the mechanism of action of these penetration enhancers. Overall, this work provided further mechanistic insight into the role of SC lipids in skin resistance and capacitance.

• 성인간호학회지
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• 제23권5호
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• pp.472-481
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• 2011

Purpose: The aim of the study was to identify the effects of aroma-foot-reflexology on premenstrual syndrome, dysmenorrhea and lower abdominal skin temperature of nursing students. Methods: This study used a pretest-posttest quasi-experimental study design. The participants were divided into two groups, a control group with 37 students and a treatment with 24 students. A 35 minute three times a week aroma-foot-reflexology was carried out for the treatment group. The data were analyzed using SPSS/WIN 17.0 program. Results: The results showed that aroma-foot reflexology was significantly effective in reducing premenstrual syndrome and dysmenorrhea, and raised lower abdominal skin temperature of the students. Conclusion: The results of this study indicated that aroma-foot-reflexology is an effective nursing intervention in reducing premenstrual syndrome and dysmenorrhea and in improving lower abdominal skin temperature. It is, therefore, recommended that the aroma-foot reflexology should be a clinical practice as an effective nursing intervention to reduce premenstrual syndrome and dysmenorrhea and to improve lower abdominal skin temperature of nursing students.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5257-5264
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• 2016

Background: Though people of color (POC) are less likely to become afflicted with skin cancer, they are much more likely to die from it due to delay in detection or presentation. Very often, skin cancer is diagnosed at a more advanced stage in POC, making treatment difficult.The purpose of this research was to improve awareness regarding skin cancers in people of color by providing recommendations to clinicians and the general public for early detection and photo protection preventive measures. Methods: Data on different types of skin cancers were presented to POC. Due to limited research, there are few resources providing insights for evaluating darkly pigmented lesions in POC. Diagnostic features for different types of skin cancers were recorded and various possible risk factors were considered. Results: This study provided directions for the prevention and early detection of skin cancer in POC based on a comprehensive review of available data. Conclusions: The increased morbidity and mortality rate associated with skin cancer in POC is due to lack of awareness, diagnosis at a more advanced stage and socioeconomic barriers hindering access to care. Raising public health concerns for skin cancer prevention strategies for all people, regardless of ethnic background and socioeconomic status, is the key to timely diagnosis and treatment.

• Journal of Ginseng Research
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• 제47권1호
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• pp.133-143
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• 2023

Background: Past studies suggested that ginseng extracts and ginseng-derived molecules exerted significant regulatory effects on skin. However, no reports have described the effects of ginseng-derived nanoparticles (GDNPs) on skin cell proliferation and wound healing. In this study, we investigated whether GDNPs regulate the proliferation of skin cells and promote wound healing in a mouse model. Methods: GDNPs were separated and purified via differential centrifugation and sucrose/D2O gradient ultracentrifugation. GDNP uptake, cell proliferation and cell cycle progression were measured by confocal microscopy, CCK-8 assay and flow cytometry, respectively. Cell migration and angiogenic effects were assessed by the wound scratch assay and tube formation assay, respectively. ELISA was used to detect extracellular matrix secretion. The relevant signaling pathway was confirmed by western blotting. The effects of GDNPs on skin wound healing were assessed by wound observation, HE staining, and western blotting. Results: GDNPs possessed the essential features of exosomes, and they were accumulated by skin cells. Treatment with GDNPs notably enhanced the proliferation of HaCaT, BJ and HUVECs. GDNPs also enhanced the migration in HaCaT cells and HUVECs and angiogenesis in HUVECs. GDNPs increased the secretion of MMP-1, fibronectin-1, elastin-1, and COL1A1 in all three cell lines. GDNPs regulated cell proliferation through the ERK and AKT/ mTOR pathways. Furthermore, GDNPs facilitated skin wound healing and decreased inflammation in a mouse skin wound model. Conclusion: GDNPs can promote skin wound healing through the ERK and AKT/mTOR pathways. GDNPs thus represent an alternative treatment for chronic skin wounds.

• Biomolecules & Therapeutics
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• 제32권2호
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• pp.249-260
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• 2024

New supplements with preventive effects against skin photodamage are receiving increasing attention. This study evaluated the anti-photoaging effects of salmon nasal cartilage proteoglycan (SPG), acting as a functional material for skin health. We administered SPG to in vitro and in vivo models exposed to ultraviolet B (UVB) radiation and assessed its moisturizing and anti-wrinkle effects on dorsal mouse skin and keratinocytes and dermal fibroblasts cell lines. These results showed that SPG restored the levels of filaggrin, involucrin, and AQP3 in the epidermis of UVB-irradiated dorsal skin and keratinocytes, thereby enhancing the keratinization process and water flow. Additionally, SPG treatment increased the levels of hyaluronan and skin ceramide, the major components of intercellular lipids in the epidermis. Furthermore, SPG treatment significantly increased the levels of collagen and procollagen type 1 by down-regulating matrix metalloproteinase 1, which play a crucial role in skin fibroblasts, in both in vitro and in vivo models. In addition, SPG strongly inhibited mitogen-activated protein kinase (MAPKs) signaling, the including extracellular signal-regulated kinase, c-Jun N-terminal kinase (JNK), and p38. These findings suggest that dietary SPG may be an attractive functional food for preventing UVB-induced photoaging. And this SPG product may provide its best benefit when treating several signs of skin photoaging.

• 대한화장품학회지
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• 제41권1호
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• pp.63-71
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• 2015

보습제는 피부과에서 가장 흔하게 사용하는 제품 중 하나로, 피부장벽을 유지시키고 피부가 촉촉하고 건강하게 보이게 하며, 영유아의 정상적인 피부발달에 매우 중요하게 작용한다. 하지만 보습제 도포가 정상 영유아의 피부에 어떠한 영향을 미치는지에 대한 연구는 제한적이다. 이에 건강한 정상 영유아에서 일반적인 보습제 도포가 피부에 미치는 영향을 알아보고자 본 연구를 진행하였다. 31명의 피부염이 동반되지 않는 건강한 6 - 36개월 연령의 영유아를 대상으로, 하루 2회 목욕 후 눈과 기저귀 착용 부위를 제외한 전신에 존슨즈 베이비 내츄럴너리싱 로션을 4주간 도포하였다. 임상적 평가는 도포 전후, 1주, 4주에 실시하였다. 매 방문시 피부수분도와 경표피수분손실도, 피부산도 및 거칠기를 측정하였으며 피부표면을 촬영하여 비교하였고 보습제 도포 후 발생한 피부 발진을 포함한 모든 부작용을 기록하였다. 보습제 도포 후 피부수분도는 통계적으로 유의하게 증가하였으며, 경표피수분손실도와 거칠기는 통계적으로 유의하게 감소하였다. 피부산도는 약산성으로 조절되었으며, 육안적으로 피부표면은 매끄럽게 변화한 것이 관찰되었다. 임상 시험 기간 동안 부작용은 관찰되지 않았다. 본 실험을 통해 보습제 도포가 영유아의 피부에 있어 수분을 증가시키고, 피부장벽기능 증강과 약산성의 피부산도 조절 및 거칠기의 호전을 야기하며, 4주간의 보습제 도포가 미치는 영향의 정도를 확인할 수 있었다.

• 한국산학기술학회논문지
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• 제13권7호
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• pp.2886-2894
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• 2012

본 연구는 서울소재 대학교에 재학 중인 여대생을 대상으로 피부미용전공과 비전공 여학생들의 피부건강관리의 관심도와 피부상태, 인식 및 관리 행위의 차이점 및 관련성을 파악하고자 하였다. 전공자들과 비전공자들의 대한 비교 분석은 동일한 생활권에서 궁극적으로 전문 학습과 비 전문학습의 일반적인 상태에 대한 지식과 행위를 의미하는 것으로, 연구결과는 다음과 같이 나타났다. 전공 여대생이 비전공 여대생에 비해 피부건강에 대한 관심도가 높은 것으로 유의미한 차이가 있었다(p<.01). 피부미용 전공 여대생은 복합성 피부, 비전공 여대생은 건성 피부가 많은 것으로 유의미한 차이를 보였다(p<.05). 피부 관리 실태에서 색조화장 후 전공여부에 따른 이중세안 정도, 각질 정리 횟수, 마사지나 팩 관리횟수, 선크림 사용 항목에서 각각 유의미한 차이가 있었다(p<.01, p<.001, p<.01, p<.01). 오백식품 및 인스턴트식품의 영향정도와 수분섭취 항목에서 각각 유의미한 차이를 보였다(p<.001).(p<.05). 화장품 사용은 다양한 채널을 통해 효율적인 구매를 하는 경향이었으며, 탁월한 기능이 있을 때는 경제적 부담이 있어도 구입 의향 항목에서 적극적인 성향인 것으로 유의미하게 나타났다(p<.001). 본 연구의 결과는 피부미용 산업 및 교육 분야에 기초자료로 활용되고자 하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제19권6호
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• pp.905-908
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• 2006

The purpose of this research was to study the effects of kefir whey (kefir whey, peptides, lactic acid) on skin care properties including skin lightening effect and acne treatment. The final aim was to develop a new cosmetic product and enhance the value of dairy products. The results of skin lightening tests showed that all three kefir whey components (kefir whey, peptides and lactic acid) had inhibitory ability against melanin synthesis. Furthermore, copper chelating analysis demonstrated that both kefir whey and kefir whey peptides could chelate the copper in tyrosinase, which might explain the mechanism of inhibition. The ability for acne treatment indicated that lactic acid level higher than 60 mg/ml could inhibit the growth of Propionibacterium acne, whereas no inhibition was found with other components.

• 대한수의학회지
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• 제53권3호
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• pp.185-187
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• 2013

An 11-year-old, toy poodle dog was presented with dermatologic lesions and mammary gland tumor (MGT) evaluation. A solitary, lobulated MGT (size $2.5{\times}3.5$ cm) was affecting the 5th left mammary gland. Firm, oval plaque skin lesions were present on the left dorsal carpal area. The skin lesions were alopecic and salivary staining. The dog had historical separation anxiety and excessive licking of skin lesions were observed. Based on the clinical and histopathologic examinations, MGT was diagnosed with mammary complex adenoma and the skin lesions were diagnosed with acral lick dermatitis. Behavior modification treatment using oral clomipramine was effective.

• 대한화장품학회지
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• 제16권1호
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• pp.18-29
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• 1990

In this report, the variation of skin surface between before treatment and after treatment was investigated by skin image analyzer. The 30 volunteers were applied cream and lotion on the forearm Inside for 4 weeks, and the measurement parameter of skirl surface was adopted peak, length, height, and width. The results were as follows ; 1. variation trends of parameters was showed that number of peaks were increased, but length, height and width were decreased. 2. The order of improvement for skin surface are as follow ; height > length > peak > width. 3. And also disclosed that the number of peak has a correlation with width, and length has a correlation with height.