• Nutritional Sciences
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• 제2권2호
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• pp.119-124
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• 1999

Food allergies play an important role in Atopic Dermatitis (AD). Dietary manipulation is essential in the management of AD. However, there has been a paucity of data reporting the prevalence of food allergies in AD patients in Korea. In this study, the Food Open Challenge Tests (FOCT) were conducted to investigate food allergies in AD patients. The skin-prick test and the detection of specific IgE, as well as allergy history of patient were used to detect food allergies in all AD patients. Elimination diet was conducted for two weeks prior to FOCTs. The prevalence of food allergies by FOCT is as follows: milk (67.3%); chicken (64.2%); pork (62.8%); eggs (61.0%); beef(55.4%) ; wheat (52.0%) and soybean (45.2%). Allergenic food items in Korean AD patients were different from people in other foreign countries. The seven major foods those tested positively by FOCTs were completely eliminated from the replaced diets for two weeks, and were subsequently reintroduced one at a time. Results from FOCTs were not comparable with allergy history or skin-prick tests or specific IgE detection. The sensitivity and specificity of skin-prick tests and specific IgE detection were lower than FOCTs. Allergy history, skin-prick tests, and specific IgE detection are useful for the identification of food allergen but its clinical significance differed according to food items. Therefore, we conclude that even though a 10-day delay was necessary after food challenge, FOCT is a useful and valid method to confirm food allergies and may be essential for the effective control of food allergies for treatment of AD.

• Biomolecules & Therapeutics
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• 제10권4호
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• pp.246-252
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of their adverse effect on users; dermatitis, allergic contact dermatitis and photo allergic contact dermatitis. The unscientific idea that higher SPF sunsreen is good for health mealeads many users to tend to prefer higher SPF sunscreen. In the toxicological aspect, the need to investigate the safety of sunscreens is steadily increasing. However, there were few studies on the correlation between sun protection factor (SPF) and the safety of sunscreens. The objective of this study was to assess whether there was a correlation between SPF and the safety of sunscreens. We measured in vitro SPF index using homosalate as a standard and examined the toxicity tests such as primary skin irritation tests, ocular irritation test and skin sensitization test. Homosalate (HS), octyl methoxycinnamate (OMC), octyl salicylate (OS), octocrylene (OC) as UVB organic filter and benzophenone-3 (BP3), butyl methoxy dibenzoil methane (BMDM) as UVA organic filter, and titanium dioxide (TD), zinc oxide (ZO) as inorganic filters were used. The skin irritation indexes in rabbits treated with HS, OMC, OS, BP3, and BMDM were significantly increased as SPF indices were increased. Neither ocular irritation in rabbits nor skin sensitization in guinea pigs were increased. It suggests that there might be a good correlation between SPF and the skin irritation indices of organic UV filters and skin irritation might be one of most sensitive index to assess the safety of sunscreens.

• 한국정보전자통신기술학회논문지
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• 제15권6호
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• pp.477-484
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• 2022

본 연구는 집속형초음파자극시스템의 카트리지부를 시료로 사용하여 의료기기 안전성 평가 기준인 GLP(Good Laboratory Practice)에 관한 시험 중 동물실험을 통한 피부 자극 시험 및 피부 감작성시험을 진행하였다. New Zealand White Rabbit 암컷 6마리를 이용하여 IACUC 승인 후 시험을 진행하였으며, 실험기간 동안 사망한 개체 수는 없었으며, 실험동물에서 어떤 이상 증상도 관찰되지 않았다. 극성, 비극성 자극 지수는 모두 '0.0'으로 나타났다. 또한, 피부감작성 평가의 경우 IACUC 승인을 통한 기니피그 30마리를 통하여 대조군 및 실험군으로 나누어 시험검체 및 공시험액을 별도의 희석 없이 용출액 자체를 사용하여 모든 유도 및 유발단계를 적용하였다. 실험결과대조동물의 피부반응 등급은 0등급이었으며, 시험동물의 피부반응에서 1등급 이상을 나타내는 동물은 없었다. 두 시험 결과에서 피부의 이상 증상은 발견되지 않았으며, 인체에 적용하여 환자를 치료할 경우 시험에 사용된 시험재료로부터 피부의 이상 증상이 생기는 질환 등은 나타나지 않는지에 관하여 안정성을 알아 보고자 하였다.

• Steel and Composite Structures
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• 제4권2호
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• pp.113-132
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• 2004

Double skin composite element (DSCE) is a novel form of construction comprising two skins of profiled steel sheeting with an infill of concrete. DSCEs are thought to be applicable as shear or core walls in a building where they can resist in-plane loads. In this paper, the behaviour of DSCE subjected to combined bending and shear deformation is described. Small-scale model tests on DSCEs manufactured from micro-concrete and very thin sheeting were conducted to investigate the flexural and shear behaviour along with analytical analysis. The model tests provided information on the strength, stiffness, strain conditions and failure modes of DSCEs. Detailed development of analytical models for strength and stiffness and their performance validation by model tests are presented.

• 한방안이비인후피부과학회지
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• 제15권2호
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• pp.210-219
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• 2002

Background and Objectives The diagnosis of allergic rhinitis includes detailed clinical history, physical examination and the use of either in vivo or vitro tests for relevant allergens. Skin test has been used the most commonly. Recently MAST CLA is used for determination of serum spcecific IgE, This study attempted to find out the distribution of Sasang Constitution and to compare the MAST CLA with skin tests in allergic rhinitis patients. Methods Skin tests, MAST CLA and Sasang Constitution study were performed for 35 allergic rhinitis patients who visited Kyunghee Oriental Medical Center from Sept. 2001 to Nov. 2001. Results 1. The ratio between male and female was 1:1.5. the peak age was the thirties(42.9$\%$) 2. 45.7$\%$ of patients had family history of allergic diseases and allergic rhinitis was the most common. 3. 51.4$\%$ of patients lived in A.P.T. and in preference of cool and warm, 54.3$\%$ of patients prefered both of cool and warm. 4. Among 24 cases who were consulted to dept. of Sasang, 45.8$\%$ was Taeumin. 5. 65.7$\%$ of patients reacted positive to skin test and the common offending allergen was D. pteronyssinus(82.6$\%$). 6. 25.7$\%$ of patients reacted positive to MAST CLA and the common offending allergen was D. farinae(88.9$\%$). 7. Among 22 cases who was performed skin test and MAST CLA the sensivity and specificity of MAST CLA was 27.4$\%$ and 94.9$\%$. There was significant correlations between MAST CLA and skin test(p=0.005, r=0.574, 1, spearman correlation coefficienct).

• 한국지반공학회논문집
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• 제39권1호
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• pp.5-14
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• 2023

말뚝이 근입된 지반의 융기는 말뚝에 추가적인 상향 주면 마찰력을 발생시켜 말뚝의 안정성을 저해할 수 있다. 본 연구에서는 말뚝의 일부에 지반 변형에 능동적으로 대응 가능한 부재가 삽입되어 말뚝에 작용하는 상향 주면 마찰력을 감소시킬 수 있는 새로운 말뚝 기초 양식을 제안하였다. 제안된 말뚝의 실효성을 검증하기 위하여 지반 변형 대응 부재로서 유압 실린더가 적용된 말뚝을 설계 및 제작하였다. 일반 말뚝과 제안된 말뚝을 대상으로 지반 융기 모사 실험을 수행하여 선단 하중, 주면 마찰력과 지반 변형 대응 부재의 팽창량에 따른 선단 하중의 변화를 분석하였다. 실험 결과, 매우 적은 양의 실린더 부재의 팽창에도 말뚝에 작용하는 인발 마찰력이 완전히 상쇄되며 이에 따라 선단 하중이 증가하였다. 그러나 실린더 부재의 과도한 팽창은 상향 마찰력의 감소를 넘어 부주면 마찰력을 발생시키므로 지반 팽창량 및 말뚝의 허용 변위를 고려한 적절한 지반 변형 대응 부재의 팽챵량 산정이 필요하다.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2005년도 춘계학술발표대회 논문집
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• pp.46-50
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• 2005

Smart skin, a multi-layer structure of composed of a round shape antenna, was designed and fabricated. Tests and analyses was conducted to study its behavior under compressive loads. It was confirmed that the designed smart skin failed due to premature buckling before compression failure. Numerical prediction of structural behavior of smart skin by MSC.NASTRAN agreed well with experimental data.

• 임상간호연구
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• 제21권3호
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• pp.309-318
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• 2015

Purpose: The purpose of this study was to examine the effects of foot mats on reducing levels of fatigue, discomfort, lower extremity edema and skin temperature in scrub nurses during surgery. Methods: This study employed one group repeated measures design in which 16 scrub nurses (ages 22-38) stood on steel footstools (SF) during scrub as the conventional test and stood on SF with foot mats as the experimental test. Levels of fatigue, discomfort, lower extremity edema and skin temperature were measured before the first surgical hand scrub and right after the first surgery of the day for 3 consecutive days in both tests. Results: The changes in levels of fatigue and discomfort were significantly different between tests (p<.001~.033). Edema, determined by the differences in circumferences of the ankles and calves before and after the surgery was also significantly different between groups (p=.001~.011). However, the change in skin temperature on the foot tops of both feet was not different between tests (p=.351~.467). Conclusion: The results of this study show that using foot mats on top of the steel footstool is effective in reducing the levels of fatigue, discomfort and lower extremity edema in scrub nurses during surgery.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.138-138
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary and cumulative skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.250-250
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• 1996

Eye irritation, primary skin irritation and skin sensitization tests for Aloewhite were tested in New Zealand White rabbits and Hartley guinea pig. In primary skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and primary Irritation Index(PII) was 0.47, indicating Aloewhite as mildly irritating material, In ocular irritation test, any injury on iris, conjunctival membrane, and cornea in New Zealand White rabbits was not observed. No injuries of the ocular mucous membrane were also recorded. Skin sensitization was tested in guinea Peg after intradermal and epicutaneous induction and graded I with zero % sensitization rate. These results indicate that Aloewhite was not considered to be irritant in test organs of animals.