Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1996.04a
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- Pages.250-250
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- 1996
Eye Irritation, Skin Irritation and Skin Sensitization tests for Aloewhite in Animals
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Kim, Hyung-Sik
(Division of Toxicology, School of Pharmacy, Sung Kyun Kwan University)
;
- Kwack, Seung-Jun (Division of Toxicology, School of Pharmacy, Sung Kyun Kwan University) ;
- Kim, Kyu-Bong (Division of Toxicology, School of Pharmacy, Sung Kyun Kwan University) ;
- Lee, Seung-Ki (Division of Toxicology, School of Pharmacy, Sung Kyun Kwan University) ;
- Park, Hyun-Sun (Division of Toxicology, School of Pharmacy, Sung Kyun Kwan University) ;
- Hong, Che-Young (Division of Toxicology, School of Pharmacy, Sung Kyun Kwan University) ;
- Ahn, Mi-Young (Division of Toxicology, School of Pharmacy, Sung Kyun Kwan University) ;
- Jo, Tea-Hyung (NamYang Aloe Co., Manny(B/D)) ;
- Oh, Sun-Tack (NamYang Aloe Co., Manny(B/D))
- Published : 1996.04.01
Abstract
Eye irritation, primary skin irritation and skin sensitization tests for Aloewhite were tested in New Zealand White rabbits and Hartley guinea pig. In primary skin irritation test of male New Zealand White rabbits, body weights were not significantly changed and primary Irritation Index(PII) was 0.47, indicating Aloewhite as mildly irritating material, In ocular irritation test, any injury on iris, conjunctival membrane, and cornea in New Zealand White rabbits was not observed. No injuries of the ocular mucous membrane were also recorded. Skin sensitization was tested in guinea Peg after intradermal and epicutaneous induction and graded I with zero % sensitization rate. These results indicate that Aloewhite was not considered to be irritant in test organs of animals.
Keywords