• Journal of the Korean Applied Science and Technology
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• v.27 no.1
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• pp.20-28
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• 2010

Melanoma is the most aggressive form of skin cancer and is the fastest growing type of cancer in the United States. We report here the synthesis of a novel series of quinazolinylmethoxybenzene derivatives 1a-c and their antiproliferative activities against A375 human melanoma cell line. Among them, urea compound 1a ($IC_{50}\;=\;4.8\;{\mu}M$) having 4-chloro-3-trifluoromethylphenyl moiety showed superior antiproliferative activity to Sorafenib ($IC_{50}\;=\;5.5\;{\mu}M$) as a reference compound. These results will helpful for designing structure of a therapeutic agent for the treatment of melanoma.

• Archives of Pharmacal Research
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• v.27 no.11
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• pp.1132-1135
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• 2004

In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable inhibitory activity. Especially, sanggenon D is revealed as a potent inhibitor ($IC_{50}$ =7.3$\mu$ M), compared to the reference compound, kojic acid ($IC_{50}$ =24.8 $\mu$M). However, the prenylation with isoprenyl group or the vinylation to flavonoid molecules did not enhance tyrosinase inhibitory activity.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.2459-2463
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• 2005

Optical coherence tomography (OCT) is high resolution medical imaging system which is obtaining image inside biological objects with non-destructive method. OCT system is based on Michelson interferometer with a reciprocating mirror in the reference arm and a biological object in the sample arm. The obtained OCT image suffers from a granular or mottled image, called speckle. Speckle is caused by random interferences between reflected coherence waves. In this paper, we propose effective speckle reduction method that uses wavelet transform. With wavelet domain image, sub-windowing and thresholding are performed. Finally, speckle reduction experiments for Misgurnus mizolepis skin and rat eye images are shown.

• 한국전산유체공학회:학술대회논문집
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• 1998.11a
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• pp.1-6
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• 1998

From surface flow visualization on a MIRA notchback reference model using oil flow technique, the topology of the singular points of the skin friction lines are delineated. Separation and reattachment lines at the front screen, at the A-pillar, at the C-pillar and on the rear side of the car including the trunk have been identified. It is worth to mention that two vortices emerging from the top of the trunk coil in the opposite direction as that vortices starting from the C-pillar edge. The positions of the singular points and the separation and reattachment lines and the foci of the vortices provide a sensitive database for validation of CFD-codes

• Proceedings of the IEEK Conference
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• 2002.06c
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• pp.13-16
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• 2002

This paper proposes a method to track hand gesture and to recognize the gesture pattern using Kalman filter and continuous dynamic programming (CDP). The positions of hands are predicted by Kalman filter, and corresponding pixels to the hands are extracted by skin color filter. The center of gravity of the hands is the same as the input pattern vector. The input gesture is then recognized by matching with the reference gesture patterns using CDP. From experimental results to recognize circle shape gesture and intention gestures such as “Come on” and “Bye-bye”, we show the proposed method is feasible to the hand gesture-based human -computer interaction.

• Journal of the Korean Applied Science and Technology
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• v.26 no.3
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• pp.297-305
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• 2009

Melanoma is the most serious type of skin cancer as a malignant tumor of melanocytes. In this work, the syntheses of a novel series of benzaminoquinoline derivatives 1a-c and their antiproliferative activities against A375 human melanoma cell line were described. All the compounds ($IC_{50}=0.78-1.02{\mu}M$) showed superior antiproliferative activities to Sorafenib ($IC_{50}=5.58{\mu}M$) as a reference compound. These results suggested that benzaminoquinoline derivatives have potentials as a therapeutic agent for the treatment for melanoma.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.7
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• pp.1566-1573
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• 1997

In this paper, we propose a favorite color correction algorithm for color enhancement in color application system which represent preferred colors for viewer's demands. The proposed algorithm corrects skin color which is widely used as a reference color for color control of color application system, blue color which is directly related to tri-stimulus values, and green color which has higher visual sensitivity. In the proposed algorithm, the vaiation range of phase detector output voltage was minimized for the favorite color saturation changes, thus the favorite from the burst signal for the phase detector characteristic, thus the favorite color was easilty detected from the other color without overlapping of correctionranges.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.171.5-171
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• 2001

Information that is acquired by adhered sensors on a body has been commonly used for the three-dimensional real-time motion capture algorithm. This paper describes realtime motion capture algorithm using computer vision. In a real-time image sequence, human body silhouette is extracted use a background subtraction between background image and the reference image. Then a human standing posture whether forward or backward is estimated by extraction of skin region in the silhoutte. After then, the principal axis is calculated in the torso and the face region is estimated on the principal axis. Feature points, which are essential condition to track the human gesture, are obtained ...

• Korean Journal of Fisheries and Aquatic Sciences
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• v.24 no.5
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• pp.345-355
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• 1991

In order to effectively utilize the by-products of sea-food, the utilization of enzyme-modified flounder(Limanda aspera) skin gelatin as an emulsifier was investigated. In the experiment, the gelatin was extracted from the flounder skin with the heat-treatment at $60^{\circ}C$ and in pH 5.0 for 3 hrs with four volumes of distilled water and emulsifiers were enzymatically modified L-leucine alkyl esters$(L-leucine-OC_n$ : n= 2, 4, 6, 8 and 10) to the gelatin$(EMFSG-C_2,\;EMFSG-C_4,\;EMFSG-C_6,\;EMFSG-C_8,\;EMFSG-C_{10})$ for improving the functional properties such as emulsifying activity, emulsifying viscosity, whippability, electric conductivity, critical micelle concentration and interface tension, etc. Also, the functional properties of the L-leucine alkyl ester modified gelatins were compared with those of Tween-60 as reference. Molecular weights of the enzymatically modified flounder skin gelatin(EMFSG) were 20.5kDa. in $EMFSG-C_2.\;19.5 kDa.\;in\;EMFSG-C_4\;and\;16.5kDa.\;in\;EMFSG-C_6,\;EMFSG-C_8$ and $EMFSG-C_{10}$. respectively. Emulsifying activity and emulsifying viscosity in the modified gelatins were risen with increase of carbon number of the introduced L-leucine alkyl esters. Among the modified gelatins, $EMFSG-C_6$ exhibited the highest emulsifying stability and foaming stability, whereas $EMFSG-C_8$ showed the highest whippability. The electric conductivities of the all $EMFSG-C_n$ were linearly risen to critical micelle concentration(CMC) , therefore $EMFSG-C_{10}$ exhibited the lowest CMC value and interface tension, and dense particles in the microscopic observation. In conclusion, the best quality in functional properties was assured on $EMFSG-C_{10}$.

• Science of Emotion and Sensibility
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• v.19 no.2
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• pp.27-34
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• 2016

The effects of aroma mixed oil with Chamomile, Lavender and Sandalwood on atopic dermatitis in NC/Nga mice were examined. The NC/Nga mice were divided into BMAC group, FK 506 Oinment (Tacrolimus Hydrate) group, and CLS group to get curative power of CLS. The amount of total IgE and IgG1 was measured and the severity of atopic dermatitis was assessed by the scoring procedure in NC/Nga mice. Topically applied CLS significantly suppressed the level of serum IgE and IgG1 in NC/Nga mice and FK506, used as reference drugs for atopic dermatitis, also exhibited suppressive effects against level of IgE and IgG1. The level of IgE was lower in the CLS group than in the FK506 group while the serum IgG1 level in the FK506 group was lower than in the CLS group. The treatment with FK506 and CLS reduced the skin inflammation index, especially the severity degree of atopic dermatitis in the skin lesioned NC/Nga mice by naked eyes was improved by treatment of FK506 and CLS. The results suggest that treatment of CLS in NC/Nga mice with atopic dermatitis have an beneficial therapeutic effects on reducing the level of IgE and IgG1 and accelerating repair of skin lesion.