• Journal of the Korean Dietetic Association
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• v.4 no.2
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• pp.212-224
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• 1998

The purpose of this study was to investigate nutrients intake, Rohrer index, serum cholesterol level, blood pressure and others for clinical and nutritional study on school children in Taejon. This survey was carried out in October, 1995. The subjects were 362 children, 6 to 11 years old. The results were summarized as follows. By Rohrer index, 4.6% of the children was lean, 69.6% was normal, 17.4% was overweight and 8.6% was obese group. Systolic blood pressure, diastolic blood pressure and skin fold thickness of all subjects were 111.7$\pm$15.7mmHg, 69.8$\pm$14.9mmHg and 14.5$\pm$7.3mm respectively. Systolic blood pressure and skin fold thickness were increased with Rohrer index. Total cholesterol, urea nitrogen and creatinine levels in blood were 160.8$\pm$23.9mm/dl, 11.5$\pm$3.5mm/dl and 0.71$\pm$0.12mm/dl respectively but not significantly different among groups. These levels have a slight tendency to increase in obese group but not significantly different among groups. Hematocrit and hemoglobin levels were 41.3$\pm$4.7%, 13.1$\pm$1.6g/dl. These levels of 11 years old girls were lower than same aged boys. Composition ratio of total energy intakes were 65% of CHO, 13% of protein and 22% of fat. Energy and most nutrients intakes were insufficient except for P and vitamin C. Especially the amount of vitamin A, Fe, Zn and folate intakes were lower than halves of RDA'S. Most nutrients intake were not significantly different among groups. Pearson' correlation in Rohrer index with nutrients intakes were all negative correlation significantly different of K, Na and Thiamin.

• Journal of Pharmaceutical Investigation
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• v.41 no.6
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• pp.337-345
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• 2011

The objective of this work is to investigate the effect of chemical enhancer and current on the flux of donepezil hydrochloride (DH) through skin. Ethanol and N-methyl pyrrolidone (NMP) were used as chemical enhancers in combination with iontophoresis. We also have studied the effect of pH on flux and evaluated the role of electroosmosis. In vitro flux study was performed at $33^{\circ}C$, using side-by-side diffusion cell and full thickness hairless mouse skin. Passive flux of DH without enhancer was very small. As the concentration of enhancer increased, passive flux increased. After current application, flux increased markedly and the time to reach maximum decreased. Without enhancer, maximum flux was about 50 fold larger than that obtained without current. These results indicate that electromigration is playing a major role for the transport. As the enhancer concentration increased, flux also increased. NMP and ethanol increased not only the passive delivery, but also the iontophoretic delivery. Flux results indicate that ethanol has better ability than NMP in enhancing the transport of DH. The magnitudes of increase in flux by these enhancers indicate that there is a large synergistic effect in flux enhancement. Flux results from pH study showed that electroosmotic flow is reversed at low pH and the flux is hindered. These results provided some information on the flux enhancing ability of ethanol and NMP in combination with iontophoresis. The data also provided some mechanistic insights into the role of electromigration and electroosmosis on flux through skin.

• Journal of Korean Academy of Nursing
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• v.33 no.3
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• pp.405-413
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• 2003

Purpose: This study was performed to investigate effects of behavior modification on obesity index, skinfold thickness, body fat, serum lipids, serum leptin in obese elementary school children. Method: Forty seven students were selected from two elementary schools. Twenty four children in one school were assigned to experimental group and twenty three children in another school were assigned to control group. Experimental group was received 60～70 minutes of behavior modification once a week for 8 weeks. Result: Obesity index of the experimental group was significantly decreased after behavior modification. But there was no significant difference between two groups. The increase of skin fold thickness was significantly low in the experimental group compared to the control group. Percentage of body fat and fat mass were significantly decreased in the experimental group. Fat free mass was significantly increased in the experimental group. HDL-C, triglyceride and serum leptin between the experimental group and control group showed no significant difference. Conclusion: These results indicate that behavior modification is effective in decreasing percentage of body fat and fat mass, in less increasing skinfold thickness and in increasing fat free mass. In conclusion, behavior modification can be used as effective strategy for managing obesity in elementary school children.

• Journal of Korean Academy of Nursing
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• v.3 no.3
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• pp.73-77
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• 1973

A study on the nutritional status for school-children has been carried out 1,700 school- children of Song-do primary school located in Song-do beach, Busan, Korea, from November to-December, 1972. The evaluation of the nutritional status has been carried out through skin-fold thickness and hemoglobin. The summarized results were as follows. : 1. Skinfolds thickness 1) Subcellular skinfolds thickness . Among boys, that was 3.5mm in the age 6 and 5.4mm in the age 11 Among girls, that was 4.2mm in the age 6 and 7.6mm in the age 11. Girls were thicker than toys in the all age. 2) Upper-arm skinfolds thickness Among boys, that was 5.0mm in the age 6 and 6.8mm in the age 11. Among girls, that was 6.2mm in the age 6 and 8.7mm in the age 11. Girls were thicker than toys in the all age. 3)Abdominal skinfolds thickness. Among boys, that was 4.0mm in the age 6, and 6.4mm in the age 11. Among girls that was 4.0mm in the age 0, and 8.4mm in the age 11. Girls were thicker than boys in the all age. 2. Hemoglobin Proportional range of hemoglobin were observed as 12.2-12.8 gm/㎗.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.2
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• pp.219-224
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• 1994

The purpose of this study was to investigate the percentage of body fat by measurement of skin-fold thickness and to figure out the relationship between the daily energy intake and expenditure among male and female college students. Measurements of height, weight , skinfold thickness, percent body fat, lean body mass were made, 새심 daily energy expenditure and dietary intake survey were performed on 164 (male 86, female 78) college students. The survey was conducted between October 10, 1993-November 20, 1993. The results are as follows : 1) The average height and wegiht of the surveyed men and women were respectively 172.$\pm$0.6cm, 62.2$\pm$0.8kg and 160.8$\pm$ 0.5cm, 51.5$\pm$0.6kg, BMI of those surveyed were 20.9$\pm$0.2 and 19.9$\pm$0.2 and body density of those surveyed were 1.06$\pm$0.0 and 1.05$\pm$0.0 , and the percentage of body fat of those surveyed were 17.3$\pm$0.5% and 23.2$\pm$0.4% , and IBM of those surveyed were 51.2$\pm$0.6kg and 39.5$\pm$0.4kg. 2) Mean skin-fold thickness at 4 sites of the surveyed men and women were respectively 11.6$\pm$0.5mm and 18.3$\pm$0.6mm. 3) Average calorie intake of male and female were 2121$\pm$54kcal , 1906$\pm$28kcal respectively 70.5:14.2:15.3 and 68.0:14.0:18.0. 5) Activity time record of subjects reveal that there was a trend for males to spend more time in moderate and high activity and less time in light activity compared to females. Total daily energy expenditure of male and female group were respectively 2784$\pm$51kcal and 2073$\pm$32kcal. 6) The skinfold thickness showed negative correlation with body density but it showed positive correlation with the percentage of body fat. The lean body mass showed positive correlation with physical activity and energy intake showed positive correlation with physical activity also.

• Archives of Plastic Surgery
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• v.33 no.5
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• pp.541-545
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• 2006

Purpose: There are many methods for the reconstruction of the facial defect after an excision of a skin cancer; such as skin graft, local flap, free flap, etc... Skin graft has its' limitations; it could remain in different color with in regards of the recipient to donor, with an unfavorable scar. Free flap can lead to big donor site morbidity with long operation time and uncontrolled scar as a disadvantage factor. Compared to the prior, local flap offers several merits; sufficient blood supply, good tissue quality and short operation time. We revised 'V-Y-S flap' for the facial defect, which proved to have favorable outcomes. Methods: Total 7 V-Y-S flaps were performed to patients with skin cancers(six squamous cell carcinoma and one basal cell carcinoma). Two of these flaps were combined with composite grafts, one with full thickness skin graft. Six patients were female and one male. The average diameter of defects after excision was 2.3 cm. The follow-up period was 18 months maximally. Results: We treated seven facial skin cancers with 'V-Y-S flap'. There were no flap necrosis, cancer recurrence and scar contracture as a result. Furthermore, this method also offers a favorable central scar line that is parallel to the nasolabial fold and the nasojugal groove, especially in the nasolabial area and superomedial side of the cheek. With this method, we could cover a maximum diameter of 4cm facial defect. Conclusion: In conclusion, it is suggested that V-Y-S flap is a useful method to cover facial defects after the excision of a skin cancer.

• Journal of Environmental Health Sciences
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• v.31 no.1
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• pp.7-14
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• 2005

Exposure of skin to UVB radiation can cause the induction of inflammation and impairment of contact hypersensitivity(CHS) response. Several studies have shown that polyphenolic compounds isolated from EGb 761 afford protection against UVB. In this study, we demonstrated that topical application of EGb 761, before 1MED(1.4 KJ/$m^2$), 1.5MED (2.1 KJ/$m^2$), 2MED (2.8 KJ/$m^2$) of UVB exposure to ICR mice prevented UVB-induced inflammation and inhibition of the contact hypersensitivity response. The skin-fold swelling from 1MED, 1.5MED, 2MED of UVB exposure highly significantly increased after twice irradiation. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to UVB exposure reduced skin thickness compared to non-treated mice. Exposure of shaved abdominal skin of mice to 1MED, 1.5MED and 2MED of UVB radiation resulted in suppression of contact sensitization through the skin to 56.23%, 65.12%, 74.02%, compared to normal unirradiated skin. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to or 5 days after exposure to 1MED and 2MED of UVB resulted in protection against suppression of contact hypersensitivity in mouse dorsal skin. These protective effects were dependent on the dose of EGb 761 employed. The present study show that EGb 761 protect UVB-induced inflammation and immune suppression. Also, we suggest that EGb 761 can provide protection from photoimmunosuppression.

• Archives of Craniofacial Surgery
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• v.14 no.2
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• pp.107-110
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• 2013

Background: Basal cell carcinoma (BCC) is the most common skin cancer. About 74% cases of basal cell cancer occur on the head and neck. Basal cell carcinoma on the face may have a higher degree of subclinical spread than tumors arising elsewhere. And incompletely excised BCCs become more aggressive when they recur. So the surgical removal and reconstruction of BCC located on the face are important to make perfect curing and cosmetic results. Methods: A retrospective study was done with 128 patients (137 cancers) who were treated with BCC on the face since 1987 to 2011. General data of these cases such as the primary site of cancer, age and sex of the patients, operative methods, and recurrence rate were reviewed. Results: The ratio of men to women was 1:1.4. And 86.9% of the patients with BCC were older than the age of 50 years with the mean age of 65.8 years. The distribution of facial basal cell carcinoma was on the nose, eyelids, cheek, and nasolabial fold. Surgical methods for treatment were local flap, full thickness skin graft, primary closure, and split thickness skin graft. Specifically, local flap consists of V-Y advancement flap, cheek advancement flap, limberg flap, forehead flap, nasolabial flap, rotation flap, transposition flap, bilobed flap, and island flap. Six cases recurred and all of them were treated with reoperation. Conclusion: The authors reviewed facial basal cell carcinoma cases in our hospital. This study might be helpful to choose appropriate operation method to manage BCC on face in Korea.

• Korean Journal of Community Nutrition
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• v.2 no.3
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• pp.327-337
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• 1997

The purpose of this study was to investigate the differences in anthropometric, hematologic, and lipidologic data between normocholesterolemia and hypercholesterolemia and influencing factors in hypercholesterolemia in middle-aged men in Kwang-ju. 179 middle-aged men were involved. Anthropometric data(body weight, height, body circumferences and skinfold thickness) and hematologic data(blood pressure, fasting blood glucose, albumin and hemoglobin) were measured. Bleed lipid profile(total cholesterol, tr- iglyceride, phospholipid, HDI-cholesterol, LDL-cholesterol and VLDL-cholesterol) were analyzed. To determined using questionnaire. The subjects were classified as hypercholesterolemic based on The Guideline for Korean Hyperlipidemia. body mass index, systolic blood pressure, waist and hip circumference, and triceps, subcostal, abdomen, subscapular and suprailliac skinfold thicknesses of the hypercholesterolemic group were significantly higher than in the normocholesterolemic group. The concentrat- ion of cholesterol, triglyceride, phospholipod. HDL-cholesterol, LDL-cholesterol and VLDL -cholesterol of the hypercholesterolemic group were significantly higher than normocholesterolemic group. The concentration of cholesterol has a significantly positive correlation with body mass index, diastolic blood pressure, waist circumference, waist/thigh ratio and skinfold thickness(triceps, subcostal, abdomen, and supraillic skin- fold thickness). The general tendency of socioeconomec status, frequencyu of meat intake, smoking amounts and duration and duration and drinking frequencies and amount were higher in the hypercholesteolemic group but not significant. In conclusion, hypercholesterolemia in middle-aged men was closely correlated with upper body fat obesity and most of them had an accompanied high triglyceride level tendency.

• Journal of Pharmaceutical Investigation
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• v.41 no.1
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• pp.9-17
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• 2011

The objective of this work is to study transdermal delivery of calcitonin using iontophoresis and to evaluate various factors which affect the transdermal transport. We have studied the effect of polarity, current density, drug concentration, penetration enhancers (isopropyl myristate [IPM] and ethanol) and laser treatment on transdermal flux and the results were compared. We also investigated the iontophoretic flux from microemulsions containing calcitonin together with oleic acid (OA) or IPM. In vitro flux study was performed at $33^{\circ}C$, using side-by-side diffusion cell and full thickness hairless mouse skin. Anodal delivery at pH 3.0 was much larger than cathodal and passive delivery, due to the positive charge of calcitonin. Cumulative amount delivered (CUM) by cathodal or passive delivery was close to zero for 10 hours. The pretreatment of skin by neat IPM markedly increased the CUM anodically. CUM increased as the current density, drug concentration or the duration of IPM treatment increased. Microemulsion containing IPM or oleic acid was prepared and the phase diagram was constructed. CUM also increased when IPM was incorporated into a microemulsion. OA microemulsion showed similar enhancing effect to IPM microemulsion. The delivery of calcitonin from 70% (v/v) ethanol aqueous solution showed a large increase in flux. Laser treatment of skin before flux experiment exhibited about 2 fold increase in total calcitonin amount transported for 12 hours, when compared to that delivered by IPM microemulsion. Based on these results, we have evaluated the possibility of delivering enough amount of calcitonin to reach the therapeutic level. The data suggest that it is highly possible to deliver clinically effective amount of calcitonin using iontophoresis patch with small area (<10 $cm^2$).