• Clinical and Experimental Pediatrics
• /
• v.51 no.4
• /
• pp.377-382
• /
• 2008

Purpose : The aim of this study is to assess the usefulness of skin test by an inactivated, 1/50 diluted solution of attenuated varicella vaccine in evaluating the immune status to varicella. Methods : Total 41 subjects (22 males, 19 females, aged 1-32 years) were enrolled from July to August, 2005. Past medical history including varicella infection, varicella vaccination were investigated through questionnaires. The skin test solution was prepared from solution of attenuated varicella vaccine(Oka strain) which was inactivated by exposure to room temperature for 10 days and diluted at 1/50 with normal saline. Skin test was done by injecting 0.1 mL of the solution intradermally into the volar surface of the right forearm and sterile normal saline was used as a control on the left forearm. Positive reaction was defined when the transverse diameter of the induration was 5 mm or more. Serum varicella zoster virus specific IgG antibody test by ELISA (enzyme-linked immunosorbent assay) was done. Results : In adults, the sensitivity of the varicella zoster virus skin test compared to ELISA was 94.7% and the positive predictive value was 100%. In children, both the positive predictive value and specificity were 100% but the sensitivity and the negative predictive value were 50% and 30.7% respectively. Children showed smaller skin test reactivity compared to adults. Conclusion : The varicella zoster virus skin test using inactivated, 1/50 diluted solution of attenuated varicella vaccine was proved as one of the useful tools for evaluating the immunity and susceptibility of the varicella zoster virus.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.1
• /
• pp.15-18
• /
• 2005

The methodology of constitution diagnosis is main concern in sasang constitutional medicine, but highly reliable method is not yet established. So we statistically analyzed the relationship between the constitution and characteristic factors of skin such as thickness, stiffness, roughness, and touch-feeling, using 1079 clinical data registered to SCIB(Sasang constitution Information Bank), and the following results are obtained: The skin of Taeeumin are more thick or more stiff or more rough than other constitutions. The skin of Soeumin are more soft or more feeble or more feeble-refined than other constitutions. The skin of Soyangin are more slippery or more thin or more slippery-refined than other constitutions. The differences written above were proved to be meaningful enough by Chi-square test.

• The Korean Journal of Food And Nutrition
• /
• v.26 no.4
• /
• pp.990-995
• /
• 2013

In the pursuit of practical usage for Codonopsis lanceolata and development of functional processed food material, the research on the product characterization is being performed through the manufacturing of Yanggaeng which is extracted from the Codonopsis lanceolata skin concentrate. By adding Codonopsis lanceolata skin extracts (0, 40, 60, 80, 100%) to the product, the chemical property characterization and organoleptic test of the produced Yanggaeng are being conducted. The scavenging effects on DPPH free radical have a significant proportional relationship with the addition of Codonopsis lanceolata skin extracts as 61.30 for 100% added group as compared with 52.72 for the null-addition group. It is considered that the antioxidative activity increases with the addition of the Codonopsis lanceolata skin extraction as the SOD similar activity rate was increased to 49.23% from 39.31%, the flavor preference was ranked as 80%>60%>0%>100%>40% showing that 60~80% of Codonopsis lanceolata skin extraction addition seems to be the proper amount.

• The Journal of Korean Medicine
• /
• v.29 no.1
• /
• pp.117-133
• /
• 2008

Objectives : Since ancient times, Koreans have applied medicinal spabaths for treatment of various diseases. The objective of this study was to investigate the effect of strontium, one of the common ingredients of such baths, experimentally on acute skin barrier damage. Materials and Methods : Male hairless mice, average weight 20g, were divided into six groups. Each group consisted of five mice. The first was the normal, non-treated group. The second was the control group with acute skin barrier damage intentionally induced by TS. The third was the Ba-Sr1 group bathed in 1mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fourth was the Ba-Sr7 group bathed in 7mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fifth was the Sr1 group bathed in 1mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. The sixth was the Sr7 group bathed in 7mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. External changes of skin, skin erythema level, transepidermal water loss level, and GOT and GPT level of each group were checked immediately before and after TS, 3 hrs, 5 hrs and 24 hrs after inducing acute skin barrier damage. Then, tissue samples were made and examined for damage to epithelial cells, stratum corneum, change of mucous polysaccharide in dermis and amount of mast cells. Statistical analysis was performed by one way-ANOVA, Scheffe and Duncan for a post hoc test and pairwise comparison for comparing for difference between each time. Statistical significance was achieved if the probability was less than 5% (p<0.05) Results : 1. From skin erythema and TEWL level indicating the function of the skin barrier, we can know that it is helpful to the skin barrier to bathe in a water solution including a low concentration of strontium. 2. In the control group with acute skin barrier damage induced by TS, skin barrier damage persisted until 3-5 hrs and recovered after 5-24 hrs. Differently from the control group, in the case of taking a bath in a water solution including strontium, skin barrier damage recovered after only 3-5 hrs. Therefore, the bath with a water solution including strontium can promote recovery of the skin barrier. 3. Bathing in water solution including a higher concentration of strontium was more beneficial to recovery of skin barrier damage. 4. There was no influence on serum GOT and GPT from bathing in a water solution including strontium. Conclusions : The strontium was effective for recovery and mitigation of acute skin barrier damage induced by tape stripping. I suggest that strontium (Sr) can be used as an external treatment medicine, addedinto bath water to treat acute skin barrier damage.

• Journal of Oriental Medical Thermology
• /
• v.2 no.1
• /
• pp.17-23
• /
• 2003

Purpose The cold hypersensitivity is a subjective symptom and it is very difficult to evaluate the severity. It is possible to detect cold hypersensitivity by measuring the skin temperature on DITI, but there is limitation only using DITI to find the objective grade of the symptom. To set a new objective standard for the diagnosis of cold hypersensitivity, we examined the relationship between the Visual Analogue Scale (VAS) score for the cold hypersensitivity and the change of skin temperature on hands by cold stress test Method 23 patients with symptom of cold hypersensitivity were participated as subjects who visited the women medical center of Kangnam Kyunghee Korean Hospital, Kyung Hee Univ. from May 1, 2002 to August 31, 2002. There were all carefully examined to rule out other disease such as obesity, skin diseases, spinal nerve lesions and external wounds. Thermographic observations for this study were made using DITI. We performed cold stress test three times to compare with the results from thermographic observations by DITI: first, after 15 minutes-resting, second, right after 1 minutes soak in $20^{\circ}C$ water, the third for last, 10 minutes after the soak. VAS score was chosen to determine the severity of cold hypersensitivity. Result 1 male and 22 female patients were participated ranging in age from 22.17 to 45.21. There was a significant negative correlation between the recovery rate of finger skin temperature after cold stress test and the VAS score. And there was a significant positive correlation between the difference of finger skin temperature and the back and palm of hands after cold stress test and the VAS score. Conclusion In cold hypersensitivity patients, the cold stress test combined with DITI could be a accurate method for the objective evaluation of cold hypersensitivity, especially good at deciding the severity by numeric values. Using a more strict criterion, as diagnosing of cold hypersensitivity, and longer follow-up may improve the validity of the results attained in clinical trials.

• Journal of Korean Public Health Nursing
• /
• v.2 no.2
• /
• pp.45-61
• /
• 1988

Clonorchiasis should be realized as an important public health problems in Korea by their wide distribution, high prevalence rate and heavy infection intensity. This study was designed to obtain the infection rate, contributing factors as well as the behavior of infected persons among the factory workers in Pohang area where that parasite still remains as a problem. Study was undertaken from September '86 to October '87. Clonorchiasis skin test was performed for 3180 factory workers, and stools of skin test positive reactors were examined. Praziquantel was prescribed to stool examination positive persons for clonorchis sinensis ova. After one year. stool examination was repeated for them who received medicine. At the same time. a structured questionnaire was given and the results were analyzed and compared with control group. The results of this study are summarized as follows; 1. The infection rate of Clonorchis sinensis. 1) Clonorchiassis skin test positive rate was $26.2\%$ (834/3180). 2) Stool(Clonorchis sinensis ova) positive rate among skin test positive reactors was $21.6\%$ (129/598) All 129 infected persons were male. 2. Contributing factors of Clonorchis sinensis infection. 1) The chance of infection was higher in low-educated peple(p<0.01) 2) Stool(Clonorchis sinensis ova)positive rate was higher among the persons who reside near the riverside now(p<0.01), or among the persons who long history of riverside residence(p<0.01) 3) The infection rate was higher in thoes who like sliced raw fresh water fishes than in those who like cooked fishes(p<0.05). 4) Correct answering rate for questions about the cause and route of Clonorchis sinensis infection was low in infected persons. 5) The infection rate was lower among those who had experience of previous clonorchiasis test(p<0.01). 6) Family members of infected persons show higher rates of infection(p <0.01). 3. Treatment effect and compliance of infected person to treatment. 1) After one year, negative stool conversion rate was $85.4\%$. 2) $70.8\%$ of infected persons took the medicine; Only $3.1\%$ of them consulted to physician to know the medication effect; As many as $29.4\%$ of them continued to consume raw fresh water fishes. As a conclusion, City of Pohang area, Hyung San River in the center, is an endemic area of clonorchiasis. Current clonorchiasis control system seemed to be ineffective; many of the skin test positive group did not submitted their stool for examination; only $70.8\%$ of infected persons took the medicine even though the drugs were given free of charge; $29.4\%$ continued to consume raw fresh water fishes after taking medicine. Therefore. proper education program should be provided to improve the compliance to treatment. Follow-up for infected cases is mandatory to prevent waste of restricted budget.

• Annals of Occupational and Environmental Medicine
• /
• v.34
• /
• pp.26.1-26.13
• /
• 2022

It is important to assess the blood flow of fingers in the verification of hand-arm vibration syndrome. In the Republic of Korea, most assessments of the blood flow in the fingers are performed using a cold provocation test with finger skin color change. However, this test is a non-objective method with a relatively low sensitivity, leading to possible social and legal problems. Thus, we reviewed the characteristics of several tests that assess the blood flow in the fingers. Among these tests, using the radioactive isotope method, Raynaud's scan has a relatively higher sensitivity and specificity than other tests, provides objective results, and is approachable in many hospitals. So we suggest using Raynaud's scan as an alternative test when cold provocation test with finger skin color change is negative in vibration exposed worker.

• Toxicological Research
• /
• v.28 no.1
• /
• pp.1-4
• /
• 2012

Bee venom (Apis mellifera L., BV) has been used as a cosmetic ingredient for antiaging, anti-inflammatory and antibacterial functions. The aim of this study was to access the skin sensitization of BV, a Buehler test was conducted fifty healthy male Hartley guinea pigs with three groups; Group G1 (BV-sensitization group, 20 animals), group G2 (the positive control-sensitization group, 20 animals), and group G3 (the ethyl alcohol-sensitization group, 10 animals). The exposure on the left flank for induction was repeated three times at intervals of one week. Two weeks after the last induction, the challenge was performed on the right flank. No treatment-related clinical signs or body weight changes were observed during the study period. The average skin reaction evaluated by erythema and edema on the challenge sites and sensitization rate in the BV-sensitization group at 30 hours were 0.0 and 0%, respectively, which are substantially low compared with in positive control group (average skin reaction: 0.55, sensitization rate: 40%) and identical with in vehicle control group, representing a weak sensitizing potential. The average skin reaction and sensitization rate observed at 54 hours were 0.0 and 0% in the BV-sensitization group, respectively, and 0.25 and 20% in the positive control group, respectively. It was concluded that BV classified to Grade I, induced no sensitization when tested in guinea pigs and may provide a developmental basis for a cosmetic ingredient or external application for topical uses.

• CELLMED
• /
• v.10 no.3
• /
• pp.22.1-22.7
• /
• 2020

Introduction: Qūbā (Tinea Corporis) is a very common disease widely prevalent worldwide. 20 - 25 % individuals suffer for this stubborn disease. Unani System of Medicine offers its treatment. There are many pharmacopoeial formulations indicated for various types of dermatophytic infections. In this study clinical efficacy and safety of the topical Unani formulation Marham Kharish Jadeed (a compound drug in the dosage form of an ointment) was assessed and compared with a standard conventional medicine. Materials and methods: A clinical study was conducted on 60 participants of qūbā randomized into test and control groups (n=30 in each group). The participants were clinically diagnosed and confirmed by microscopy of skin scrapings. The efficacy of the Unani formulation was assessed in terms of TSS score and elimination of fungal elements from the skin lesions. The data collected were analyzed statistically. Results and discussion: The study showed that the Unani formulation had comparatively better efficacy clinically than conventional medicine Terbinafine hydrochloride 1% cream in terms of reduction of itching, erythema, scaling, peripheral raised margins of the lesion comparing to baseline. In this study, 27 participants in test group and 18 participants in control group were completely cured (≥75% reduction in TSS Score with Mycological Cure) after 4 weeks of treatment. The efficacy of the Unani formulation was found significant statistically. The individual drugs of the formulations having analgesic (Musakkin), blood purifier (Muṣaffi-i-Dam), demulcent (Mulaṭṭif), antifungal (Qātil-i-fafūndῑ), detergent (Jālῑ), refrigerant (Mubarrid) and antiseptic (Dāfi'-i-'Ufūnat) properties might be responsible for the efficacy of Unani formulation. Conclusion: The findings of the study suggested that the Unani formulation was found effective and safe in the management of qūbā. No local and systemic adverse effect was reported during the study.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.41 no.3
• /
• pp.501-516
• /
• 2017

Skin colors of females between the ages of 25-35 from Korea, China, and Vietnam were measured in Seoul, Beijing, and Hanoi using the Minolta CM-600d spectrophotometer. CIE Lab and Munsell HVC data of the face (forehead and both cheeks) and body (neck and arm) were analyzed using t-test, Analysis of Variance (ANOVA), Duncan's Multiple Range Test, Linear Regression Analysis, and K-Means Cluster Analysis using SPSS software. Korean females showed the highest L and V values for the face and body; Vietnamese females showed the highest b value in the face and the highest a value in the body. Higher L and b values for the face were related to higher L and b values of the body; this relationship was more prominent in Korean females. The younger age group (25-29) showed higher L values and lower b values than the older age group (30-35). Females from Korea, China, and Vietnam were grouped into Type 1 and Type 2 based on skin color. Type 1 had darker skin with more redness and yellowness and Type 2 had lighter skin with less redness and yellowness. A total of 88.2% of Korean females belonged to Type 2, 80.4% of Vietnamese females were Type 1, and Chinese females indicated an even distribution of Type 1 and Type 2.