• International Journal of Stem Cells
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• v.17 no.3
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• pp.298-308
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• 2024

Sine oculis homeobox 1 (Six1) is an important factor for embryonic development and carcinoma malignancy. However, the localization of Six1 varies due to protein size and cell types in different organs. In this study, we focus on the expression and localization of Six1 in male reproductive organ via bioinformatics analysis and immunofluorescent detection. The potential interacted proteins with Six1 were also predicted by protein-protein interactions (PPIs) and Enrichr analysis. Bioinformatic data from The Cancer Genome Atlas and Genotype-Tissue Expression project databases showed that SIX1 was highly expressed in normal human testis, but low expressed in the testicular germ cell tumor sample. Human Protein Atlas examination verified that SIX1 level was higher in normal than that in cancer samples. The sub-localization of SIX1 in different reproductive tissues varies but specifically in the cytoplasm and membrane in testicular cells. In mouse cells, single cell RNA-sequencing data analysis indicated that Six1 expression level was higher in mouse spermatogonial stem cells (mSSCs) and differentiating spermatogonial than in other somatic cells. Immunofluorescence staining showed the cytoplasmic localization of Six1 in mouse testis and mSSCs. Further PPIs and Enrichr examination showed the potential interaction of Six1 with bone morphogenetic protein 4 (Bmp4) and catenin Beta-1 (CtnnB1) and stem cell signal pathways. Cytoplasmic localization of Six1 in male testis and mSSCs was probably associated with stem cell related proteins Bmp4 and CtnnB1 for stem cell development.

• Journal of Applied Reliability
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• v.1 no.1
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• pp.65-78
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• 2001

Recently, Six Sigma to increase market share , decrease costs, and grow profit margin has been adopted by some leading companies in the world. Six Sigma is expected as the optimal movement to raise the quality level remarkably and to make enterprise culture and organization based on customer and market orientation. In this paper, we study on the idea of Six Sigma, the Internal and external success case, the reliability tools using in the Six Sigma, and the difference between the existing quality movement and Six Sigma. Also, we discuss the role of reliability In Six Sigma..

• Journal of Korean Society for Quality Management
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• v.45 no.1
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• pp.1-10
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• 2017

Purpose: Most enterprises adopt six sigma acts to maximize the business performance with raising the executiveness for the project improvements in each parts. But there are little studies about six sigma actual operations in manufacturing whether the six sigma improvements that have injected a lot of budget, efforts, labours and time are run properly. Methods: This study select 31 interviewees who have MBB or BB from 5 large enterprises running six sigma over 10 years and 5 SMEs running six sigma over 5 years to understand and review the operational status of six sigma actions in manufacturing industry and to secure representativeness. This study identify the operational status of six sigma actions and key factors enhancing or impeding execution of six sigma projects through face-to-face interviews and online surveys by e-mail. Results: This study figured out the operational status of six sigma actions and key factors enhancing or impeding execution of six sigma projects. We used SPSS 16.0 for the reliability and the validity of survey data. Conclusion: There can be a lot of different factors that affect six sigma project improvements besides the key factors from this study. More study need to think of the organization characteristics and the basic conditions and to remedy the unreasonable points and defects rather than following foreign companies and enterprises.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.3
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• pp.414-419
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• 2008

The six-port correlator is comprised of a power divider and three hybrid couplers. In this paper, the six-port phase correlator using three-arm branch $90^{\circ}$ hybrid coupler were designed with the center frequency of 11.85 GHz. The performances for the six-port phase correlator was analyzed by using ADS2003A tool. Three-arm six-port phase correlator provides more wide dynamic frequency range than that of six-port using the conventional hybrid coupler in range of circa five times, which is range of 10.8 to 12.3GHz (1.5 GHz). The phase errors among the output ports of the six-port phase correlator are below $5^{\circ}$. The six-port Phase correlator was fabricated to evaluate the Performance of the proposed six-port phase correlator. The measured performance of the six-port phase correlator shows the good accordance with the simulation data.

• Journal of Sasang Constitutional Medicine
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• v.33 no.1
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• pp.1-21
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• 2021

Objective The purpose of this study was to examine the correlation between the Cold-damage Six-meridian disease of Qibo (岐伯六經病證) and Sasang Constitutional Symptomatology (四象體質病證), presented in Discourse on the Origin of Eastern Medicine (醫源論) of Longevity and Life Preservation in Eastern Medicine (Donguisusebowon, 東醫壽世保元). Method The process of development from Cold-damage Six-meridian disease of Qibo (岐伯六經病證) to Six Meridians Physical Symptoms and Medicines (六經形證用藥) in the chapter Cold(寒門) of the Treasure Mirror of Eastern Medicine (Donguibogam, 東醫寶鑑) was investigated. And the correlation between Six Meridians Physical Symptoms and Medicines (六經形證用藥) and Sasang Constitutional Symptomatology (四象體質病證) was considered. Results and Conclusions 1. The Cold-damage Six-meridian disease of Qibo (岐伯六經病證) in the chapter Heat Treatise (熱論篇) of Basic Questions (素問) had evolved into Six Meridians Physical Symptoms and Medicines (六經形證用藥) in the chapter Cold(寒門) of the Treasure Mirror of Eastern Medicine (Donguibogam, 東醫寶鑑) through Book for Life Saving (Huorenshu, 活人書), a work of Zhu Gong (朱肱), Six Books on Cold Damage disease (Shanghanliushu, 傷寒六書), a work of Tao Hua (陶華) and Introduction to Medicine (YixueRumen, 醫學入門), a work of Li Chan (李梴). 2. The correlation between the Cold-damage Six-meridian disease of Qibo (岐伯六經病證) and Sasang Constitutional Symptomatology (四象體質病證) can be analyzed and understood through Six Meridians Physical Symptoms and Medicines (六經形證用藥) in the chapter Cold(寒門) of the Treasure Mirror of Eastern Medicine (Donguibogam, 東醫寶鑑). 3. Greater Yang meridian disease of Qibo (岐伯) is related to Soyangin early stage of Lesser-Yang Wind-Injury symptomatology and Soyangin early stage of Chest-Heat symptomatology, Yang Brightness meridian disease and Greater Yin meridian disease to Taeeumin Liver-Heat symptomatology, Lesser Yin meridian disease to Soyangin Chest-Heat symptomatology, Lesser Yang meridian disease to Soyangin early stage of Lesser-Yang Wind-Injury symptomatology and Reverting Yin meridian disease to Soeumin Reverting Yin symptomatology of Greater Yang disease.

• International Journal of Quality Innovation
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• v.6 no.1
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• pp.1-7
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• 2005

Six sigma is much less of a technical program than it is a leadership and cultural change program. Nevertheless, most of literatures on six sigma have mainly focused on technical and tactical aspects. This paper introduces a self-assessment for six sigma initiative in a major Korean software company. The self-assessment gives a valuable clue to how to manage leadership and cultural aspects of six sigma initiative.

• Journal of Power Electronics
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• v.12 no.1
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• pp.128-135
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• 2012

In this paper, different switching tables proposed for the Direct Torque Controlled (DTC) of a six-phase induction machine are simulated and implemented. A six-phase induction motor has 64 space voltage vectors which result in increased complexity in the selecting of inverters switching. The unsuitable selection of a switching table leads to large harmonics especially at low speed and it also reduces drive efficiency. A six-phase induction machine has large zero sequence harmonic currents of the order $6{\kappa}{\pm}1$. These harmonic currents are varied in various techniques. Decreasing this loss is essential in a six-phase induction machine. The main purpose of this paper is to improve the ST-DTC of six-phase induction machines to reduce the voltage and current harmonics and the torque pulsation. Selecting a suitable method for minimizing these harmonics is very important.

• 대한상한금궤의학회지
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• v.5 no.1
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• pp.19-29
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• 2013

Objective : The purpose of this study is to analyze the naming of 'A diagnostic system based on Shanghanlun six meridian patterns and provisions' and to suggest an alternative naming. Methods : 1. The meaning of 'Six meridian(六經)' was reviewed on existing theories and Shanghanlun provisions. 2. Comparing the name of diangostic system with the term in 'Korean Standard Classification of Diseases-6(KCD-6)' and term in 'WHO international standard terminologies on traditional medicine in the western pacific region' was done. Results : 'Six meridian' is customary used in the Shagnhanlun study but its meaning is not match with original Shanghanlun system and could possibly make misunderstanding. So 'Disease pattern identification' is suitable than 'Six meridian' for this diagnostic system. Conclusions : This study suggests that using 'A disease pattern identification diagnostic system based on Shanghanlun provisions.'is more appropriate instead of using the name of the six meridian diagnostic system.

• 대한상한금궤의학회지
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• v.5 no.1
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• pp.1-17
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• 2013

Objective : The purpose of this study is to help korean medical doctors write case reports based on Shanghanlun six clinical patterns and provisions accurately and effectively. Methods : To achieve the purpose of this study, we reviewed Shanghanlun six clinical patterns and provisions. After this, we formed a case report form according to the importance of Korean medical terms in Shanghanlun. Results : Through this study, we got the consistency and unity of case reports based on Shanghanlun six clinical patterns and provisions. Conclusions : This case report form is designed for gathering clinical data which are organized clearly according to the diagnostic system based on Shanghanlun six clinical patterns and provisions.

• Journal of Korean Medical classics
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• v.35 no.1
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• pp.59-79
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• 2022

Objectives : Huangyuanyu's interpretation of the six channel diseases of the Shanghanlun were examined based on contents on the six channel qi metabolism theory in his works, Shanghanxuanjie, Shanghanshuoyi, and Sishengxinyuan. Methods : Contents related to the six channel qi metabolism theory in the Shanghanxuanjie, Shanghanshuoyi, and Sishengxinyuan were extracted and examined to identify a fundamental principle from the perspective of the six channel qi metabolism theory. Characteristics of each of the six channel diseases were organized. Results : Huang's understanding of the six channel diseases in the Shanghanlun could be summarized by the six channel. Its features could be explained as following. First, in examining the principles of the controlling qi[司氣] and constitutionally influenced transformation[從化], the rise and fall of the body's yang qi was emphasized. Second, center qi[中氣] was considered important, the taiyin Spleen being the key to life and death. Third, the pathology of 'earth dampness/water cold/wood stagnation' due to weakness of the center qi was suggested. Fourth, the principle of boosting-yang-suppressing-yin was emphasized in treatment, with criticism of the nurturing-yin-extinguishing-fire method. Conclusions : In understanding the six channel diseases in the Shanghanlun, Huangyuanyu focused on the body's yang qi and center qi based on key theories such as the 'five circuits and six qi' and 'six channel qi metabolism' theories. His perspective could be helpful in understanding Zhangzhongjing's work more comprehensively.