• CELLMED
• /
• v.10 no.2
• /
• pp.16.1-16.8
• /
• 2020

Standardization of drug deals with confirmation of drug identity and determination of drug quality and purity. Unani herbal formulations are used in traditional medicine for the treatment of various diseases. Cancer is a disease which causes abnormal, uncontrolled growth of body tissue or cells, which tend to proliferate in an uncontrolled way. Spread of cancer from site of origin to other organs of the body is called metastasis. It is a hyper proliferative disorder involving, transformation, dysregulation of apoptosis, invasion and angiogenesis. The present study aimed to standardize a classical Unani formulation (CUF) described as anticancer properties. The CUF has been used for anti-cancerous activity (Dāfi'-i-saraṭān) in human population by Unani physicians for centuries. The standardization parameters carried out for classical Unani formulation are pharmacognostical studies, physicochemical parameters, high-performance thin layer chromatography (HPTLC), microbial load, aflatoxins, and heavy metals revealing specific identities and to evaluate Pharmacopoeial standards. Experiment and the data obtained established the Pharmacopoeial standards for this formulation for identification and quality control purpose. The CUF has been successfully standardized and standard operating procedures (SOPs) for its preparation has been laid down which may serve as a standard reference in future. The standardization data of this formulation may be used as a standard guideline for preparation of the formulation in future.

• Proceedings of the Korea Contents Association Conference
• /
• 2006.11a
• /
• pp.547-550
• /
• 2006

The criterion which judges an information retrieval system performance is to how many accurately retrieve an information that the user wants. The search result which uses only homograph has been appears the various documents that relates to each meaning of the word or intensively appears the documents that relates to specific meaning of it. So in this paper, we suggest semantic information retrieval technique using relation within User-Word Intelligent Network(U-WIN) to solve a disambiguation of query In our experiment, queries divide into two classes, the homograph used in terminology and the general homograph, and it sets the expansion query forms at "query + hypemym". Thus we found that only web document search's precision is average 73.5% and integrated search's precision is average 70% in two portal site. It means that U-WIN-Based semantic information retrieval technique can be used efficiently for a IR system.

• Korean Journal of Clinical Pharmacy
• /
• v.23 no.4
• /
• pp.300-306
• /
• 2013

Background: 6-year College of Pharmacy curriculum had started in Korea, and the students in college of pharmacy are supposed to have student practice in the hospital pharmacy, community pharmacy, pharmaceutical company and administration to experience the role of pharmacists in advance. However, despite Korean Association of Pharmacy Education provided its own teaching plan, most Pharmacy Schools and the hospital pharmacy have difficulty in performing the desirable student practice program because they seldom experienced it. So, we reported the student practice program in the hospital pharmacy conducted by Yonsei University College of Pharmacy prior to the other numerous universities and the evaluation of survey on the student pharmacy practice program. Method: Severance Hospital, Gangnam Severance Hospital and National Health Insurance Service Ilsan Hospital took part in the student pharmacy practice program of Yonsei University. Students took 8-week pharmacy practice in Severance Hospital or Gangnam Severance Hospital plus 4-week pharmacy practice in National Health Insurance Service Ilsan Hospital. Also, students had once-a-week presentation class at school. A survey was conducted to evaluate the student practice program. Results: The presentation class was considerably helpful to share their own experiences at different practice sites in different hospitals, but there were some disadvantages that students could not experience the specific pharmacy practice site on the day of once-a-week presentation at school and so on. The results of the survey on the student practice program reported that students were satisfied with the overall practice program and presentation class at school. Also, they answered that the student practice program in the hospital pharmacy was significantly helpful for planning of the future career. Conclusion: Through the performance of the student practice program in Yonsei University, the adjustment of the student practice program in the hospital is planned to provide better experience of practice to the students and the results will be helpful for the student practice in the hospital of the other colleges of pharmacy.

• Economic and Environmental Geology
• /
• v.40 no.6
• /
• pp.833-841
• /
• 2007

The groundwater heat pump system(GWHP) is one of the most efficient ground source heat pump system(GSHP) which uses low grade and shallow geothermal energy for cooling and heating purpose. The GWHP system shall be designed properly based on peak block load performance and optimum pumping rate of groundwater comparable to ground coupled heat pump system(GCHP). The optimum pumping rate depends on groundwater temperature at a specific site, size of plate heat exchanger, and total head loss occurred by whole system comprising pumps and pipings. The required optimum flow rates of the system per RT are ranged from 3.8 to 9.8lpm being less than the typical building loop flow of 9.5 to 11.4lpm.

• 한국태양에너지학회:학술대회논문집
• /
• 2008.04a
• /
• pp.135-141
• /
• 2008

In this paper a novel tracking system is described, regarding the influence of shadow between array, aimed at improving the efficiency of PV tracking system. Comparing with a building site versus capacity power, domestic solar powers have a limited siting. Therefore, each array interferes with the shadow of other arrays. The loss by influence of those shadow can be compensated for by means of control algorithm of the tracking device. The paper suggests a method controlling an altitude for length which is received the shadow influence of PV array. By using an azimuth of current solar position and the length between arrays, the controller of tracking device is able to calculate the length between actual arrays and make a comparison of the shadow length at a specific time with the length between arrays. When the shadow length is longer than the length between arrays, the controller of tracking device can adjust a position by compensating error altitude of the length between arrays at an altitude of current solar position. In the paper, we develop the control algorithm able to minimize the loss caused by the influence of shadow on the PV tracking system, and compared this with conventional output system. The controller has been tested in the laboratory with proposed algorithm and shows excellent performance

• Korean Journal of Construction Engineering and Management
• /
• v.9 no.6
• /
• pp.147-155
• /
• 2008

In the 1970s, increasing penetration of the housing co-housing policy, reconstruction be a great success to improve 1990‘s Old aged apartment's performance. However, in case of reconstruction, it causes the problem such as city environment destruction, resource waste, real-estate speculation etc. With the trend of sustainable construction and resource recycling, remodeling gets more attention than before. In case of country's remodeling, conventional method causes some problems such as delayed construction period and increased cost. Therefore, efforts that obtain economical efficiency are required to power remodeling through use of prefabrication method like PC technology that is useful for reduction effect of construction period, cost and site labor and excellent quality. This research indicates reduceing factor for facilitating prefabrication method and technology selecting framework through specific of Expanding Floor method and remodeling cases to increase the efficiency of remodeling, considers construction parties approaching plan for prefabrication as occasion that powers remodeling.

• Fisheries and Aquatic Sciences
• /
• v.18 no.1
• /
• pp.73-80
• /
• 2015

To examine the interrelationship between transgenic insertion patterns and transgene expression profiles in established transgenic fish lines, four stable transgenic marine medaka Oryzias dancena germlines harboring ${\beta}$-actin regulator-driven RFP reporter constructs were selected. The established transgenic strains were characterized with regard to their transgenic genotypes (insertion pattern, concatemer formation, and transgene copy number based on genomic Southern blot hybridization and qPCR assay) and expression characteristics at the mRNA (qRT-PCR), protein (western blot), and phenotypic (fluorescent appearance) levels. From comparative examinations, it was found that transgenic expression at both the transcription and translation levels could be significantly downregulated in transgenic strains, potentially through methylation-mediated transgene silencing that was particularly associated with the formation of a long tail-to-head tandem concatemer in the chromosomal integration site(s). When this occurred, an inverse relationship between the transgene copy number and fluorescence intensity was observed in the resultant transgenic fish. However, with the other transgenic genotype, transgenic individuals with an identical Southern blot hybridization pattern, containing a tandem concatemer(s), had very different expression levels (highly robust vs. low expression strengths), which was possibly related to the differential epigenetic modifications and/or degrees of methylation. The concatemer-dependent downregulation of transgene activity could be induced in transgenic fish, but the overall pattern was strain-specific. Our data suggest that neither a low (or single) transgene copy number nor tandem transgene concatemerization is indicative of strong or silenced transgene expression in transgenic fish carrying a ubiquitous transgene. Hence, a sufficient number of transgenic lineages, with different genotypes, should be considered to ensure the establishment of the best-performance transgenic line(s) for practical applications.

• Asian-Australasian Journal of Animal Sciences
• /
• v.20 no.9
• /
• pp.1349-1353
• /
• 2007

Calcineurin is a calmodulin dependent protein that functions as a regulator of muscle cell growth and function. Agents capable of interacting with calcineurin could have important applications in muscle disease treatment as well as in the improvement of livestock production. Calsarcins comprise a family of muscle-specific calcineurin binding proteins which play an important role in modulating the function of calcineurin in muscle cells. Recently, we described the first two members of the calsarcin family (calsarcin-1 and calsarcin-2) in the pig. Here, we characterized the third member of the calsarcin family, calsarcin-3, which is also expressed specifically in skeletal muscle. However, unlike calsarcin-1 and calsarcin-2, the calsarcin-3 mRNA expression in skeletal muscle kept rising throughout the prenatal and postnatal development periods. In addition, radiation hybrid mapping indicated that porcine calsarcin-3 mapped to the distal end of the q arm of pig chromosome 2 (SSC2). A C/T single nucleotide polymorphism site in exon 5 was genotyped using the denaturing high performance liquid chromatography (DHPLC) method and the allele frequencies at this locus were significantly different among breeds.

• Journal of the Korean Geotechnical Society
• /
• v.19 no.4
• /
• pp.287-298
• /
• 2003

The feasibility of using neural networks to model the complex relationship between piezocone measurements and the undrained shear strength of clays has been investigated. A three layered back propagation neural network model was developed based on actual undrained shear strengths, which were obtained from the isotrpoically and anisotrpoically consolidated triaxial compression test(CIUC and CAUC), and piezocone measurements compiled from various locations around the world. It was validated by comparing model predictions with measured values about new piezocone data, which were not previously employed during development of model. Performance of the neural network model was compared with conventional empirical method, direct correlation method, and theoretical method. It was found that the neural network model is not only capable of inferring a complex relationship between piezocone measurements and the undrained shear strength of clays but also gives a more precise and reliable undrained shear strength than theoretical and empirical approaches. Furthermore, neural network model has a possibility to be a generalized relationship between piezocone measurements and undrained shear strength over the various places and countries, while the present empirical correlations present the site specific relationship.

• Asian-Australasian Journal of Animal Sciences
• /
• v.18 no.4
• /
• pp.524-531
• /
• 2005

Two experiments were conducted to standardize in ovo injection of amino acids (AA) and to evaluate the effect of in ovo injection of limiting AA(s) on pre and post hatch growth performance, immune response and development of digestive organs. Combinations of essential and non-essential amino acids (Lys+Arg, Lys+Met+Cys, Thr+Gly+Ser, Ile+Leu+Val and Gly+Pro) were injected into 50 eggs in each treatment group at 14 d of embryonic age. Standardization of injection site, needle length and embryonic age revealed that when AA were injected in to the broad end of the egg with a 11 mm needle and at the narrow end with a 24 mm needle both at the 7$^{th}$ and 14$^{th}$ d of incubation there was poor hatchability. However, better hatchability was recorded when the AA were injected in the narrow end of the egg with a 11 mm needle and in the broad end with a 24 mm needle on the 14$^{th}$ d of incubation. The chick to egg weight ratio was higher (p<0.018) when AA were injected on the 14$^{th}$ d of incubation. When a combination of amino acids were injected a 63.6 or 63.2 g difference in body weight of bird at 21 d was recorded between uninjected control and Ile+Leu+Val or Gly+Pro group, respectively. Higher feed intake (p<0.047) was recorded in the AA injected groups and feed conversion ratio (FCR) was numerically better in Gly+Pro, Lys+Met+Cys AA injected groups than in the uninjected control. Significantly higher immune response to cell mediated (p<0.033) and humoral (p<0.002) immunity was observed in in ovo amino acid injected birds, especially in Lys+Met+Cys, Thr+Gly+Ser or Ile+leu+Val groups. The digestive organ weights at 21 d did not differ between specific AA injected groups and the uninjected control. In ovo injected amino acids may act as immunomodulators and their role in gastrointestinal development needs further research.