• Journal of Radiation Protection and Research
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• 제25권2호
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• pp.75-80
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• 2000

월성원전 주변에서 실측된 공기중 및 솔잎중 삼중수소 농도와 INDAC 코드 예측치의 비교 평가를 수행하였다. 또한, 방사성물질의 환경중 방출유형, 풍속분류, 지형 고려 유무 등에 따른 삼중수소 예측치의 변화를 측정치와 비교 평가함으로써, 규제실무에 적용할 수 있는 최적 기상자료 입력방안을 도출하였다 공기중 및 솔잎중 삼중수소 농도와 INDAC 코드 예측치의 비교평가 결과, 월성원전 주변 삼중수소 농도 예측치는 측정값의 불착실성, 지현의 복잡성, 해륙풍의 영향 등의 제한점에도 불구하고 규제검증에 필요한 정도의 보수성을 유지하면서도 삼중수소의 거동을 잘 모사함을 확인할 수 있었다. 또한, INDAC 코드에 적용된 솔잎중 삼중수소 농도의 평가방법론 즉, 대기내 수분중의 삼중수소 농도의 절반이 식물체내에 골고루 분포되어 있다고 가정하는 것은 규제 검증에 필요한 보수성을 확보하고 있음을 알 수 있었다. 최적 기상자료 입력방안의 도출을 위한 민감도 분석 결과, 혼합방출 및 지형을 고려하지 않는 경우에는 실측치 대비 과소 평가되는 부분이 있어 규제실무에 적용하기에는 적합하지 않은 것으로 나타났다. 따라서, 혼합방출을 고려하는 경우에는 58m 기상자료와 지형자료에 근거하여 대기확산인자를 평가하여야 하는 것으로 나타났다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1997년도 하계학술대회 논문집 D
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• pp.794-796
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• 1997

The superconducting magnetic energy storage (SMES) system is considered to be useful to charge or release an energy in power system because of the high efficiency and quick response. But we need much capital to construct and to operate a SMES. A site and capacity of SMES are important elements for effective operating and planning. In this paper, we proposed a performance function to determine an optimal site and capacity of SMES according to variety condition of power system such as fault point. In addition, to demonstrate the validity of a proposed method, the simulations were carried out on two-machine 5-bus system.

• Nuclear Engineering and Technology
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• 제50권8호
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• pp.1289-1297
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• 2018

Preliminary surface soil Derived Concentration Guideline Levels (DCGLs) were derived conforming to the Multi-Agency Radiation Site Survey and Investigation Manual (MARSSIM) procedure for the site release and reuse of Kori Unit 1 in Korea. Based on the decommissioning experiences of the U.S. nuclear power plants, a suite of residual radionuclides was determined, and uncertainties contributed to the resultant dose by the input parameters were quantified via the sensitivity analysis of parameters. The peak of the mean dose was obtained via the probabilistic analysis of the RESRAD (RESidual RADioactivity)-ONSITE code. Consequently, $DCGL_w$ of Kori Unit 1 in accordance with two scenarios, industrial worker and residential farmer scenario, were derived and the results were compared respectively with other NPPs. It could be used as a basic guideline for establishing regulatory standards for reuse planning, designing the site characterization surveys and implementing final status survey (FSS).

• 대한약리학회지
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• 제32권1호
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• pp.57-66
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• 1996

파충류 골격근의 근소포체에서 칼슘유리 채널의 존재를 밝히고저 뱀 골격근에서 근소포체를 분리하여 SDS-PAGE 전기영동, RyR의 정제, $[^3H]ryanodine$ 결합실험 및 $^{45}Ca$ 유리 실험으로 아래와 같은 결과를 얻었다. 1) 뱀골격근 소포체도 단일 band의 high molecular weight 단백을 가지고 있고, 그 mobility는 포유류 골격근의 것과 유사했다. 2) RyR의 정제과정에서 얻어진 $[^3H]ryanodine$의 peak 결합 분획에서 high molecular weight의 단백분획이 발견되었다. 3) 뱀 골격근 SR vesicles에 대한 $[^3H]ryanodine$의 maximum binding site와 Kd값은 각각 6.36 pmole/mg protein과 17.62nM이었으며, $[^3H]ryanodine$의 특이성 결합은 칼슘과 AMP에 의해 유의성있게 증가되었고 (P<0.005), tetracaine에 의해 억제되지 않았으나 ruthenium red와 $MgCl_2$에 의해 일부만 억제되었다. 4) 근 소포체로부터 $^{45}Ca$ 유리는 낮은 농도의 칼슘 $(1{\sim}10{\mu}M)$과 AMP에 의해 증가되었고 (P<0.05), 고농도의 칼슘 $(300{\mu}M)$, tetracaine, ruthenium red 또는 $MgCl_2$에 의해 억제되었다 (P<0.05). 이상의 실험성적으로 파충류 (뱀)의 골격근에도 칼슘유리 채별이 있어 근 수축시 세포내 칼슘 농도 조절에 관여할 수 있을 것으로 여겨지며, 채널의 기능적 특징 일부가 포유류의 것과 유사한 것으로 사료된다.

• 폴리머
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• 제26권5호
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• pp.691-700
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• 2002

항암제가 함유된 생분해성 고분자 디바이스를 이용한 국소전달요법은 종양 부위에 고농도로 약물을 전달시킬 수 있는 이유로 약물의 효율성을 증가시킬 수 있다. 1,3-bis(2-chloroethyl)-1-nitro-sourea (BCNU, carmustine)는 뇌종양 치료를 위하여 가장 일반적으로 사용되는 화학요법적 약물이다. 표적 부위까지 항암제를 효과적으로 전달하기 위한 이식제의 설계는 중요한 인자이다. 본 연구에서 약물의 방출경향을 조절하기 위해서 생분해성 웨이퍼의 첨가제와 다양한 제형 변화로부터 BCNU의 방출패턴을 조사하였다. 각각 3.85, 10, 20 및 30%의 BCNU를 함유한 PLGA 웨이퍼를 다양한 형태(직경 3, 5 및 10 mm, 두께 0.5, 1 및 2 mm)로 직접 압축성형법에 의해 제조하였다. 생체외 방출실험에서 BCNU 함유 PLGA 웨이퍼로부터 약물 방출거동은 웨이퍼의 포기 약물 함유량, 무게, 직경, 두께, 부피, 표면적 및 PLGA 분자량뿐만 아니라 첨가제의 종류와 같은 다양한 변수로 조절했다. 웨이퍼로부터 약물의 방출은 BCNU 함유량 및 염화나트륨 (NaCl)과 폴리엔비닐피롤리돈 (PVP)이 증가할수록 촉진되었다. 또한, BCNU가 함유된 PLGA 웨이퍼의 무게와 형태변화에 대한 조사를 통하여 다양한 기하학적 인자들과 첨가제의 효과를 고찰하였다.

• Archives of Plastic Surgery
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• 제42권2호
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• pp.150-158
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• 2015

Background Fat is widely used in soft tissue augmentation. Nevertheless, it has an unpredictably high resorption rate. Clinically, external expansion with negative pressure is used to increase fat graft survival. In this study, fat graft recipient sites were preconditioned by external application of negative pressure in order to test for improvements in vascularity and fat graft survival. Methods Negative pressure was applied randomly to either the left or right dorsal ear of 20 New Zealand male white rabbits at a pressure of -125 mm Hg. The negative pressure was removed one week after the skin perfusion was measured. The skin flap at each ear was elevated, and 1 g of fat was grafted above the dorsal perichondrium. After one week, the fat weight, microvessel density, mature vessel density of the skin and fat, and amount of glycerol released were measured. Three months after the grafting, the same measurements were performed, with the exception of glycerol release. Results The fat survival rate of the experimental group ($75.4%{\pm}3.9%$) was higher than that of the control group ($53.1%{\pm}4.3%$) (P<0.001). Skin perfusion was higher in the experimental group. The glycerol release in the experimental group was significantly higher than in the control. The microvessel density of the skin and fat was significantly higher in the experimental group. Three months after the grafting, the skin and fat mature vessel density was significantly higher in the experimental groups. Conclusions Negative pressure prior to fat grafting increased the vascularity of the recipient site, and, accordingly, enhanced fat graft survival.

• 동의생리병리학회지
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• 제26권3호
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• pp.314-319
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• 2012

Itching is one of the major diagnostic criteria of atopic dermatitis (AD) and one of its most troublesome symptoms that provokes the desire to scratch. Effective control of itching is believed to be one of the basic approaches in controlling AD. The purpose of this study was undertaken to investigate the antipruritic effect of ethanol extracts from Perillae Japonicae Semen leaves (PJSL) and Chaenomelis Fructus (CF) on the scratching behavior induced by pruritogen such as compound 48/80 or substance P in hairless mice. PJSL or CF treatment inhibited histamine release in HMC-1 stimulated compound 48/80 or substance P in a dose-dependant manner. In particularly, co-treatment PJSL ($50{\mu}g/mL$) plus CF ($100{\mu}g/mL$) significantly inhibited histamine release in HMC-1 stimulated compound 48/80 or substance P. PJSL, CF or PJSL plus CF was administered orally for 2 h and then compound 48/80 ($50{\mu}g/site$) or substance P ($100{\mu}g/site$) was injected into rostral back, and scratching of the injected site by the hind paw was counted for 1 h. PJSL or CF administration reduced the scratching behavior induced by compound 48/80 as well as substance P in a dose-dependent manner. Furthermore, co-administration of PJSL and CF markedly suppressed the scratching behavior induced by compound 48/80 as well as substance P. These suppressive effects were synergistically increased by their combination. From the preliminary observations, we considered that ethanol extracts from PJSL and CF could be an effective natural materials for itching treatment.

• 한국안전학회지
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• 제32권2호
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• pp.52-58
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• 2017

One of the most important elements of the management of chemical accident is threat zone estimation of fires, explosions and toxic gas dispersion based on chemical releases. The threat zone estimation is going to be standard of emergency response for the first defender and base line data of off-site risk assesment (hereinafter referred to as "ORA") and risk management plan (hereinafter referred to as "RMP"). Generally, ALOHA form EPA(U.S.) and Kora(from KOREA MINISTRY OF ENVIRONMENT) has been used for the off-site consequence analysis in Korea. However it is hard to predict accurate consequences rapidly in case of emergency. Hydrochloric acid is a multipurpose raw material used in many industrial applications such as chemical, metal and food industries. It is usually treated in concentrations from 10 ~ 35 %, and release accident have occurred frequently. In this study, we have developed a simplified estimating method and equation to calculate threat zone easily in case of emergency due to release accident of hydrochloric acid.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2004년도 학술논문집
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• pp.368-376
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• 2004

영광부지의 추적자 확산실험결과의 자료동화를 통하여 Gaussian plume 모형의 확산인자의 수정과 추적자 방출률 평가를 수행하였다. 부지 주변의 여러 지점에서 관측한 실험결과에 선형계획법을 적용하여 확산평가에 있어선 가장 불확실성이 크다고 알려진 확산인자를 수정하였다. 원자력 비상시 초기 대응평가에 사용되는 정보 가운데 가장 큰 불확실성을 포함한 선원항 정보를 추적자 농도 분포로부터 추정하였다. 실험 당시의 추적자 방출량을 모른다고 가정하고 Gaussina plume 모형의 예측치와 확산실험의 실측치를 이용한 최소자승법을 적용하여 방출률을 추정하였다. 확산인자를 수정한 후 Gaussian plume 모형의 예측력은 방출점으로 3km 및 8km 떨어진 포집선 두 경우 모두 증가하는 것으로 나타났다. 실험당시의 방출률을 모른다고 가정하고 관측지점의 농도에 최소자승법을 적용한 결과 24%이내에서 실제 방출률을 양호하게 추정하고 있음을 확인할 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제34권1호
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• pp.57-71
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• 2004

The objective of this study was to provide a better understanding of SUPAC-IR and its application in handling postapproval changes to immediate release solid oral dosage forms. Originally, SUPAC-IR was aimed at reducing the regulator burdern of the industry when they were making postapproval changes, but still at maintaining the formulation quality and performance of a drug product. The postapproval changes that were covered under SUPAC-IR included variations in the components ad composition of formulation, the site of manufacturing, batch size, manufacturing equipment, and manufacturing process. The guidance defined levels of changes, based on the likelihood of risk ocurrence and potential impact of postapproval changes upon the safety and efficacy of a drug product I suggested what a type of fing report should be submitted to the FDA for each level of change. Chemist, manufacturing, and control tests to be executed were also recommended for each change level The important tests specified in the guidance included batch release, stability, in vitro dissolution, and in vivo bioequivalence tests. However, there have been strong demands on revising the current SUPAC-IR in order to resolve some issues and to improve its usefulness in evaluating postapproval changes to immediate release solid oral dosage forms. In particular, the rigorous requirement of case C dissolution test and the definition of batch size were challenged by both academia and the industry. A revision work was in progress to reflect these inputs and to expand the utility of SUPAC-IR. As a result of these concerted efforts, an updated 2nd version of SPAC-IR would be likely to be issued ver soon to the public.