• Journal of the Institute of Electronics and Information Engineers
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• v.54 no.3
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• pp.39-51
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• 2017

Recently, looking at construction sites with either large or small scale, accidents like collision, fall, etc. occur often. These accidents lead to not only damage of human lives but also serious economic loss. In case of large scale constructions sites, safety management systems are used to reduce industrial accidents. However in construction sites with small scale, those systems cannot be applied due to problems such as lack of compatability and high installation expense. In this case, just by putting on safety gears can also reduce industrial accidents. Therefore, in this paper, a safety management systems that can be used at both large and small scale construction sites is proposed. This safety management system consists of a smart module, a repeater and a gateway, and a monitoring system. The smart module, which is detachable, is attached to a safety helmet. This module transfers the current status of the user to the monitoring system through the repeater and the gateway. The repeater transfers the data received from the smart module to the gateway, and the gateway sends the data from the repeater to the monitoring system. The monitoring system shows the user status to the safety supervisor by displaying the data - temperature, height, intensity of illumination, images - received from the smart module. The safety supervisor can monitor the user status in real-time and take immediate action in case of emergency through this monitoring system.

• Applied Biological Chemistry
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• v.41 no.7
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• pp.489-495
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• 1998

The optimum culture condition of Scopulariopsis brevicaulis for the production of ${\alpha}$-galactosidase was as follows: Tryptone 1.5%, $NH_4NO_3$ 0.2%, Raffinose 2.5%, $KH_2PO_4$ 0.5%, yeast extract 0.5%, pH 7.0, $27^{\circ}C$. The optimum pH and temperature for the enzyme activity of ${\alpha}$-galactosidase producing Scopulariopsis brevicaulis were pH 7.0 and $27^{\circ}C$, respectively. The enzyme was relatively stable at $pH\;6.0{\sim}8.0$ and at temperature below $40^{\circ}C$. The activity of the enzyme was inhibited by $Ag^{2+},\;Hg^{2+},\;Cu^{2+}$, p-chloromercuribenzoic acid and Iodine. These results would indicate the presence of -SH groups in the catalytic site of the enzyme. Km value was 1.9 mM for $p-nitrophenyl-{\alpha}-D-galactopyranoside$ and Vmax value was $9.66{\times}10^2\;{\mu}M/min$. Sugar constituents of culture broth were identified by HPLC that the enzyme liberated sucrose, glucose and fructose from raffinose and raffinose was significantly decreased.

• Journal of Life Science
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• v.18 no.4
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• pp.461-466
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• 2008

Transforming growth $factor-{\beta}$ ($TGF-{\beta}$)-dependent apoptosis is important in the elimination of damaged or abnormal cells from normal tissues in vivo. Gadd45b has been known to participate in $TGF-{\beta}-induced$ apoptosis by the activation of p38 kinase. In this report, we show that Gadd45b is an immediate-early response gene for $TGF-{\beta}$ during apoptosis in EpH4 cells. To elucidate the molecular mechanism of $TGF-{\beta}-induced$ Gadd45b gene expression, we cloned the 5'-flanking region of the mouse Gadd45b gene. When transfected into EpH4 cells, this 5'-flanking region conferred promoter activity and inducibility by $TGF-{\beta}$. Deletion analyses demonstrated that the minimal promoter activity was detected in the proximal region 220 bp upstream of the transcription initiation site. We also found that the proximal Gadd45b promoter is activated by $TGF-{\beta}$ through the action of Smad2, Smad3, and Smad4. Finally, we show that the expression of Gadd45b gene by $TGF-{\beta}$ is suppressed in EpRas cells in which $TGF-{\beta}$ could not induce apoptosis, suggesting that Gadd45b may be a crucial target for $TGF-{\beta}-induced$ apoptosis in EpH4 cells.

• Journal of the Korean Society of Earth Science Education
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• v.14 no.2
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• pp.146-158
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• 2021

We are to introduce an example of ESD in connection with SDGs through liberal arts courses opened at the College of Education. We analyzed the awareness of the carbon footprint expressed by 42 preservice teachers in a class designed in connection with SDGs 13 goal, 'climate action'. The pre-service teachers wrote a carbon diet diary, a checklist for the level of practice that emits carbon in daily life, and freely expressed the source and proportion of their carbon emissions through the carbon footprint drawing activity. In items of electricity use, public transportation use, and garbage disposal, the level of practice was positive, but water use was analyzed in a negative way. The pre-service teachers who expressed the carbon footprint in 2-3 items reached a majority, showing limitations in recognizing the carbon emission situation in their daily life. Pre-service teachers will be the main actors of education on the environmental issues of the earth at the school site, and the carbon literacy of pre-service teachers will directly or indirectly affect students. We hope that various ESD programs linked to the 17 SDGs will be developed and applied to the educational field to contribute to sustainable global environmental education.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.2
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• pp.357-368
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• 2018

For well over 100 years, oil has enabled remote communities to generate electricity and enjoy the benefits of a consistent electrical supply. Relying solely on oil for electricity generation has left island and remote communities exposed to several risks and drawbacks. Oil-based electricity generation is often more expensive and subject to price volatility, which can result in the use of risky fuel hedging strategies. The residents of islands and remote communities express concern over the future impacts of climate change or insist on their opinions for the corresponding action with reduction of carbon emissions. These risks and drawbacks can be overcomed with continuing cost reductions in solar, wind, and energy storage technologies by maker. Reducing costs is not always a straightforward process, relying on more diversely and renewably arranged renewable energy sources led to reduced local construction cost in every situation reviewed in this study. In this paper, a convenient and simple design solution which will facilitate the optimum location and transmission route of renewable energy facility using GIS(Geographic Information System) is proposed. The suggested solutions exercised to the case of geomoon island using GIS and identified by local site survey.

• The Korean Journal of Pharmacology
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• v.26 no.2
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• pp.167-176
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• 1990

In the present study, we examined the effects of tamoxifen and LY117018 on various parameters for the estrogenic actions in order to understand the mechanism by which tamoxifen and LY117018 act on the uterine cells in 21-23 day old immature rats. Tamoxifen and LY117018 stimulated uterine weight and uterine contents of DNA, protein, and peroxidase activity in the absence of estradiol while inhibited above parameters in the presence of estradiol. Both cytosolic and nuclear progesterone receptors were increased by the treatment of tamoxifen and LY117018 as well as estradiol, but estradiol-induced increase in the progesterone receptors were reduced by the treatment of antiestrogens. These effects were enhanced by the multiple injections of antiestrogens. It seemed that tamoxifen was more agonistic than LY117018 but less antagonistic than LY117018, judged by their effects on various parameters for the estrogenic action. The affinities of estradiol, tamoxifen, and LY117018 for the estrogen receptor were $0.17{\pm}0.01nM(100%)$, $1.10{\pm}0.01nM(6.3%)$, and $0.23{\pm}0.01nM(77%)$, respectively. Furthermore, LY117018 was the competitive ligand for the estrogen receptor in dose-related manner but tamoxifen was not. Following estradiol treatment, nuclear estrogen receptor was sharply increased by 1 h, reaching the maximum by 16 h, while tamoxifen and LY117018 slightly increased nuclear estrogen receptor by 1 h and then decreased thereafter. It is therefore concluded that LY117018 is a competitive antagonist for the estrogen receptor with less estrogenic activity, compared to tamoxifen with low affinity to the estrogen receptor, and tamoxifen may act through other binding site than the estrogen receptor.

• Korean Journal of Biological Psychiatry
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• v.9 no.1
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• pp.25-33
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• 2002

Serotonin transporter(5-HTT) is one of the major action site of antidepressants in neuronal cells. According to the recent studies, it is known that the functional polymorphism in the promoter region of the 5-HTT gene(5-HTT linked polymorphism repetitive element in promoter region, 5-HTTLPR) is associated with antidepressant responsiveness, and the distributions of 5-HTTLPR is various among the different populations. Our preliminary study suggested that it is possible to measure the endophenotype of 5-HTTLPR genotype by examining the pharmacodynamic research of the 5-HTT in platelet membranes. However, there are limitations to predicting the antidepressant responsiveness only from the endophenotypic characteristics of 5-HTT gene promoter polymorphism, and therefore we propose to use the pharmacogenomic methods for overcoming these limitations. We found that the significant correlations existed among the genetic polymorphisms of biogenic amine transporters whose structure and characteristics are similar to the 5-HTT, and the predictable odds ratio of antidepressant responsiveness are increased significantly by combining the effect with other associated polymorphisms, compared to the effect of 5-HTT promoter polymorphism only. These results support the hypothesis that antidepressant treatment has to be individualized according to the genetic and ethnic background of depressed patients. It would be possible to develope the evaluation tools to predict the antidepressant responsiveness and its side effect profile, if scientists reveal the genes related to the action mechanism as well as the metabolism of antidepressants so as to discover the interaction of those genes and contribution of endogenotypes toward antidepressant responsiveness.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.13 no.1
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• pp.3-14
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• 2002

Childhood psychic trauma appears to be a crucial factor in the development of serious disorders both in childhood and in adulthood. Traumatized children show strong tendency to revisualize or re-feel a traumatic events. Play and behavioral reenactments are frequent manifestations of both the single blow and the long-standing traumas in childhood. Those children who suffer the results of single, intense terror appear to exhibit detailed memory, retrospective reworkings and misperceptions. In long-standing or repetitive trauma, children would show psychic numbing, self-hypnosis, dissociation and rage. Child's brain is undergoing critical and sensitive periods of differentiation. During this time, developing central nervous system is exquisitely sensitive to stress. Stressor-activated neurotransmitters and hormones can play major roles in neurogenesis, migration, synaptogenesis, and neurochemical differentiation. Internal opiate system operates in some trauma and causes the victim to fail to respond, to avoid, to shut off feelings. Evidence is also accumulating in traumatology that dysfuntion of locus coeruleus and ventral tegmental neucleus system leads to catecholamine receptors hypersensitivity. This change result in hypervigilance, increased startle, affective lability, and increased autonomic nervous system hyperreactivity. Another site of action of trauma on the brain is hypothalamic-pituitary-adrenal axis. Individuals with PTSD do not have enough cortisol to halt the alarm reaction. When children are exposed to long-standing extreme events, massive attempts to protect the psyche and to preserve the self are put into gear. These developmental traumas mobilize various kinds of defense mechanisms. Massive denial, dissociation, self anesthesia, identification with aggressor and aggression turned against the self often lead to profound character changes in the youngsters.

• Microbiology and Biotechnology Letters
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• v.17 no.6
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• pp.580-586
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• 1989

Penicillium sp. CB-20 was selected for strong polygalacturonase activity among various strains of molds found in soil. The optimum pH for the enzyme activity was 5.0 and optimum temperature was 4$0^{\circ}C$. The enzyme was relatively stable in acidic condition and unstable by heat treatment. The activation energy, Km and V$_{max}$ for the polygalacturonase were 2.499 Kcal/mol, 2.13$\times$10$^{-2}$mol/l, and 104.17 $\mu$mol/min. The activity of polygalacturonase was inhibited by Ag$^{+}$, Cu$^{++}$, Pb$^{++}$, Fe$^{+++}$, $Ca^{++}$, Na$^+$, Mn$^{++}$. The enzyme can be inactivated by the treatment ethylenediamintetra acetic acid, 2,4-dinitrophenol and $H_2O$$_2$. The results indicate the possible involvement of histidine, chelate and terminal amino group as active site. The enzyme was endo-type polygalacturonase.

• Journal of Digital Contents Society
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• v.13 no.1
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• pp.1-11
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• 2012

The BBS of Web Site is a space of informational communication to share information. At the moment, countless information is shared through various kinds of BBS. The shared information through the Web BBS can be gains to someone and losses to the other. Thus, for a long time, there have been many researches about technologies, which monitor information uploaded to Web BBS in real-time and inform the results to subjects. For BBS monitoring, existing methods have utilized direct approaches to DB or open API. Also, e-mail addresses have been utilized to inform results to subjects. However, there are two main problems for these methods. The one is a problem on closed BBS, which cannot be accessed, and the other is impossibility of supporting real-time alarm to e-mail. Especially, the real-time support for services, such as monitoring, is extremely important, since the main purpose of monitoring is based on the counter action for the result. The mobile Web has a merit to be accessed in anywhere, so that it is quite suitable for services requiring real-time support. However, the real-time support of mobile device has not been utilized enough, because each mobile phone has different standards of contents so that the contents should be pre-created. This paper suggests a technology that overcomes pitfalls of mobile Web while it is out of standard, and shows how the effect can be maximized through services such as monitoring, which requires the real-time support.