• Journal of Integrative Natural Science
• /
• v.8 no.1
• /
• pp.75-79
• /
• 2015

Thromboxane A2 receptors (TXA2-R) are the G protein coupled receptors localized on cell membranes and intracellular structures and play pathophysiological role in various thrombosis/hemostasis, modulation of the immune response, acute myocardial infarction, inflammatory lung disease, hypertension and nephrotic disease. TXA2 receptor antagonists have been evaluated as potential therapeutic agents for asthma, thrombosis and hypertension. The role of TXA2 in wide spectrum of diseases makes this as an important drug target. Hence in the present study, homology modeling of TXA2 receptor was performed using the crystal structure of squid rhodopsin and night blindness causing G90D rhodopsin. 20 models were generated using single and multiple templates based approaches and the best model was selected based on the validation result. We found that multiple template based approach have given better accuracy. The generated structures can be used in future for further binding site and docking analysis.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
• /
• 2001.10a
• /
• pp.220-226
• /
• 2001

It is important to estimate exactly wave forces acting on various types of offshore structures under the severe environmental conditions in the ocean site. This paper presents an easy experimental method which deals with transient waves. The proposed scheme made it possible to generate breaking waves at any position in the wave tank by changing the maximum slope of the component waves. The theoretical and experimental methods were investigated by generating concentrated waves which acted on a single and multiple cylinders. The waves forces increased rapidly when the models encountered breaking waves. The theoretical results underestimates the forces due to breaking waves. Therefore, the effects due to breaking waves should be considered carefully in the design process of a structure under the influence of breaking waves.

• Journal of Ocean Engineering and Technology
• /
• v.15 no.4
• /
• pp.8-13
• /
• 2001

It is important to estimate exactly wave forces acting on various types of offshore structures under the severe environmental conditions in the ocean site. This paper presents an easy experimental method which deals with transient waves. The proposed scheme made it possible to generate breaking waves at any position in the wave tank by changing the maximum slope of the component waves. The theoretical and experimental methods were investigated by generating concentrated waves which acted on a single and multiple cylinders. The waves forces increased rapidly when the models encountered breaking waves. The theoretical results underestimates the forces due to breaking waves. Therefore, the effects due to breaking waves should be considered carefully in the design process of a structure under the influence of breaking waves.

• Environmental Analysis Health and Toxicology
• /
• v.25 no.2
• /
• pp.169-177
• /
• 2010

Ecological risk assessment (ERA) has been used to establish environmental quality standards or evaluate ecological risk in site-specific areas. The scope of ERA was expanded based on regions, and the concept of regional-scale ecological risk assessment was recently introduced in developed countries. In the present study, regional ERA approaches of relative risk model (RRM), contaminants in aquatic and terrestrial ecosystems (CATS) model, and procedure for ecological tired assessment of risks (PETAR) in advanced countries were extensively investigated. Regional ERA was compared with traditional ERA process. Stressors, receptor and response in traditional ERA were replaced with sources of stressors, habitats, and ecological impacts, respectively in regional ERA. This study introduces the concept and assessment process of regional ERA, and provides a wide perspective how the relative ERA could be applied in Korean ecosystem.

• Journal of Microbiology and Biotechnology
• /
• v.12 no.1
• /
• pp.77-83
• /
• 2002

A bacterial consortium capable of utilizing a variety of polycyclic aromatic hydrocarbons has been isolated from a former manufactured gas plant site. The consortium consisted of four members including Arthrobacter sp., Burkholderia sp., Ochrobacterium sp., and Alcaligenes sp., which were identified and characterized by the patterns of fatty acid methyl esters (FAME analysis) and carbon source utilization (BIOLOG system). With the individual members, the biodegradation characteristics of aromatic hydrocarbons depending on different growth substrates were determined. FAME analyses demonstrated that microbial fatty acid profiles changed to significant extents in response to different carbon sources, and hence, such shift profiles may be informative to characterize the biodegradation potential of a bacterium or microbial community.

• Proceedings of the Earthquake Engineering Society of Korea Conference
• /
• 2001.04a
• /
• pp.58-65
• /
• 2001

It is essential to know exactly what the response of the seismograph is inclusive of characteristic of the seismic sensors before using it for detailed seismic study. This is because the recorded earthquake data can be more or less affected by the overall system and need to be corrected properly to the analysis`s best to obtain the right results. In this respect, two basic earthquake data processing techniques are introduced and applied, for validation purpose, to real data from KEPRI seismic monitoring system which were established for determining the site-specific characteristics of the earthquakes around the Nuclear Power Plants. One is conventional instrumental correction technique for velocity data and the other is for removing acausal ringing originate from using linear phase FIR filter. These techniques are all implemented in the time domain using digital filtering process and shows the desired results when applied to real earthquake data.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2008.03a
• /
• pp.1417-1421
• /
• 2008

Temperature variation affect the response of asphalt pavement and should be considered in the evaluation of performance of the pavement. In this paper, HWAW method is applied to evaluate shear wave velocity(or shear modulus) of the asphalt pavement with temperature. HWAW method which is based on time-frequency analysis using harmonic wavelet transform have been developed to determine phase and group velocities of waves. This method minimize effect of noise and is not affected by mode jump effect which cause erroneous result when surface wave method is applied to pavement evaluation. In order to estimate the applicability of HWAW method, field tests were performed in 1 site and preliminary correlation between shear wave velocity(shear modulus) and asphalt pavement average temperature.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2008.04a
• /
• pp.795-800
• /
• 2008

The sound transmission loss is a key index to evaluate the acoustic performance of a car-body structure at the high frequency range. From this paper, a new validation method for in-situ sound transmission loss is proposed. First, in-situ sound transmission loss is measured by using PU intensity probe on the condition of complete vehicle. Second, validation test, which is consisted of internal, external and total frequency response function test, is performed by using volume acceleration source and microphones. Then, these test results are compared to validate the accuracy of in-situ sound transmission loss. Finally, the test result of in-site method is compared with results of two reverberant room test method and SEA analytical method. The reliability of in-situ method is confirmed by these procedures.

• Structural Engineering and Mechanics
• /
• v.31 no.1
• /
• pp.93-112
• /
• 2009

In this study seismic analyses of steel structures were carried out to examine the effect of ground motion characteristics and structural properties on energy demands using 100 earthquake ground motions recorded in different soil conditions, and the results were compared with those of previous works. Analysis results show that ductility ratios and the site conditions have significant influence on input energy. The ratio of hysteretic to input energy is considerably influenced by the ductility ratio and the strong motion duration. It is also observed that as the predominant periods of the input energy spectra are significantly larger than those of acceleration response spectra used in the strength design, the strength demand on a structure designed based on energy should be checked especially in short period structures. For that reason framed structures with buckling-restrained-braces (BRBs) were designed in such a way that all the input energy was dissipated by the hysteretic energy of the BRBs, and the results were compared with those designed by conventional strength-based design procedure.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1990.04a
• /
• pp.31-36
• /
• 1990

The probabilistic characteristics of wind loads have been analyzed using statistical data on wind speeds, pressure coefficient, exposure coefficient, and gust factor. The wind speed data collected in 25 nationwide weather stations have been modified to be consistent in measuring height, exposure condition as well as averaging time, Having performed Monte Carlo simulation for various heights and site conditions, the statistical models of wind loads were determined, in which Type-I extreme value distribution has been applied. The models also incorporate a reduction factor of 0.85 to account for the reduced probability that the maximum wind speed will occur in a direction most unfavorable to the response of structure.