• Journal of Chest Surgery
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• 제56권5호
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• pp.346-352
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• 2023

Background: A significant proportion of cardiac surgery intensive care unit (CSICU) patients require long-term ventilation, necessitating tracheostomy placement. The goal of this study was to evaluate the long-term postoperative outcomes and complications associated with percutaneous dilatational tracheostomy (PDT) in CSICU patients. Methods: All patients undergoing PDT after cardiac, thoracic, or vascular operations in the CSICU between January 1, 2013 and January 1, 2021 were identified. They were evaluated for mortality, decannulation time, and complications including bleeding, infection, and need for surgical intervention. Multivariable regression models were used to identify predictors of early decannulation and the complication rate. Results: Ninety-three patients were identified for this study (70 [75.3%] male and 23 [24.7%] female). Furthermore, 18.3% of patients had chronic obstructive pulmonary disease (COPD), 21.5% had history of stroke, 7.5% had end-stage renal disease, 33.3% had diabetes, and 59.1% were current smokers. The mean time from PDT to decannulation was 39 days. Roughly one-fifth (20.4%) of patients were on dual antiplatelet therapy and 81.7% had anticoagulation restarted 8 hours post-tracheostomy. Eight complications were noted, including 5 instances of bleeding requiring packing and 1 case of mediastinitis. There were no significant predictors of decannulation prior to discharge. Only COPD was identified as a negative predictor of decannulation at any point in time (hazard ratio, 0.28; 95% confidence interval, 0.08-0.95; p=0.04). Conclusion: Percutaneous tracheostomy is a safe and viable alternative to surgical tracheostomy in cardiac surgery ICU patients. Patients who undergo PDT have a relatively short duration of tracheostomy and do not have major post-procedural complications.

• Journal of Medicine and Life Science
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• 제18권3호
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• pp.41-48
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• 2021

The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors. Most therapeutic drugs for ADHD have so far targeted biological causes, primarily by regulating catecholaminergic neurotransmitters. However, ADHD drugs that are clinically treated have various problems in their addictiveness and drug stability; thus, it is recommended that efficacy and safety should be secured through simultaneous prescription of multiple drugs rather than a single drug treatment. Accordingly, it is necessary to develop drugs that newly target pathogenic mechanisms of ADHD. In this study, we attempt to confirm the possibility of developing new drugs by reviewing dopamine-related developmental mechanisms of neurons and their correlation with ADHD. Histone deacetylase inhibitors (HDACi) can regulate the concentration of intracellular dopamine in neurons by expressing vesicular monoamine transporter 2 and inducing the exocytosis of neurotransmitters to the synaptic cleft, thereby promoting the development of neurons and signal transmission. This cellular modulation of HDACi is expected to treat ADHD by regulating endogenous catecholamines such as dopamine. Although studies are still in the preclinical stage, HDAC inhibitors clearly have potential as a therapeutic agent with low addictiveness and high efficacy for ADHD treatment.

• 현장농수산연구지
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• 제10권1호
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• pp.153-167
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• 2008

High temperature and natural sun light are considered as the core conditions for high quality and large quantity of Phellinus baumii production. However still now on there has been a mistake of excessively cutting off the natural light by spreading the closing nets on the mushroom cultivating house. For an example there are many houses where the closing nets under the roofs be extended to cover the sides of the houses, which way prevents the mushrooms in the houses from receiving sufficient natural sun light and getting the temperature sufficiently to grow so that the quantity and quality of the produced mushrooms are lowered even though the mushrooms can grow in those conditions. In order to avoid this mistake, the closing nets must be placed on the roofs of the houses only without dropping them to cover the sides. Further more when the closing nets are placed triply at the beginning stage of Phellinus baumii's growth in the house, the nets restrain the internal temperature of the house going up and intercept the natural bright light flowing into the house so that the growing tardiness occur to the Phellinus baumii. Therefore the roof only must have been covered by the closing net for 65% cutting off the light until May, and then covered by double folded the net for June, triple folded the net for July and August, double folded the net for September, and the single net for October. When the ventilation in the house has been maintained until the house tightly balloon out through controling lifting force of internal air, the Phellinus baumii can grow well while the bed logs themselves aren't dried out. Marketing is also very much important as well as increasing quality and quantity of Phellinus baumii production.

• 한국환경생태학회지
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• 제37권1호
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• pp.13-34
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• 2023

Many ecologists try to understand plant communities and societies' changing processes by interacting with environmental factors. Plant communities formed in the sidings of streams, which are more dynamic than forest vegetation, are closely related to the disturbance regime of streams. U. pumila, which forms communities at the edges of streams, is distributed over the central and northern regions of the Korean Peninsula. In this study, we intended to explain the regeneration of U. pumila communities in the upstream region of the Namhangang River. Heights from the stream surface to the mid-high points of communities increased when the age class of U. pumila communities increased. On the other hand, the height of U. pumila tended to increase and decrease as the age class increased. The richness (S), evenness (J'), diversity (H'), and maximum diversity (H'max) also showed a tendency to increase and then decrease as the age class increased. On the other hand, the number of stems per individual and density (D) decreased as the age class increased. Seedlings of U. pumila failed to regenerate in the communities at the intermediate or higher stage of the age class. Regeneration of seedlings occurred in the spaces formed by the flooding, which occurred periodically in streams. After regeneration, U. pumila communities grew like a single organism. On the other hand, the plant species consisting of U. pumila communities exhibited a process in which the S and H' increased and then decreased as they developed. In other words, we determined that the changes in the species compositions were associated with changes in each species' environment and community. A space where seeds can regenerate seedlings should be provided for the regeneration of U. pumila communities. In the mid/upstream region of the Namhangang River, where the present study focused, newly formed communities were rare because the space required to regenerate U. pumila ceased to exist. Accordingly, we suggest securing an appropriate space for the regeneration of seedlings to maintain the U. pumila communities in the upstream region of the Namhangang River.

• Nuclear Engineering and Technology
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• 제55권2호
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• pp.452-459
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• 2023

The core power control is an important issue for the study of dynamic characteristics in China initiative accelerator driven subcritical system (CiADS), which has direct impact on the control strategy and safety analysis process. The CiADS is an experimental facility that is only controlled by the proton beam intensity without considering the control rods in the current engineering design stage. In order to get the optimized operation scheme with the stable and reliable features, the variation of beam intensity using the continuous and periodic control approaches has been adopted, and the change of collimator and the adjusting of duty ratio have been proposed in the power control process. Considering the neutronics and the thermal-hydraulics characteristics in CiADS, the physical model for the core power control has been established by means of the point reactor kinetics method and the lumped parameter method. Moreover, the multi-inputs single-output (MISO) logical structure for the power control process has been constructed using proportional integral derivative (PID) controller, and the meta-heuristic algorithm has been employed to obtain the global optimized parameters for the stable running mode without producing large perturbations. Finally, the verification and validation of the control method have been tested based on the reference scenarios in considering the disturbances of spallation neutron source and inlet temperature respectively, where all the numerical results reveal that the optimization method has satisfactory performance in the CiADS core power control scenarios.

• 한국컴퓨터정보학회논문지
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• 제14권10호
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• pp.1-10
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• 2009

현대의 프로세서 아키텍처에서 정확한 분기 예측은 시스템의 성능에 지대한 영향을 끼친다. 최근의 연구들은 예측 정확도뿐만 아니라, 예측 지연시간 또한 성능에 막대한 영향을 끼친다는 것을 보여준다. 하지만, 예측 지연시간은 간과되는 경향이 있다. 본 논문에서는 분기 예측지연시간을 극복하기 위한 분기 선예측 기법을 제안한다. 이 기법은 분기장치를 인출 단계에서 분리함으로써, 분기 예측기가 명령어 인출 장치로부터의 아무런 정보도 없이 스스로 분기 예측을 진행 가능하게 한다. 또한, 제안된 기법을 지원하기 위해, BTB의 구조를 새롭게 개선하였다. 실험 결과는 제안된 기법이 동일한수준의 분기 예측정확도를 유지하면서, 대부분의 예측지연시간을 은폐한다는 것을 보여준다. 더욱이 제안된 기법은 항상 1 싸이클의 예측 지연시간을 가지는 이상적인 분기 예측기를 사용한 경우보다도 더 나은 성능을 보여준다. 본 논문의 실험 결과에 따르면, 기존의 방식과 비교했을 때, 최대 11.92% 평균 5.15%의 IPC 향상을 가져온다.

• Structural Engineering and Mechanics
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• 제86권5호
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• pp.589-605
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• 2023

This paper investigates the ductility demands of steel frames equipped with self-centring fuses under near-fault earthquake motions considering multiple yielding stages. The study is commenced by verifying a trilinear self-centring hysteretic model accounting for multiple yielding stages of steel frames equipped with self-centring fuses. Then, the seismic response of single-degree-of-freedom (SDOF) systems following the validated trilinear self-centring hysteretic law is examined by a parametric study using a near-fault earthquake ground motion database composed of 200 earthquake records as input excitations. Based on a statistical investigation of more than fifty-two (52) million inelastic spectral analyses, the effect of the post-yield stiffness ratios, energy dissipation coefficient and yielding displacement ratio on the mean ductility demand of the system is examined in detail. The analysis results indicate that the increase of post-yield stiffness ratios, energy dissipation coefficient and yielding displacement ratio reduces the ductility demands of the self-centring oscillators responding in multiple yielding stages. A set of empirical expressions for quantifying the ductility demands of trilinear self-centring hysteretic oscillators are developed using nonlinear regression analysis of the analysis result database. The proposed regression model may offer a practical tool for designers to estimate the ductility demand of a low-to-medium rise self-centring steel frame equipped with self-centring fuses progressing in the ultimate stage under near-fault earthquake motions in design and evaluation.

• 기록학연구
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• 제77호
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• pp.109-150
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• 2023

이 글은 진보당 형사사건기록을 역사적 관점으로 해석하는 기존 연구 동향과는 달리 경찰-검찰-재판으로 연결되는 하나의 완결된 유기적인 기록군, 즉 기록의 생애주기적 관점 속에서 진보당 형사사건기록이 기록의 속성을 어떻게 나타내고 있는지 기록학적 시각으로 새롭게 분석한 것이다. 먼저 생산기관별로 편철된 기록물의 형태와 기관별로 주요하게 생산된 사건기록이 무엇인지 출처별 특성을 기관별로 위임된 법령을 통해 살펴보았다. 이후 경찰·검찰·특무대에서 생산한 수사기록과 기소 이후 재판과정에서 생산된 공판기록을 살펴보면서 기록이 가지는 특성에 대해 평가하였다. 특히 진보당 형사사건기록이 가지는 증거로서 불충분한 지점과 위법성에 대해 기록 특성의 관점으로 접근하여 형사소송법의 증거력 이전에 기록이 증거로서 효력을 가지는 기록학적 속성인 신뢰성, 진본성, 무결성 모두를 가지지 못하는 기록임을 증명했다.

• Journal of Chest Surgery
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• 제56권6호
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• pp.403-411
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• 2023

Background: The concept of oligo-recurrence has not been generally applied in esophageal cancer. This study aimed to determine the prognostic significance of the number of recurrences in esophageal cancer. Methods: Patients with squamous cell carcinoma who underwent curative esophagectomy with R0 or R1 resection and who experienced a confirmed recurrence were included. The study included 321 eligible participants from March 2001 to December 2019. The relationship between the number of recurrences and post-recurrence survival was investigated. Results: The mean age was 63.8±8.1 years, and the majority of the participants (97.5%) were men. The median time to recurrence was 10.7 months, and the median survival time after recurrence was 8.8 months. Multiple recurrences with simultaneous local, regional, and distant locations were common (38%). In terms of the number of recurrences, single recurrences were the most common (38.3%) and had the best post-recurrence survival rate (median, 17.1 months; p<0.001). Patients with 2 or 3 recurrences showed equivalent survival to each other and longer survival than those with 4 or more (median, 9.4 months; p<0.001). In the multivariable analysis, the significant predictors of post-recurrence survival were body mass index, minimally invasive esophagectomy, N stage, R0 resection, post-recurrence treatment, and the number of recurrences (p<0.05). Conclusion: After esophagectomy, the number of recurrences was the most significant risk factor influencing post-recurrence survival in patients with esophageal cancer. In esophageal cancer, oligo-recurrence can be defined as a recurrence with three or fewer metastases. More intensive treatment might be recommended if oligo-recurrence occurs.

• 한국BIM학회 논문집
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• 제13권3호
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• pp.1-11
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• 2023

In order to use BIM as a tool for improving the productivity and quality of products in the construction industry, a BIM model must be created from the design stage first. Infrastructure structures such as bridges and tunnels are mainly created based on three-dimensional alignment in the generation of BIM models. Especially, generation of BIM models based on three-dimensional linearity has high task difficulty and algorithms for automating BIM modeling for railway infra structures have been suggested in previous studies. This study improved the BIM modeling automation algorithm of railway infrastructures and developed a system based on the algorithm so that it can be easily used by ordinary users. The system was built as an add-in system of Autodesk's Revit. As an improvement first, it is possible to arrange different libraries for each pattern, enabling various uses. In addition, it can be created models of several members with a single process and the system can automatically places structures that are added periodically, such as Rock Bolt and Fore Polling. Finally, 3D length information and volume for each pattern are automatically calculated for more accurate 3D-based volume calculation. This study contributes to increasing user accessibility by building a BIM modeling automation algorithm into a system. The system is expected to improve the efficiency of BIM modeling creation of linear-based infra structures, including railway infrastructure.