• The Korean Journal of Physiology and Pharmacology
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• v.10 no.3
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• pp.137-141
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• 2006

The systolic and diastolic pressures in anesthetized Sprague-Dawley male rats were greatly decreased after single-dose of Cd treatment without significant changes in heart rate. There was a fluid-shift into the third space and/or -loss through the kidney, since plasma $Na^+$ concentration and hematocrit ratio were significantly increased by acute Cd exposure. The present study showed that the sustained hypotensive effect of single-dose Cd on the cardiovascular system might have resulted from the systemic hypovolemia. Furthermore, renal excretion of electrolytes, including $Na^+$ and $K^+$, and urine flow rate were increased by Cd intoxication. Interestingly, the ratio of $Na^+/K^+$ excretion was increased and reached the maximum level 3 hours after Cd injection and returned to the normal level after 7 hours. Nevertheless, there was no difference in the regression analysis of $Na^+$ excretion and urine flow rate in both groups. Therefore, the increase in the urine volume seemed to enhance the excretion of $Na^+$. This study strongly suggest that the hypotensive effect of Cd is mediated by systemic $Na^+$ loss through the kidney and/or hypovolemia via fluid-shift.

• The KSFM Journal of Fluid Machinery
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• v.1 no.1 s.1
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• pp.58-63
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• 1998

To investigate turbine flow fields under realistic conditions, a rotating turbine test facility has been developed at the Inha University Propulsion Laboratory. The experimental facility consists of an air inlet, settling chamber, single turbine stage test section, and diffuser. This turbine has a design flow coefficient of 0.55 and work coefficient of 1.88. The turbine test rig has four features. First, a large scale test section improves space resolution. Second, low speed rpm enhances safety and reduces required power, Third, DC motor/generator is able to regenerate blower power. Fourth, various types of experiment can be carried out.

• The KSFM Journal of Fluid Machinery
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• v.11 no.1
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• pp.52-60
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• 2008

Staggered dimples printed on opposite walls of an internal cooling channel are formulated numerically and optimized to enhance heat transfer performance. Nusselt number and friction factor based objectives are considered and a weighted average surrogate model is used to approximate the data generated by numerical simulation. The dimpled channel shape is defined by three geometric design variables, and the design point within design space are selected using Latin hypercube sampling. A weighted-sum method for multi-objective optimization is applied to integrate multiple objectives into a single objective. By the optimization, the objective function value is improved largely and heat transfer rate is increase much higher than pressure loss increase due to shape deformation. Channel with vertically non-symmetric optimum dimples is tested and found that the best appears if dimples on opposite wall are displaced by one quarter of dimple spacing.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.8
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• pp.1424-1429
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• 2007

This paper presents a simple and reliable one-touch type multi-immunosensing lab-on-a-chip (LOC) detecting antibodies as multi-disease markers using electrochemical method suitable for a portable point-of-care system (POCS). The multi-stacked LOC consists of a PDMS space layer for liquids loading, a PDMS valve layer with 50 im in height for the membrane, a PDMS channel layer for the fluid paths, and a glass layer for multi electrodes. For the disposable immunoassay which needs sequential flow control of sample and buffer liquids according to the designed strategies, reliable and easy-controlled on-chip operation mechanisms without any electric power are necessary. The driving forces of sequential liquids transfer are the capillary attraction force and the pneumatic pressure generated by air bladder push. These passive fluid transport mechanisms are suitable for single-use LOC module. Prior to the application of detection of the antibody as a disease marker, the model experiments were performed with anti-DNP antibody and anti-biotin antibody as target analytes. The flow test results demonstrate that we can control the fluid flow easily by using the capillary stop valve and the PDMS check valves. By the model tests, we confirmed that the proposed LOC is easily applicable to the bioanalytic immunosensors using bioelectrocatalysis.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.6C
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• pp.267-274
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• 2012

The conventional approach to evaluate the contaminant transport in soils adopts the macro-scale implementation while the pore configuration and network is a dominant factor to determine the fate of contaminant. However, the observation of fate and transport at pore scale may not be readily approachable because of the computational expenses to solve Navier-Stokes equation. We herein present the 2D Lattice-Boltzmann method that enables to assess the local fluid velocity and density efficiently for the case of single phase and multi-components. The solute fate spatio-temperal space is explicitly determined by the advection of fluid flow. Two different types of idealized pore space provides the path of fluid. Also, solute transport, the velocity field and average concentration of solute are computed in steady state. Results show that the pore geometry such as tortuosity mainly affect the solute fate. It highlights the significance of the pore configuration and shape in granular soils and rock discontinuity in spite of the equivalent porosity.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.29 no.4
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• pp.231-236
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• 2016

A three-electrode type reflective display (electronic paper) is designed to apply an independent electric field to each three electrodes of the cell including two electric-type of particles and electrically neutral color fluid, so single color realization is possible. In particular, the movement of particles and optical properties are decided by the electric field between two electrodes on the lower substrate. So, the effect of electric field by the distance between two electrodes on the lower substrate is studied with electrode spacing with $10{\mu}m$, $15{\mu}m$, $20{\mu}m$, and $25{\mu}m$. By our experimentation, the driving voltage induces more reliable movement of charged particles and the optical properties as compared with the threshold voltage. We ascertain the single color realization and non-inverted particle separation is possible. So the more desirable optical properties are observed in case of the short electrode like $10{\mu}m$.

• Tunnel and Underground Space
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• v.29 no.6
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• pp.468-479
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• 2019

It is essential to comprehend coupled hydro-mechanical behavior to utilize subsurface for the recent demand for underground space usage. In this study, we developed a new simulator for numerical simulation as a tool for researching to consider the various domestic field and subsurface conditions. To develop the new module, we combined OpenGeoSys, one of the scientific software package that handles fluid mechanics (H), thermodynamics (T), and rock and soil mechanics (M) in the subsurface with FLAC3D, one of the commercial software for geotechnical engineering problems reinforced. In this simulator development, we design OpenGeoSys as a master and FLAC3D as a slave via a file-based sequential coupling. We have chosen Terzaghi's consolidation problem related to single-phase fluid flow at a saturated condition as a benchmark model to verify the proposed module. The comparative results between the analytical solution and numerical analysis showed a good agreement.

• The Journal of the Acoustical Society of Korea
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• v.27 no.2
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• pp.92-101
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• 2008

To dissolve the multi-layered model problems, and to complement 2-layered model's simplicity, assumed fluid-fluid-solid 3-layered model. Generally it is known that if the sediment thickness is more than 10 wavelength, the half space's influence to the in-water acoustic field could be disregarded. By tracking the maximum correlation coefficient of calculated results and experimental ones we confirmed that the requirement could be more realized. To calculate the maximum correlation coefficient we used single sensor transmission loss. On the assumption that the sediment sound velocity was 1813 m/s and frequency range 50 kHz to 120 kHz, the conversion condition was from 2.5 to 7.7 wavelength.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.1
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• pp.80-86
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• 2011

Vertical open display cabinets are widely used in shopping mall, supermarkets, retail stores. Maintaining the temperature of foods in the display cabinet is vitally important to retailers to ensure optimal food quality and safety. The purpose of this study is to reduce the infiltration of air and heat loss from ambient space to display cabinet. The three-dimensional Computational Fluid Dynamics(CFD) simulation is used for the analysis of air flow patterns and temperature distribution in refrigerated display cabinets. Under several operating conditions which vary both the inner and outer jet velocities in the range from 0.3 to 1.1 m/s, simulations were carried out. This paper presents a performance of display cabinets with single jet and double jet. The energy consumption due to thermal entrainment ratio is plotted with varying Re. It was found that the double jet system is better than single jet system in terms of temperature distribution and energy saving.

• Ocean Systems Engineering
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• v.9 no.2
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• pp.111-133
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• 2019

Flow through a scaled horizontal axis marine current turbine was numerically simulated after validation and the turbine design was optimized. The computational fluid dynamics (CFD) code Ansys-CFX 16.1 for numerical modeling, an in-house blade element momentum (BEM) code for analytical modeling and an in-house surrogate-based optimization (SBO) code were used to find an optimal turbine design. The blade-pitch angle (${\theta}$) and the number of rotor blades (NR) were taken as design variables. A single objective optimization approach was utilized in the present work. The defined objective function was the turbine's power coefficient ($C_P$). A $3{\times}3$ full-factorial sampling technique was used to define the sample space. This sampling technique gave different turbine designs, which were further evaluated for the objective function by solving the Reynolds-Averaged Navier-Stokes equations (RANS). Finally, the SBO technique with search algorithm produced an optimal design. It is found that the optimal design has improved the objective function by 26.5%. This article presents the solution approach, analysis of the turbine flow field and the predictability of various surrogate based techniques.