• 통합자연과학논문집
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• 제10권3호
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• pp.119-124
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• 2017

Glucagon-like peptide 2 receptor, a GPCR, binds with the glucagon-like peptide, GLP-2 and regulates various metabolic functions in the gastrointestinal tract. It plays an important role in the nutrient homeostasis related to nutrient assimilation by regulating mucosal epithelium. GLP-2 receptor affects the cellular response to external injury, by controlling the intestinal crypt cell proliferation. As they are therapeutically attractive towards diseases related with the gastrointestinal tract, it becomes essential to analyse their structural features to study the pathophysiology of the diseases. As the three dimensional structure of the protein is not available, in this study, we have performed the homology modelling of the receptor based on single- and multiple template modeling. The models were subjected to model validation and a reliable model based on the validation statistics was identified. The predicted model could be useful in studying the structural features of GLP-2 receptor and their role in various diseases related to them.

• Journal of Electrical Engineering and Technology
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• 제13권3호
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• pp.1147-1155
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• 2018

This paper presents an improved method to determine the internal parameters for improving accuracy of a lithium ion battery equivalent circuit model. Conventional methods for the parameter estimation directly using the curve fitting results generate the phenomenon to be incorrect due to the influence of the internal capacitive impedance. To solve this phenomenon, simple correction procedure with transient state analysis is proposed and added to the parameter estimation method. Furthermore, conventional dynamic equation for correction is enhanced with advanced RC impedance dynamic equation so that the proposed modeling results describe the battery dynamic characteristics more exactly. The improved accuracy of the battery model by the proposed modeling method is verified by single cell experiments compared to the other type of models.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2000년도 학술발표회 논문집
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• pp.20-27
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• 2000

The grid-based KlneMatic wave STOrm Runoff Modei (Kim, 1998; Kim, et al., 1998) which predicts temporal variation and spatial distribution of saturated overland flow, subsurface flow and stream flow was evaluated at two watersheds. This model adopts the single overland flowpath algorithm and simulates surface and/or subsurface water depth at each cell by using water balance of hydrologic components. The model programed by C-language uses ASCII-formatted map data supported by the irregular gridded map of the GRASS (Geographic Resources Analysis Support System) GIS and generates the spatial distribution maps of discharge, flow depth and soil moisture of the watershed.

• 한국미생물·생명공학회지
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• 제51권4호
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• pp.465-473
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• 2023

본 연구에서는 볶음 쓴메밀 '황금미소' 분말을 첨가한 배지에 단일 및 복합 프로바이오틱스를 배양하여 쓴메밀 주요성분인 rutin의 quercetin으로 생물전환능과 이의 항산화, 항염 생리활성을 평가하였다. 단일 균주 배양 시 생물전환률은 각각 LP3 89%, SL6 84%, ST3 87%로 보였으며, 프로바이오틱스 3종 복합 배양 시 97%로 단일균주와 비교하여 유의적으로 증가하였다. 배양 전 배양액과 3종의 단일 균주 배양 및 복합 균주 배양액에서 DPPH, ABTS 분석 결과, 3종 프로바이오틱스 복합 균주 배양 시 항산화 활성이 유의적으로 증가하였다. 또한, LPS에 의해 유도된 RAW 264.7 세포의 염증반응 분석결과, 산화질소 생성능, iNOS와 TNF-α의 mRNA 발현, IL-6와 IL-4 사이토카인 분비능이 3종 프로바이오틱스 복합 균주 배양 시 가장 우수한 효능을 확인하였다. 이상의 결과는 쓴메밀 혹은 rutin이 풍부한 천연물과 이의 생물전환이 가능한 CBT LP3, SL6, ST3의 복합 섭취가 rutin 성분의 quercetin으로 전환 및 항염, 항산화 등의 생리활성 효력 증대에 영향을 줄 수 있을 것으로 판단된다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 A
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• pp.276-279
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• 2004

The purpose of this paper is to describe and demonstrate how a utility-connectable inverter for photovoltaic or fuel-cell applications can be well modeled using PSCAD/EMTDC. In this paper, a single-phase IGBT inverter using SPWM is modeled. Simple voltage magnitude and phase controls are implemented using PSCAD's Pl controller, PLL, and a 'user defined' component called Modulo (found in their extensive collection of example circuits). The circuit model also takes advantage of PSCAD's interpolated firing pulse option, which provides improved simulation results by preventing errors from being introduced when switches fire between time simulation steps. Additionally, SCAD's Online Frequency Scanner for FFT is utilized for a demonstration of PSCAD's frequency-domain analysis capabilities.

• 한국환경성돌연변이발암원학회지
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• 제21권2호
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• pp.99-105
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• 2001

Sophoricoside was isolated as the inhibitor of IL-5 bioactivity from Sophora japonica (Leguminosae). It has been reported to has an anti-inflammatory effect on rat paw edema model. To develope as an anti-allergic drug, genotoxicity of sophoricoside was investigated in bacterial and mammalian cell system such as Ames bacterial reversion test, chromosomal aberration assay and single cell gel electrophoresis (Comet) assay. As results, in the range of 1,250~40 $\mu\textrm{g}$/plate sophoricoside concentrations was not shown significant mutagenic effects in Salmonella typhimurium TA 98, TA 100, TA 1535 and TA 1537 strains in Ames test. The 80% cell growth inhibition concentration (IC/SUB 80/) of sophoricoside was determined as above 5,000 $\mu\textrm{g}$/$m\ell$ in Chinese hamster lung (CHL) fibroblast cell and L5178Y mouse lymphoma cell line for the chromosomal aberration and comet assay, respectively. Sophoricoside was not induced chromosomal aberration in CHL fibroblast cell at concentrations of 700, 350 and 175 $\mu\textrm{g}$/$m\ell$ or 600, 300 and 150 $\mu\textrm{g}$/$m\ell$ in the absence or presence of S-9 metabolic activation system, respectively. Also, in the comet assay, the induction of DNA damage was not observed in L5178Y mouse lymphoma cell line both in the absence or presence of S-9 metabolic activation system. From these results, no genotoxic effects of sophoricoside were observed in bacterial and mammalian cell systems used in these experiments.

• 대한한의학방제학회지
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• 제31권4호
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• pp.389-413
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• 2023

Objectives : This study aimed to review the current trends in experimental studies on the use of natural products for treatment of gastroesophageal reflux disease (GERD). Methods : Experimental studies assessing the efficacy of natural products against GERD were searched on PubMed. Articles were selected based on predefined inclusion and exclusion criteria and then analyzed for experimental methods, interventions, and result analysis techniques. Results : A total 37 studies were included in this review. Predominantly, in vivo experiments were conducted to induce GERD through surgery, involving the ligation of the pylorus and the transitional junction between the corpus and the forestomach using 7-week-old male Sprague-Dawley rats. The acute induction model, sacrificing animals after a single administration following GERD induction, was mainly used.The utilization of cell experiments was relatively infrequent, with a focus on assessing antioxidant and anti-inflammatory effects via the treatment of the RAW 264.7 cell line with lipopolysaccharides treatment. Glycyrrhizae Radix et Rhizoma, Pinelliae Tuber, Ginseng Radix and Zingiberis Rhizoma were used as single ingredients, and herbal formula, STW-5 (iberogast), Rikkunshito (六君子湯), Banhasasim-tang (半夏瀉心湯), and Hewei Jiangni granule (和胃降逆湯) were used. Outcome analysis methods encompassed Macroscopic evaluation, esophageal function assessment, blood biomarker analysis, histological examination, protein analysis, gene expression analysis, and gastric juice analysis. Proton pump inhibitors were predominantly employed as positive controls. Conclusions : This study revealed the current trends in non-clinical research evaluating natural products for GERD. Based on the results of this study, we expect that non-clinical research on clinically effective natural products will be revitalized.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 추계종합학술대회 논문집(1)
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• pp.73-76
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• 2000

We investigate the stepwise parallel processing of the serial search which can success the co]1 search at low Ec/Io. The single path Rayleigh fading channel which is worst-case channel model is considered. The typical 3-step cell search is used. The probabilities of detection, miss and false alarm for each step are used in closed forms based on the statistics of CDMA noncoherent demodulator output. The optimal power allocation to each channel and The optimal number of post-detection integrations for each step is obtained. Also, the cumulative probability distribution of the average eel] search time for serial search methods are compared.

• Steel and Composite Structures
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• 제26권2호
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• pp.241-253
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• 2018

Mode II fracture toughness, $K_{IIC}$, of single-ply triaxially woven fabric (TWF) composite due to tow waviness and anisotropy effects were numerically and experimentally studied. The numerical wavy beam network model with anisotropic material description denoted as TWF anisotropic was first validated with experimental Mode II fracture toughness test employing the modified compact tensile shear specimen configuration. 2D planar Kagome and TWF isotropic models were additionally constructed for various relative densities, crack lengths, and cell size parameters for examining effects due to tow waviness and anisotropy. $K_{IIC}$ generally increased with relative density, the inverse of cell size, and crack length. It was found that both the waviness and anisotropy of tow inflict a drop in $K_{IIC}$ of TWF. These effects were more adverse due to the waviness of tow compared to anisotropy.

• 전기학회논문지P
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• 제59권1호
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• pp.117-122
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• 2010

The solar cells and fuel cells power are being encouraged to reduce the environmental pollution and combat the global warming. And the electric generation hybrid system is usually more reliable and less costly than the systems that use a single source of energy. HOMER provides a platform to design and simulate the power system and then to choose the optimization results. Based on the electricity demand conditions during a year, this paper simulates with the HOMER and performs the monthly average electrical production and the most feasible economical case includes the net present costs and the annualized costs of the hybrid system components.