• Title/Summary/Keyword: Single growth factor

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Fatigue Crack Growth Characteristics of $SiC_p/Al-Si$ Alloy Composites for Automotive Structures (자동차구조용 $SiC_p/Al-Si$복합재의 피로균열 진전특성에 대한 연구)

  • Koh Seungkee;Lee Haemoo
    • Transactions of the Korean Society of Automotive Engineers
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    • v.13 no.4
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    • pp.174-181
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    • 2005
  • In order to investigate the behavior of fatigue crack growth of SiC-particulate- reinforced Al-Si alloy composites, fatigue tests using single edge notched tension(SENT) specimens were performed. Composite materials were manufactured by using both permanent die casting and extrusion processes with different volume fractions of $10\%\;and\;20\%$. $SiC_p-reinfurced$ Al-Si composites showed the increased levels of threshold stress intensity factor range, ${\Delta}K_{th}$, for the increased volume fractions of SiC particles, which implies the increased fatigue crack growth resistance at the threshold or low ${\Delta}K$ levels, compared to the unreinforced Al-Si alloy. In the Paris region, however, the composites showed the increased rate of crack growth resulting in the unfavorable effects on the fatigue crack growth resistance. Critical stress intensity factor range at unstable crack growth leading to final fracture decreased as the volume fraction of SiC particle increased, because of the reduced fracture toughness of the composites. Extruded materials showed higher threshold and critical values than the cast materials.

The effect of Independent Tendency of Single Women on Consumption Values and Clothing Benefits (미혼여성의 독립적 성향에 따른 소비가치와 의복추구혜택에 관한 연구)

  • Lee, Mi-Ah;Rhee, Eun-Young
    • Journal of the Korean Society of Costume
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    • v.60 no.5
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    • pp.139-156
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    • 2010
  • The purpose of this study is to identify the independent tendency of single women, certainly worthy of study in considering their size, their growth, and their purchasing power, and to examine their effects on consumption values and clothing benefits. The data were collected from self-administrated questionnaire with 537 single women in their 20�s and 30�s on May in 2005. Data were analyzed by factor analysis, reliability analysis, K-means cluster, one way ANOVA and chi-square. Factor analysis on independent tendency resulted in three dimensional structures: marriage-independent tendency, physical independence, social independence. Five dimensions of consumption values were identified by factor analysis: conspicuous, pro-environmental. economic, enjoyable, aesthetic values. Five dimensions of clothing benefits were identified by factor analysis: individuality, well-known brand, practicality, price, social recognition pursuit. The respondents were classified to three groups by three factors of independent tendency: high independent group, social-physical independent group, low independent group. There were significant differences among these groups in demographic characteristics, consumption values and clothing benefits.

Fatigue Crack Growth Retardation after Single Overload Cycle in High Strengh Aluminium Weldments (고강도 알루미늄 합금 용접부에 있어서의 피로균열전파에 미치는 과하중 효과)

  • 이택순;김상태;김인식
    • Journal of Welding and Joining
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    • v.6 no.1
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    • pp.46-52
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    • 1988
  • Retardation or delay in fatigue crack growth due to overloads are important for the accurate prediction of fatigue lives of structural materials. In this study, retardation of fatigue crack growth in Al 6061-T6 weldments and heat affected zones (HAZ) after single overload cycle had been investigated. Retardation in both weldments and HAZ was observed. It was concluded that retardation in both weldment and HAZ was greater than in base metal due to microstructural change and crack branching and crack closure were major governing factor in retardation.

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Identification of Novel SNPs in Bovine Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Gene

  • Kim, J.Y.;Yoon, D.H.;Park, B.L.;Kim, L.H.;Na, K.J.;Choi, J.G.;Cho, C.Y.;Lee, H.K.;Chung, E.R.;Sang, B.C.;Cheong, I.J.;Oh, S.J.;Shin, Hyoung Doo
    • Asian-Australasian Journal of Animal Sciences
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    • v.18 no.1
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    • pp.3-7
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    • 2005
  • The insulin-like growth factors (IGFs), their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Insulin-like growth factor binding protein-3 (IGFBP3, OMIM #146732) is one of the proteins that bind to the IGFs. IGFBP3 is a modulator of IGF bioactivity, and direct growth inhibitor in the extravascular tissue compartment. We identified twenty-two novel single nucleotide polymorphisms (SNPs) in IGFBP3 gene in Korean cattle (Hanwoo, Bos taurus coreanae) by direct sequencing of full gene including -1,500 bp promoter region. Among the identified SNPs, five common SNPs were screened in 650 Korean cattle; one SNP in promoter (IGFBP3 G-854C), one in 5'UTR region (IGFBP3 G-100A), two in intron 1 (IGFBP3 G+421T, IGFBP3 T+1636A), and one in intron 2 (IGFBP3 C+3863A). The frequencies of each SNP were 0.357 (IGFBP3 G-854C), 0.472 (IGFBP3 G-100A), 0.418 (IGFBP3 G+421T), 0.363 (IGFBP3 T+1636A) and 0.226 (IGFBP3 C+3863A), respectively. Haplotypes and their frequencies were estimated by EM algorithm. Six haplotypes were constructed with five SNPs and linkage disequilibrium coefficients (|D'|) between SNP pairs were also calculated. The information on SNPs and haplotypes in IGFBP3 gene could be useful for genetic studies of this gene.

Association of SNP Marker in IGF-I and MYF5 Candidate Genes with Growth Traits in Korean Cattle

  • Chung, E.R.;Kim, W.T.
    • Asian-Australasian Journal of Animal Sciences
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    • v.18 no.8
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    • pp.1061-1065
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    • 2005
  • Growth rate is one of the economically important quantitative traits that affect carcass quantity in beef cattle. Two genes, bovine insulin-like growth factor I (IGF-I) and myogenic factor 5 (MYF5), were chosen as candidate genes for growth traits due to their important role in growth and development of mammals. The objectives of this study were to determine gene-specific single nucleotide polymorphism (SNP) markers of the IGF-I and MYF5 positional candidate genes and to investigate their associations with growth traits in Korean cattle. Genotyping of the SNP markers in these candidate genes was carried out using the single strand conformation polymorphism (SSCP) analysis. The frequencies of A and B alleles were 0.72 and 0.28 for IGF-I gene and 0.39 and 0.61 for MYF5 gene, respectively, in Korean cattle population examined. The gene-specific SNP marker association analysis indicated that the SNP genotype in IGF-I gene showed a significant association (p<0.05) with weight at 3 months (W3), and cows with AB genotype had higher W3 than BB genotype cows. The SNP genotype of MYF5 gene was found to have a significant effect (p<0.05) on the weight at 12 months (W12) and average daily gain (ADG), and cows with BB and AB genotypes had higher W12 and ADG compared with cows with AA genotype, respectively. However, no significant association between the SNP genotypes and any other growth traits was detected. The gene-specific SNP markers in the IGF-I and MYF5 candidate genes may be useful for selection on growth traits in Korean cattle.

Effects of Refeeding with a Protein-Free Diets Supplemented with Various Essential Amino Acids on the Plasma Insulin-Like Growth Factor-I Concentration in Fasting Young Chickens

  • Kita, K;Shibata, T.;Nagao, K.;Hwangbo, J.;Okumura, J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.3
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    • pp.406-409
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    • 2002
  • The effect of refeeding with various single essential amino acids on the recovery of plasma insulin-like growth factor-I (IGF-I) concentration in fasted young chickens was examined. Young chickens (29 days of age) were divided into 15 experimental groups. Chickens in one group were fed on the commercial diet ad libitum for 4 days. The remaining 56 chickens in 14 experimental groups were fasted. After 2 days of fasting, 52 chicks in 13 fasted groups were refed with one of the following experimental diets for 2 days. Eleven experimental diets were protein-free diets supplemented with one of 11 essential amino acids (Arg, Gly, His, Ileu, Leu, Met, Phe, Lys, Thr, Trp, Val). The remaining 2 experimental diets were a protein-free diet containing 11 essential amino acids and a protein-free diet not supplemented with amino acids. Birds in the remaining fasted group continued to be fasted for 2 days. Fasting for 2 days markedly reduced plasma IGF-I concentration. When fasted chickens were refed the protein-free diet containing either Gly alone or all essential amino acids, plasma IGF-I concentration was recovered to the level similar to that of fed chickens. Protein-free diet alone, however, failed to restore the reduced IGF-I concentration in plasma. Body weight loss modulated by feeding with protein-free diets supplemented with various single essential amino acids was associated with changes in plasma IGF-I concentrations. We concluded that body weight loss by feeding with a protein-free diet was lower than that of fasted chickens and that body weight loss associated with the decrease in plasma IGF-I concentration was modulated by feeding with protein-free diets containing various single essential amino acids.

Finite Element Analysis of Subsurface Multiple Horizontal Cracks Propagation in a Half-space Due to Sliding Contact (유한요소법을 이용한 미끄럼 접촉시 내부 복수 수평균열 전파해석)

  • 이상윤;김석삼;권영두
    • Tribology and Lubricants
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    • v.16 no.5
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    • pp.373-380
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    • 2000
  • Finite element analysis is performed on the subsurface crack propagation in brittle materials due to sliding contact. The sliding contact is simulated by a rigid asperity moving across the surface of an elastic half-surface containing single and multiple cracks. The single crack, coplanar cracks and parallel cracks are modeled to investigate the interaction effects on the crack growth in contact fatigue. The crack location is fixed and the friction coefficients between asperity and half-space are varied to analyze the effect of surface friction on stress intensity factor for horizontal cracks. The crack propagation direction is predicted based on the maximum range of shear and tensile stress intensity factors. With a coplanar crack, the stress intensity factor was increased. However, with a parallel crack, the stress intensity factor was decreased. These results indicate that the interaction of a coplanar crack increases fatigue crack propagation, whereas that of a parallel crack decreases it.

Fatigue Crack Growth Behavior of Short fiber/Particle Hybrid Metal Matrix Composites (단섬유/입자 혼합 금속복합재료의 피로균열진전 거동)

  • Oh K.H.;Jang J. H.;Han K. S.
    • Proceedings of the Korean Society For Composite Materials Conference
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    • 2004.04a
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    • pp.219-222
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    • 2004
  • The effects of short fiber and particle hybrid reinforcement on fatigue crack propagation behaviors in aluminum matrix composites have been investigated. Single and hybrid reinforced 6061 aluminum containing same 20 $Al_2O_3\;volume\%$ with four different constituent ratios of short fibers and particles were prepared by squeeze casting method and tested to check the near-threshold and stable crack growth behavior. The fatigue threshold of the composites increased with portion of particle contents and showed the improved crack resistance especially in low stress intensity range. Addition of particle instead of short fiber also increased fracture toughness due to increase of inter-reinforcement distance. These increase in both fatigue threshold and fracture toughness eventually affected the fatigue crack growth behavior such that the crack growth curve shift low to high stress intensity factor value. Overall experimental results were shown that particle reinforcement was enhanced the fatigue crack resistance over the whole stress intensity factor range.

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A New Single Nucleotide Polymorphism in the IGF-I Gene and Its Association with Growth Traits in the Nanjiang Huang Goat

  • Zhang, Chunxiang;Zhang, Wei;Luo, Hailing;Yue, Wenbin;Gao, Mingyu;Jia, Zhihai
    • Asian-Australasian Journal of Animal Sciences
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    • v.21 no.8
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    • pp.1073-1079
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    • 2008
  • The objectives of this study were to identify polymorphisms of insulin-like growth factor I (IGF-I) gene and to investigate their association with growth traits in Nanjiang Huang goats. Five hundred and ninety-two animals were used to detect the polymorphisms in the complete coding sequence, part of introns and the 5'-regulatory region of the IGF-I gene by means of PCR-SSCP. A new single nucleotide polymorphism (G to C transversion) was identified at intron 4 of the IGF-I gene in the goats. Two alleles and three genotypes were observed in this group. The frequency of G and C alleles was 54.6 and 45.4%, respectively. The statistical analysis showed that polymorphism of the IGF-I gene had a significant association (p<0.05) with birth weight (BW), body weight at 6 months (W6) and at 12 months (W12), heart girth at 2 months (G2), body length at 6 months (L6), wither height at 6 months (H6) and at 12 months (H12) and heart girth at 12 months (G12). The goats with genotype CC had significantly higher BW, W6, W12, G2, L6, H6, H12 and G12 than those with genotype GC and had significantly higher W12, H6, H12 and G12 than those with genotype GG. Therefore, genotype CC may be the most advantageous for growth traits in the Nanjiang Huang goat. However, no significant association between SNP genotypes and other growth traits was observed. These results indicated that the SNP marker of the IGF-I gene may be a potential molecular marker for growth traits in Nanjiang Huang goats.

Acoustic emission behavior during fatigue crack propagation in 304 Stainless steel (피로균열진전에 따른 304 강의 음향방출 거동)

  • Oh, Kwang-Hwan;Jung, Chang-Kyu;Yang, Yoo-Chang;Han, Kyung-Seop
    • Proceedings of the KSME Conference
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    • 2003.04a
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    • pp.213-219
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    • 2003
  • Acoustic emission behavior during fatigue crack growth test was investigated under various loading condition. To describe the acoustic emission activity, counts rate (d/dn) was related with SIFR (stress intensity factor range, K). Results indicated that SIFR could be divided into two parts according to its relationship with counts rate. For $K<25_{MPa\sqrt{m}}$, counts rate was increased as the SIFR increased. However, for values greater than $25_{MPa\sqrt{m}}$ , decreasing behavior was shown. This behavior of counts rate corresponding SIFR was keeping the same trend regardless of load range or crack length. Acoustic emission response to the single overload was sudden drop and slow recovery in counts rate like crack growth retardation. Under variable loading condition, counts rate of each loading block was same as that of constant amplitude loading. Overall experimental data was somewhat scattered since sensitive characteristics of acoustic emission method. However, these empirical relations indicated that counts rate was uniquely correlate with single parameter, SIFR.

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