• Journal of KIISE:Computer Systems and Theory
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• v.35 no.9_10
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• pp.441-451
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• 2008

Currently, the X.509 proxy certificate is widely used to delegate an entity's right to another entity in the computational grid environment. However it has two drawbacks: the potential security threat caused by intraceability of a delegation chain and the inefficiency caused by an interactive communication between the right grantor and the right grantee on the delegation protocol. To address these problems for computational grids, we propose a new delegation protocol without additional cost. We use an ID-based key generation technique to generate a proxy private key which is a means to exercise the delegated signing right. By applying the ID-based key generation technique, the proposed protocol has the delegation traceability and the non-interactive delegation property. Since the right delegation occurs massively in the computational grid environment, our protocol can contribute the security enhancement by providing the delegation traceability and the efficiency enhancement by reducing the inter-domain communication cost.

• Journal of Korea Multimedia Society
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• v.12 no.1
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• pp.1-15
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• 2009

This paper presents an assignment method of the multidimensional type inheritance indexes (MD-TIXs) to support the processing of XML queries in XML databases. MD-TIX uses a multidimensional index structure for efficiently supporting nested predicates that involve both nested element and type inheritance hierarchies. In this paper, we have analyzed the strategy of the query processing by using the MD-TIXs, and presented an assignment method of the MD-TIXs in the framework of complex queries, containing conjunctions of nested predicates, each one involving an Xpath having target types or domain types substitution. We first consider MD-TIX operations caused by updating of XML data-bases, and the use of the MD-TIXs in the case of a query containing a single nested predicate. And then, we consider the assignments of the MD-TIXs in the framework of more general queries containing nested predicates over overlapping paths that have common subpaths.

• Journal of KIISE:Software and Applications
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• v.26 no.9
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• pp.1095-1104
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• 1999

객체지향 시스템의 개발은 클래스를 통해서 이루어진다. 즉, 문제 영역에 존재하는 중요한 대상 또는 개념을 클래스로 모델링하고, 이로부터 생성된 객체들 사이의 메시지 교환을 통해서 시스템은 구축된다. 또한, 클래스는 정보 은닉을 제공함으로써, 객체지향 시스템의 재사용성과 유지보수성에 상당한 기여를 한다. 그러나, 설계 단계에서 실세계의 대상을 부적절하게 모델링하거나, 또는 유지보수 단계에서 클래스에 무분별한 변경을 가하는 경우 클래스의 품질은 악화될 수 있고, 이는 결국 시스템을 유지보수 하거나 확장하는데 상당한 장애를 초래한다.응집도는 모듈의 구성 요소들 사이의 연관성 정도를 나타내는 척도로서 전통적으로 모듈의 품질을 평가하기 위한 기준으로 사용되어 왔다. 이 논문에서는 클래스의 품질을 평가하는 방법으로서의 클래스 응집도를 제안한다. 즉, 클래스가 실세계의 대상을 적절하게 모델링한다면, 그 구성요소들 사이에 밀접한 관련이 있고 결국 높은 응집도를 가지게 될 것이다. 반대로 실세계의 대상에 대한 적절한 모델이 아니라면, 그 클래스의 구성 요소들 사이에는 밀접한 관련성이 없을 것이고 따라서 낮은 응집도를 보일 것이다.Abstract Object-oriented systems are developed by means of classes; that is, classes captures the essential entities or concepts in the problem domain, and the system is embodied by the interactions of objects instantiated from the classes. In addition to the basic units of object-oriented systems, classes serves as the units of encapsulation, which considerably promote the modifiability and the extensibility of them. However, improper modeling in the design phase or uncontrolled changes during the maintenance phase can degrade the quality of classes, which leads to systems cumbersome to maintain and extend.Cohesion refers to the degree of connectivity among the elements of a single module, and is being used as a factor which characterizes the quality of a module. In this paper, we propose a new cohesion metric for assessing the quality of classes. If a class captures properly the essential features of objects, the members of the class surely have strong relationship among them. On the contrary, the poor relationship among class members can indicate that the class is not a proper model of objects.

• Journal of Microbiology and Biotechnology
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• v.24 no.12
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• pp.1644-1653
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• 2014

Wuyiencin is produced by Streptomyces ahygroscopicus var. wuyiensis CK-15 and is widely used as an antifungal agent in agriculture. Analysis of wuyiencin biosynthetic gene clusters reveals wysR, a member of the LAL-family of transcriptional regulatory genes. WysR consists of an N-terminal PAS domain and a LuxR family C-terminal helix-turn-helix motif. However, the roles of wysR in wuyiencin biosynthesis are largely unknown. In this study, we showed that inactivation of wysR resulted in the complete loss of wuyiencin production, which could be restored by complementation with a single copy of wysR. Furthermore, we successfully increased wuyiencin production to a significantly higher level by overexpression of wysR in S. wuyiensis CK-15. Quantitative real-time RT-PCR analysis showed that WysR regulates wuyiencin biosynthesis by modulating other putative regulatory genes. Thus, WysR was identified as an activator of wuyiencin biosynthesis, and overexpression of wysR gene proved to be an effective strategy for improving wuyiencin production.

• Journal of Microbiology and Biotechnology
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• v.17 no.11
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• pp.1862-1867
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• 2007

An individual's immune response is critical for host protection from many different pathogens, and the responsiveness can be assessed by the amount of cytokine production upon stimulating bacterial components such as lipopolysaccharide (LPS). The difference between individuals in their peripheral blood mononuclear cells (PBMC) responsiveness to LPS, a Gram-negative endotoxin, was investigated from 27 healthy individuals. We observed a large variation in $IFN{\gamma}$ production among different individuals. The PBMC of the consistently three highest and three lowest $IFN{\gamma}$ producers were investigated. Since previous studies described that a single point mutation in the coding region of TLR2 and TLR4 is linked to the individual responsiveness to pathogenic bacterial infections, we first examined the known point mutations in the coding region of $TLR2^{Pro681His}$, $TLR4^{Pro714His}$ located in the cytoplasmic regions of the Toll-like domain as well as $TLR4^{Asp299Gly}$ located in the extracellular region. None of these mutations were associated with an individual's responsiveness to LPS, despite the presence of $TLR4^{Asp299Gly}$ mutation. Further investigation revealed that the variation of PBMC responsiveness to LPS among healthy individuals was due to constitutive expression levels of TLR4 and TLR2. This result is consistent with an aging-related low expression of Toll-like receptors in the mouse model of LPS responsiveness. The present study therefore suggests that the constitutive expression levels of TLR2 and TLR4 may contribute to the individual response to LPS.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.3B
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• pp.65-71
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• 2005

The primary function of the Internet routers is to forward incoming packets toward their final destinations. IP address lookup is one of the most important functions in evaluating router performance since IP address lookup should be performed in wire-speed for the hundred-millions of incoming packets per second. With CIDR, the IP prefixes of routing table have arbitrary lengths, and hence address lookup by exact match is no longer valid. As a result, when packets arrive, routers compare the destination IP addresses of input packets with all prefixes in its routing table and determine the most specific entry among matching entries, and this is called the longest prefix matching. In this paper, based on parallel multiple hashing and prefix grouping, we have proposed a hardware architecture which performs an address lookup with a single memory access.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.7B
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• pp.697-710
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• 2004

Differentiated services (DiffServ) model has been prevailed as a scalable approach to provide quality of service in the Internet. However, there are difficulties in providing the guaranteed service in terms of end-to-end systems since differentiated services network considers quality of service of aggregated traffic due to the scalability and many researches have been mainly focused on per hop behavior or a single domain behavior. Furthermore quality of service may be time varying according to the network conditions. In this paper, we study dynamic class mapping mechanism to guarantee the end-to-end quality of service for multimedia traffics with the minimum network cost over differentiated services network. The proposed algorithm consists of an effective implementation of relative differentiated service model, quality of service advertising mechanism and dynamic class mapping mechanism. Finally, the experimental results are provided to show the performance of the proposed algorithm.

• Polymer(Korea)
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• v.37 no.3
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• pp.405-410
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• 2013

The effect of styrene-ethylene/butylene-styrene (SEBS) on the blend of polyphenylene sulfide (PPS) and polyethylene terephthalate (PET) was investigated. The blends were extruded by a single screw extruder equipped with a Maddock mixing screw, and their molded properties were examined. After the binary blends were prepared on the whole compositions of PPS/PET (80/20, 60/40, 40/60, 20/80), the thermal, rheological, mechanical properties and morphology of the blends were analyzed. The results showed the significant decline in the properties of the blends owing to the incompatibility between PPS and PET phases. As a basic blend composition, the PPS/PET (40/60) blend was selected by considering cost efficiency. To this basic blend, SEBS was added as a compatibilizer. With increasing SEBS addition, the mechanical properties were improved. From the domain size reduction observed in morphology, it might be due to the enhancement of compatibility between linear PPS and PET phases by addition of SEBS.

• Composites Research
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• v.30 no.4
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• pp.247-253
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• 2017

In this study, the mechanical behavior and interface properties of boron nitride nanotube-poly(methyl methacrylate) nanocomposites are predicted using the molecular dynamics simulations and the double inclusion model. After modeling nanocomposite unit cell embedding single-walled nanotube and polymer, the stiffness matrix is determined from uniaxial tension and shear tests. Through the orientation average of the transversely isotropic stiffness matrix, the effective isotropic elastic constants of randomly dispersed microstructure of nanocomposites. Compared with the double inclusion model solution with a perfect interfacial condition, it is found that the interface between boron nitride nanotube and polymer matrix is weak in nature. To characterize the interphase surrounding the nanotube, the two step domain decomposition method incorporating a linear spring model at the interface is adopted. As a result, various combinations of the interfacial compliance and the interphase elastic constants are successfully determined from an inverse analysis.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8377-8382
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• 2016

Background: The aim of this study was to evaluate any association between a single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409, C>G) and the development and prognosis in patients with hepatocellular carcinoma (HCC). Materials and Methods: Two hundred heathy controls and 388 HCC cases were included: 211 with HBV, 98 patients with HCV, 29 with alcoholic steatohepatitis (ASH) and 52 with non-alcoholic steatohepatitis (NASH). The SNP was determined by real-time PCR based on TaqMan assays. Results: The prevalence of rs738409 genotypes CC, CG and GG in controls was 91 (45.5%), 88 (44.0%), and 21 (10.5%), respectively, while the corresponding genotypes in all patients with HCC was 158 (40.7%), 178 (45.9%), and 52 (13.4%). The GG genotype had significantly higher distribution in patients with ASH/NASH-related HCC compared with controls (OR=2.34, 95% CI=1.16-4.71, P=0.018), and viral-related HCC cases (OR=2.15, 95% CI=1.13-4.08, P=0.020). However, the frequency of the GG genotype was similar between controls and patients with viral-related HCC. At initial diagnosis, HBV-related HCC were larger and at more advanced BCLC stage than the other HCC groups. There were no significant differences between the GG and non-GG groups regarding clinical characteristics, tumor stage and overall survival. Conclusions: These data suggest an influence of the PNPLA3 polymorphism on the occurrence of HCC in patients with ASH/NASH but not among those with chronic viral hepatitis. However, the polymorphism was not associated with the prognosis of HCC.