• 약학회지
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• 제56권6호
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• pp.352-357
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• 2012

FGFR3 is a member of the fibroblast growth factor receptor family which interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Accumulated evidence suggests that aberrant regulation of FGFR3 and genetic alterations are implicated in the development and progression of various cancers. Despite a high incidence of FGFR3 over-expression, no such investigation has been performed in hepatocellular carcinoma. Thus, we investigated genetic alterations of the FGFR3 gene in 73 cases of hepatocellular carcinoma by single-strand conformational polymorphism (SSCP) and sequencing. One silent mutation (A369A) was found in the extracellular domain of FGFR3, and one genetic alteration in the immunoglobulin-like III domain of FGFR3 appeared to be polymorphism. Taken together, we concluded that over-expression of FGFR3 in hepatocellular carcinoma is not associated with genetic alterations of FGFR3 gene, and we suggest that there could be another underlying mechanism of aberrant FGFR3 expression in hepatocellular carcinoma.

• ETRI Journal
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• 제41권2호
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• pp.235-241
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• 2019

In this paper, we propose a rank-weighted reconstruction feature to improve the robustness of a feed-forward deep neural network (FFDNN)-based acoustic model. In the FFDNN-based acoustic model, an input feature is constructed by vectorizing a submatrix that is created by slicing the feature vectors of frames within a context window. In this type of feature construction, the appropriate context window size is important because it determines the amount of trivial or discriminative information, such as redundancy, or temporal context of the input features. However, we ascertained whether a single parameter is sufficiently able to control the quantity of information. Therefore, we investigated the input feature construction from the perspectives of rank and nullity, and proposed a rank-weighted reconstruction feature herein, that allows for the retention of speech information components and the reduction in trivial components. The proposed method was evaluated in the TIMIT phone recognition and Wall Street Journal (WSJ) domains. The proposed method reduced the phone error rate of the TIMIT domain from 18.4% to 18.0%, and the word error rate of the WSJ domain from 4.70% to 4.43%.

• Geosystem Engineering
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• 제21권5호
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• pp.251-261
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• 2018

With the urbanization in recent years, the power line interference noise in electromagnetic signal is increasing day by day, and has gradually become an unavoidable component of noises in magnetotelluric signal detection. Therefore, a kind of power line interference noise elimination method based on independent component analysis in wavelet domain for magnetotelluric signal is put forward in this paper. The method first uses wavelet decomposition to change single-channel signal into multi-channel signal, and then takes advantage of blind source separation principle of independent component analysis to eliminate power line interference noise. There is no need to choose the layer number of wavelet decomposition and the wavelet base of wavelet decomposition according to the observed signal. On the treatment effect, it is better than the previous power line interference removal method based on independent component analysis. Through the de-noising processing to actual magnetotelluric measuring data, it is shown that this method makes both the apparent resistivity curve near 50 Hz and the phase curve near 50 Hz become smoother and steadier than before processing, i.e., it effectively eliminates the power line interference noise.

• Current Applied Physics
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• 제18권11호
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• pp.1327-1337
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• 2018

This paper investigates the vibration behavior of pristine and defected triangular graphene sheets; which has recently attracted the attention of researchers and compare these two types in natural frequencies and sensitivity. Here, the molecular dynamics method has been employed to establish a virtual laboratory for this purpose. After measuring the different parameters obtained by the molecular dynamics approach, these data have been analyzed by using the frequency domain decomposition (FDD) method, and the dominant frequencies and mode shapes of the system have been extracted. By analyzing the vibration behaviors of pristine triangular graphene sheets in four cases (right angle of 45-90-45 configuration, right angle of 60-90-30 configuration, equilateral triangle and isosceles triangle), it has been demonstrated that the natural frequencies of these sheets are higher than the natural frequency of a square sheet, with the same number of atoms, by a minimum of 7.6% and maximum of 26.6%. Therefore, for increasing the resonance range of sensors based on 2D materials, nonrectangular structures, and especially the triangular structure, can be considered as viable candidates. Although the pristine and defective equilateral triangular sheets have the highest values of resonance, the sensitivity of defective (45,90,45) triangular sheet is more than other configurations and then, defective (45,90,45) sheet is the worst choice for sensor applications.

• 드라이브 ㆍ 컨트롤
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• 제19권1호
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• pp.26-33
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• 2022

This study dealt with a self-propelled spinach harvester, which is capable of carrying out sequential harvesting work. This study aimed to find the cause of the harvester's occasional performance deterioration, which occurs in the process of simplifying the hydraulic circuit, using a multi-domain analysis model. The study was carried out in the following manner. First, a hydraulic system analysis model, which combines linear motion, rotary motion, hydrodynamic behavior, and an electrical signal, was developed through SimulationX software, specialized in multi-domain analysis. Second, a scenario for single behavior and coupled behavior was set out on an actuator basis. Third, the flow rate of the hydraulic system, which is not required for the movement of the actuator, was quantitatively analyzed. The results showed that a change in oil temperature was the cause of the harvester's occasional performance deterioration. And the higher the oil temperature, the more serious the performance deterioration, especially as the number of actuators operated simultaneously was small.

• 한국연안방재학회지
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• 제1권4호
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• pp.149-155
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• 2014

Flexible risers have been used extensively in recent years for floating and early production systems. Such risers offer the advantage of having inherent heave compliance in their catenary thereby greatly reducing the complexity of the riser-to-rig and riser-to subsea interfaces. Another advantage with flexible risers is their greater reliability. Concerns about fatigue life, gas permeation and pigging of lines have been overcome by extensive experience with these risers in production applications. In this paper, flexible riser analysis results were compared through coupled and uncoupled dynamic analyses methods. A time domain coupled analysis capability has been developed to model the dynamic responses of an integrated floating system incorporating the interactions between vessel, moorings and risers in a marine environment. For this study, SPM (Single Point Mooring) system for an FSU in shallow water was considered. This optimization model was integrated with a time-domain global motion analysis to assess both stability and design constraints of the flexible riser system.

• 한국해양공학회지
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• 제38권2호
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• pp.53-63
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• 2024

Submerged breakwaters can be installed underneath floating structures to reduce the external wave loads acting on the structure. The objective of this study was to establish an optimization analysis framework to determine the corresponding shape and position of the submerged breakwater that can minimize or maximize the external forces acting on the floating structure. A two-dimensional frequency-domain boundary element method (FD-BEM) based on the linear potential theory was developed to perform the hydrodynamic analysis. A metaheuristic algorithm, the advanced particle swarm optimization, was newly coupled to the FD-BEM to perform the optimization analysis. The optimization analysis process was performed by calling FD-BEM for each generation, performing a numerical analysis of the design variables of each particle, and updating the design variables using the collected results. The results of the optimization analysis showed that the height of the submerged breakwater has a significant effect on the surface piercing body and that there is a specific area and position with an optimal value. In this study, the optimal values of the shape and position of a single submerged breakwater were determined and analyzed so that the external force acting on a surface piercing body was minimum or maximum.

• 한국음향학회지
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• 제29권2호
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• pp.141-147
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• 2010

본 논문은 혼합 음성 신호로부터 크기와 위상 정보를 모두 고려하여 목표 음성 신호를 추출하고 향상하는 음성 분리 알고리듬을 제안한다.기존 연구에서는 혼합된 음성 신호의 로그 전력 스펙트럼 값이 시간-주파수 영역에서 서로 독립이라고 가정한 통계적 모델을 적용하기 때문에 음성 분리 결과 파형에 불연속을 야기한다. 본 논문에서는 이러한 불연속을 감소시키기 위하여 시간-주파수 영역에서의 스무딩 필터를 적용한다. 음성 분리 성능을 더욱 향상시키기 위하여 음성 신호의 크기와 함께 위상 정보를 고려하는 통계적 모델을 제안한다. 실혐 결과, 제안된 알고리즘이 기존의 크기 정보만을 사용한 알고리즘에 비하여 1.5 dB의 화자대간섭비 (SIR)를 개선하는 것으로 나타난다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권8호
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• pp.1183-1189
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• 2017

Objective: Owing to the public availability of complete genome sequences, including avian species, massive bioinformatics analyses may be conducted for computational gene prediction and the identification of gene regulatory networks through various informatics tools. However, to evaluate the biofunctional activity of a predicted target gene, in vivo and in vitro functional genomic analyses should be a prerequisite. Methods: Due to a lack of quail genomic sequence information, we first identified the partial genomic structure and sequences of the quail SH3 domain containing ring finger 2 (SH3RF2) gene. Subsequently, SH3RF2 was knocked out using clustered regularly interspaced short palindromic repeat/Cas9 technology and single cell-derived SH3RF2 mutant sublines were established to study the biofunctional activity of SH3RF2 in quail myoblast (QM7) cells during muscle differentiation. Results: Through a T7 endonuclease I assay and genotyping analysis, we established an SH3RF2 knockout (KO) QM7#4 subline with 61 and 155 nucleotide deletion mutations in SH3RF2. After the induction of myotube differentiation, the expression profiles were analyzed and compared between regular QM7 and SH3RF2 KO QM7#4 cells by global RNA sequencing and bioinformatics analysis. Conclusion: We did not detect any statistically significant role of SH3RF2 during myotube differentiation in QM7 myoblast cells. However, additional experiments are necessary to examine the biofunctional activity of SH3RF2 in cell proliferation and muscle growth.

• 한국결정성장학회지
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• 제16권2호
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• pp.49-52
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• 2006

저손실 Ti:$LiNbO_3$ 광도파로 기판에 외부전계 인가법을 사용하여 주기적으로 도메인을 반전시켰다. $LiNbO_3$의 -Z 면에 Ti 패턴 형성 후 약 $1060^{\circ}C$에서 열처리 과정을 통해 광도파로를 형성하였으며, 제작된 광도파로의 광전송 손실은 ${\sim}0.1dB/cm$ 였다. 도메인 반전을 위해 +Z면에 주기적인 전극 패턴을 형성하였으며, 외부전계의 균일한 인가를 위해 LiCl 전해 용액을 사용하여 도메인을 반전 시켰다. 선택적 화학식각을 통해, 약 $16{\mu}m$의 도메인 반전 주기를 확인 할 수 있었으며, 주기적 도메인 반전구조를 갖는 Ti : $LiNbO_3$ 도파로의 비선형 특성을 측정하였다.