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A Study on the Reliability and Factor analysis of Pattern Identification for Tic Disorders in children (틱(Tic) 장애의 한의변증유형 설문지에 대한 신뢰도 및 요인분석 연구)

  • Wei, Young-Man;Lee, Go-Eun;Jung, Song-Hwa;Lee, Hee-Kyung;Lyu, Yeoung-Su;Kang, Hyung-Won
    • Journal of Oriental Neuropsychiatry
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    • v.23 no.1
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    • pp.59-82
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    • 2012
  • Objectives : We purposed to objectify the pattern diagnosis of Tic disorders through factor and reliability analysis regarding a pattern identification questionnaire concerning Tic disorders in children. Methods : We chose and studied 144 children who were pattern-diagnosed out of 200 tic disordered children who visited H hospital in Seoul from January 2006 to April 2011. Results : 1. TTD (50%) was the most common type and the occurrence rate in male children was higher(4.76:1). Also, the rate of hospital visits was highest at the age 8(23.6%). 2. In results concering pattern diagnosis, Gan-poong-nae-dong was most frequently diagnosed in 53 patients (36.8%), and Dam-hwa-yo-sin (42 patients), Gan-sin-um-her (30 patients), and Bee-her-gan-wang (6 patients). 3. In an attempt to verify the reliability of the questionnaire, the coefficient regarding the whole questions (Cronbach ${\alpha}$) came to 0.909. Moreover, the reliability coefficient foreach sub factor was 0.687 in Ganpoong-nae-dong, 0.817 in Dam-hwa-yo-sin, 0.851 in Bee-her-gan-wang, and 0.726 in Gan-sin-um-her, respectively. Thus, their consistency was ensured. 4. In exploratory factor analysis concerning the most common five questions in the questionnaire, the questions of Dam-hwa-yo-sin and Gan-poong-nae-dong appeared to be part of different factors. While, Gan-sin-um-her and Bee-her-gan-wang questions showed that they belong to the same factors. 5. In factor analysis excluding both Gan-sin-um-her and Bee-her-gan-wang questions, both showed significant results; however, the one excluding Gan-sin-um-her showed improved results. Conclusions : From the above results concerning the Pattern Identification Questionnaire for Tic Disordered children, three separated patterns of Bee-her-gan-wang, Dam-hwa-yo-sin, Gan-poong-nae-dong are thought to be available for clinical use. However, further validity studies are needed.

Cloning and Characterization of Soybean IFS (Isoflavone Synthase) Genes from Korean Cultivar, Sinpaldalkong (신팔달콩 유래 IFS (isoflavone synthase)유전자 클로닝 및 기능 규명)

  • Park, Hayng-Mi;Shin, Sang-Hyun;Ko, Jong-Min;Yi, Gi-Hwan;Nam, Min-Hee;Chung, Young-Soo;Chung, Won-Bok;Lee, Jai-Heon;Park, Seong-Whan
    • Journal of Life Science
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    • v.14 no.1
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    • pp.38-44
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    • 2004
  • Two genes, SinIFS1 and SinIFS2 from Korean soybean cultivar, Sinpaldalkong known as one of isoflavonerich cultivars, were cloned with PCR and degenerate primers. The sequences of two genes were analyzed with previously reported IFS genes of leguminous plants and their expression pattern in various environmental conditions was surveyed. The genomic clone of SinIFS1 contained 1,828bp nucleotides and encoded a polypeptide of 521 amino acids, and 1912bp nucleotides and a polypeptide of 521 amino acids for SinIFS2. Both genes included several conserved motifs, oxygen binding and activation (A/G-G-X-E/D-T-T/S), ERR triad (E...R....R), and heme binding (F-X-X-G-X-R-X-C-X-G) domain, which are typical in any member of cytochrome P45O superfamily. Very high sequence homology (>98%) was observed in the comparison with other IFSs of legumes. In the northern blot analysis to check the expression and increase of SinIFS1 to various environmental renditions (low temperature, light, dark, UV, and fungal elicitor), the most significant induction, more than 6 times of transcript level compared to the dark treatment as a control, was observed from the fungal elicitor treatment. The next up-regulated expression was from UV treatment (4${\times}$), low temperature and light conditions.

The Effect of NO Donor on Contraction, Cytosolic $Ca^{2+}$ Level and Ionic Currents in Guinea-pig Ileal Smooth Muscle

  • Kwon, Seong-Chun;Park, Ki-Young;Ahn, Duck-Sun;Lee, Young-Ho;Kang, Bok-Soon
    • The Korean Journal of Physiology and Pharmacology
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    • v.4 no.1
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    • pp.33-40
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    • 2000
  • This study was designed to clarify the mechanism of the inhibitory action of a nitric oxide (NO) donor, 3-morpholino-sydnonimine (SIN-1), on contraction, cytosolic $Ca^{2+}$ level $([Ca^{2+}]_i)$ and ionic currents in guinea-pig ileum. SIN-1 $(0.01{\sim}100\;{\mu}M)$ inhibited 25 mM KCl- or histamine $(10\;{\mu}M)-induced$ contraction in a concentration-dependent manner. SIN-1 reduced both the 25 mM KCl- and the histamine-stimulated increases in muscle tension in parallel with decreased $[Ca^{2+}]_i.$ Using the patch clamp technique with a holding potential of -60 mV, SIN-1 $(10\;{\mu}M)$ decreased peak Ba currents $(I_{Ba})$ by $30.9{\pm}5.4%$ (n=6) when voltage was stepped from -60 mV to +10 mV and this effect was blocked by ODQ $(1\;{\mu}M),$ a soluble guanylyl cyclase inhibitor. Cu/Zn SOD (100 U/ml), the free radical scavenger, had little effect on basal $I_{Ba},$ and SIN-1 $(10\;{\mu}M)$ inhibited peak $I_{Ba}$ by $32.4{\pm}5.8%$ (n=5) in the presence of Cu/Zn SOD. In a cell clamped at a holding-potential of -40 mV, application of $10\;{\mu}M$ histamine induced an inward current. The histamine-induced inward current was markedly and reversibly inhibited by $10\;{\mu}M$ SIN-1, and this effect was abolished by ODQ $(1\;{\mu}M).$ In addition, SIN-1 markedly increased the depolarization-activated outward $K^+$ currents in the all potential ranges. We concluded that SIN-1 inhibits smooth muscle contraction mainly by decreasing $[Ca^{2+}]_i$ resulted from the inhibition of L-type $Ca^{2+}$ channels and the inhibition of nonselective cation currents and/or by the activation of $K^+$ currents via a cGMP-dependent pathway.

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Pharmacognostical Studies on a Folk Medicine "SinKyungCho" (민간약 신경초의 생약학적 연구)

  • Bae, Ji-Yeong;Goo, Young-Min;Park, Jong Hee;Ahn, Mi-Jeong
    • Korean Journal of Pharmacognosy
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    • v.44 no.4
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    • pp.326-331
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    • 2013
  • A Korean folk medicine, "SinKyungCho" has been used to cure common cold and rheumatis. While this crude drug has similar morphological feature to that of Rubia species, the botanical origin has never been studied pharmacognostically. Therefore, in order to clarify the botanical origin of "SinKyungCho", the morphological and anatomical characteristics of Rubia species growing in Korea, i.e. R. akane, R. chinensis var. glabrescens, R. cordifolia var. pratensis, R. cordifolia var. sylvatica were studied. Especially, differing from the other three species, R. cordifolia var. pratensis has 2-4 cork cell layers under the endodermal cell layer. R. cordifolia var. sylvatica showed the largest number of parenchyma cell layers in cortex by 8-17. While the average ratio of stele to root transverse section is over 45% for R. akane and R. cordifolia var. pratensis, the ratio is under 45% for R. chinensis var. glabrescens and R. cordifolia var. sylvatica. According to these morphological criteria, the folk medicine "SinKyungCho" from Korean traditional market was proved to be the underground part of R. akane.

The Toughness of Polyurethane and Epoxy Resins IPNs (폴리우레탄-에폭시 IPNs의 강인성)

  • Kim, Jong Seok;Hong, Suk Pyo
    • Applied Chemistry for Engineering
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    • v.9 no.3
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    • pp.445-450
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    • 1998
  • Interpenetrating polymer networks(IPNs) were prepared from castor oil-type polyurethanes(PUs) and epoxy resin. Two types of PU were prepared by using polypropylene ether glycol(PPG) as a chain extending agent and caster oil(CO) as a crosslinking agent. COPU/epoxy simultaneous interpenetrating polymer networks(SINs) based on CO had a better compatibility over the all composition than PPGPU/epoxy SINs based on PPG. The flexural strength of all PPGPU/epoxy SINs was decreased with decreasing entanglement of networks. COPU/epoxy SINs showed the higher fracture toughness and mechanial properties than the PPGPU/epoxy SINs. Fracture surfaces of all of the SINs showed the localized shear deformation and crack deflection rather than generation of stress whitening associated with the cavitation.

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New Serial and Parallel Sin+Cos PSS1A PSS Design and Analysis

  • Lee Sang-Seung;Li Shan-Ying;Jang Gwang-Soo;Park Jong-Keun;Moon Seung-Il;Yoon Yong-Tae
    • KIEE International Transactions on Power Engineering
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    • v.5A no.4
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    • pp.378-384
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    • 2005
  • This paper proposes a new series and parallel Sin+Cos PSS (power system stabilizer) for the purpose of improving the existing PSS1A's performance. The purpose of the PSS is to enhance the damping of power system oscillations through injection of auxiliary signals for an excitation control terminal. The proposed series and parallel Sin+Cos PSS is connected adding the Sin+Cos terms additionally with the serial and parallel connection in a conventional PSS1A. The proposed controller is aimed at considering the damping of oscillation when it changes parameter fluctuations or operational load variations in a power system. The electric power system used is the KEPCO system and the voltage of the power transmission line is 154kV and 345kV. The PSCAD/EMTDC package is used to authorize the effect of the proposed controller. Simulations were shown by and compared with the waveforms for frequency, voltage and electric power.

Environmental Changes of the Rivers in Taegu Area after a Heavy Rain (대구지방 하천의 집중 강우후의 수계환경의 변화)

  • Lyu, Seung-Won;Song, Seung-Dal
    • The Korean Journal of Ecology
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    • v.6 no.2
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    • pp.81-89
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    • 1983
  • The change of environmental factors with flow rates were studied quantitatively for two rivers, the Nakdong River and the Sin stream, which have different basins in ecosystem structures, during short period after a heavy rain. In the Nakdong River, transparency, DO, alkalinity and hardness were negatively correlated with the flow rate by logarithmic function, but the concentration of SiO2 was relatively constant regardless of the flow chage. In the Sin stream, transparency, alkalinity, hardness and the concentration of NH3-N, NO2-N and SO4= showed negative correlation with the flow rate by logarithmic function. The ratios of maximum to minimum values for aquatic environmental factors during the samller than that for flow rate in the respective rivers (28 in the Nakdong R.; 50 in the Sin S.). Immediately after the heavy rain, the concentrations of NO2-N, NH3-N and PO4-P in the Sin stream were 8, 6 and 1 times as high as those in the Nakdong River, respectively, but in the stable flow state, those became 94, 25 and more than 10 times, respectively. The load for most of the dissolved environmental constituents changed similarly to the flow rate in both rivers. It is notable that, at the stable flow state, the loads for NH3-N (59g/sec) and NO2-N (3.3g/sec) in the Sin stream were 4.3 and 1.3 times as high as those in the Nakdong River.

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