• 한국컴퓨터정보학회논문지
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• 제19권12호
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• pp.219-225
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• 2014

Gompertz modeling은 고령화 사회에 접어들기 시작하며 노령인구 예측에 성공적인 결과를 보여줌으로써 최근 많은 주목을 받고 있다. 또한 항암 치료제의 독성으로 인해 발생할 수 있는 부작용을 미연에 방지하고자 보다 효과적인 치료제의 사용에 관한 의료 생체분야에서 활발한 개발이 시도되어 왔으나 전임상 및 임상실험으로의 응용이 가능한 모델링은 극히 제한적이며, 모델링의 검증을 위한 생체실험의 분석 시스템의 최적화가 힘들다는 한계가 있다. 본 논문에서는 Gompertz modeling을 응용하여 새로운 겸형적혈구의 약물유출 예측시스템을 개발하고, 여기된 광증감제의 겸형적혈구 부착을 통해 효과적인 약물유출 제어방법을 ex-vivo 실험을 통해 검증하여 최적화된 예측 시스템의 결과를 비교 분석 할 수 있었다. 따라서 이와 같이 최적화된 Gompertz modeling을 이용한 새로운 약물전달 시스템이 항암치료에 반영된다면 부작용에 기인한 환자들의 신체적 고통과 치료를 위한 경제적 부담을 경감시키는 효과를 유도하며, 나아가 항암 치료제의 정확한 전달률을 증가시켜 보다 효과적인 항암치료를 기대할 수 있다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.168.1-168.1
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• 2014

We developed poly (3,4-ethylene dioxylene thiophene):poly (styrene sulfonic acid) (PEDOT:PSS)-free organic solar cells (OSCs) using buffer and anode combined Ta doped $In_2O_3$ (ITaO) electrodes. To optimize the ITaO electrodes, we investigated the effect of $Ta_2O_5$ doping power on the electrical, optical, and structural properties of the co-sputtered ITaO films. The optimized ITaO film doped with 20 W $Ta_2O_5$ radio frequency power showed sheet resistance of 17.11 Ohm/square, a transmittance of 93.45%, and a work function of 4.9 eV, all of which are comparable to the value of conventional ITO electrodes. The conventional bulk heterojunction OSC with ITaO anode showed a power conversion efficiency (PCE) of 3.348% similar to the OSCs (3.541%) with an ITO anode. In addition, OSCs fabricated on an ITaO electrode successfully operated without an acidic PEDOT:PSS buffer layer and showed a PCE of 2.634%, which was much higher than the comparable no buffer OSC with an ITO anode. Therefore, co-sputtered ITaO electrodes simultaneously acting as a buffer and an anode layer can be considered promising transparent electrodes for cost-efficient and reliable OSCs because they can eliminate the use of an acidic PEDOT:PSS buffer layer.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2002년도 생물공학의 동향 (X)
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• pp.381-384
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• 2002

Response surface methodology (RSM) was successfully applied to optimize for the production of Ganoderma lucidum in batch fermentations using the whey (40,000 mg latose/L) as substrate. This study was performed according to the central composite design (CCD) with respect to pH and temperature, where the designed intervals were 3.3$22.9^{\circ}C$$37.1^{\circ}C$, respectively. A second-order factorial design of the experiments was used to build empirical models providing a quantitative interpretation of the relationships between the two variables. The optimum conditions to maximize the production of G. lucidum were pH 4.2 and $28.3^{\circ}C$. At optimum conditions, the mycelial dry weight (MDW) and residual soluble COD (SCOD) were simultaneously used to evaluate the biokinetic coefficients assocoated with substrate inhibition model by nonlinear least squares method with 95% confidence interval. The. maximum microbial growth rates (${\mu}m$), half saturation coefficient ($K_s$), and the inhibition substrate concentration ($K_{is}$) were determined to be 0.095 l/hr, 128,000 mg SCOD/L and 49,000 mg SCOD/L, respectively. And the microbial yield coefficient (Y), biomass decay rate coefficient ($K_d$), and the maintenance energy coefficient ($m_s$) were determined to be 0.37 mg MDW/mg SCOD, 0.001 1/hr, and 0.0015 1/hr, respectively.

• 한국산학기술학회논문지
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• 제17권2호
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• pp.1-7
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• 2016

차축 감속기와 차륜으로 구성된 고속철도차량 2차 구동장치는 일체형 조립체이지만, 상이한 기술사양으로 인하여 이들의 예방정비 주기는 서로 다르다. 특히, 이들은 완전분해 정비주기에 따라 매번 동시에 탈부착 작업을 수행한다. 따라서 불필요한 완전분해 정비를 감소하고 높은 열차 가용도를 유지하기 위해서는 신뢰성 중심 유지보수 관점에서 예방정비 비용의 최적화가 중요하다. 본 연구에서는 실제 정비이력으로부터 두 구성품들에 대한 결함나무 분석을 수행하고, 각 하부부품들의 치명도를 고려한 수정된 신뢰도를 각각 평가하였다. 두 구성품에 대한 예방 정비비용의 최적화는 기준 신뢰도 및 개선율을 고려한 유전자 알고리즘으로부터 구하였다. 비용의 최적화는 개체의 적합도 함수에 대한 최대값으로부터 얻는다. 유전자 알고리즘에 의한 최적의 완전분해 정비주기는 285만km로서, 기존 방법의 총비용과 비교하여 약 21% 감소하였다.

• 융합신호처리학회논문지
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• 제4권1호
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• pp.41-48
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• 2003

본 논문에서는 DGS(Defected Ground Structure)에 대한 새로운 등가 회로를 제안하였으며, 이를 IMT-2000용 AB급 대전력 증폭기 설계에 적용하여 증폭기의 성능을 향상시켰다. 새로운 DGS 등가 회로는 병렬의 LC 공진기와 병렬 형태의 캐패시턴스로 구성되어 금속 접지면에 에칭된 결함으로 인한 프린징(fringing) 효과를 반영하도록 하였으며, 전력 증폭기 출 단 정합 회로를 최적화하기 위하여 사용되었다. 이전의 논문에서도 하모닉 성분의 억제와 증폭기의 효율 개선을 위하여 DGS를 사용하였으나 DGS 등가 회로의 해석은 없었으며(1), 본 논문에서는 이를 개선하여 회로 시뮬레이션을 통한 정한 DGS의 등가 회로를 AB급 증폭기의 출력 단 정합회로에 적용함으로써 성능 향상과 함께 증폭기 제작 후에 튜닝이 거의 필요없는 정확한 설계 방법을 제시하였다. 이와 같이 제안된 전력 증폭기의 설계 방법은 정확한 설계 결과를 제공함으로써 최적 부하 조건과 하모닉 성분의 제거 성능을 동시에 만족시킬 수 있었다. 제안된 방법의 효과를 입증하기 위하여 DGS를 적용한 기존의 방법과 새로이 제안된 방법을 사용하여 20W급의 전력 증폭기를 설계 및 제작하였으며, 그 측정 결과를 비교하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권12호
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• pp.5375-5400
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• 2016

IOMMU is a hardware unit that is indispensable for DMA. Besides address translation and remapping, it also provides I/O virtual address space isolation among devices and memory access control on DMA transactions. However, currently commodity virtualization platforms lack of IOMMU virtualization, so that the virtual machines are vulnerable to DMA security threats. Previous works focus only on DMA security problem of directly assigned devices. Moreover, these solutions either introduce significant overhead or require modifications on the guest OS to optimize performance, and none can achieve high I/O efficiency and good compatibility with the guest OS simultaneously, which are both necessary for production environments. However, for simulated virtual devices the DMA security problem also exists, and previous works cannot solve this problem. The reason behind that is IOMMU circuits on the host do not work for this kind of devices as DMA operations of which are simulated by memory copy of CPU. Motivated by the above observations, we propose an IOMMU para-virtualization solution called PVIOMMU, which provides general functionalities especially DMA security guarantees for both directly assigned devices and simulated devices. The prototype of PVIOMMU is implemented in Qemu/KVM based on the virtio framework and can be dynamically loaded into guest kernel as a module, As a result, modifying and rebuilding guest kernel are not required. In addition, the device model of Qemu is revised to implement DMA access control by separating the device simulator from the address space of the guest virtual machine. Experimental evaluations on three kinds of network devices including Intel I210 (1Gbps), simulated E1000 (1Gbps) and IB ConnectX-3 (40Gbps) show that, PVIOMMU introduces little overhead on DMA transactions, and in general the network I/O performance is close to that in the native KVM implementation without IOMMU virtualization.

• Journal of Communications and Networks
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• 제14권6호
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• pp.662-671
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• 2012

Plug-in hybrid electric vehicles (PHEVs) will be widely used in future transportation systems to reduce oil fuel consumption. Therefore, the electrical energy demand will be increased due to the charging of a large number of vehicles. Without intelligent control strategies, the charging process can easily overload the electricity grid at peak hours. In this paper, we consider a smart charging and discharging process for multiple PHEVs in a building's garage to optimize the energy consumption profile of the building. We formulate a centralized optimization problem in which the building controller or planner aims to minimize the square Euclidean distance between the instantaneous energy demand and the average demand of the building by controlling the charging and discharging schedules of PHEVs (or 'users'). The PHEVs' batteries will be charged during low-demand periods and discharged during high-demand periods in order to reduce the peak load of the building. In a decentralized system, we design an energy cost-sharing model and apply a non-cooperative approach to formulate an energy charging and discharging scheduling game, in which the players are the users, their strategies are the battery charging and discharging schedules, and the utility function of each user is defined as the negative total energy payment to the building. Based on the game theory setup, we also propose a distributed algorithm in which each PHEV independently selects its best strategy to maximize the utility function. The PHEVs update the building planner with their energy charging and discharging schedules. We also show that the PHEV owners will have an incentive to participate in the energy charging and discharging game. Simulation results verify that the proposed distributed algorithm will minimize the peak load and the total energy cost simultaneously.

• Archives of Plastic Surgery
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• 제47권2호
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• pp.194-197
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• 2020

Anterior neck burns represent a major reconstructive challenge due to severe sequalae including restriction in movement and poor aesthetic outcomes. Common treatment options include skin grafting with/without dermal matrices, and loco-regional and distant free flap transfers with/without prior tissue expansion. Such variation in technique is largely influenced by the extent of burn injury requiring resurfacing. In order to optimize like-for-like reconstruction of the anterior neck, use of wide, thin and long flaps such as the anterolateral thigh (ALT) perforator flap have been reported with promising results. Of note, some patients have a tendency towards severe scar contractures, which may be contributed by the greater extent of inflammation during wound healing. We report our experience at 4 years' followup after secondary reconstruction of severe, anterior neck burn contractures in two patients by harvesting the ALT flap with a butterfly design. This technique provides adequate wound resurfacing of the burned neck and surrounding areas, and provides good neck extensibility by addressing both anterior and lateral aspects of the scar defect simultaneously. Such a flap design reduces tension on wound edges and thus, the risk of contracture recurrence in what remains a particularly challenging type of burn reconstruction.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2008년도 하계학술발표대회 논문집
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• pp.288-293
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• 2008

The cooling load in winter is significant in many commercial buildings and hotels because of the usage of office equipments and the high efficiency of wall insulation. The development of a multi-heat pump that can cover heating and cooling simultaneously for each indoor unit is required. In this study, the performance of a multi-heat pump with 3-piping system was investigated as a function of refrigerant charge and its performance was analyzed in cooling mode, heating mode, and heat recovery mode. COP in the heating or cooling mode showed little dependence on refrigerant charge at overcharge conditions, while those were strongly dependent on refrigerant charge at undercharge conditions and outdoor inlet temperature. In the heat recovery mode, the performance of the system was very sensitive to charge amount at all conditions. Optimum charge amount in the heat recovery mode was 14% lower than that in the cooling mode at the standard condition because the refrigerant only passed the indoor units. It is required to store the excessive refrigerant charge in a storage tank to optimize the system performance at operating modes.

• Bulletin of the Korean Chemical Society
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• 제34권4호
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• pp.1232-1236
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• 2013

The Cu cation binding sites of $[Cu(I){\cdot}d(CpG){\cdot}d(CpG)-2H]^{-1}$ complex have been investigated to explain the $[Cu{\cdot}DNA]$ biological activity caused by the Cu association to DNA. The structure of $[Cu(I){\cdot}d(CpG){\cdot}d(CpG)-2H]^{-1}$ complex was investigated by electrospray ionization mass spectrometry (ESI-MS). The fragmentation patterns of $[Cu(I){\cdot}d(CpG){\cdot}d(CpG)-2H]^{-1}$ complex were analyzed by MS/MS spectra. In the MS/MS spectra of $[Cu(I){\cdot}d(CpG){\cdot}d(CpG)-2H]^{-1}$ complex, three fragment ions were observed with the loss of d(CpG), {d(CpG) + Cyt}, and {d(CpG) + Cyt + dR}. The Cu cation binds to d(CpG) mainly by substituting the $H^+$ of phosphate group. Simultaneously, the Cu cation prefers to bind to a guanine base rather than a cytosine base. Five possible geometries were considered in the attempt to optimize the $[Cu(I){\cdot}d(CpG){\cdot}d(CpG)-2H]^{-1}$ complex structure. The ab initio calculations were performed at B3LYP/6-31G(d) level.