• Korean Journal of Acupuncture
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• v.30 no.4
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• pp.298-304
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• 2013

Objectives : We examined mutual inhibitory effects of combined acupoints in arthritic pain induce by carrageenan(CA). Electroacupuncture(EA) is considered a potentially useful treatment for arthritis. Although the analgesic effect of acupuncture is well documented, little is understood about its biological basis. There are many previous studies of positive effect of combined acupoint, this study was conducted to see the mutual inhibitory effects produced by combined acupoint(ST36 and PC7) on arthritic rats. Methods : For the induction of inflammatory pain rat model, CA was injected into the knee joint cavity. There are four groups; EA was applied to bilateral PC7 acupoints(PC7 group), ST36 acupoints(ST36 group), and both PC7 and ST36 acupoints(ST36+PC7 group) except for the control group. The pain level were assessed to determine the change in weight bearing force. We also examined the COX-2 expression in dorsal horn using immunohistochemistry and western blot analysis. Results : The ST36+PC7 group data showed the significant reduction of weight bearing force and the induction of COX-2 protein expression compared with the ST36 group. Conclusions : Simultaneous EA applied to the ST36 and PC7 acupoints reduced the analgesic effect of the ST36 group on knee inflammatory pain.

• Journal of Life Science
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• v.19 no.10
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• pp.1360-1367
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• 2009

Liver fibrosis is a process of healing and scarring in response to chronic liver injury. Following injury, an acute inflammation response takes place resulting in moderate cell necrosis and extracellular matrix damage. To develop a novel therapeutic approach in hepatic fibrogenesis, we examined the simultaneous suppression of the transcription factors NF-$\kappa$B and Sp1, which regulate acute inflammation and continuous deposition of extracellular matrix in liver fibrosis. We employed chimeric decoy oligodeoxynucleotide containing the consensus sequences of both NF-$\kappa$B and Sp1 binding sites, to suppress these transcription factors simultaneously. Treatment of chimeric decoy oligodeoxynucleotide reduced the activity of hepatic stellate cells in vitro, and decreased the expression of fibrotic and proinflammatory gene responses in a mouse model of liver fibrosis. These results suggest that chimeric decoy oligodeoxynucleotide strategy can be a potential therapeutic application to prevent liver fibrosis.

• Journal of Information Technology and Architecture
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• v.9 no.2
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• pp.177-186
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• 2012

Navy establishes the Naval Task Forces (TF) for many kinds of maritime operations. Then the TF in the maritime environment performs simultaneous component operations such as ASUW (Anti-Surface Warfare), ASW (Anti-Submarine Warfare), AAW (Anti-Aircraft Warfare), and assault operations. The TF consists of many tactical systems for the completion of missions C4I, VOIP (Voice Over Internet Protocol), DMHS (Digital Massage Handling System), and TDLs (Tactical Data Links) such as LINK-11, 16, ISDL (Inter Site Data Link). When the TF executes naval operations to complete a mission, we are interested in the kill chain for the maritime operations in the TF. The kill chain is a standard procedure for the naval operations to crush enemy defenses. Although each ship has a procedure about a manual for 'how to fight', it leave something to be desired for the TF detailed kill chain currently. Therefore, in this paper, we propose the naval TF's kill chain to perform the naval operations. Then, the operational effectiveness of the TF in the kill chain environment is determined through operation scenarios of TDL system implementation. It is to see the operational information sharing effect to a data link model based on MND-AF OV 6c (statement of tracking operational status) in the maritime operations applied to TDL and is to identify improvements in information dissemination process. We made the kill chain of maritime TF for the effective naval operations.

• The Korea Journal of Herbology
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• v.30 no.1
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• pp.33-42
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• 2015

Objectives : The aim of this study was to evaluate the antitumor effects of Cheongpyesagan-tang(CST) and YKK012 on colon cancer. Methods : MTT assay was used to evaluate the cytotoxicity of Single herbs and combinations of CST and YKK012 on murine colon cancer cells, Colon 38. To explain effects of apoptosis in colon cancer, we performed the western blot. Effects of CST and YKK012 on antitumor activity of CPT-11 using the murine colon38 allograft tumor in BDF1 mice. Results : Single herbs and combinations of CST and YKK012 was tested in vitro, Rhei Radix (RH) and Scutellariae Radix (SC) and YKK012 showed dose-response cytotoxicity on Colon 38. This might be due to the apoptosis, as we see Bax and Caspase-3, which are apoptotic factors, was expressed in RH and SC treated cells. YKK012 also showed increased expression of Caspase-3. In mouse colorectal cancer xenograft model of colon38 cells, herbal combinations showed tendencies of tumor regression, but was not significant. Furthermore, because toxicity was observed in CST group, we reduced the dose of CST for the next experiment. The anti-tumor effects of herbal combinations were insufficient to be used as single anti-tumor agent. With simultaneous usage of CPT-11, contrary to that CST showed no synergistic effects, YKK012 which was composed by the combination of four $ER{\beta}$ selective herbs, significantly reduced the size of tumor and Bax expression was increased. Conclusions : We suggest YKK012 can be a effective cancer adjuvant therapy with CPT-11 on colon cancer.

• Management & Information Systems Review
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• v.32 no.3
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• pp.107-125
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• 2013

This study deals with a strategic decision making in two level supply chain network design. This study presents more realistic mathematical model than the previous studies by considering simultaneous location of plants and distribution centers, determination of capacity level for both plants and distribution centers, and upper limit condition for numbers of locating plants and distribution centers. This paper tries to help the strategic decision making for two level supply chain network design. For this purpose, three different sized numerical examples are generated and optimal solutions are obtained by applying Excel Solver program. And sensitivity analysis is performed for the biggest sized example problem, which has 10 potential plants, 20 potential distribution centers, and 200 customer zones. After the plants being located are fixed, optimal minimum costs are obtained and compared for each of 7 different numbers of distribution centers to be located. As the number of distribution centers increases, changes in inbound transportation cost and outbound transportation cost can be derived. In case of considering cost as well as customer satisfaction level for two level supply chain network design, the analysis of this changes may help more sophisticated decision making.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.1
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• pp.35-42
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• 2020

Electromechanical Actuator(EMA) for flight vehicles generally serves to control the fin deflection angle or the thrust vector angle. This paper deals with design and development of EMA for both aerodynamic control and thrust vector control. In this paper, a novel compact EMA is proposed that can simultaneously control both the tail fin and the jet vane with one actuator and detach the jet vane after vertical launch and rapid turn of the flight vehicle so as to increase efficiency during flying to target. To do this, we designed the EMA using a push-push link mechanism and derived a mathematical model. The mathematical model is validated by comparing simulation result and experimental data. The performance and reliability of the proposed EMA have been verified through performance test, environmental test and ground test. The proposed EMA is expected to be useful as an EMA for flight vehicles because of its simple and compact structure, as well as its performance and reliability.

• Journal of Korean Society of Transportation
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• v.24 no.5 s.91
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• pp.109-121
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• 2006

The road should be designed in the consistent alignment which the driver can drive safely. Also, proper highway environments in order to maintain optimal operational speeds on highway sections should be provided In design stage, for highway environments, it is essential for an operational speed estimation model to different highway environments. If a method which could evaluate the status of the road safety is developed through this operational speed estimation model, it is possible to provide safe and more comfortable highways to road users. In the study factors to effect on operational speeds are classified into three groups horizontal & vertical alignments and traffic operation characteristic factors. Factors are chosen to effect on operational speeds by using collation analysis as classifications of tangent sections, horizontal curve sections and vertical curve sections. In order to develop operational speed estimation models in express highways, multi-regression analysis has been used in this study using the selected factors. This study has meaning that the developed estimation models for operational speeds and evaluation of degree of safety to horizontal and vortical alignments simultaneous. In order to represent whole area of the country with the developed models, the models should be re-analyzed with vast data related with road alignment factors in the near future.

• Journal of Korean Society of Transportation
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• v.23 no.2
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• pp.143-150
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• 2005

Estimation of trip distribution, estimated O-D matrix must satisfy the condition that the sum of trips in a row should equal the trip production, and the sum of trips in a column should equal the trip attraction. In most cases the iterative calculation for convergence is needed to satisfy this condition. Most of all present convergence of iterative methods may results a big difference between estimated value and converged value, and from this, the trip distribution patterns may be changed. This paper presents a new convergence of iterative method that comes closer to meeting the convergence condition and gives the maximum likelihood estimation for calculating a distribution patterns from the trip distribution estimation model. The newly developed method differs from existing methods in three important ways. First, it simultaneously considers both the convergence condition and the distribution patterns. Second, it computers simultaneous convergence of rows and columns instead of iterating respectively. Third, instead of using the growth rates to the trip production, trip attraction, it uses the differences between trip production and sum of trips in a row, and trip attraction and sum of trips in a column. Using 38 by 38 O-D matrix, this paper compared the Fratar method and the Furness method to the newly developed method and found that this method was superior to the other two methods.

• Phonetics and Speech Sciences
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• v.13 no.1
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• pp.53-64
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• 2021

According to Demand and Capacity Model (DCM), external and internal environments influence the disfluency of children who stutter (CWS). This study investigated the effects of simultaneous changes in motoric and linguistic demands on CWS and children who do not stutter (CWNS). Participants were 4-6 years old CWS and CWNS. A sentence imitation task with changes in speech rate, utterance length, and sentence complexity was used to examine their effects on children's disfluency. When the utterance length changed, CWS showed more disfluency regardless of utterance length and as the speech rate changed, CWS showed more disfluency at fast speech rate than CWNS. When the utterance length and speech rate changed, at fast speech rate, CWS showed more disfluency in both utterances than CWNS. When sentence complexity changed, CWS showed more disfluency than CWNS in complex sentences. Changes in linguistic elements such as speech rate, utterance length, and sentence complexity affect disfluency in CWS, especially when they were exposed to faster, longer, and more complex sentences. This indicates that CWS are vulnerable to fast and complex speech motor control and language processing ability than CWNS. Thus, this study suggests that parents and therapists consider both the speech rate and the utterance length when talking with CWS.

• Natural Product Sciences
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• v.27 no.2
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• pp.86-98
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• 2021

This study was designed to characterize the effect of ginsenoside-Rg2 (Rg2), one of panaxatriol saponins isolated from Korean ginseng root, on the release of catecholamines (CA) in the perfused model of the rat adrenal medulla, and also to establish its mechanism of action. Rg2 (3~30 µM), administered into an adrenal vein for 90 min, depressed acetylcholine (ACh)-induced CA secretion in a dose- and time-dependent manner. Rg2 also time-dependently inhibited the CA secretion induced by 3-(m-chloro-phenyl-carbamoyl-oxy)-2-butynyltrimethyl ammonium chloride (McN-A-343), 1.1-dimethyl-4-phenyl piperazinium iodide (DMPP), and angiotensin II (Ang II). Also, during perfusion of Rg2, the CA secretion induced by high K⁺, veratridine, cyclopiazonic acid, methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoro-methyl-phenyl)-pyridine-5-carboxylate (Bay-K-8644) depressed, respectively. In the simultaneous presence of Rg2 and N^ω-nitro-L-arginine methyl ester hydrochloride ʟ-NAME), the CA secretion induced by ACh, Ang II, Bay-K-8644 and veratridine was restored nearly to the extent of their corresponding control level, respectively, compared to those of inhibitory effects of Rg2-treatment alone. Virtually, NO release in adrenal medulla following perfusion of Rg2 was significantly enhanced in comparison to the corresponding spontaneous release. Also, in the coexistence of Rg2 and fimasartan, ACh-induced CA secretion was markedly diminished compared to the inhibitory effect of fimasartan-treated alone. Collectively, these results demonstrated that Rg2 suppressed the CA secretion induced by activation of cholinergic as well as angiotensinergic receptors from the perfused model of the rat adrenal gland. This Rg2-induced inhibitory effect seems to be exerted by reducing both influx of Na⁺ and Ca²⁺ through their ionic channels into the adrenomedullary cells as well as by suppressing Ca²⁺ release from the cytoplasmic calcium store, at least through the elevated NO release by activation of NO synthase, which is associated to the blockade of neuronal cholinergic and AT₁-receptors. Based on these results, the ingestion of Rg2 may be helpful to alleviate or prevent the cardiovascular diseases, via reduction of CA release in adrenal medulla and consequent decreased CA level in circulation.