• Preventive Nutrition and Food Science
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• v.18 no.1
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• pp.18-22
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• 2013

To investigate radical scavenging effects and protective activities of bitter melon (Momordica charantia) against oxidative stress, in vitro and a cellular system using LLC-$PK_1$ renal epithelial cells were used in this study. The butanol (BuOH) fraction of bitter melon scavenged 63.4% and 87.1% of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals at concentrations of 250 and $500{\mu}g/mL$, respectively. In addition, the BuOH fraction of bitter melon effectively scavenged hydroxyl radicals (${\cdot}OH$). At all concentrations tested, the scavenging activity of the BuOH fraction was more potent than that of the positive control, ascorbic acid. Furthermore, under the LLC-$PK_1$ cellular model, the cells showed a decline in viability and an increase in lipid peroxidation through oxidative stress induced by pyrogallol, a generator of superoxide anion ($O_2{^-}$). However, the BuOH fraction of bitter melon significantly and dose-dependently inhibited cytotoxicity. In addition, 3-morpholinosydnonimine (SIN-1), a generator of peroxynitrite ($ONOO^-$) formed by simultaneous releases of nitric oxide and $O_2{^-}$, caused cytotoxicity in the LLC-$PK_1$ cells while the BuOH fraction of bitter melon ameliorated oxidative damage induced by $ONOO^-$. These results indicate that BuOH fraction of bitter melon has protective activities against oxidative damage induced by free radicals.

• Speech Sciences
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• v.10 no.2
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• pp.111-128
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• 2003

Aerodynamic study is valuable information about the vocal efficiency in translating airflow to acoustic signal. The purpose of this study was to investigate the differences between trained singers and untrained controls under different two pitch by simultaneous using the airway interruption method and electroglottography (EGG). Under singing a Korean lied 'Gene', 20 (Male 10, Female 10) trained singers were studied on two one-octave different tone. Mean flow rate (MFR) , subglottic pressure (Psub) and intensity were measured with aerodynamic test using the Phonatory function analyzer (Nagashima Ltd. Model PS 77H, Tokyo, Japan). Closed quotients (Qx), jitter and shimmer were also investigated by electroglottography using Lx speech studio (Laryngograph Ltd, London, UK). These data were compared with those of normal controls. MFR and Psub were increased on high pitch tone in all subject groups. Statistically significant increasing of Qx and intensity were observed in male trained singers on high pitch tone (Qx;p = .025, intensity;p < .001). Beacasue of increasing of Qx and intensity, vocal efficiency was also significantly increased in male singers (p < .001). The trained singers' phonation was more efficient than untrained singers. The result means that the trained singers can increase the loudness with little changing of mean flow rate, subglottic pressure but more increasing of glottic closed quotients.

• Journal of Mechanical Science and Technology
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• v.19 no.9
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• pp.1695-1705
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• 2005

Reaction wheels and thrusters are commonly used for the satellite attitude control. Since satellites frequently need fast maneuvers, the minimum time maneuvers have been extensively studied. When the speed of attitude maneuver is restricted due to the wheel torque capacity of low level, the combinational use of wheel and thruster is considered. In this paper, minimum time optimal control performances with reaction wheels and thrusters are studied. We first identify the features of the maneuvers of the satellite with reaction wheels only. It is shown that the time-optimal maneuver for the satellite with four reaction wheels in a pyramid configuration occurs on the fashion of single axis rotation. Pseudo control logic for reaction wheels is successfully adopted for smooth and chattering-free time-optimal maneuvers. Secondly, two different thrusting logics for satellite time-optimal attitude maneuver are compared with each other: constant time-sharing thrusting logic and varying time-sharing thrusting logic. The newly suggested varying time-sharing thrusting logic is found to reduce the maneuvering time dramatically. Finally, the hybrid control with reaction wheels and thrusters are considered. The simulation results show that the simultaneous actuation of reaction wheels and thrusters with varying time-sharing logic reduces the maneuvering time enormously. Spacecraft model is Korea Multi-Purpose Satellite (KOMPSAT)-2 which is being developed in Korea as an agile maneuvering satellite.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.9
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• pp.7-13
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• 2010

In this paper, we proposed a processor architecture that is suitable for next generation embedded applications, especially for personal information devices such as smart phones, tablet PC. Latest high performance embedded processors are developed to achieve high clock speed. Because increasing performance makes design more difficult and induces large overhead, architectural evolution in embedded processor field is necessary. Among more enhanced processor types, out-of-order superscalar cannot be a candidate for embedded applications due to its excessive complexity and relatively low performance gain compared to its overhead. Therefore, new architecture with moderate complexity must be designed. In this paper, we developed a low-cost SMT architecture model and compared its performance to other architectures including scalar, superscalar and multiprocessor. Because current personal information devices have a tendency to execute multiple tasks simultaneously, SMT or CMP can be a good choice. And our simulation result shows that the efficiency of SMT is the best among the architectures considered.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.1
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• pp.178-203
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• 2018

In this paper, authors have been evaluated the Frame Error Rate (FER) performance of IEEE 802.11 a/g/p standard 5 GHz frequency band WLAN over Rayleigh and Rician distributed fading channels in presence of Additive White Gaussian Noise (AWGN). Orthogonal Frequency Division Multiplexing (OFDM) based transceiver is implemented by using real-time signal processing frameworks (IEEE 802.11 Blocks) in GNU Radio Companion (GRC) and Ettus USRP N200 is used to process the symbol over the wireless radio channel. The FER is calculated for each sub-carrier conventional modulation schemes used by OFDM such as BPSK, QPSK, 16, 64-QAM with different punctuated coding rates. More precise SNR is computed by modifying the SNR calculation process of YANS and NIST error rate model to estimate more accurate FER. Here, real-time signal constellations, OFDM signal spectrums etc. are also observed to find the effect of multipath propagation of signals through flat and frequency selective fading channels. To reduce the error rate due to the multipath fading effect and Doppler shifting, channel estimation (CE) and equalization techniques such as Least Square (LS) and training based adaptive Least Mean Square (LMS) algorithm are applied in the receiver. The simulation work is practically verified at GRC by turning into a pair of Software Define Radio (SDR) as a simultaneous transceiver.

• Journal of Korean Society of Water and Wastewater
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• v.25 no.6
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• pp.815-824
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• 2011

In this study, a non-thermal plasma system was employed to simultaneously remove odorous compounds and organic sludge. The system consisted of two reactors; the first one was the non-thermal plasma reactor where ozone was produced by the plasma reaction and the ozone oxidized hydrogen sulfide, the model odorous compound, and then the ozone-laden gas stream was introduced to the second reactor where wasted sludge was disintegrated and solubilized by ozone oxidation. In this study, the gas retention time (GRT) and the hydraulic retention time (HRT) were changed in the two-reactor system, and the effects of GRT and HRT on reduction efficiencies of odor and sludge were determined. As the GRT increased, the ozone concentration increased resulting in an increasing efficiency of hydrogen sulfide removal. However, the overall ozone loading rate to the second sludge reactor was the same at any GRT, which resulted in an insignificant change in sludge reduction rate. When HRTs in the sludge reactor were 1, 2, 4 hours, the sludge reduction rates were approximately 30% during the four-hour operation, while the rate increased to 70% at the HRT of 6 hours. Nevertheless, at HRTs greater than 4 hours, the solubilization efficiency was not proportionally increased with increasing specific input energy, indicating that an appropriate sludge retention time needs to be applied to achieve effective solubilization efficiencies at a minimal power consumption for the non-thermal plasma reaction.

• Journal of the Korean Wood Science and Technology
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• v.43 no.5
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• pp.600-612
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• 2015

We investigated the optimization of the organosolv pretreatment of yellow poplar for bioethanol production. Response surface methodology was used to determine the optimal conditions of three independent variables (reaction temperature, reaction time, and sulfuric acid (SA) concentration). Reaction temperature is the most significant variable in the degradation of xylan and lignin in the presence of an acid catalyst, and ethanol production increased with a decrease in the lignin content. The highest ethanol concentration ($42.80g/{\ell}$) and theoretical ethanol yield (98.76%) were obtained at $152^{\circ}C$ (2.5 bar) with 1.6% SA for 16 min. However, because of excessive degradation of the raw material, the overall ethanol yield was less than under other pretreatment conditions which has approximately 50% of WIS recovery rate after pretreatment. The optimal conditions for the maximum overall ethanol yield ($146^{\circ}C$ with 1.22% SA for 15.9 min) were determined with a predicted yield of 17.11%, and the experimental values were very close (17.15%). Therefore, the quadratic model is reliable.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.2
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• pp.263-269
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• 2012

Code-Division Multiple-Access(CDMA) allows several users simultaneous access to a common channel by assigning a distinct pseudonoise sequence called spectrum code to each user. Each user in a CDMA system uses a assigned spectrum code to modulate their signal. Choosing the codes used to modulate the signal is very important in the performance of CDMA systems. The best performance will occur when there is good separation between the signal of a desired user and the signals of other users. The receiver synchronizes the code to recover the data. The use of an independent code allows multiple users to access the same frequency band at the same time. In this paper we propose a generalized model of non-linear binary sequence using trace function and analyze cross-correlation of these sequences. These sequences with low correlation, large linear span and large family size, in a direct-sequence spread spectrum communication system, help to minimize multiple access interference, increase security degree of system and enlarge user number.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2027-2033
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• 2014

Background: We aimed to assess RET proto-oncogene polymorphisms in three different Iranian families with medullary thyroid cancer (MTC), and performed molecular dynamics simulations and free energy stability analysis of these mutations. Materials and Methods: This study consisted of 48 patients and their first-degree relatives with MTC confirmed by pathologic diagnosis and surgery. We performed molecular dynamics simulations and free energy stability analysis of mutations, and docking evaluation of known RET proto-oncogene inhibitors, including ZD-6474 and ponatinib, with wild-type and mutant forms. Results: The first family consisted of 27 people from four generations, in which nine had the C.G2901A (P.C634Y) mutation; the second family consisted of six people, of whom three had the C.G2901T (P.C634F) mutation, and the third family, who included 12 individuals from three generations, three having the C.G2251A (P.G691S) mutation. The automated 3D structure of RET protein was predicted using I-TASSER, and validated by various protein model verification programs that showed more than 96.3% of the residues in favored and allowed regions. The predicted instability indices of the mutated structures were greater than 40, which reveals that mutated RET protein is less thermo-stable compared to the wild-type form (35.4). Conclusions: Simultaneous study of the cancer mutations using both in silico and medical genetic procedures, as well as onco-protein inhibitor binding considering mutation-induced drug resistance, may help in better overcoming chemotherapy resistance and designing innovative drugs.

• Journal of Korean Society of Forest Science
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• v.96 no.1
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• pp.40-47
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• 2007

The objectives of this study were to derive site index and stem volume prediction equation based on stem analysis data for Larix leptolepis in Jinan region. The function for site index was developed by algebraic difference equation method. Polymorphic site index family curves with base age of 40 were presented based on the Schumacher height equation. The best stem volume prediction equation was suggested as $V=0.00260+0.00000399D^2H$. The simultaneous F-test using this equation showed that the estimated tree stem volumes were not significantly different (${\alpha}=0.05$ level) from the observed stem volumes for model evaluation. Therefore, site index and volume prediction equations prepared in this study could provide an indication of site quality and basic information for making of yield table, and could be used for rational forest management of Larix leptolepis stands grown in Jinan region.