• Title/Summary/Keyword: Simulation Based

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Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

  • Yoo, Su Woong;Park, Hee-Jin;Oh, Gyungseok;Hwang, Soonjoo;Yun, Misun;Wang, Taejun;Seo, Young-Seok;Min, Jung-Joon;Kim, Ki Hean;Kim, Eung-Sam;Kim, Young L.;Chung, Euiheon
    • Current Optics and Photonics
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    • v.1 no.1
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    • pp.51-59
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    • 2017
  • In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.

NES Model Development: Expert System for Nitrogen Fertilizer Applications to Cornfields (NES 모델 개발 : 질소비료 적정 시용에 대한 전문가체계)

  • Kim, Won-Il;Jung, Goo-Bok;Fermanian, T.W.;Huck, M.G.;Park, Ro-Dong
    • Korean Journal of Soil Science and Fertilizer
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    • v.34 no.1
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    • pp.55-63
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    • 2001
  • N fertilizer recommendations to optimize with consideration to maximum crop yields, maximum profits, and minimum N losses to ground or runoff water, an advisory system. Nitrogen Expert System (NES), was developed. The system was to estimate the optimal rate of N fertilizer application cornfields in Illinois. NES was constructed using Smart Elements, a knowledge-based system that manages the expertise of human experts. NES was reinforced by addition of the effect of a productivity index (PI), soil organic matter content (SOM), and pre-sidedressing of nitrate concentration (PSNT) to the optimal N fertilizer recommendation. NES contains 49 rules, 1 class, 14 objects, and 2 properties. NES was successfully operated, showing N recommendations with inputs of three soil properties including PI, SOM, and PSNT. NES can reduce N loss to the environment, but adherence to the recommendations may also reduce farmers income. Therefore, NES will be more effective by evaluating both environmental damage assessment and other economic agricultural management parameters and other soil physico-chemical parameters.

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Multi-Hop Vehicular Cloud Construction and Resource Allocation in VANETs (VANET 망에서 다중 홉 클라우드 형성 및 리소스 할당)

  • Choi, Hyunseok;Nam, Youngju;Lee, Euisin
    • KIPS Transactions on Computer and Communication Systems
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    • v.8 no.11
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    • pp.263-270
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    • 2019
  • Vehicular cloud computing is a new emerging technology that can provide drivers with cloud services to enable various vehicular applications. A vehicular cloud is defined as a set of vehicles that share their own resources. Vehicles should collaborate with each other to construct vehicular clouds through vehicle-to-vehicle communications. Since collaborating vehicles to construct the vehicular cloud have different speeds, directions and locations respectively, the vehicular cloud is constructed in multi-hop communication range. Due to intermittent wireless connectivity and low density of vehicles with the limited resources, the construction of vehicular cloud with multi-hop communications has become challenging in vehicular environments in terms of the service success ratio, the service delay, and the transmitted packet number. Thus, we propose a multi-hop vehicular cloud construction protocol that increases the service success ratio and decreases the service delay and the transmitted packet number. The proposed protocol uses a connection time-based intermediate vehicle selection scheme to reduce the cloud failure probability of multi-hop vehicular cloud. Simulation results conducted in various environments verify that the proposed protocol achieves better performance than the existing protocol.

A Study on the Thermal Flow of Waste Heat Recovery Unit (WHRU) for Ship's Organic Rankine Cycle Power Generation System using CFD Method (CFD를 활용한 선박고온도차발전용 WHRU의 열유동 해석에 관한 연구)

  • Whang, Dae-jung;Park, Sang-kyun;Jee, Jae-hoon;Bang, Eun-shin;Oh, Cheol
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.27 no.5
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    • pp.647-655
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    • 2021
  • The IMO (International Maritime Organization) is discussing the improvement of energy ef iciency of ships in order to reduce greenhouse gas emissions from ships. Currently, by applying an ORC power generation system using waste heat generated from ships, high energy conversion efficiency can be expected from ships. This technology uses an organic medium based on Freon or hydrocarbons as the working fluid, which evaporates at a lower temperature range than water. Through this, it is possible to generate steam (gas) and generate power at a low and low temperature relatively. In this study, the analysis of heat flow between the refrigerant and waste heat in the ORC power generation system, which is an organic Rankine cycle, is analyzed using 3D simulation techniques to determine the temperature change, velocity change, pressure change, and mass change of the fluid flowing of the WHRU (Waste Heat Recovery Unit) inside and the outside the structure. The purpose of this study is to analyze how the mass change affects the structure, and this study analyzed the heat transfer of the heat exchanger from the refrigerant and the exhaust gas of the ship's main engine in the ORC power generation system using this technique.

Defining the Tumour and Gross Tumor Volume using PET/CT : Simulation using Moving Phantom (양전자단층촬영장치에서 호흡의 영향에 따른 종양의 변화 분석)

  • Jin, Gye-Hwan
    • Journal of the Korean Society of Radiology
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    • v.15 no.7
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    • pp.935-942
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    • 2021
  • Involuntary movement of internal organs by respiration is a factor that greatly affects the results of radiotherapy and diagnosis. In this study, a moving phantom was fabricated to simulate the movement of an organ or a tumor according to respiration, and 18F-FDG PET/CT scan images were acquired under various respiratory simulating conditions to analyze the movement range of the tumor movement by respiration, the level of artifacts according to the size of the tumor and the maximum standardized uptake value (SUVmax). Based on Windows CE 6.0 as the operating system, using electric actuator, electric actuator positioning driver, and programmable logic controller (PLC), the position and speed control module was operated normally at a moving distance of 0-5 cm and 10, 15, and 20 reciprocations. For sphere diameters of 10, 13, 17, 22, 28, and 37 mm at a delay time of 100 minutes, 80.4%, 99.5%, 107.9%, 113.1%, 128.0%, and 124.8%, respectively were measured. When the moving distance was the same, the difference according to the respiratory rate was insignificant. When the number of breaths is 20 and the moving distance is 1 cm, 2 cm, 3 cm, and 5 cm, as the moving distance increased at the sphere diameters of 10, 13, 17, 22, 28, and 37 mm, the ability to distinguish images from smaller spheres deteriorated. When the moving distance is 5 cm compared to the still image, the maximum values of the standard intake coefficient were 18.0%, 23.7%, 29.3%, 38.4%, 49.0%, and 67.4% for sphere diameters of 10, 13, 17, 22, 28, and 37 mm, respectively.

Analysis of the Evacuation Safety in a Fire at Welfare Center for Disabled (장애인복지관 화재 시 피난안전성 분석)

  • Park, Sunah;Lee, Jai Young
    • Journal of the Korea Convergence Society
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    • v.12 no.12
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    • pp.315-322
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    • 2021
  • This study analyzes the Required Safe Egress Time (RSET), in the event of a fire at a welfare center for the disabled, using the emergency passage according to the floor arrangement of users to evaluate the safety and the difference in RSET for each emergency passage using the Pathfinder simulation program to suggest an efficient evacuation method. As a result of RSET, it was found that there is no problem in evacuation safety for the current state of the facility's personnel allocation by satisfying the standard RSET in case of fire, and evacuation can be completed safely by evacuating through stairs rather than using elevators if possible. It is necessary for employees to be provided sufficient education and training in advance so that they can evacuate effectively with the disabled in case of fire. This study gives significance in saving many precious lives and safely evacuate in case of fire as evacuation routes were secured through the design, construction and operation of facilities for the disabled and the RSET was shortened through regular evacuation practices. It is necessary to discuss the further RSET studies based on the automatic fire shutters open or not when a fire occurs at a specific location following the installation of automatic fire shutter at the entrance of each floor of the facilities.

Development of the Radiological Range of Positron Emitting Radionuclides (양전자 방출 핵종의 방사선학적 비정에 대한 제안)

  • Jang, Dong-Gun;Lee, Sang-Ho
    • Journal of the Korean Society of Radiology
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    • v.15 no.6
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    • pp.849-853
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    • 2021
  • PET images used in medical diagnoses are created using positron emitting radionuclides. The radiation used for imaging is generated at 0.511 MeV by p-annihilation. The CSDA range is the distance the particle radiation flew physically, and it is different from the range shown in PET images. This study proposes a novel method that uses radiological criteria to measure this range. The experiment was conducted by applying the MCNP6 simulation to positron emitting nuclides 18F, 11C, 13N, and 15O. Radiological criteria were based on the location of the p-annihilation event, which is also the image signal. Results showed the radiological range of positrons to be 2.3, 3.9, 5.0, and 7.9 mm for 18F, 11C, 13N, and 15O, respectively. The higher the positron energy, the larger its difference from the CSDA range. Positron emitting nuclide is being developed and studied as a nuclide for dosimetry or radiotherapy. Further research needs to be conducted into various positron ranges.

A Study on 8 × 4 Dual-Polarized Array Antenna for X-Band Using LTCC-Based ME Dipole Antenna Structure (LTCC 기반 ME Dipole 안테나 구조를 활용한 X-Band 용 8 × 4 이중편파 배열안테나에 관한 연구)

  • Jung, Jae-Woong;Seo, Deokjin;Ryu, Jong-In
    • Journal of the Microelectronics and Packaging Society
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    • v.28 no.3
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    • pp.25-32
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    • 2021
  • In this paper, the Magneto-Electric(ME) dipole array antenna with dual-polarization in the X-Band is proposed and it is implemented and measured. The proposed array antenna is composed of 32 single ME dipole antenna and a Teflon PCB. 1 × 1 ME dipole antenna is implemented dual-polarization by radiating vertical polarization and horizontal polarization from two pairs of radiators. 2-port feeding structures are realized by lamination process using LTCC. And, each port independently feeds the radiator through a Γ-shaped feeding strip with isolation between ports. The Teflon PCB used in the antenna array has a 4-layer structure, and 2-port is fed through the top and bottom layers. The λg/4 transformer is applied to the transmission line of the Teflon PCB for impedance matching of the arrayed antenna and the Teflon PCB, and the optimal parameters are obtained through simulation. The measured maximum antenna gains of port 1 was 18.2 dBi, Cross-pol was 1.0 dBi. And the measured maximum antenna gains of port 1 was 18.1 dBi, Cross-pol was 3.2 dBi.

A Study on Detection Algorithm of Open Phase Fault in Grid-Connected Transformer for PV System (태양광전원 연계용변압기의 결상사고 검출 알고리즘에 관한 연구)

  • Kang, Kab-Seok;Tae, Dong-Hyun;Lee, Hu-Dong;Rho, Dae-Seok
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.5
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    • pp.22-33
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    • 2021
  • In the case of open phase faults caused by the disconnection of distribution feeders interconnected to a PV system, many problems can occur depending on the core type and wiring method of the grid-connected transformers. Moreover, open phase faults are difficult to detect because the open phase voltage of the existing protection relay (Open Phase Relay (47)) can be maintained, even though a disconnection fault occurred, depending on the wiring method and the iron core type of the grid-connected transformer for a PV system. Therefore, this paper proposes a novel algorithm to detect open phase faults by comparing the currents and phases between the primary and secondary sides of a grid-connected transformer. In addition, this paper presents the modeling of a distribution system and protection devices for detecting open phase faults using PSCAD/EMTDC S/W, and implements a test protection device for detecting open phase faults based on the above-mentioned modeling. The simulation and test results confirmed that the proposed algorithm is useful for detecting open phase faults according to the wiring method and iron core type of grid-connected transformer for a PV system because operation slope and unbalance rate of the primary current exceed the setting value (30[%]) of the protection device.

Design of Physical Layer and Performance Analysis for MX-S2X, Ship Centric Direct Communication with the Mitigation of Multi-path Fading on Sea Environment (해상 다중경로 페이딩 극복을 위한 선박중심 직접통신(MX-S2X) 물리계층 설계 및 성능 분석)

  • Ryu, Hyung-Jick;Yoo, Hae-Sun;Kim, Won-Yong;Kim, Bu-Young;Shim, Woo-Seong
    • Journal of Navigation and Port Research
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    • v.45 no.6
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    • pp.352-359
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    • 2021
  • This paper presents the definition and importance of ship-centric direct communication concerning ship safety of maritime autonomous and unmanned ships. It also proposes the concept of MX-S2X communication based on high frequency for wide-bandwidth technology and describes the design and simulation result for the physical layer of MX-S2X. It considered high-speed communication as well as overcoming maritime multi-path fading required to be resolved in the marine environment. The physical layer of MX-S2X communication was designed to overcome the occurrence of error-floor caused by multi-path fading even with receiving sufficient signal strength. To this purpose, a performance analysis was conducted on the physical layer by applying the channel model of the actual maritime communication environment. As a result of the performance analysis of the MX-S2X physical layer, it was confirmed that the BER error-floor observed in the VDE physical layer test was overcome, and it operated within the SNR 2dB degradation range compared to the AWGN channel. It is expected that this will show enough performance suitable for short-distance ship-centered direct communication and can be used for direct communication of maritime autonomous ships, unmanned ships, and group navigation of themshortly.