• 대한의사협회지
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• 제61권11호
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• pp.662-669
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• 2018

The cutaneous melanoma has been regarded as rare disease entity in Korea for long time but it shows a silent growth recently. Furthermore the management of cutaneous melanoma including staging system, surgical principle, sentinel lymph node biopsy and subsequent complete node dissection and, most importantly, immunotherapy and target therapy against cutaneous melanoma recently. The incidence of cutaneous melanoma is steadily increasing in Korea but its increase is rapid recent 2 decades to 4.3 times and should be greater soon according to the steeper increase of life expectancy. New staging system proposed by American Joint Committee on Cancer (2017) includes changes in individual TNM category and stage groups, particularly from a prognostic viewpoint. Dermoscopy has been successfully introduced in the differential diagnosis of pigmented skin lesion focusing on cutaneous melanoma by non-invasive simple diagnostic tool. Sentinel lymph node biopsy was a issue of long debate whether survival benefit is real or not. Temporary conclusion about this question is reached after two large scale studies and immediate complete node dissection should be performed in a certain situations. Most important change is drug therapy focusing on immunotherapy and target therapy. Braf- and MEK-inhibitor, immune checkpoint inhibitor and PD-1 blocker has been proved to be effective as a sole or combination regimen against advanced and/or high-risk adjuvant setting of cutaneous melanoma. In conclusion, these remarkable changes will be reviewed shortly here.

• 한국컴퓨터정보학회논문지
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• 제24권2호
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• pp.111-118
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• 2019

Recent trends in modern warfare are increasing in importance for air warfare, information warfare, and warfare. The technology of the weapon system software is rapidly developing, and the silent information war to hack it is still going on. Currently, the FA-50 aircraft has a function that can be initialized by a simple switch operation to protect the main military information in the event of an emergency. However, there are limitations in the existing Zeroize function, and this study was carried out to supplement this. First, we compare and analyze the memory structure of aircraft operating in our military, and examined the currently implemented Zeroize function. Second, we reviewed various methods to overcome the limitation of existing Zeroize function. Third, we implement the existing Zeroize function without additional manipulation. In this paper, we propose that the implementation of this feature will enable us to protect our military data more securely and suggest that we should continue to look for ways to enhance security for our technology in the future.

• Journal of Microbiology and Biotechnology
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• 제29권5호
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• pp.667-686
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• 2019

Streptomyces are attractive microbial cell factories that have industrial capability to produce a wide array of bioactive secondary metabolites. However, the genetic potential of the Streptomyces species has not been fully utilized because most of their secondary metabolite biosynthetic gene clusters (SM-BGCs) are silent under laboratory culture conditions. In an effort to activate SM-BGCs encoded in Streptomyces genomes, synthetic biology has emerged as a robust strategy to understand, design, and engineer the biosynthetic capability of Streptomyces secondary metabolites. In this regard, diverse synthetic biology tools have been developed for Streptomyces species with technical advances in DNA synthesis, sequencing, and editing. Here, we review recent progress in the development of synthetic biology tools for the production of novel secondary metabolites in Streptomyces, including genomic elements and genome engineering tools for Streptomyces, the heterologous gene expression strategy of designed biosynthetic gene clusters in the Streptomyces chassis strain, and future directions to expand diversity of novel secondary metabolites.

• Journal of Audiology & Otology
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• 제25권1호
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• pp.43-48
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• 2021

Background and Objectives: Conflicting mechanisms have been reported about spontaneous reversal of positional nystagmus during head-roll maneuver in patients with benign paroxysmal positional vertigo (BPPV). The objective of this study is to review the reports about the characteristics and possible mechanisms of reversing positional nystagmus and to present seven new cases. Subjects and Methods: Seven cases (5 males, 2 females; 4 left-sided, 3 right-sided) were recruited among 732 patients with BPPV seen outpatient clinic between 2009 and 2019. Diagnosis of lateral canal canalolithiasis was confirmed when transient geotropic nystagmus was documented during head-roll test. Reversing positional nystagmus was analyzed in each case and clinical characteristics of the patients were documented. Results: The age of patients was ranging between 30 to 64 years (46.44±10.91). Duration of symptoms was short (21.34±19.74). Six of them had a story of head trauma. Initial latency was short. First, intense geotropic nystagmus was observed following provocative head-roll position on the affected side. There was short "silent phase". Then, a longer second-phase of reversed nystagmus was noted. Total duration of nystagmus was 78.40±6.82 seconds. Maximal slow phase velocity was 24.05±6.34 deg/sec. All patients were cured with barbeque maneuver. Conclusions: Ipsilateral reversing positional nystagmus during head-roll maneuver is due to lateral canal canalolithiasis. Mechanism is likely to be due to endolymphatic double flow. Bilateral cases may be due to simultaneous co-existence of canalolithiasis and cupulolithiasis. Longer recording of nystagmus is recommended not to miss the cases with spontaneous direction-changing positional nystagmus.

• 대한청각학회지
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• 제25권1호
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• pp.43-48
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• 2021

Background and Objectives: Conflicting mechanisms have been reported about spontaneous reversal of positional nystagmus during head-roll maneuver in patients with benign paroxysmal positional vertigo (BPPV). The objective of this study is to review the reports about the characteristics and possible mechanisms of reversing positional nystagmus and to present seven new cases. Subjects and Methods: Seven cases (5 males, 2 females; 4 left-sided, 3 right-sided) were recruited among 732 patients with BPPV seen outpatient clinic between 2009 and 2019. Diagnosis of lateral canal canalolithiasis was confirmed when transient geotropic nystagmus was documented during head-roll test. Reversing positional nystagmus was analyzed in each case and clinical characteristics of the patients were documented. Results: The age of patients was ranging between 30 to 64 years (46.44±10.91). Duration of symptoms was short (21.34±19.74). Six of them had a story of head trauma. Initial latency was short. First, intense geotropic nystagmus was observed following provocative head-roll position on the affected side. There was short "silent phase". Then, a longer second-phase of reversed nystagmus was noted. Total duration of nystagmus was 78.40±6.82 seconds. Maximal slow phase velocity was 24.05±6.34 deg/sec. All patients were cured with barbeque maneuver. Conclusions: Ipsilateral reversing positional nystagmus during head-roll maneuver is due to lateral canal canalolithiasis. Mechanism is likely to be due to endolymphatic double flow. Bilateral cases may be due to simultaneous co-existence of canalolithiasis and cupulolithiasis. Longer recording of nystagmus is recommended not to miss the cases with spontaneous direction-changing positional nystagmus.

• 한국농업기계학회:학술대회논문집
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• 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.II
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• pp.162-169
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• 2000

This study was carried out to develop a continuously variable-speed transmission(CVT) for agricultural tractor. A full-toroidal CVT mechanism with four discs and six rollers was selected as a device for changing speed ratio continuously. In the step of system layout design, the sizes of roller cylinders and end-load cylinder, which were critical factors for controlling the variator, were designed. Also the control pressure range was designed to limit the contact pressure of variator. In order to make the maximum speed of vehicle as 30km/h, the planetary gear and the six pairs of gears were designed. Also the hydraulic clutch, silent chain, hydraulic manifold and electronic controller were designed. After the design, a prototype with CVT controller was developed and tested. The speed of vehicle was changed continuously to the speed set by driver and the settling time was about 0.52 second at the step-response test (reduction ratio of variator 2.0 to 1.0), which was acceptable as a response time for working with tractor.

• 분석과 대안
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• 제3권2호
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• pp.33-57
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• 2019

After the tragic incident of the sinking of Sewol in spring 2014, Korean migrants in Britain began to hold street protests in London. These protestors condemned the Korean government for the lack of appropriate responses to the accident, and for its failure to conduct proper investigation on the issue. The small group of protestors held silent street protests every month at Trafalgar Square, despite not gaining much media coverage nor public attention. These migrants' almost three-year long protest outside their homeland is puzzling. Not only did they live in Britain for a long time to the extent that they regard the country as their second home, but they also exert scant amount of influence on the political landscape in South Korea. What can then account for these individuals' participation in activism related to their homeland politics? In this paper, we utilize the concept of 'moral identity' to explain the behaviors of Korean migrants involved in the street protests. These migrants had strong 'moral identity', which triggered a sense of responsibility to act when their cherished moral values were jeopardized. Korean migrants who possessed a strong sense of moral identity placed huge importance on living in accordance with their moral values. It is a way of upholding their self-esteem and sustaining their ideal self.

• International Journal of Advanced Culture Technology
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• 제11권2호
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• pp.310-314
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• 2023

In this paper, we show that the limitations of Holter monitoring and Wearable Electrocardiogarphy Devices and their arrhythmia detection. Sudden death caused by cardiovascular disease, often referred to as the "silent killer" due to its unpredictable nature, is a major health concern. Electrocardiography (ECG) is a basic diagnostic tool for detecting heart disease, but its limitations make it difficult to detect arrhythmia, a significant indicator of an irregular heart state. To address this limitation, a long-term continuous ECG recording device has been developed, Holter ECG device and wearable device. A significant number of studies have focused on the differences between Holter monitoring and wearable devices. The Holter tests were useful for detecting regularly occurring arrhythmias, whereas wearable patches were better at detecting random and infrequent arrhythmias. Wearable patches were effective in detecting episodes of arrhythmia and myocardial ischemia. Despite the concern, wearable devices had less signal loss than Holter monitoring and patients also preferred wearable devices over Holter monitoring due to convenience. These results could mean that the wearable devices can perfectly replace the Holter test.

• 영어영문학
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• 제56권6호
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• pp.1235-1253
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• 2010

Lucy Snowe, the heroine and narrator of Charlotte Brontë's Villette, has oftentimes been studied in terms of her silence. However, the critics' approach to Lucy's silence has been mostly negative as her silence has often been interpreted as an illustration of her sense of absence, powerlessness, unreliability, or mental deprivation. Lucy's silence, however, is complex in nature as the functions and meanings of her silence vary depending on when, why, and how silence is performed. This article particularly looks into the moments in which Lucy's silence generates multifarious meanings and resonances depending on the contexts in and the purpose for which it is exercised, such as a sense of wholeness, marginality, power and individuality. First of all, Lucy's silence about herself during the recount of her childhood days at Bretton implies the feeling of entirety and peacefulness where the identification of the "I" becomes unnecessary. Second, Lucy's silence in relation to Paulina at Bretton denotes her social marginality and powerlessness. Third, as an older self/narrator, Lucy chooses to be silent in order to exert power over the readers. And lastly, Lucy's conscious refusal to tell the readers what she already knows also serves to reveal her sense of individuality. Through the instances of Lucy Snowe's silence in Bronte's Villette, I demonstrate the possibility to reveal various aspects of one's self through silence.

• 한국군사과학기술학회지
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• 제27권2호
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• pp.167-176
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• 2024

Lip-reading is the task of inferring the speaker's utterance from silent video based on learning of lip movements. It is very challenging due to the inherent ambiguities present in the lip movement such as different characters that produce the same lip appearances. Recent advances in deep learning models such as Transformer and Temporal Convolutional Network have led to improve the performance of lip-reading. However, most previous works deal with English lip-reading which has limitations in directly applying to Korean lip-reading, and moreover, there is no a large scale Korean lip-reading dataset. In this paper, we introduce the first large-scale Korean lip-reading dataset with more than 120 k utterances collected from TV broadcasts containing news, documentary and drama. We also present a preprocessing method which uniformly extracts a facial region of interest and propose a transformer-based model based on grapheme unit for sentence-level Korean lip-reading. We demonstrate that our dataset and model are appropriate for Korean lip-reading through statistics of the dataset and experimental results.