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Iontophoresis Enhances Transdermal Delivery of Methylene Blue in Rat Skin (I): The Effect of Current Application Duration

  • Lee, Jae-Hyoung;Choi, Eun-Young
    • The Journal of Korean Physical Therapy
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    • v.23 no.6
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    • pp.77-84
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    • 2011
  • Purpose: The objectives of this study were to determine the enhancing effect of iontophoresis method as it transdermally deliver methylene blue (MB) using visual examination, in terms of penetration depth and tissue distribution in the skin, and to determine the effect of application duration on the efficacy of iontophoresis. Methods: Twenty-four male Sprague-Dawley rats were randomly divided into 5-, 10-, 20-, and 40-minute groups. These rats were exposed to either topical or anodic iontophoresis of 1% MB using a direct current of $0.5mA/cm^2$ for 5, 10, 20, and 40 minutes. Using cryosections of rat tissues, the penetration depth of MB was measured using light microscopy. Results: Significant differences in the penetration depth (F=54.20, p<0.001) were detected among the four groups. Post hoc comparisons of the penetration depth of MB data pooled across groups showed no significant difference between all topical application groups and 5-minute iontophoresis group, but did reveal a significant difference in the penetration depth between all topical application groups and 5-minute iontophoresis group versus 10-minute group, between the 10-minute and 20-minute group, and between the 20-minute and 40-minute iontophoresis group (p<0.05). Conclusion: The results demonstrate that iontophoresis enhances transdermal delivery of MB across stratum corneum of skin barrier by visual examination. Furthermore, the penetration depth of iontophoretic transdermal delivery of MB was dependent on the application duration. The duration of iontophoresis is one of the important factor in the efficacy of iontophoresis application.

Effects of Rotation Direction during Curved Walking on Gait Parameters in Stroke Patients (뇌졸중 환자의 회전 보행 시 회전 방향이 보행 특성에 미치는 영향)

  • Jung, Kyeoung-Man;Joo, Min-Cheol;Jung, Yu-Jin
    • Quality Improvement in Health Care
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    • v.23 no.2
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    • pp.11-20
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    • 2017
  • Purpose: The purpose of this study was to determine the effects of rotation direction during curved walking on gait parameters in stroke patients. Methods: A group of thirty subjects with stroke (Berg Balance Scale score${\geq}41$ were fifteen, Berg Balance Scale score${\leq}40$ were fifteen) were enrolled in this study. Testing indications included two directions for rotation in each subject. These indications were for rotation toward the affected and unaffected side in stroke patients. The gait speed, affected side single support duration, affected side double support duration were recorded. The obtained data were analyzed by using paired t-test and Wilcoxon signed rank test in the group that are below and above 40 points of Berg Balance Scale score. Results: There was significant increase affected side single support duration was turned the affected side in stroke patients that presented a Berg Balance Scale score${\geq}41$ (p<.05). There were significant increase gait speed, affected side single support duration, and significant decrease affected side double support duration while subjects were turned the affected side in stroke patients that presented a Berg Balance Scale score${\leq}40$ (p<.05). Conclusion: This result may be effective to rotate in the paralyzed direction to improve the ability of the paralyzed lower limb to gain weight during gait training for stroke patients with a Berg Balance Scale score<40. Therefore, walking training program for hemiplegic patient needs to be suggested in the direction of turning for suitable balance ability.

A Single-Center Retrospective Study on the Effects of Korean Medicine in 342 Traffic Accident Cases

  • Jeong, Jin-Ho;Ku, Jaseung;Hwang, Ji Hye
    • Journal of Pharmacopuncture
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    • v.24 no.3
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    • pp.122-137
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    • 2021
  • Objectives: In South Korea, traffic accident victims can be treated under automobile insurance coverage. Korean medicine (KM) clinics have reported the largest number of automobile insurance fee claims among medical institutions. This study investigated the status of the KM automobile insurance system in a single KM clinic. Methods: We retrospectively surveyed the medical charts of 342 traffic accident patients treated at the Jisung KM clinic between January 2009 and June 2017. Results: Most of the patients were men and in their 30s. The most common method of locating the clinic was an internet search. The most common traffic accident type was collision between vehicles (83.63%), with 70.76% of patients visiting during the most acute phase. The major disease codes included S434, M4836, F072, S0600, and S3350. The most frequent treatment period was within 1 month of the accident, and most patients received 10 or fewer treatments. The mean treatment duration and number of treatments were 37.68 ± 45.11 days and 11.68 ± 10.63 treatments, respectively. The initial pain numerical rating scale (NRS), 7.32 ± 0.96, decreased to 3.57 ± 1.40 at the end of treatment, with a symptom improvement score of 1.87 ± 0.60. Regarding sex, age, disease duration, location at the time of the accident, presence of additional and psychological symptoms, and chuna, there were statistically significant differences in treatment duration and number of treatments. A higher number of treatments and the longer treatment duration was associated with a higher initial NRS, lower post-treatment NRS, and better improvement score. Since the introduction of traffic accident (TA) pharmacopuncture, the rate of use of a single type of pharmacopuncture increased; however, no significant differences in treatment duration and number, NRS before and after treatment, and improvement score were observed between treatment groups before and after TA pharmacopuncture. No adverse reactions were observed for any treatment. Conclusion: This study confirmed the previous findings of a high treatment effect of KM under automobile insurance. We also observed significant correlations based on a detailed medical status, which may explain the increasing use of KM in the automobile insurance system. Additional multi-center studies in different regions are needed.

A Retrospective Clinical Investigation of Delayed Eruption of Premolars in the Mandible

  • Sookyung Park;Hyuntae Kim;Ji-Soo Song;Teo Jeon Shin;Young-Jae Kim;Hong-Keun Hyun
    • Journal of the korean academy of Pediatric Dentistry
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    • v.50 no.4
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    • pp.469-482
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    • 2023
  • This study aimed to investigate the treatment options for the delayed eruption of mandibular premolars and identify the predictors of spontaneous eruption using panoramic radiography. The prevalence of delayed mandibular premolar eruption in this retrospective analysis, comprising 254 patients (aged 9 - 15 years), was 5.19%, with no significant difference based on gender. The mandibular second premolars were most affected (4.39%) compared to the first premolars (0.76%). No significant difference in prevalence was observed between the left and right sides. Among the treated mandibular premolars, primary molar-related lesions were identified as the leading cause (7.85%) of delayed tooth eruption. The treatment duration varied based on the Nolla stage, eruption stage, and treatment method. Teeth with Nolla stage 7 or lower had a treatment duration of 22.89 ± 11.96 months, whereas those with stage 8 or higher had a 15.02 ± 6.34 month duration. The deeper the tooth was located in the bone, the longer the treatment period became. The treatment duration varied depending on the treatment method, and statistically, there was no significant difference. The treatment durations for affected mandibular premolars increased with the depth of impaction angle of inclination. In this study, the treatment duration for delayed eruptions varied depending on the Nolla stage, eruption stage, and treatment method. Variations in the impaction depth and inclination angle across various treatment approaches, as explored in this study, might offer valuable insights into the selection of the most suitable management options for delayed tooth eruptions.

Assessment of Nutritional Status in Elderly Dialysis Patients (노인 투석환자의 영양상태 평가)

  • 노유자;하혜정;고혜영;박옥순
    • Journal of Korean Academy of Nursing
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    • v.26 no.2
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    • pp.304-319
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    • 1996
  • It is important to evaluate nutritional status of elderly patients receiving dialysis, since wasting and malnutrition are their common problems. This study aims at assessing their nutritional status by the type and duration of dialysis. The nutritional status such as somatic fat and protein storage was evaluated with anthropometric measure including weight/height ratio, triceps skinfold thickness and midarm muscle circumference. It was also measured with albumin, transferrin, C3 and IGF-1 and calorie and protein intakes. The general clinical condition of patients was evaluated with the severity of uremia and metabolic acidosis. which were measured through the levels of serum urea, creatinine and bicarbonateion. The data were analyzed by using t-test, ANOVA, Wilcoxon-rank sums test, Scheffe test, Kruskal-Wallis test and Pearson correlation coefficients. The results are following : 1. There was no significant difference in the calorie and protein intakes by the type and duration of dialysis received. 2. As for the anthropometric measures, no significant difference was found by the type of dialysis in body mass index triceps skinfold thickness and midarm muscle circumference. Yet these anthropometric measures differed significantly by the duration of dialysis in those elderly patients receiving hemodialysis(HD group), but this finding was not found in those receiving continuous ambulatory peritoneal dialysis(CAPD). 3. Regarding the indicators of uremia and metabolic acidosis, blood urea nitrogen(BUN) and creatinine were lower in the CAPD group than in the HD group, whereas bicarbonate ion was higher in the CAPD group than in the HD group, with no statistical significance. In the HD group, creatinine increased significantly with the increase of the duration of dialysis. 4. Serum trasferrin and C3 were significantly higher in the CAPD group than in the HD group. However. each of biochemical indices did not show statistical significance by the duration of dialysis in both HD and CAPD groups. 5. Anthropometric measures were significantly associated with dietary intake. Significant correlations were observed between biocarbonate ion, BUN and creatinine. In addition, the correlations between serum protein and albumin and between transferrin and C3 were statistically significant. Yet, IGF-1 revealed no significant correlation with other nutritional indices. The above findings indicate that there were no difference in nutritional status measured with protein and calorie intakes between the type and duration of dialysis, but CAPD seems to benefit correcting uremia and metabolic acidosis than HD. Studies of dietary management for dialysis patients need to be pursued in order to improved the quality of aged patients receiving dialysis.

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Factors affecting children's sleep duration and sleep time poverty (아동의 수면시간과 수면시간 빈곤에 영향을 미치는 요인: 가족특성과 아동의 생활시간을 중심으로)

  • Koh, Sun-Kang
    • Journal of Family Resource Management and Policy Review
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    • v.21 no.3
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    • pp.141-159
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    • 2017
  • The main purpose of this study is to investigate factors that influence sleep duration and sleep time poverty in terms of family characteristics, child characteristics, and time use. A series of data analyses were conducted on children's time use in two-parent families based on the 2013 Korean Children and Youth Panel Survey. One major finding is that children's sleep duration and the probability of having a sleep time poverty are related to their mothers' job classifications. The factors influencing the duration of sleep time and the sleep time poverty are similar in terms of family characteristics and children's time use. The mother's job classification, family income, number of younger siblings, number of older siblings, children's private tutoring hours, computer game hours, and TV hours are statistically significant factors affecting the duration of sleep time and the probability of having a sleep time poverty. However, the factor with greatest influence on sleep time duration is private tutoring hours and the factor most affecting sleep time poverty is computer game hours. The mother's job classification is a relatively powerful determinant for predicting her children's sleep duration and sleep time poverty.

Menstrual Pattern Changes in Laparoscopic Sterilization Patients Whose Last Pregnancy was Terminated by Therapeutic Abortion-A Two- Year Follow-Up Study-

  • Kwak, Hyun-Mo;Chi, I-Cheng;Gardner, Stephen D.;Laufe, Leonard E.
    • Clinical and Experimental Reproductive Medicine
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    • v.10 no.1
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    • pp.1-6
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    • 1983
  • Women were used as their own controls in the comparison of presterilization and poststerilization menstrual patterns. Five parameters were studied: regularity of cycle length, duration and amount of flow and incidence of dysmenorrhea and intermenstrual bleeding. Three parameters in the electrocoagulation group (regularity of cycle length and duration and amount of flow) and one parameter in the tubal ring group (duration of flow) showed significant changes after sterilization. However, by controlling for the effect of previous contraceptive methods used, no significant menstrual pattern changes following sterilization were discerned in either technique group.

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Sleep Patterns and Early Adjustment in 1- to 3-year-old Children in Daycare (영유아의 수면양상과 어린이집 초기 적응)

  • Kim, Jinwook
    • Journal of Families and Better Life
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    • v.32 no.2
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    • pp.41-52
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    • 2014
  • The present study investigated the sleep patterns 1-to 3-year-old children and examined whether their sleep patterns would predict their early adjustment to daycare centers. The participants were 239 young children attending daycare centers in Seoul. The data on children's sleep patterns were collected by parent report. Children's adjustment to daycare was assessed by daycare providers' reports. The data were analyzed by means of Chi-square test, t-test, Pearson's correlation, ANOVA and discriminant analysis. The results were as follows: Children from dual-earner families had shorter nocturnal sleep duration than those from single-earner families. There was no significant relation between daytime sleep duration and sleep-onset time at night. It was found that children who go to bed earlier were more likely to get sufficient sleep without nocturnal wakefulness. Age and total sleep duration were seen to be significant variables when it came to discriminating between the adjustment versus maladjustment groups.

Sufficiency of the spectral shape in predicting peak and cumulative structural earthquake responses

  • Abdollahzadeh, Gholamreza;Sazjini, Mohammad
    • Earthquakes and Structures
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    • v.15 no.6
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    • pp.629-637
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    • 2018
  • In recent years, selection of strong ground motion records by means of intensity measures representing the spectral shape of the earthquake excitation has been studied by many researchers. These studies indicate the adequacy of this record selection approach in reduction of the scattering of seismic responses. In present study, this method has been studied more in depth to reveal the sufficiency of the spectral shape in predicting structural seismic responses such as the plastic deformation and the dissipated hysteresis energy which are associated with cumulative properties of the selected records. For this purpose, after selecting the records based on the spectral shape, the correlation of some seismic responses and strong ground motion duration of earthquake records are explored. Findings indicate strong correlation of some structural responses with the significant duration of the records. This fact implies that the spectral shape could not reflect all characteristics of the strong ground motion and emphasizes the importance of additional criteria along with the spectral shape in the record selection.

Relations between Information Items of Job Posting and Vacancy Duration in Mid-level Labour Market - by GLM, Decision Tree

  • Kim, Hyoungrae;Jeon, Dohong
    • Journal of the Korea Society of Computer and Information
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    • v.21 no.4
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    • pp.89-96
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    • 2016
  • In this paper, we study the relationship between vacancy duration and information items of a job posting by using generalized linear models and a decision tree analysis w.r.t. the three factors such as company characteristics, employment conditions, and constraints. The results indicate that the employment conditions rather than company characteristics are more influential to the vacancy duration. These effects are presumed to be based on the complex relations between the decisions of the employers and the job seekers. And in this paper we suggest the need to provide personalized and profiled labor market information tailored for a quick decision to job seekers and employers. Policy implication is that since employer's decision affects the vacation duration, employers may had better to provide a comprehensive labour market information including supply and demand of the required skills in order to reduce the time for judgment on the cost-effectiveness.