• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1975-1979
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• 2013

Aim: To investigate the level of expression of proto-oncogene Wip1 and its physiological significance in colorectal cancer. Methods: Immunohistochemistry, semi-quantitative RT-PCR, and Western blotting were used to analyze Wip1 mRNA and protein expression in 120 cases of colorectal cancer and normal tissues to study relationships with clinical symptoms and disease prognosis. Results: The level of Wip1 protein expression was found to be significantly higher in colorectal cancer tissues (85% (102/120)) than in normal tissues (30% (36/120)) (P<0.05). The relative amount of Wip1 protein in colorectal cancer tissue was also found to be significantly higher (P<0.05) than in normal tissues ($1.060{\pm}0.02$ and $0.640{\pm}0.023$, respectively). Semi-quantitative RT-PCR showed average Wip1 mRNA expression levels to be $1.113{\pm}0.018$ and $0.658{\pm}0.036$ for colorectal cancer tissue and adjacent normal tissue (P<0.05). The level of Wip1 protein expression was not correlated with age, gender, or tumor site, but appeared linked with lymph node metastasis, Dukes stage, histological grade, and liver metastasis. Individuals with high and low levels of Wip1 expression showed statistically significant differences in the five-year overall survival and recurrence-free survival rates (P<0.05). Conclusion: Wip1 mRNA and protein are highly expressed in colorectal cancers and may be associated with colorectal cancer development and progression.

• The Journal of Korean Medicine
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• v.22 no.2
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• pp.84-93
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• 2001

This research was to find out the protective and healing effects of both the Jiguyangwi-tang and the Gamijiguyangwi-tang on the gastric mucosa injuries by cyclophosphamide. At first, Jiguyangwi-tang and Gamijiguyangwi-tang extract were administered to the mice before one week, and then integral administration of those two drugs(each herbal extract and cyclophosphamide) were followed for another one week, respectively. After finishing those treatments, I have examined the state of the both ulcer and inflammation on the damaged gastric mucosa cell and watched the level of proliferating cell nuclear antigen(PCNA), Bcl-2, and apoptosis. These results were as follows, 1. Gastric mucosa inflammation have more significantly reduced in groups of integral administration of Jiguyangwi-tang plus cyclophosphamide, Gamijiguyangwi-tang plus cyclophosphamide and cyclophosphamide then in group of single cyclophosphamide. 2. Gastric ulcer have been reduced in groups of integral administration of Jiguyangwi-tang plus cyclophosphamide, Gamijiguyangwi-tang plus cyclophosphamide and cyclophosphamide then in group of single cyclophosphamide. But the significance have not shown. 3. PCNA level have more significantly elevated in integral administration of Jiguyangwi-tang plus cyclophosphamide and Gamijiguyangwi-tang plus cyclophosphamide and cyclophosphamide then in group of single cyclophosphamide. 4. The significance of both apoptosis induction and bcl-2level have not noticed among all groups. 5. Between Jiguyangwi-tang and Gamijiguyangwi-tang, the differance of effect was not admitted in statistically From these results, it is suggested that Jiguyangwi-tang and Gamijiguyangwi-tang are useful medicines in protecting gastric inflammation and ulcer, that is gastrointestinal side-effect of cyclophosphamide. The preventing effect of Jiguyangwi-tang and Gamijiguyangwi-tang may be through the 'affecting the period of cell division', but not the inhibition of apoptosis.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.1
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• pp.139-144
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• 2008

Generally, real system that is the object of decision-making is very variable and sometimes it lies situations with uncertainty. To solve these problem, it has used statistical methods as significance level, certainty factor, sensitivity analysis and so on. In this paper, we propose a method for fuzzy decision-making based on MFAC(Multiple Fuzzy Alpha Cut) to improve the definiteness of classification results with similarity evaluation. In the proposed method, MFAC is used for extracting multiple a ${\alpha}$-level with proximity degree at proximity relation between relative Hamming distance and max-min method and for minimizing the number of data which are associated with the partition intervals extracted by MFAC. To determine final alternative of decision-making, we compute the weighted value between extracted data by MFAC From the experimental results, we can see the fact that the proposed method is simpler and more definite than classification performance of the conventional methods and determines an alternative efficiently for decision-maker by testing significance of sample data through statistical method.

• Journal of Korea Port Economic Association
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• v.27 no.2
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• pp.27-38
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• 2011

The paper aims at examining the behavioral characteristics of the passenger car export of Gunsan, Pyeongtaek, and Ulsan port. This is accomplished by modelling export demand as exchange rate and the Unites States industrial production. All series span the period January 2001 to December 2010. I first show that both the series and the residuals are stationary at the 5 percent significance level. The result cannot reject the null hypothesis of a unit root in each of the level variables and of a unit root for the residuals from the cointegration regression at the 5 percent significance level. I hitherto make use of forecast error decomposition and historical decompositions The forecast error decomposition indicates that car export is endogenous to industrial production and exchange rate. The historical decompositions for the export show that the entire difference between actual export and the base forecast can be attributed to industrial production shocks since exchange rate moves closer to the actual data or the base forecast. It indicates that industrial production outperforms exchange rate in explaining the passenger car exports.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.4
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• pp.153-163
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• 2022

Purpose : The purpose of this study was to investigate the differences between uncertainty of chronic diseases and quality of life with regard to elderly people. Methods : The participants of this study were 350 elderly people, aged over 65 years. The collected data were analyzed using the SPSS Window program and the general characteristics of the participants and sub-domains of quality of life were analyzed by several frequency analyses and descriptive statistics such as mean, standard deviation, skewness, and kurtosis. Further, the differences between the sub-domains of uncertainty and sub-domains of quality of life were analyzed through independent t-test and one-way ANOVA. In order to reach conclusive results, post-test was analyzed by the Scheffe test. In addition, Pearson's correlation analysis was performed to determine the correlation between the target categories. A significance level of 𝛼=.05 was used to verify statistical significance. Results : As a result of examining "uncertainty" with respect to general characteristics, such as older age, low educational background, and chronic diseases, it was observed that the more intense these factors became, the more the level of uncertainty increased. In addition, it was also noted that except "accompanying diseases" in social domain, the participants enjoyed a high level of quality of life. The correlation was noted between domains of complexity and sociality (p<.01), domains of inconsistency and sociality (p<.01), domains of complexity and living environment (p<.01), domains of inconsistency and living environment (p<.01), and total score of uncertainty and total quality of life (p<.01). Conclusion : In this study, differences were found between "uncertainty" and "quality of life" of elderly people; the correlation between the sub-domains based on general traits was found to be negative (-). This suggests that objective evidence can be presented for the prevention of diseases by using mental health programs for the elderly in future.

• Journal of the Daesoon Academy of Sciences
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• v.28
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• pp.165-206
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• 2017

In Daesoon Jinrihoe (The Society of Daesoon Truth), pilgrimages can serve as a medium to experience and spread Daesoon Thought. The purpose of this study is to gauge the empirical impact that the motive of a pilgrimage has on the satisfaction level of the participant and the participant's willingness to revisit the holy place. This study further suggests a variety of propositions to promote pilgrimages and thereby Daesoon Thought. This study employs hierarchical analysis for measuring the correlation between all factors the pilgrimage can entail and also the moderator variables (holy places) in the pilgrimage. The study reveals that empirical motive is one of the most influential factors in determining a given participant's level of satisfaction and willingness to revisit said holy place. It is also revealed also that the religious significance of a holy place plays an important role in satisfaction and future revisitation. This study claims pilgrimages are a form of learning and cultural exchange which promotes Daesoon Thought that enables maturity of religious faith. Thereby, all stake holders in the Daesoon Jinrihoe community including clergy should increase their efforts to raise awareness and recognition of Daesoon Truth.

• Journal of the Korean Institute of Landscape Architecture
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• v.28 no.4
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• pp.66-74
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• 2000

The purpose of this study is to research and analyze the distribution of night illumination level at urban neighborhood parks and to show its characteristics. And this is used basic data ensuring safety and satisfying aesthetic and psychological desires of people who use urban neighborhood parks at night. To research and analyze the distribution of illumination level at urban neighborhood parks at night. To research and analyze the distribution of illumination level at urban neighborhood parks, I selected 8 urban neighborhood parks as the subject of research in this study, set the measuring standard of illumination level, and measured the illumination level by the measuring standard. The results of this study are as follows; 1. Currently, total average illumination level of urban neighborhood parks was lower than the minimum standard of illumination level I KS A 3011-1993. 2. Average illumination level of each place in urban neighborhood parks appeared variously from low level to high level. But this was lower than the minimum standard illumination level in KS A3011-1993 like total average illumination level. 3. The higher was total average illumination level of urban neighborhood parks, the more various was brightness of places. Although users' aesthetic and mental desire or behavioral aspect relate with safety cannot be found by only survey and analyses of illumination level, it is judged that first, illumination level of the standard of the lightness should be analyzed to find user's mental states and behaviors in external space at night. Therefore, it is considered that this study, which analyzed characteristics illumination level as basic data, has a significance. The study continuing for other illuminative environmental factors suitable in the place is required because the brightness of places may not be measured by only illumination level. And the proper illumination level in outdoor places should be showed in considering psychological and behavioral aspects of human as people may have their own sense of brightness.

• Journal of the Korea Safety Management & Science
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• v.11 no.4
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• pp.153-159
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• 2009

This study was conducted in search of the acceptance level of air traffic services from domestic airlines pilot's perspective in comparison with male controllers and female controllers. Pilots responded to the questionnaire that female ATC controllers are of significance to male controllers in terms of pronunciation, accuracy of English grammar, attitude and kindness. Besides, The ICAO aviation English proficiency level four test revealed that female controllers were found superior to male controllers in terms of rating scales of holistic descriptors.

• Journal of Oriental Neuropsychiatry
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• v.24 no.1
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• pp.93-102
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• 2013

Objectives : The purpose of this study is to investigate the practice level of Yangseng according to nicotine dependence. Methods : The subjects of this study were 137 male smokers in their thirties and forties, who visited Wonmi Public Health Center. They were evaluated with Fagerstorm's test for nicotine dependence (FTND) and Tool in Measuring Yangseng (TMY). By FTND score, they were divided into three groups; the mild nicotine dependent group, moderate group and severe group. Results : In TMY score, there were statistically significant differences in the characteristics of Diet, Activity & Rest, Sleep and total score among the three groups. The value of FTND comparing the values of Mind, Diet, Activity & Rest, Sleep and total score in this study resulted in negative correlations, which showed statistical significance. Conclusions : The above results suggest that there are significant relations between nicotine dependence and the practice level of Yangseng. These results can be used for planning a smoking cessation program and a Yangseng health promotion program based on Korean traditional medicine.

• Journal of Biosystems Engineering
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• v.23 no.4
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• pp.335-342
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• 1998

The objectives of this study were to evaluate respiration characteristics and develop empirical respiratory rate equations for short gain rough rice. The carbon dioxide concentrations generated from mush rice at four level temperatures(10, 20, 30, 4$0^{\circ}C$) and 4 level moisture contents(17.2, 21.5, 25.9, 31.6％, d.b.) were measured by gas chromatography. The respiratory rates' increased exponentially with gain temperature and also with moisture content The relationship between respiratory rate and gain temperature fitted the Arrehenius' and Core's equations very well. Two empirical respiratory rate equations were presented as a function of gain temperature and moisture content. The values of determination coefficient for the developed respiratory rate equations were 0.999, and the result of t-test showed that there were no significant differences between predicted and measured respiratory rates on significance level of 1%. Therefore, it appeared that respiratory rates predicted by the respiratory rate equations agreed well with measured values. An equation for predicting dry matter losses of rough rice during storage was presented by modifying the respiratory rate equations based on chemical reaction of decomposition of carbohydrate.