• Molecules and Cells
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• 제39권1호
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• pp.6-19
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• 2016

Redox signalling comprises the biology of molecular signal transduction mediated by reactive oxygen (or nitrogen) species. By specific and reversible oxidation of redoxsensitive cysteines, many biological processes sense and respond to signals from the intracellular redox environment. Redox signals are therefore important regulators of cellular homeostasis. Recently, it has become apparent that the cellular redox state oscillates in vivo and in vitro, with a period of about one day (circadian). Circadian timekeeping allows cells and organisms to adapt their biology to resonate with the 24-hour cycle of day/night. The importance of this innate biological timekeeping is illustrated by the association of clock disruption with the early onset of several diseases (e.g. type II diabetes, stroke and several forms of cancer). Circadian regulation of cellular redox balance suggests potentially two distinct roles for redox signalling in relation to the cellular clock: one where it is regulated by the clock, and one where it regulates the clock. Here, we introduce the concepts of redox signalling and cellular timekeeping, and then critically appraise the evidence for the reciprocal regulation between cellular redox state and the circadian clock. We conclude there is a substantial body of evidence supporting circadian regulation of cellular redox state, but that it would be premature to conclude that the converse is also true. We therefore propose some approaches that might yield more insight into redox control of cellular timekeeping.

• The Korean Journal of Physiology and Pharmacology
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• 제5권2호
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• pp.139-146
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• 2001

L-type $Ca^{2+}$ channels play an important role in regulating cytosolic $Ca^{2+}$ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated the role of some kinase activators and inhibitors in the regulation of the L-type $Ca^{2+}$ channel currents in rat pituitary $GH_3$ cells using the patch-clamp technique. Phorbol 12,13-dibutyrate (PDBu), a protein kinase C (PKC) activator, and vanadate, a protein tyrosine phosphatase (PTP) inhibitor, increased the $Ba^{2+}$ current through the L-type $Ca^{2+}$ channels. In contrast, bisindolylmaleimide I (BIM I), a PKC inhibitor, and genistein, a protein tyrosine kinase (PTK) inhibitor, suppressed the $Ba^{2+}$ currents. Forskolin, an adenylate cyclase activator, and isobutyl methylxanthine (IBMX), a non-specific phosphodiesterase inhibitor, reduced $Ba^{2+}$ currents. The above results show that the L-type $Ca^{2+}$ channels are activated by PKC and PTK, and inhibited by elevation of cyclic nucleotides such as cAMP. From these results, it is suggested that the regulation of hormone secretion by various kinase activity in $GH_3$ cells may be attributable, at least in part, to their effect on L-type $Ca^{2+}$ channels.

• 한국통신학회논문지
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• 제39C권9호
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• pp.880-886
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• 2014

열차제어시스템은 최근의 컴퓨터 기술의 발달에 따른 자동화 및 지능화에 따라 소프트웨어에의 의존성이 더욱 증가하고 있으며, 동시에 소프트웨어의 오류 내재 가능성이 높아지고 실제 장애발생으로 인한 위험비용도 증가하고 있다. 이에 따라 열차제어시스템 소프트웨어의 무결성 검증이 매우 중요한 이슈가 되고 있으며, 이 중에서 열차제어 소프트웨어 기능안전성 검증을 위한 블랙박스 테스팅 도구의 필요성이 제기되고 있으나, 기존 상용도구들은 사용하기 어렵고 복잡하여 실제 현장에서 적용이 거의 되지 않고 있다. 본 논문에서는 이러한 분석을 바탕으로 열차제어시스템 소프트웨어 기능안전성 검증을 위한 실제 사용하고 있은 인터페이스를 통한 새로운 개념의 블랙박스 테스팅 도구를 제안하였다. 현재 제안한 도구의 설계 및 프로토타입이 개발되어 열차제어시스템 소프트웨어 테스팅에 시범적용 중에 있다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2002년도 하계학술대회 논문집 B
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• pp.1205-1207
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• 2002

As going through technical transition of signal control logic to mechanic, electric, electronic etc., railway signalling system utilizing computer control technology has recently been developed and used since railroad service had been firstly started in 1825 by beginning that horseman kept red color sign and notified something wrong existence and nonexistence of front route to train driver in the Britain. In this paper, the domestic technical change process of signalling technology to be a basic of train control technology is discussed and then reviewed about technical trend of advanced nation's development.

• 전기학회논문지
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• 제65권1호
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• pp.208-213
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• 2016

In order to detect the exact position of high-speed train, it is necessary to obtain location information from the transponder tag installed along the track. When the transponder tag receives the energizing signal from the train, it sends a telegram to the reader, which includes location information. In high-speed railway environment, this telegram can be corrupted by electromagnetic interference caused by onboard electric train power equipments or wayside devices. In order to assess the performance of transponder system under this harsh environment, we carried out field test using HEMU-430X. Field test results are briefly introduced and discussed for the evaluation of the transponder system under development.

• 한국통신학회논문지
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• 제14권6호
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• pp.621-632
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• 1989

기존망이 ISDN으로 가는 과도기적 단계에서 발생할 수 있는 다양한 망 접속 및 가입자/망간 접속에 대처하기 위해서는 각종 정합 장치 및 이에 적용될 실현 기준과 알고리즘의 개발이 필수적이다. 본 논문에서는 ISDN신호 방식과 기준망의 신호 방식을 정합 시킬 수 있는 방안을 연구, 검토한 후 ISDN 가입자 단말 장치를 기존망이 효과적으로 수용 가능한 신호 정합 방안을 제안하였다. 또한 이에 기초한 신호 정합 장치를 구현하여 본 연구의 타당성과 그 효용성을 검증하였다.

• 전자공학회논문지B
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• 제28B권5호
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• pp.369-381
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• 1991

In this paper, design algorithms for SMP(Single Mated Pair) and MMP (Multipli Mated Pair) structure of CCS (Common Channel Signaling) network are proposed through the study of the structure of CCS network. High reliability and fast messagy transfer time are the most important requirements for the CCS network. Based on it, three parameters such as monotraffic, reliability (maximum isolated SP(Signalling Point) number when any two STP(Signalling Transfer Points) fail and total network cost are defined. And the proposed algorithms different from preexisted algorithm that minimizes total network cost, maximize monotraffic with two constraints, reliability and total network cost. Comparing the experimental results of the proposed algorithms with those of the preexisted algorithm that minimizes total network cost, shows that the proposed algorithms produce a more reliable topology that has more monotraffic and a little higher total network cost. Additionaly, with the results of the proposed algorithms, SMP and MMP structures are compared.

• 한국철도학회:학술대회논문집
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• 한국철도학회 1998년도 창립기념 춘계학술대회 논문집
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• pp.427-435
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• 1998

In this paper will be presented an algorithm for designing of a railway interlocking table which is a document describing the functional specification of the interlocking device. The ability to produce an interlocking table has been handed down in the signalling engineers society. And the signalling engineer makes the most of his expertise to produce an interlocking table. But, the expertise has not yet been organized into technical system, the core of the expertise is a hard nut to crack. Therefore, we analyze into signal engineering expertise, and propose a generalization of interlocking notion. Also, an algorithm is drawn up based on a train route setting principle to solve practical and general problems by computer And the performance of the algorithm is evaluated for test program based on AutoCAD technology. The evaluation result shows that it can be utilized as the effective algorithm for computer control of the signalling system as interlocking device, that it improved in safety

• 대한전기학회:학술대회논문집
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• 대한전기학회 2000년도 하계학술대회 논문집 B
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• pp.1387-1389
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• 2000

Railway signalling system is required to be high safety against collision, derailment and collision at level crossing and to be high availability. The signalling system is usually divided into automatic train control, interlocking and centralized traffic control systems and each system must be high fail safe and availability. This study focused on reliability calculation of vital systems in train control system.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2001년도 학술 발표회 진행표 및 논문초록
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• pp.54-54
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• 2001

The effects of protein kinase C inhibitors, chelerythrine and bisindolylmaleimide I, on acetylcholine activated $K^{＋}$ currents ( $I_{KACh}$) were examined in atrial myocytes of mice using patch clamp technique. Chelerythrine and bisindolylmaleimide I inhibited $I_{KACh}$ in reversible and dose-dependent manners. Half maximal effective concentrations were 0.49 $\pm$ 0.01 $\mu$M for chelerythrine and 98.69 $\pm$ 12.68 nM for bisindolylmaleimide I.(omitted)