• 비파괴검사학회지
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• 제22권6호
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• pp.649-658
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• 2002

As an attempt to further improve the reliability and effectiveness of ultrasonic testing (UT), a two-dimensional numerical simulator of UT was developed. The simulator models the wave medium (or test object) using the mass-spring lattice model (MSLM) that consists of mass-points and springs. Some previous simulation results, obtained by using MSLM, are briefly reviewed in this paper, for propagation, reflection, and scattering of ultrasonic waves. Next, the models of transmitting and receiving piezoelectric transducers are introduced with some numerical results, which is a main focus of this paper. The UT simulator, established by combining the transducer models with the MSLM, was used to simulate many UT setups. In this paper, two simple setups are considered as examples, and their simulated A-scan signals are discussed. The potential of the MSLM, transducer models, and the UT simulator developed in this study to be used in the actual UT is confirmed.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2813-2818
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• 2015

Objective: To investigate the regulatory effect of curcumin on expression of signal transducer and activator of transcription 3 (STAT3) in skin squamous cell carcinoma tissues as well as possible mechanisms of curcumin in prevention and treatment of skin squamous cell carcinoma. Materials and Methods: Highly invasive A431 cells were treated with curcumin at various doses .The cytotoxic effects of treatment with 5, 10, 15, 20, 25, 30, 35, 40 and 50 umol/L curcumin for 24, 48 and 72 hours on A431 cells were measured by MTT assay. The invasion capacity of cells treated with 5, 10 and 15 umol/L curcumin was measured by Transwell test, while adhesive ability was assessed by cell adhesion assay. The effects of 5,10 and 15 umol/L curcumin on expression levels of STAT3 were determined by Western blotting and on transcription levels of STAT3 mRNA by RT-PCR. Results: Treatment with curcumin at a doses of more than 15 umol/L for more than 24 hour inhibited the growth of A431 cells in a time-and dose-dependent fashion (p<0.001). The doses of 15 umol/L and less for 24 hours showed no significant cytotoxic effects on the cells, survival rates being more than 85%.The invasion and adhesive abilities decreased gradually with the increasing curcumin concentration, 15 umol/L exerting the strongest inhibitory effects (p<0.05). Curcumin showed significant dose-dependent inhibitory effects on the transcription level of STAT3 mRNA (p<0.05). Conclusions: Curcumin may reduce the invasive ability of A431 cells by inhibiting the activation of STAT3 signal pathway and expression of STAT3 as a target gene in the pathway.

• 한국전자통신학회논문지
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• 제12권1호
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• pp.53-60
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• 2017

현재 대부분의 초음파를 이용한 거리 측정 기술은 송신부로부터 수신기까지 초음파가 진행하는 시간 즉, TOF(: Time of Flight)를 측정하여 그 동안 음파가 진행한 거리를 산출하는 방법을 활용한다. 이 경우 거리 측정 정확도를 높이기 위해서는 정확한 TOF의 측정이 필요하다. 본 논문은 정확한 TOF를 산출하기 위해 초음파 송수신기의 수학적 모델을 이용하여 수신된 파형의 수학적 모델을 얻어내고 이를 바탕으로 TOF를 산출하는 방식을 제안한다. 이 방식은 트리거링 후부터 수신된 파형를 이미 얻어진 수학적 모델과 최소자승법을 이용하여 비교하여 초음파 신호가 수신기에 도달한 시점을 역으로 추정하는 방식이다. 제안된 방법을 사용할 경우 트리거링 시점의 변동에 의한 영향을 줄일 수 있음을 실험을 통하여 확인하였다.

• 융합신호처리학회논문지
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• 제15권2호
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• pp.64-69
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• 2014

초음파(Ultrasound) 시스템은 진단의학분야, 수중통신, 센서네트워크 등 현대산업분야에 광범위하게 사용되는 복잡한 무선 신호처리 시스템 중 하나이다. 최근에는 초음파 시스템의 소형화가 본격화 되고 있다. 본 논문에서는 소형화되고, 모바일화 되는 진단 초음파시스템에 적합한 혼성 저잡음증폭기(Low Noise Amplifier, LNA)를 개발 하였다. 제안된 LNA는 5dB이하의 낮은 잡음특성을 가지고, 다양한 초음파 변환기(Transducer)의 임피던스매칭을 위해 피드백 저항값들을 전기적으로 조정할 수 있도록 설계하였다. 주파수는 10kHz에서 150MHz까지 초음파주파수 전 대역을 지원할 수 있고, 슬립모드를 지원한다. 시스템의 특성에 맞춰 각각의 변환기를 통해 -17.8dB-29.5dB의 이득을 갖는다. 기존의 LNA와 비교해서 비슷한 성능에 소모전력은 최대 90%를 줄일 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제23권3호
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• pp.227-233
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• 2002

이식형 인공중이는 음질과 주파수 특성이 우수하며 기존의 공기전도형 보청기가 가지는 고이득에서의 왜곡과 음향 피이드백에 의한 링잉 현상을 해소할 수 있어 차세대 보청기로 주목받고 있다 특히 두 개의 영구자석을 같은 극기리 접착한 후 코일내부에 위치시킨 타동 전자 트랜스듀서 방식의 이식형 인공중이는 외부의 자기장에 대해 영향을 받지 않으며 진동효율이 높고 자석과 코일의 간격조정이 필요 없는 동시에 주파수 응답특성이 우수하다. 본 연구에서는 이식형 인공중이에 사용하위해 개발된 타동 전자 트랜스듀서의 음향 모델을 구현한 후 정상인의 귀의 청각 모델에 적용시켜 트랜스듀서를 통하여 내이로 전달되는 신호의 주파수 특성을 해석하였다. 해석된 결과를 정상인의 귀의 주파수 특성과 비교함으로써 인공중이를 사용할 경우와 정상인의 귀와의 신호전달 특성 차이를 조사하였고 이를 통하여 정상인의 청각특성에 가까운 신호를 전달시킬 수 있는 인공중이의 설계가 가능하도록 하였다.

• Restorative Dentistry and Endodontics
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• 제26권2호
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• pp.134-140
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• 2001

The polymerization shrinkage of composite resins is an important drawback although the composites have many advantages-more esthetic and conservative than metallic restoratives etc. The purposes of this research were to develop a new measurement method and to manufacture an instrument that can measure the initial dynamic volumetric shrinkage of composite resins during polymerization. The instrument was basically an electromagnetic balance that constructed with a force transducer using position sensitive photo detector(PSPD) and a negative feedback servo amplifier of proportional-derivative(PD) controller. The volumetric change of composites during polymerization was detected continuously as buoyancy change in distilled water by means of Archimedes's principle. It was converted to continuous electrical voltage signal in real time. The signal was properly conditioned and filtered and then it was stored in computer by a data acquisition(DAQ) board. By using this electronic instrument. the dynamic patterns of the polymerization shrinkage of eight commercial(Z-100, DenFil, AeliteFil, Z-250, P-60, SureFil, Synergy compact, and Tetric ceram) composite resins were measured and compared. The results were as follows. 1. From this project of developing instrument, the ability has been achieved that can acquire and process data of electrical signal transformed from various physical phenomenon by using temperature, displacement. photo. and force transducer. As a consequence, the instrumentation and measurement system used to analyze the physical characteristics of various dental materials in dental research field can be designed, manufactured and implemented in lab. 2. This instrument has some advantages. It was insensible to temperature change and could measure true dynamic volumetric shrinkage in real time without complicated process. It showed accuracy and high precision results with small standard deviation. 3. The polymerization shrinkage of composites was significantly different between brands and ranged from 2.47％ to 3.89％, The order of polymerization shrinkage was as follows, in order of increasing shrinkage, SureFil, P60, Z250, Z100, Synergy compact. DenFil, Tetric ceram, and AeliteFil. 4. The polymerization shrinkage rate per unit time, dVol％/dt, showed that the instrument can provide an indirect research method for polymerization reaction kinetics.

• Animal cells and systems
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• 제9권3호
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• pp.139-144
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• 2005

The attractant (orange light) or repellent (white light) signal is transmitted from SRI (Sensory Rhodopsin I) via protein-protein interaction with its transducer Htrl (Halobacterial Transducer for Sensory Rhodopsin I) which in turn controls a cytoplasmic phospho-transfer pathway that modulates flagella motor switching in Halobacterium salinarum. Some mutations in both SRI and Htrl showed an unusual mutant phenotype called inverted signaling, in which the cell produces a repellent response to normally attractant light. Twelve mutations at the Glutamate 56 (E56) position in the second transmembrane helix of Htrl were introduced by site-specific random mutagenesis. Almost all E56 mutants showed orange-light inverted responses in pH and temperature-dependent manners except E56D and E56Y. Except for these two mutants, all mutants accelerated the $S_{373}$ decay compared to wild-type at $18^{\circ}C$. This supported that there is an interaction between SRI and the second transmembrane of Htrl. Also a structural model of Htrl based on the Tar crystal structure and the secondary structure prediction program proposed the E56 residue to be in the middle of the proton channel. The most important observation is that the E56 mutant provides the evidence that this residue is very sensitive for signal relay, which can be explained by the open and closed conformations of the channel (A and R conformations) in SRI, as was postulated by the unified conformational shuttling model for transport and signaling.

• Journal of Electrochemical Science and Technology
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• 제14권1호
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• pp.51-58
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• 2023

The effective detection of human chorionic gonadotropin (HCG) is considerably important for the clinical diagnosis of both of early pregnancy and nonpregnancy-related diseases. In this work, a simple and sensitive electrochemical sandwich-type immunosensing platform was designed by synthesizing b-cyclodextrin (CD) functionalized graphene (CD/GN) hybrid as simultaneously sensing platform and signal transducer coupled with rhodamine b (RhB) as probe. In brief, GN offers large surface area and high conductivity, while CD exhibits superior host-guest recognition capability, thus the primary antibody (Ab1) of HCG can be bound into the cavities of CD/GN to form stable Ab1/CD/GN inclusion complex; meanwhile, the secondary antibody (Ab2) and RhB can also enter into the cavities, producing RhB/Ab2/CD/GN complex. Then, by using Ab1/CD/GN as sensing platform and RhB/Ab2/CD/GN as signal transducer (in which RhB was signal probe), a simple sandwich-type immunosensor was constructed. Under the optimum parameters, the designed immunosensor exhibited a considerable low analytical detection of 1.0 pg mL^-1 and a wide linearity of 0.002 to 10.0 ng mL^-1 for HCG, revealing the developed sandwich-type electrochemical immunosensing platform offered potential real applications for the determination of HCG.

• 한국해양공학회지
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• 제28권1호
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• pp.55-63
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• 2014

In this paper, we propose an threshold-based Schur algorithm for estimating the media characteristics of sub-bottom multi-layers by using the signal generated by a parametric array transducer. We use the KZK model to generate a parametric array signal, and use the proposed threshold-based Schur algorithm for estimating the reflection coefficients of multiple sea bottom layers. Using computer simulation, we verify that the difference frequency component generated by the KZK model prevails over the signals of primary frequencies at long range. For the simulation, we use the transmit signal generated by the KZK and the reflected signal obtained from a lattice filter model for the seawater and sub-bottom of multi-level non-homogeneous layers. Through the simulation, we verify that the proposed threshold-based Schur algorithm can give much more accurate and efficient estimates of the reflection coefficients than methods using received signal, matched filter output signal, and normal Schur algorithm output.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1993년도 춘계학술대회 논문집
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• pp.198-203
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• 1993

In this study, byusing EMAT(Electro Magnetic Acoustic Transducer) the artificial slit is installed on 12B-SUS pipe test piece. By mading 4 cycle SH-bust wave (EMA) incidence to 45 .deg. angle, the signaldata of pulse, which is recevied from EMAT translated intodigital-signal-processing-method SSP and Deconvolution method by using FACOM. Results of these indicated that (1) this method of this study shows exellent result more than Ultrasonic testing method; (2) noise is well removed by SSP using signal dataa and resolving power and S/N ratio are advanced; (3) regradless of Ultrasonic wave, whichhas properties of generalstainless steel is generated into multiscattering and reflection phenomena, the resolving power of more than two times is progressed by being translated into Decon-volution method; and (4) as addition-averaging-processing number is increaing, the resolving power and S/N ratio are improved and the satisfactory signal is obtained.